scholarly journals Socio-Demographic Factors and Epidemiological Characteristics of HIV-Positive Pregnant Women with High Risk of Vertical Transmission of the Immunodeficiency Virus

2021 ◽  
Vol 11 (4) ◽  
pp. 564-569
Author(s):  
Anastasiya Vanyarkina ◽  
Alla Petrova ◽  
Lyubov Rychkova ◽  
Ekaterina Moskaleva ◽  
Evgeniya Novikova
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Social History ◽  
Vertical Transmission ◽  
Inflammatory Diseases ◽  
Virus Transmission ◽  
Hiv Positive ◽  
Hiv Positive Women ◽  
Immunodeficiency Virus ◽  
Epidemiological Characteristics

The purpose of this study was to determine the features of the course of pregnancy, delivery, and the postpartum period in HIV-positive women with a high risk of HIV vertical transmission. Methods and Results: A retrospective, longitudinal cohort study of mother-child pairs for the period from 2017 to 2019 was conducted in the Irkutsk City Perinatal Center (level III). The clinical observation group included HIV-positive women (n=213) and their newborn children with a high risk of perinatal immunodeficiency virus transmission (n=214). The findings of the conducted study demonstrated that most HIV-seropositive women with a high risk of HIV vertical transmission had an aggravated social history, a high prevalence of pelvic inflammatory diseases, and a high incidence of opportunistic and AIDS-defining conditions. Evaluation of PMTCT preventive complex showed that the target parameters in women with a high risk of HIV transmission were not reached: the first stage was performed for 49.3% of pregnant women with good ART adherence, the second stage – for 97.1% of obstetric patients, the third stage – in 100% of HIV perinatally exposed children. HIV RNA was detected in 3.7% of children, which evidences their antenatal infection. Conclusion: Development of efficient communication with HIV-positive women aimed at preservation of their health and decrease of logistic barriers to access to medical care.

scholarly journals Human papillomavirus (HPV) genotypes and HPV16 variants in human immunodeficiency virus-positive Italian women

2008 ◽  
Vol 89 (6) ◽  
pp. 1380-1389 ◽  
Author(s):  
Maria Lina Tornesello ◽  
Maria Luisa Duraturo ◽  
Paolo Giorgi-Rossi ◽  
Matilde Sansone ◽  
Roberto Piccoli ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Papillomavirus ◽  
High Risk ◽  
Hiv Positive ◽  
Sequencing Analysis ◽  
Hiv Positive Women ◽  
Immunodeficiency Virus ◽  
Hpv Genotypes ◽  
Italian Women ◽  
Hiv Negative

Human immunodeficiency virus (HIV)-positive women have high rates of cervical squamous intraepithelial lesions (SIL) and concurrent human papillomavirus (HPV) infections with a variety of genotypes whose oncogenic risk is poorly documented. The prevalence and persistence of HPV genotypes and HPV16 variants were analysed in 112 HIV-positive and 115 HIV-negative Italian women. HIV-positive women were more likely than HIV-negative women to be infected by HPV at the initial examination (39.3 vs 13.9 %, P<0.001) and to have a higher period prevalence of HPV infection over a 3-year follow-up (43.8 % vs 17.4 %, P<0.001), regardless of CD4+ cell counts and anti-retroviral therapy. ‘High-risk’ and ‘probable high-risk’ HPVs (types 16, 18, 31, 33, 35, 45, 52, 58 and 66), among the 20 different viral genotypes identified, were predominant in HIV-positive (33.9 %) compared with HIV-negative (13.9 %) women. Among HIV-infected women, with normal cytology as well as with SIL of any grade, the most common genotypes were HPV16 followed by HPV81, -58, -72, -33 and -62. HPV16 isolates from 18 HIV-positive and eight HIV-negative women were classified into variant lineages based on sequencing analysis of E6 and E7 genes and the long control region. Whilst the HPV16 G350 European variant was prevalent in both HIV-positive (10.7 %) and -negative women (3.5 %), HPV16 African 2 variant was only detected in HIV-positive women (3.6 %), suggesting different sexual mixing behaviours. The increased prevalence of uncommon viral genotypes and HPV16 variants in HIV-positive Italian women underscores the need to target a wide range of HPV types in cervical screening of high-risk women.

scholarly journals Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique

Viruses ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 24
Author(s):  
Cremildo Maueia ◽  
Alltalents Murahwa ◽  
Alice Manjate ◽  
Soren Andersson ◽  
Jahit Sacarlal ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Papillomavirus ◽  
High Risk ◽  
Hiv Positive ◽  
Study Cohort ◽  
Hpv Prevalence ◽  
Hiv Positive Women ◽  
Immunodeficiency Virus ◽  
Hpv Types ◽  
Hiv Negative

Background: Human papillomavirus (HPV) infection is now a well-established cause of cervical cancer and other anogenital cancers. An association between human immunodeficiency virus (HIV) infection and higher HPV incidence and prevalence are commonly reported. This study was conducted to demonstrate HPV prevalence, genotypes and its characteristics, according to the HIV status in women from Maputo in Mozambique. Methods: A total of 233 participants with ages ranging from fourteen to forty-five were included. Cervical samples were collected, DNA extracted, and HPV genotyping was performed using the HPV Direct Flow CHIP Kit. Results: In total, 177 HIV-negative and 56 HIV-positive women were included in the analysis. The overall HPV prevalence was 63% and was significantly higher among HIV-positive women (79% versus 58% among HIV-negative women; p = 0.005). The prevalence of multiple HPV type infections was 32%. High-risk HPV types 52, 68, 35, 18 and 16 were the most frequent. A higher proportion of HIV-positive women had multiple HPV types compared with HIV-negative women. Conclusions: This study demonstrated a high prevalence of HPV in the study cohort. HIV-positive women were identified as having the highest HPV prevalence and infection with multiple HPV types across all ages. High-risk genotypes were the most commonly found.

scholarly journals The Human papillomavirus among women living with Human Immunodeficiency Virus in Morocco A prospective cross-sectional study

2018 ◽  
Vol 12 (06) ◽  
pp. 477-484 ◽  
Author(s):  
Ahd Ouladlahsen ◽  
Naouar Fayssel ◽  
Rajaa Bensghir ◽  
Hanâ Baba ◽  
Hassan Lamdini ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Papillomavirus ◽  
High Risk ◽  
Hpv Infection ◽  
Hiv Positive ◽  
Cell Counts ◽  
Hiv Positive Women ◽  
Immunodeficiency Virus ◽  
High Prevalence ◽  
Hpv Types

Introduction: Women infected with human immunodeficiency virus (HIV) have a higher risk of contracting human papillomavirus (HPV) infections and are more prone to develop cervical cancer. The objective of this study was to determine the prevalence of HPV and its association with risk factors among Moroccan women living with HIV/AIDS. Methodology: We enrolled 251 HIV-infected non-pregnant women in Morocco from February 2013 to September 2016. Sociodemographic, lifestyles, behavioral and clinical data were collected. Polymerase chain reaction followed by sequencing were performed for molecular detection and HPV genotyping in cervical samples, respectively. Results: Abnormal cervical smears were found in 34/246 patients (13.82%). The overall prevalence of HPV was 74.50%. HPV 58 was the most prevalent (39.29%) followed by HPV 18 (10.71%), HPV 70 (8.93%), HPV 33 (7.14%), HPV 6 (6.25%) and other genotypes (< 3%). Overall, high-risk HPV (HR-HPV) types were present in 75% (84/112) of patients and the prevalence of HR-HPV types in samples with abnormal Pap was higher than in normal Pap (55/83, 66.27% vs. 28/83, 33.33%, p < 0.0001). Univariate analyses showed that none of the socio-demographic and behaviors factors was associated with HPV infection. Moreover, Pap results were not affected by HPV status (p = 0.532). Whereas, CD4 T-cell counts above 200/mm3 at enrolment were apparently not protective to HPV infection. We found a high prevalence of HPV infection and HR-HPV types among HIV-positive women that significantly associated with abnormal Pap. Conclusion: Our findings suggest a high prevalence of HPV infection with high-risk types was observed among HIV-positive women warrant to implement a regular screening by Pap smear.

scholarly journals Periodontal Manifestations in Pregnant Women : Study of 208 pregnancies at the CHU Gabriel Touré, Bamako

2017 ◽  
Author(s):  
Ousseynou Diawara ◽  
Boubacar Ba ◽  
A Niang ◽  
A Bocoum ◽  
E.D Tchonang Mani ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Pregnant Women ◽  
Medical Records ◽  
High Frequency ◽  
Analytical Study ◽  
Married Women ◽  
Hiv Positive ◽  
Hiv Positive Women ◽  
Chu Gabriel Touré ◽  
Epidemiological Characteristics

Aims: The aims of this study was to investigate the epidemiological characteristics of periodontal disease observed in pregnant women attending antenatal clinics in the Department of Obstetric Gynecology CHU- Gabriel Touré of Bamako.Materials and Methods: We realized a transverse, analytical study based on the observation of the periodontal status of pregnant women over 2 months (May-July 2013), 208 observations identified prenatally. Data were collected from medical records, entered and analyzed using SPSS 19.0 software.Results: We included 189 cases (90, 90 %). The age group most affected was that of 20-29 years (52, 40 %) with a mean age of 26, 88 and extremes ranging from 10 to 45 years. Married women were represented, with 94, 70 % of the cases, they were multigravidae in 71, 00 % of cases. Housewives accounted for 40, 40 %. HIV positive women represented 14, 00 % of the sample. The CPITN index corresponding to the scaling was greater in patients, between 11 weeks and 41 weeks 'gestation.Conclusion: This study shows the high frequency of periodontal disease in pregnant women, hence the importance of partnership between healths professional's reproduction and those of oral cavity.

scholarly journals Identification of Genetic Variants of Human Papillomavirus in a Group of Mexican HIV/AIDS Patients and Their Possible Association with Cervical Cancer

2021 ◽  
Vol 70 (4) ◽  
pp. 501-509
Author(s):  
FELIPE ORTIZ-GUTIÉRREZ ◽  
LILIA SÁNCHEZ-MINUTTI ◽  
JOSÉ F. MARTÍNEZ-HERRERA ◽  
INDIANA D. TORRES-ESCOBAR ◽  
ELIAS B. PEZZAT-SAID ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Genetic Variants ◽  
Direct Relationship ◽  
Low Risk ◽  
Hiv Positive ◽  
Hiv Positive Women ◽  
Immunodeficiency Virus ◽  
Regional Population ◽  
Polymerase Chain

Infections caused by the human immunodeficiency virus (HIV) and human papillomavirus (HPV) cause thousands of deaths worldwide each year. So far, there has been no consensus on whether there is a direct relationship between the incidence of neoplasms and the immunosuppression caused by HIV that could help understand if coinfection increases the likelihood of cervical cancer. The objective of the study was to identify the presence of genetic variants of HPV in a group of HIV-positive women and their possible association with cervical cancer. Cervical samples were taken from HIV-positive patients for cytological analysis to identify the HPV genotype by polymerase chain reaction (PCR) and sequencing. The most preva¬lent L1 capsid protein mutations in the HPV genotype were ana¬lyzed in silico. Various types of HPV were identified, both high-risk (HR) and low-risk (LR). The most prevalent genotype was HPV51. Analysis of the L1 gene sequences of HPV51 isolates showed nucleo¬tide variations. Of the samples analyzed in Puebla, Mexico, HPV51 had the highest incidence (17.5%, 7/40). Different mutations, which could be used as population markers, were detected in this area, and they have not been reported in the L1 databases for HPV51 in Mexico. Genotypes 6, 14, 86, 87, 89, and 91, not detected or reported in samples from patients with HPV in Mexico, were also identified. Data from the population analyzed suggest no direct relationship between HIV immunosuppression and cervical cancer, regardless of the high- or low-risk HPV genotype. Furthermore, it is possible to develop regional population markers for the detection of HPV based on the mutations that occur in the sequence of nucleotides analyzed.

scholarly journals Persistent Low-Risk and High-Risk Human Papillomavirus Infections of the Uterine Cervix in HIV-Negative and HIV-Positive Women

2017 ◽  
Vol 5 ◽  
Author(s):  
Sally N. Adebamowo ◽  
Oluwatoyosi Olawande ◽  
Ayotunde Famooto ◽  
Eileen O. Dareng ◽  
Richard Offiong ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Uterine Cervix ◽  
Low Risk ◽  
Hiv Positive ◽  
Papillomavirus Infections ◽  
Hiv Positive Women ◽  
Hiv Negative

scholarly journals Describing Point of Entry into Care and Being Lost to Program in a Cohort of HIV Positive Pregnant Women in a Large Urban Centre in Uganda

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Rachel Musomba ◽  
Frank Mubiru ◽  
Shadia Nakalema ◽  
Hope Mackline ◽  
Ivan Kalule ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Older Women ◽  
First Trimester ◽  
Hiv Positive ◽  
Urban Centre ◽  
Factors Associated ◽  
Point Of Entry ◽  
Art Initiation ◽  
Hiv Positive Women

Introduction. We aim to describe the time of entry into care and factors associated with being lost to program (LTP) in pregnant women on Option B Plus in an integrated HIV and antenatal care (ANC) clinic in Uganda. Methods. We included all pregnant women enrolled into the integrated HIV-ANC clinic from January 2012 to 31st July 2014, while the follow up period extended up to October 30th 2015. LTP was defined as being out of care for ≥3 months. Results. Overall 856 women were included. Only 36.4% (86/236) of the women were enrolled in the first trimester. Overall 69 (8.1%) were LTP. In the multivariate analysis older women (HR: 0.80 per five-year increase, CI: 0.64–1.0, and P=0.060) and women on ART at the time of pregnancy (0.58, CI: 0.34–0.98, and P=0.040) were more likely not to be LTP. Among women already on ART at the time of pregnancy no factor was associated with LTP. Conclusion. Our results suggest the need for interventions to enhance prompt linkage of HIV positive women to HIV services for ART initiation and for increased retention particularly in young and ART naive women.

scholarly journals Perencanaan Memiliki Anak pada Wanita dengan HIV Positif di Kota Semarang

2019 ◽  
Vol 14 (2) ◽  
pp. 108
Author(s):  
Nastiti Bandari Pratiwi ◽  
Zahroh Shaluhiyah ◽  
Antono Suryoputro
Keyword(s):  
Pregnant Women ◽  
Quantitative Research ◽  
Qualitative Data ◽  
Hiv Treatment ◽  
Hiv Positive ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
Hiv Positive Women ◽  
Women With Hiv ◽  
Fertile Women

Background: Pregnant women with HIV positive is potential risk to transmit the virus to their infants. Prevention Mother to Child Transmittion (PMTCT) program is a solution for HIV women if they want to have children. However, most pregnant women detected HIV positive when they have been pregnant for more than 6 months through Provider initiated test and counselling (PITC). On the other hand, the data shows that the increasing number of HIV positive women who have been willing to have children.  This research aims to identify and examine the factors influence the plan of having children among HIV-positive women who access HIV treatment in Kariadi Hospital Semarang. Method: This study employs a quantitative research design with cross sectional approach, followed by qualitative study to explore the feeling and attitudes of women with HIV positive to plan of having children. There were 31 women involved in this study, selected with the criteria of fertile women HIV positive who have been taking antiretroviral therapy in Kariadi Hospital and willing to participate in this study. Qualitative data collected from two women who has been planning to have children. Quantitative data were analyzed by univariate, Chi-Square and multiple logistic regression. Whilst, qualitative data employ content analysis.Results: There were 16% of women with HIV positive who have been intending to have children in this study. The rest have not planned it because they worried if their pregnancy and delivery could transmit HIV to their infants. CD4 cell count, ARV access and women’s attitudes have significant correlation to the intention of having children among women with HIV positive. Comprehensive information about PMTCT and ARV were needed to deliver to fertile women with HIV positive.

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