A predictive model for early diagnosis of keratoconus

Cross Sectional Study ◽

Bivariate Analysis ◽

Diagnostic Model ◽

Cross Sectional ◽

Logistic Regression Models

Abstract Background: The diagnosis of keratoconus in the early stages of the disease is necessary to initiate an early treatment of keratoconus. Furthermore to avoid possible refractive surgery that could produce ectasias. This study aims to describe the topographic, pachymetric and aberrometry characteristics in patients with keratoconus, subclinical keratoconus and normal corneas. Additionally to propose a diagnostic model of subclinical keratoconus based in binary logistic regression models Methods: The design was a cross-sectional study. It included 205 eyes from 205 patients distributed in 82 normal corneas, 40 subclinical keratoconus and 83 established keratoconus The rotary Scheimpflug camera (Pentacam® type) analyzed the topographic, pachymetric and aberrometry variables. It performed a descriptive and bivariate analysis of the recorded data. A diagnostic and predictive model of subclinical keratoconus was calculated with the statistically significant variables Results: Statistically significant differences were observed when comparing normal corneas with subclinical keratoconus/ in variables of the vertical asymmetry to 90º and the central corneal thickness. The binary logistic regression model included the minimal corneal thickness, the anterior coma to 90º and posterior coma to 90º. The model properly diagnosed 92% of cases Conclusions: The differential diagnosis between normal cases and subclinical keratoconus depends on the mínimum corneal thickness, the anterior coma to 90º and the posterior coma to 90º.

A predictive model for early diagnosis of keratoconus

10.21203/rs.2.21162/v3 ◽

2020 ◽

Author(s):

GRACIA CASTRO-LUNA ◽

ANTONIO PÉREZ-RUEDA

Keyword(s):

Logistic Regression ◽

Predictive Model ◽

Early Stage ◽

Corneal Thickness ◽

Cross Sectional Study ◽

Bivariate Analysis ◽

Diagnostic Model ◽

Cross Sectional

Abstract Background: The diagnosis of keratoconus in the early stages of the disease is necessary to initiate an early treatment of keratoconus. Furthermore, to avoid possible refractive surgery that could produce ectasias. This study aims to describe the topographic, pachymetric and aberrometry characteristics in patients with keratoconus, subclinical keratoconus and normal corneas. Additionally to propose a diagnostic model of subclinical keratoconus based in binary logistic regression models Methods: The design was a cross-sectional study. It included 205 eyes from 205 patients distributed in 82 normal corneas, 40 early-stage keratoconus and 83 established keratoconus. The rotary Scheimpflug camera (Pentacam® type) analyzed the topographic, pachymetric and aberrometry variables. It performed a descriptive and bivariate analysis of the recorded data. A diagnostic and predictive model of early-stage keratoconus was calculated with the statistically significant variables Results: Statistically significant differences were observed when comparing normal corneas with early-stage keratoconus/ in variables of the vertical asymmetry to 90º and the central corneal thickness. The binary logistic regression model included the minimal corneal thickness, the anterior coma to 90º and posterior coma to 90º. The model properly diagnosed 92% of cases with a sensitivity of 97.59%, specificity 98.78%, accuracy 98.18% and precision 98.78%Conclusions: The differential diagnosis between normal cases and subclinical keratoconus depends on the mínimum corneal thickness, the anterior coma to 90º and the posterior coma to 90º.

A model of visual limitation in patients with keratoconus

Scientific Reports ◽

10.1038/s41598-020-76489-1 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Antonio Pérez-Rueda ◽

Gracia Castro-Luna

Keyword(s):

Visual Acuity ◽

Logistic Regression ◽

Operating Characteristic ◽

Spherical Aberration ◽

Area Under The Curve ◽

Cross Sectional Study ◽

Cross Sectional ◽

Corrected Visual Acuity

Abstract This paper aims to calculate a relevance model of visual limitation (V.L.) in keratoconus patients based on refractive and topographic parameters. A cross-sectional study was carried out in Torrecárdenas Hospital, Almería, Spain, between February 2018 and July 2019. It included 250 keratoconus patients. Two groups were created according to a grading system of V.L. based on RETICS (Red Temática de Investigación Cooperativa en Salud) classification: keratoconus patients with no V.L. (best spectacle-corrected visual acuity (BSCVA) ≤ 0.05 logMAR) and keratoconus patients with V.L. (BSCVA > 0.05 logMAR). Correlations and a binary logistic regression were established. V.L. was correlated with maximum curvature (r = 0.649, p < 0.001) and root mean square higher-order aberrations (HOARMS) (r = 0.625, p < 0.001). Binary logistic regression included V.L. as the dependent variable and spherical equivalent, HOARMS, spherical aberration and interaction between the anterior and posterior vertical coma as independent variables. The model was a good fit. Area under the curve (A.U.C.) of receiver operating characteristic (R.O.C.) curve was 0.924, sensitivity 91.90%, specificity 83.60%, accuracy 88.94%; and precision 91.17%. Binary logistic regression model of V.L. is a good fit model to predict the early loss of visual acuity in keratoconus patients.

Antenatal care use and its determinants among migrant women during the first delivery: a nation-wide cross-sectional study in China

BMC Pregnancy and Childbirth ◽

10.1186/s12884-019-2520-3 ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Xue Tang ◽

Lulu Ding ◽

Yuejing Feng ◽

Yi Wang ◽

Chengchao Zhou

Keyword(s):

Logistic Regression ◽

Antenatal Care ◽

Pregnant Women ◽

Cross Sectional Study ◽

Multivariate Logistic Regression Model ◽

Migrant Women ◽

Cross Sectional ◽

Logistic Regression Models ◽

Primiparous Women

Abstract Background Reasonable use of antenatal care (ANC) services by pregnant women played a crucial role in ensuring maternal and child safety and reducing the risk of complications, disability, and death in mothers and their infants. This study aimed to investigate the ANC use, and to explore the factors associated with ANC use among migrant women during the first delivery in China. Methods This study used the data of National Health and Family Planning Commission of People Republic of China in 2014. A total of 1505 migrant primiparous women were included in our current analysis. Frequencies and proportions were used to describe the data. Chi-square tests and multivariate binary logistic regression models were performed to explore the determinants that affect the number of times migrant women used ANC during their first delivery. Results Of the 1505 participants, 279 (18.54%) women received the ANC less than 5 times, and 1226 (81.46%) women used the ANC at least 5 times during the first delivery. The multivariate logistic regression model showed that migrant primiparous women with college and above education(P < 0.05;OR = 2.57;95%CI = 1.19–5.55), from the households with higher monthly income (P < 0.01;OR = 2.01;95%CI = 1.30–3.13), covered by maternity insurance(P < 0.01;OR = 2.01;95%CI = 1.28–3.18), with maternal health records (P < 0.001;OR = 2.44;95%CI = 1.61–3.69), migrating across county (P < 0.05;OR = 2.57;95%CI = 1.14–5.81), having migration experience before pregnancy(P < 0.05;OR = 1.37;95%CI = 1.03–1.81) were more likely to use ANC for at least five times. Conclusions This study demonstrated that there were still some migrant maternal women (18.54%) who attended the ANC less than 5 times. Targeted policies should be developed to improve the utilization of ANC among migrant pregnant women.

Predictive model for early diagnosis of keratoconus

10.21203/rs.2.21162/v1 ◽

2020 ◽

Author(s):

GRACIA CASTRO-LUNA ◽

ANTONIO PÉREZ-RUEDA

Keyword(s):

Early Diagnosis ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Cross Sectional Study ◽

Bivariate Analysis ◽

Diagnostic Model ◽

Sectional Study ◽

Cross Sectional ◽

Recorded Data ◽

Topographic Parameters

Abstract Background To describe the topographic, pachymetric and aberrometry characteristics in patients with keratoconus, subclinical keratoconus/forme fruste and normal corneas. Calculate a diagnostic model of subclinical keratoconus/forme fruste. Methods The design was a cross-sectional study. It included 205 eyes from 188 patients distributed in 82 normal corneas, 40 subclinical keratoconus/forme fruste and 83 established keratoconus The topographic, pachymetric and aberrometry variables obtained by rotary Scheimpflug camera (Pentacam® type) were analyzed. A descriptive and bivariate analysis of the recorded data was performed. A diagnostic model of subclinical keratoconus/forme fruste was calculated. Results Statistically significant differences were obtained when comparing normal corneas with subclinical keratoconus/forme fruste in variables of vertical asymmetry and corneal thickness.The regression model was calculated with the minimum corneal thickness and the anterior coma to 90º and posterior coma to 90º. Conclusions The diagnosis of subclinical keratoconus/forme fruste depends on the central corneal thickness, and two aberrometric topographic parameters the anterior coma to 90º and posterior coma to 90º.

Association between the HTR2C rs1414334 C/G gene polymorphism and the development of the metabolic syndrome in patients treated with atypical antipsychotics

PeerJ ◽

10.7717/peerj.2163 ◽

2016 ◽

Vol 4 ◽

pp. e2163 ◽

Cited By ~ 3

Author(s):

José María Rico-Gomis ◽

Antonio Palazón-Bru ◽

Irene Triano-García ◽

Luis Fabián Mahecha-García ◽

Ana García-Monsalve ◽

...

Keyword(s):

Metabolic Syndrome ◽

Logistic Regression ◽

Regression Models ◽

Atypical Antipsychotics ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Logistic Regression Models ◽

The Metabolic Syndrome

Few studies have assessed the association between the rs1414334 C/G polymorphism in the HTR2C gene and the development of the metabolic syndrome in patients treated with atypical antipsychotics. To provide further evidence, a cross-sectional study was conducted in Spain between 2012 and 2013 in 166 patients with these characteristics. In these patients, the association between the polymorphism and the presence of the metabolic syndrome was determined by implementing binary logistic regression models adjusted for variables associated with the metabolic syndrome. We did not confirm previous claims that the C allele of the polymorphism was linked to the metabolic syndrome: the association was in the opposite direction and non-significant. This conclusion held after taking gender and lifestyle variables into account.

Canine Gastrointestinal Nematodiases and Associated Risk Factors in Kigali City, Rwanda

Journal of Parasitology Research ◽

10.1155/2021/9956256 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Pie Ntampaka ◽

François Niragire ◽

Philip Njeru Nyaga ◽

Gervais Habarugira

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Feeding Practices ◽

Toxocara Canis ◽

Cross Sectional Study ◽

Capital City ◽

Cross Sectional ◽

Animal Products

Canine nematodes pose a public health risk to humans and livestock; however, the prevalence of canine nematodiases in Rwanda is unknown. This study aimed at determining the prevalence of canine nematodiases and identifying the risk factors for such infections in Kigali, the capital city of Rwanda. A cross-sectional study involved 93 dogs selected across Kigali city. Faecal samples were collected from apparently healthy dogs, and nematode eggs were identified and quantified using the McMaster technique. Risk factors for canine nematodiases were analysed by a multivariable binary logistic regression model. The overall prevalence of gastrointestinal (GI) nematodiases in dogs was 33.3% (95% CI: 23.8–42.9). The most prevalent species was Ancylostoma spp with 32.3% (95% CI: 22.8–41.8). Nearly 38.7% and 3.2% of the dogs infected with Ancylostoma spp and Toxocara canis had high egg counts per gram (EPG) of faeces (≥550), respectively. Approximately 96.8% of dogs infected with nematodes had monoinfection. Logistic regression analysis showed that dog’s age (1 to 2.5 years old), location (Gasabo and Kicukiro districts), and feeding practices were significantly associated with prevalence of canine nematodiases. In particular, the adjusted odds ratio (AOR) was more than 5 times higher for dogs fed on uncooked animal products and leftovers from households and restaurants compared to those who ate food prepared for them. The AOR was also about 16 times higher for dogs that scavenged and ate leftovers from households compared to those who ate food prepared for them. The findings of this study indicate that the prevalence of GI nematodes in domestic dogs in Kigali city, Rwanda, was 33.3% (95% CI: 23.8–42.9). The identified nematodes, namely, Ancylostoma spp. and Toxocara canis, are zoonotic, and dogs and humans are at risk of contracting these nematodes. The factors associated with canine GI nematodes in Kigali city include feeding practices and the dog’s age and location (district). Dog owners need to rethink procedures for deworming and feeding their dogs. Again, the public should be made aware of the role of dogs in transmitting zoonotic nematodes to humans.

The number of household members as a risk factor for peptic ulcer disease

Scientific Reports ◽

10.1038/s41598-021-84892-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Mi Hong Yim ◽

Keun Ho Kim ◽

Bum Ju Lee

Keyword(s):

Peptic Ulcer ◽

Peptic Ulcer Disease ◽

Cross Sectional Study ◽

Living Alone ◽

Cross Sectional ◽

Ulcer Disease ◽

Logistic Regression Models ◽

Household Members ◽

H Pylori

AbstractPeptic ulcer disease (PUD) is caused by many sociodemographic and economic risk factors other than H. pylori infection. However, no studies reported an association between PUD and the number of household members. We showed the number of family members affected by PUD based on sex in a Korean population. This cross-sectional study used 1998–2009 data from the Korea National Health and Nutrition Examination Survey of the Korea Centers for Disease Control and Prevention. Multiple binary logistic regression models adjusted for confounders were constructed to analyze the association of PUD with the number of household members. The number of household members was associated with PUD, age, body mass index (BMI), waist circumference, systolic blood pressure, hemoglobin, glucose, location (urban/rural), income, education level, stress, current drinking, and smoking in both sexes. Men with other household members had a higher PUD risk compared to men or women living alone (reference), and the opposite was observed for women. Men with 4 household members had a higher PUD risk than men living alone in the model adjusted for age, BMI, income, location, education, and stress (OR = 2.04 [95% CI 1.28–3.27], p value = .003). Women with more than 6 household members had a lower PUD risk than women living alone in the adjusted model (OR = 0.50 [0.33–0.75], p value = .001). Women with more household members had a lower PUD risk. However, more men had PUD than women regardless of the number of household members.

MO376CLINICAL OUTCOMES OF ACUTE KIDNEY INJURY FOLLOWING SNAKE BITE INJURIES

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfab082.0030 ◽

2021 ◽

Vol 36 (Supplement_1) ◽

Author(s):

Weerakit Naweera ◽

Thapat Wannarong

Keyword(s):

Acute Kidney Injury ◽

Logistic Regression ◽

Kidney Injury ◽

Cross Sectional Study ◽

Renal Recovery ◽

Binary Logistic Regression Analysis ◽

Cross Sectional ◽

Hospital Arrival ◽

Russell’S Viper

Abstract Background and Aims Snakebite is a common animal bite injury in tropical countries. Acute kidney injury (AKI) is an important complication in snakebite patients. This study aimed to comprehensively investigate the clinical profiles and outcomes of patients following hematotoxin-related snakebite associated with kidney impairment. Method We conducted a hospital-based, cross-sectional study of 238 patients with hematotoxin-related snakebite injuries. Data were retrieved from the King Narai Hospital Registry from October 2014 to August 2020. The prevalence of complications associated with snakebite injuries, including acute kidney injury (AKI) and its severity, was determined. Univariate and Multivariate predictors of AKI diagnosis were evaluated using binary logistic regression analysis Results A total of 238 patients, with 63.4% men, median (IQR) age 49.8 (39-61) years and median duration from injury to a hospital arrival of 1 hour (0.5-2) hours, were injured by Green pit viper (85.7%), Russell’s viper (12.6%) and Malayan pit viper (1.7%). AKI mostly occurred in Russell’s viper group 66.7%. An AKI was reported in thirty (12.6%, 95% CI: 8.7 % - 17.5%) patients, with the severity of 66.7% stage one, 6.7% stage two, 26.6% stage three by KDIGO classifications, and 13.3% requiring hemodialysis. Complete renal recovery was seen in twenty-two patients (73.3%), while partial renal recovery was 23.3%. Other complications included 84.4 % limb cellulitis, 4.6% significantly bleeding, 2.5% hypotension, 25.6% prolonged venous clotting time (VCT), 46.7% prolonged prothrombin time (PT), and 14.3% prolonged partial thromboplastin time (PTT). Of total patients, 60.1% were treated with anti-venom. Mortality was relatively low (0.4%). In multivariable logistic regression analyses, AKI was significantly associated with time to hospital arrival more than 3 hours (p = 0.04), Russell’s viper bitten (p = 0.01), clinical bleeding (p = 0.01), and prolonged PT (p < 0.01). Conclusion The prevalence of AKI in patients bitten by hematotoxin snakes was 12.6%, mostly from Russell’s viper. Factors associated with AKI outcomes were time to hospital arrival more than 3 hours, Russell’s viper bitten, clinical bleeding, and prolonged PT. Besides, one-fourth of AKI patients turned to chronic kidney disease.

What Makes a Tweet Fly? Analysis of Twitter Messaging at Four Infection Control Conferences

Infection Control and Hospital Epidemiology ◽

10.1017/ice.2017.170 ◽

2017 ◽

Vol 38 (11) ◽

pp. 1271-1276 ◽

Cited By ~ 12

Author(s):

Brett G. Mitchell ◽

Philip L. Russo ◽

Jonathan A. Otter ◽

Martin A. Kiernan ◽

Landon Aveling

Keyword(s):

Network Analysis ◽

Infection Control ◽

Infection Prevention ◽

Cross Sectional Study ◽

Infection Prevention And Control ◽

Cross Sectional ◽

Activity Networks ◽

The Uk

OBJECTIVETo examine tweeting activity, networks, and common topics mentioned on Twitter at 4 international infection control and infectious disease conferences.DESIGNA cross-sectional study.METHODSAn independent company was commissioned to undertake a Twitter ‘trawl’ each month between July 1, 2016, and November 31, 2016. The trawl identified any tweets that contained the official hashtags of the conferences for (1) the UK Infection Prevention Society, (2) IDWeek 2016, (3) the Federation of Infectious Society/Hospital Infection Society, and (4) the Australasian College for Infection Prevention and Control. Topics from each tweet were identified, and an examination of the frequency and timing of tweets was performed. A social network analysis was performed to illustrate connections between users. A multivariate binary logistic regression model was developed to explore the predictors of ‘retweets.’RESULTSIn total, 23,718 tweets were identified as using 1 of the 2 hashtags of interest. The results demonstrated that the most tweets were posted during the conferences. Network analysis demonstrated a diversity of twitter networks. A link to a web address was a significant predictor of whether a tweet would be retweeted (odds ratio [OR], 2.0; 95% confidence interval [CI], 1.9–2.1). Other significant factors predicting a retweet included tweeting on topics such as Clostridium difficile (OR, 2.0; 95% CI, 1.7–2.4) and the media (OR, 1.8; 95% CI, 1.6–2.0). Tweets that contained a picture were significantly less likely to be retweeted (OR, 0.06; 95% CI, 0.05–0.08).CONCLUSIONTwitter is a useful tool for information sharing and networking at infection control conferences.Infect Control Hosp Epidemiol 2017;38:1271–1276

Association between Free Sugars Intake and Excessive Daytime Sleepiness among Chinese Adolescents

Nutrients ◽

10.3390/nu13113959 ◽

2021 ◽

Vol 13 (11) ◽

pp. 3959

Author(s):

Yue Xi ◽

Qian Lin ◽

Qiping Yang ◽

Fang Li ◽

Hanmei Liu ◽

...

Keyword(s):

Excessive Daytime Sleepiness ◽

Daytime Sleepiness ◽

Cross Sectional Study ◽

Chinese Adolescents ◽

School Students ◽

Online Questionnaire ◽

Cross Sectional ◽

Free Sugars

This study aimed to investigate the prevalence of excessive daytime sleepiness (EDS) and explore the association between free sugars intake and EDS. In this cross-sectional study, a total of 1517 middle school students (808 boys and 707 girls) aged 12~14 years were recruited. The study was conducted in Changsha city, China. Adolescents completed an online questionnaire, including the Epworth Sleepiness Scale (ESS), sleep characteristics, a 12-item Food Frequency Questionnaire (FFQ), and other self-reported information. The ESS score ≥ ten was defined as EDS. The anthropometric indices, including height, weight, and waist circumference, were measured and recorded by uniformly trained assistants. Statistical analyses included the Chi-square test and binary logistic regression model. The mean ESS score and free sugars consumption were 6.8 ± 3.9 points and 53.1 ± 44.7 g/d, respectively. The prevalence of EDS among adolescents was 22.5%, and more girls than boys had EDS (26.1% vs. 19.4%, p < 0.05). An exceeded free sugars intake was positively associated with EDS, with the adjusted Odds Ratio (OR) with its 95% Confident Interval (95% CI) of 1.366 (1.060~1.761, p < 0.05). EDS and excessive consumption of free sugars are commonly found among Chinese adolescents. Further studies are needed to confirm whether free sugars restriction can be meaningful to improve daytime drowsiness in those with EDS.