scholarly journals CD71+erythroid cells expansion in adult sepsis: potential causes and role in prognosis and nosocomial infection prediction

2021 ◽  
Author(s):  
Guangju Zhao ◽  
Danwei Jiang ◽  
Wenchao Cai ◽  
Xiaoyan Chen ◽  
Wei Dong ◽  
...  
Keyword(s):  
Linear Regression ◽  
Critically Ill ◽  
Linear Regression Analysis ◽  
Curve Analysis ◽  
Erythroid Cells ◽  
Roc Curve Analysis ◽  
Negatively Associated ◽  
Factors Associated ◽  
Low Levels ◽  
Potential Factors

Abstract BackgroundImmune suppression contributes to nosocomial infections (NI) and poor prognosis in sepsis. Recent studies revealed CD71+ erythroid cells had unappreciated immunosuppressive functions. This study aimed to investigate the values of CD71+ erythroid cells in predicting NIs and prognosis among adult septic patients. The potential factors associated with the expansion of CECs were also explored.MethodsIn total, 112 septic patients and 32 critically ill controls were enrolled. The frequencies of CD71+cells, CD71+CD235a+ cells (CECs) and CD45+ CECs were measured by flow cytometry. The associations between CECs and NIs and 30-day mortality were assessed by ROC curve analysis, Cox and competing-risk regression model. Factors associated with the frequency of CECs were identified by linear regression analysis.ResultsThe percentage of CD71+cells, CECs, CD45+CECs were higher in septic patients than critically ill controls. In septic patients, the percentage of CD71+cells, CECs and CD45+CECs were associated with NI development, while CD71+cells and CECs were independently associated with 30-day mortality. Linear regression analysis showed that the levels of interleukin (IL)-6 and interferon (IFN)-γwere positively associated with the frequencies of CD71+cells, CECs and CD45+CECs, while IL-10 was negatively associated with them. Additionally, the levels of red blood cells (RBCs) were negatively associated with the percentage of CD45+ CECs.ConclusionsCECs were expanded in sepsis and can serve as independent predictors of the development of NI and 30-day mortality. Low levels of RBCs and high levels of IL-6 and IFN-γmay contribute to the expansion of CECs in sepsis.Trial registration: ChiCTR, ChiCTR1900024887. Registered 2 Augest 2019, http://www.chictr.org.cn/showproj.aspx?proj=38645

scholarly journals Factors associated with low levels of patient satisfaction following peripheral nerve block

2021 ◽  
pp. 0310057X2097240
Author(s):  
Anthony D Hade ◽  
Satomi Okano ◽  
Anita Pelecanos ◽  
Adrian Chin
Keyword(s):  
Patient Satisfaction ◽  
Peripheral Nerve ◽  
Nerve Block ◽  
Peripheral Nerve Block ◽  
Moderate Intensity ◽  
Post Anaesthesia Care Unit ◽  
Negatively Associated ◽  
Factors Associated ◽  
Low Levels ◽  
Anaesthesia Care

Peripheral nerve blocks can provide surgical anaesthesia as well as excellent postoperative analgesia. When questioned postoperatively, however, some patients report low levels of satisfaction with their nerve block experience. At our hospital, patients undergoing regional anaesthesia have their patient characteristics, block characteristics and postoperative feedback routinely recorded in a block registry. We analysed data from 979 consecutive patients undergoing peripheral nerve block for orthopaedic surgery to identify factors associated with low levels of patient satisfaction. The primary outcome was patient satisfaction with their peripheral nerve block (scale 1–5: 4–5 is ‘satisfied’, 1–3 is ‘not satisfied’). Eighty-nine percent (871/979) of patients reported being ‘satisfied’ with their block. Factors negatively associated with patient satisfaction were rebound pain (adjusted odds ratio (aOR) 0.19, 95% confidence interval (CI) 0.04 to 0.85 for moderate rebound pain; aOR 0.11, 95% CI 0.03 to 0.48 for severe rebound pain), discomfort during the block (aOR 0.37, 95% CI 0.16 to 0.82 for moderate discomfort; aOR 0.19, 95% CI 0.05 to 0.76 for severe discomfort) and pain in the post-anaesthesia care unit (aOR 0.30, 95% CI 0.17 to 0.55 for pain ≥8/10). Only 24% (26/108) of patients who reported being ‘not satisfied’ stated that they would be unwilling to undergo a hypothetical future nerve block. Rebound pain of at least moderate intensity, procedural discomfort of at least moderate intensity and severe pain in the post-anaesthesia care unit are all negatively associated with patient satisfaction. Of these factors, rebound pain occurs most frequently, being present in 52% (403/777) of our respondents.

scholarly journals Association between sociodemographics factors and dietary patterns during pregnancy

2014 ◽  
Vol 27 (2) ◽  
pp. 173-181 ◽  
Author(s):  
Maria Beatriz Trindade De Castro ◽  
Rita Adriana Gomes De Souza ◽  
Ana Amélia Freitas Vilela ◽  
Gilberto Kac
Keyword(s):  
Linear Regression ◽  
Marital Status ◽  
Dietary Patterns ◽  
Skin Color ◽  
Rio De Janeiro ◽  
Linear Regression Analysis ◽  
Demographic Factors ◽  
Postpartum Women ◽  
Negatively Associated ◽  
Socio Demographic Factors

OBJECTIVE: To investigate the association between socio-demographic factors and dietary patterns in pregnancy. METHODS: Cross-sectional study with baseline data from a cohort of 421 postpartum women aged 18 and 45 years resident in Rio de Janeiro, Brazil. Dietary intake was evaluated with a validated food frequency questionnaire at 15 days following delivery, having as time frame the second and third pregnancy trimesters. Dietary patterns were identified using factor analysis for principal components analysis. The association between socio-demographic factors and the identified dietary patterns was assessed with multiple linear regression analysis. RESULTS: Two dietary patterns were identified: i) healthy: fruits; green vegetables; vegetables; fish; roots, corn and potato; milk and dairy and herbal tea mate, and negatively loadings for alcohol and coffee and ii) mixed: rice; bean; flour and pasta; breads; cake and cookies; soda and juice; sugar and sweets; fatty foods; meats; chicken; and eggs. The linear regression showed that the income (β=0.0002; 95%CI: 0.0002-0.0004) and schooling (β=0.0491; 95%CI: 0.0264-0.0718) were positively associated with healthy pattern, and parity (β=-0.1044; 95%CI: -0.1665- -0.0423) and skin color (β=-0.3102; 95%CI: -0.5256- -0.0947) were negatively associated. Skin color (β=0.1647; 95%CI: 0.0378- 0.2916) and marital status (β=0.1065; 95%CI: 0.0062- 0.2067) were positively associated with mixed pattern and income (β=-0.0001; 95%CI:-0.0002- -0.0001) and schooling (β=-0.0281; 95%CI: -0.0417- -0.0146) were negatively associated. CONCLUSION: Socio-demographic factors such as income, schooling, skin color, marital status and parity were associated with dietary patterns in this sample of postpartum women residents in Rio de Janeiro.

scholarly journals Identifying Influences on Catch-up Growth Using Relative versus Absolute Metrics: Evidence from the MAL-ED Study (P10-014-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Stephanie Richard ◽  
Benjamin McCormick ◽  
Laura Murray-Kolb ◽  
Laura Caulfield
Keyword(s):  
Linear Regression ◽  
Relative Difference ◽  
Maternal Height ◽  
Z Score ◽  
Linear Regression Models ◽  
Negatively Associated ◽  
Growth Standards ◽  
Factors Associated ◽  
Catch Up ◽  
Protein Density

Abstract Objectives To identify factors associated with improvement (‘catch-up’) in height and weight from 24–60 mo of age, and to determine whether associated factors differ depending on the metric used (absolute or relative difference from WHO growth standards). Methods At seven MAL-ED sites, 942 children had anthropometry data at 24 and 60 mo, as well as information about socioeconomic status, maternal height, gut permeability (lactulose-mannitol z-score (LMZ)), dietary intake from 9–24 mo, and micronutrient status. Anthropometric changes were categorized in terms of positive changes in Height- or Weight for-Age Z-score (HAZ, WAZ) or their differences (HAD, WAD) and recovery from stunting/underweight, and then modeled using multivariate linear regression. Results 42% of the children were stunted at 24 or 60 mo, and 24% of the children were underweight at 24 or 60 mo. 44% of the children who were stunted at 24 mo were not at 60 mo, and 34% of those underweight at 24 mo were no longer at 60 mo. Among the sites, 49–92% of children had positive changes in their HAZ, whereas 25–60% had positive changes in HAD. Linear regression models indicate that female sex (-0.21 HAZ (95% CI -0.27, -0.15); -0.75 HAD (95% CI -1.07, -0.43)) and mean LMZ (-0.10 HAZ (95% CI -0.16, -0.04); -0.47 HAD (95% CI -0.73, -0.21)) were negatively associated with change in both HAZ and HAD, whereas maternal height was positively associated with change in both HAZ and HAD (0.09 HAZ (95% CI 0.03, 0.15); 0.45 HAD (95% CI 0.15, 0.75)). Similar relationships were identified for change in WAZ and WAD. Dietary protein density was negatively associated with change in WAZ and WAD (-0.05 WAZ (95% CI -0.09, -0.01); -0.11 WAD (95% CI -0.21, -0.01)), and plasma transferrin receptor concentration was positively associated with change in WAZ and WAD (0.02 WAZ (95% CI 0.0, 0.04); 0.04 WAD (95% CI 0.0, 0.08)). Conclusions Children in the MAL-ED study demonstrated recovery from stunting and underweight from 24 to 60 mo of age. Given the similarities in the factors associated with changes in HAZ and HAD (and WAZ and WAD), both be used as complementary approaches to characterize and explain catch-up growth during early childhood. Funding Sources The MAL-ED study was supported by the Bill & Melinda Gates Foundation, with grants to the Foundation for the NIH and NIH/FIC.

scholarly journals Hospitalization costs among immobile patients with hemorrhagic or ischemic stroke in China: a multicenter cross-sectional study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hongpeng Liu ◽  
Chen Zhu ◽  
Jing Cao ◽  
Jing Jiao ◽  
Baoyun Song ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Ischemic Stroke ◽  
Linear Regression ◽  
Average Length ◽  
Linear Regression Analysis ◽  
Hospital Charges ◽  
Hospital Level ◽  
Cross Sectional ◽  
Factors Associated ◽  
Hospitalization Costs

Abstract Background In this study, we aimed to analyze the hospitalization costs for immobile patients with hemorrhagic stroke (IHS) or ischemic stroke (IIS) in China and to determine the factors associated with hospitalization costs. Methods We evaluated patients with IHS and IIS hospitalized between November 2015 and July 2016 in six provinces or municipality cities of China. Linear regression analysis was used to examine the association with hospitalization costs and predictors. Results In total, 1573 patients with IHS and 3143 with IIS were enrolled and analyzed. For IHS and IIS, the average length of stay (LoS) was 17.40 ± 12.3 and 14.47 ± 11.55 days. The duration of immobility was 12.11 ± 9.98 and 7.36 ± 9.77 days, respectively. Median hospitalization costs were RMB 47000.68 (interquartile range 19,827.37, 91,877.09) for IHS and RMB 16578.44 (IQR 7020.13, 36,357.65) for IIS. In both IHS and IIS groups, medicine fees accounted for more than one-third of hospitalization costs. Materials fees and medical service fees accounted for the second and third largest proportions of hospital charges in both groups. Linear regression analysis showed that LoS, hospital level, and previous surgery were key determinants of hospitalization costs in all immobile patients with stroke. Subgroup analysis indicated that hospital level was highly correlated with hospitalization costs for IHS whereas pneumonia and deep vein thrombosis were key factors associated with hospitalization costs for IIS. Conclusions We found that hospitalization costs were notably higher in IHS than IIS, and medicine fees accounted for the largest proportion of hospitalization costs in both patient groups, perhaps because most patients ended up with complications such as pneumonia thereby requiring more medications. LoS and hospital level may greatly affect hospitalization costs. Increasing the reimbursement ratio of medical insurance for patients with IHS is recommended. Decreasing medicine fees and LoS, preventing complications, and improving treatment capability may help to reduce the economic burden of stroke in China.

scholarly journals Correlates of sedentary behaviour among adolescents and adults with hazardous, harmful or dependent drinking in South Africa

2019 ◽  
Vol 25 ◽  
Author(s):  
Karl Peltzer ◽  
Nancy Phaswana-Mafuya ◽  
Supa Pengpid
Keyword(s):  
Regression Analysis ◽  
Alcohol Use ◽  
Linear Regression ◽  
Sedentary Behaviour ◽  
Linear Regression Analysis ◽  
Alcohol Use Disorders ◽  
Older Age ◽  
Problem Drinkers ◽  
Negatively Associated ◽  
Adolescents And Adults

Background: There is lack of information on the correlates of sedentary behaviour among persons with alcohol use disorders. The study aimed to examine socio-demographic and health correlates among adolescents and adults with hazardous, harmful or probable dependent alcohol use (= problem drinking).Method: Data from the cross-sectional South African National Health and Nutrition Examination Survey (SANHANES-1) 2011–12 were analysed. From a total sample of 15 085 persons aged 15 years and older, 2849 adolescents and adults (mean age = 37.1 years, standard deviation [s.d.] = 15.1) were identified as problem drinkers, based on the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C). Multivariable logistic and linear regression were used to determine the associations between socio-demographic characteristics, health variables and high sedentary behaviour (≥8 h/day) and total minutes of sedentary behaviour a day.Results: The prevalence of high sedentary behaviour (≥ 8 h/day) was 11.9% overall (11.9% among men and 12.1% among women), and the mean (s.d.) duration of sedentary behaviour was 263 (169) min/day. In bivariate analysis, older age, population group, functional disability, cognitive impairment, having hypertension, having had a stroke and posttraumatic symptoms were correlated with high sedentary behaviour. In adjusted logistic regression analysis, older age and being Indian or Asian were positively, and having been diagnosed with angina was negatively, associated with high sedentary behaviour. In linear regression analysis, older age, not employed and having had a stroke were positively, and being of mixed race and having angina were negatively, associated with total minutes (up to 960 min/day) of sedentary behaviour in a day.Conclusion: The study provides socio-demographic and health correlates of sedentary behaviour among problem drinkers. This information can guide possible future interventions in reducing sedentary behaviour among problem drinkers.

scholarly journals Nucleated Red Blood Cells: Could They Be Indicator Markers of Illness Severity for Neonatal Intensive Care Unit Patients?

Children ◽  
2020 ◽  
Vol 7 (11) ◽  
pp. 197
Author(s):  
Rozeta Sokou ◽  
Georgios Ioakeimidis ◽  
Maria Lampridou ◽  
Abraham Pouliakis ◽  
Andreas G. Tsantes ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Critically Ill ◽  
Roc Curve ◽  
Blood Cells ◽  
Neonatal Intensive Care ◽  
Curve Analysis ◽  
Roc Curve Analysis ◽  
Nucleated Red Blood Cells ◽  
Critically Ill Neonates

Background: We aimed to assess whether nucleated red blood cells (NRBCs) count could serve as a diagnostic and prognostic biomarker for morbidity and mortality in critically ill neonates. Methods: The association between NRBCs count and neonatal morbidity and mortality was evaluated in an observational cohort of critically ill neonates hospitalized in our neonatal intensive care unit over a period of 69 months. The discriminative ability of NRBCs count as diagnostic and prognostic biomarkers was evaluated by performing the Receiver Operating Characteristics (ROC) curve analysis. Results: Among 467 critically ill neonates included in the study, 45 (9.6%) of them experienced in-hospital mortality. No statistically significant difference was found with regards to NRBCs count between survivors and non-survivors, although the median value for NRBCs was sometimes higher for non-survivors. ROC curve analysis showed that NRBCs is a good discriminator marker for the diagnosis of perinatal hypoxia in neonates with area under the curve (AUC) [AUC 0.710; 95% confidence interval (CI), 0.660–0.759] and predominantly in preterm neonates (AUC 0.921 (95% CI, 0.0849–0.0993)) by using a cut-off value of ≥11.2%, with 80% sensitivity and 88.7% specificity. NRBCs also revealed significant prognostic power for mortality in septic neonates (AUC 0.760 (95% CI, 0.631–0.888)) and especially in preterms with sepsis (AUC 0.816 (95% CI, 0.681–0.951)), with cut-off value ≥ 1%, resulting in 81.6% sensitivity and 78.1% specificity. Conclusion: NRBCs count may be included among the early diagnostic and prognostic markers for sick neonates.

scholarly journals Weight loss during cirrhosis is related to the etiology of liver disease

2012 ◽  
Vol 49 (3) ◽  
pp. 195-198 ◽  
Author(s):  
Lucilene Rezende Anastácio ◽  
Lívia Garcia Ferreira ◽  
Hélem de Sena Ribeiro ◽  
Agnaldo Soares Lima ◽  
Eduardo Garcia Vilela ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Weight Loss ◽  
Liver Disease ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Alcoholic Cirrhosis ◽  
Regression Analyses ◽  
Outpatient Appointment ◽  
Factors Associated

CONTEXT: Malnutrition is widely described in patients waiting for liver transplantation (LTx). However, risk factors associated with weight loss during liver disease have not yet been well studied. OBJECTIVES: The aim of this study was to assess weight loss and its risk factors during liver disease and up to the first appointment after transplantation. Patients who underwent LTx were retrospectively assessed for weight loss during liver disease while on the waiting list for LTx. The usual weight of the patients before disease and their weight on the first outpatient appointment after transplant were considered. Demographic, socioeconomic, lifestyle and clinical variables were collected to assess risk factors using a linear regression analysis. We retrospectively evaluated 163 patients undergoing LTx between 1997 and 2008. RESULTS: Patients lost in average 7.7 ± 12.4 kg while ill. Variables independently associated with weight loss by multiple linear regression analyses were as follows: former smoker (P = 0.03), greater body mass index (P<0.01), overweight before liver disease (P = 0.02) and indication for LTx (P = 0.01). Among these indications, patients with alcoholic cirrhosis had lost significantly more weight (P<0.01), and those with hepatitis C virus (P = 0.01) and autoimmune hepatitis (P = 0.02) had lost significantly less weight. CONCLUSIONS: Patients experienced weight loss during liver disease independent of age, sex, schooling and income; however, the etiology of liver disease was related to weight loss.

Clinical importance of the 75-g glucose tolerance test (GTT) in the prediction of large for gestational age (LGA) fetuses in non-diabetic pregnancies

2019 ◽  
Vol 47 (5) ◽  
pp. 534-538 ◽  
Author(s):  
Erdem Fadiloglu ◽  
Atakan Tanacan ◽  
Canan Unal ◽  
Duygu Aydin Hakli ◽  
Mehmet Sinan Beksac
Keyword(s):  
Linear Regression ◽  
Glucose Tolerance ◽  
Gestational Age ◽  
Maternal Age ◽  
Glucose Tolerance Test ◽  
Clinical Importance ◽  
Tolerance Test ◽  
Curve Analysis ◽  
Large For Gestational Age ◽  
Roc Curve Analysis

Abstract Objective To demonstrate clinical importance of the 75-g glucose tolerance test (GTT) in the prediction of large for gestational age (LGA) fetuses in non-diabetic pregnancies. Methods We retrospectively evaluated 75-g GTT screening results of 356 pregnancies without prompt diagnosis of gestational diabetes mellitus (GDM) between January 2013 and December 2017. Newborns with a birthweight greater than the 90th percentile were evaluated as LGA. Pregnancies with LGA and non-LGA fetuses were compared by demographic and historical factors – maternal age, gravidity, parity, birthweight, birthweek, GTT results and birthweight percentiles – via Student’s t-test. Multiple linear regression using the backward elimination method was performed to define the correlation between parameters and LGA (P-value of <0.20 was identified as the threshold). Receiver operator characteristics (ROC) curve analysis was performed for further analysis. Results The cohort was consisted of 45 (12.6%) and 311 (87.4%) pregnancies with LGA and non-LGA fetuses, respectively. Maternal age and 2nd-h GTT results were found to be significantly higher in patients with LGA newborns (P<0.001 and P=0.016, respectively). Fasting glucose levels and GTT 1st-h results were also higher (P=0.112, P=0.065). The coefficient of multiple determination (R2) was 0.055 by multiple linear regression analysis. Accordingly, GTT 2nd-h result and maternal age were statistically significant and contributed to the explanation of LGA, although the R2 value was not that much higher (P=0.016; P=0.001). Maternal age and GTT 2nd-h results were found to be associated with LGA fetuses with area under the curve (AUC) values of 0.662 and 0.608 according to ROC curve analysis. Conclusion Maternal age and 75-g GTT 2nd-h results were significantly higher in gestations with LGA newborns without GDM.

scholarly journals Change of Retinal Vessel Density After Lowering Intraocular Pressure in Ocular Hypertension

2021 ◽  
Vol 8 ◽  
Author(s):  
Xuhao Chen ◽  
Ying Hong ◽  
Haohao Di ◽  
Qianru Wu ◽  
Di Zhang ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Intraocular Pressure ◽  
Linear Regression ◽  
Ocular Hypertension ◽  
Linear Regression Analysis ◽  
Vessel Density ◽  
Factors Associated ◽  
Rnfl Thickness ◽  
Deep Layers ◽  
The Mean

Purpose: To investigate the relationship between retinal microvasculature changes and intraocular pressure (IOP) for ocular hypertension (OHT) patients and further assess the factors associated with retinal microcirculation changes.Methods: This was a single-center prospective study designed for OHT patients, which consisted of two visits. After collecting baseline data of those who met the eligibility criteria, these patients were treated with latanoprost 0.005% ophthalmic solution for 4 weeks. Peripapillary vessel density (VD) of radial peripapillary capillaries (RPC) layer, macular VD in both superficial and deep layers, and foveal avascular zone (FAZ) area were measured by optical coherence tomography angiography (OCTA) before and after the treatment. We compared the changes in IOP and VD among the two visits by paired-sample t-test. Bonferroni correction was applied. Factors associated with VD changes were analyzed by linear regression analysis.Results: Thirty-four eyes of thirty-four patients were included. The mean IOP decreased by 6.5 ± 2.2 mmHg (p &lt; 0.001). The peripapillary RPC VD increased significantly from 51.8 ± 2.5 to 53.0 ± 3.1% (Adjusted-p = 0.012). We found no significant difference in detailed sectors of the peripapillary region after correction. In the macular area, both the superficial and deep layers in foveal (superficial: 0.2 ± 1.9%, p = 0.523; deep: 0.0 ± 2.3%, p = 0.969) and parafoveal (superficial: 0.3 ± 3.0%, p = 0.565; deep: 0.5 ± 3.1%, p = 0.423) VD remained unchanged. The decrease of the mean FAZ area was insignificant (p = 0.295). The percentage of IOP reduction (β = 0.330, p = 0.031) and the baseline RNFL thickness (β = 0.450, p = 0.004) significantly correlated with the percentage of peripapillary RPC VD improvement in the multivariate linear regression analysis.Conclusion: The peripapillary VD in OHT patients increased after the reduction of IOP. The mild change of IOP did not alter the microcirculation in the macula. In addition, the percentage of IOP change and the baseline RNFL thickness were independent factors for the peripapillary RPC VD improvement.

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