scholarly journals Cognitive Network Reconstruction in Opioid Users Compared To Non-Users: Topological Analysis of Cognitive Function Through Graph Model and Centrality Measures

2021 ◽  
Author(s):  
Elnaz Gharahi ◽  
Shiva Soraya ◽  
Hamidreza Ahmadkhaniha ◽  
Bahman Sadeghi ◽  
Mandana Haghshenas ◽  
...  
Keyword(s):  
Reaction Time ◽  
Cognitive Function ◽  
Divided Attention ◽  
Topological Analysis ◽  
Graph Model ◽  
Cognitive Domain ◽  
Centrality Measures ◽  
Cognitive Network ◽  
Commission Errors ◽  
Opioid Users

Abstract Cognitive dysfunction related to opioid use disorder (OUD) requires investigation of the interconnected network of cognitive domains through behavioral experiments and graph data modeling. Here, we conducted n-back, selective and divided attention, and Wisconsin card sorting tests and then reconstructed the interactive cognitive network of subscales or domains for opioid users and non-users to identify the most central cognitive functions and their connections using graph model analysis. Then, each network was analyzed topologically based on the betweenness and closeness centrality measures. Results from the opioid users’ network show that in the divided attention module, the reaction time and the number of commission errors were the most central subscales of cognitive function. Whereas in non-users, the number of correct responses and commission errors were the most central cognitive measure. These findings corroborate that opioid users show impaired divided attention as higher reaction time and errors in performing the tasks. Divided attention is the most central cognitive function in both OUD subjects and non-users, although differences were observed between the subscales of the two groups. Therefore, divided attention is a promising target for future cognitive therapies, treatments and rehabilitation as its improvement may lead to an enhancement of overall cognitive domain performance.

scholarly journals Adjunctive cognitive remediation for schizophrenia using yoga: an open, non-randomised trial

2012 ◽  
Vol 24 (2) ◽  
pp. 91-100 ◽  
Author(s):  
Triptish Bhatia ◽  
Akhilesh Agarwal ◽  
Gyandeepak Shah ◽  
Joel Wood ◽  
Jan Richard ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Randomised Trial ◽  
Cognitive Remediation ◽  
Cognitive Domain ◽  
Medium Effect ◽  
Major Depressive ◽  
Treatment As Usual ◽  
Cognitive Domains ◽  
Yoga Therapy ◽  
Persons With Schizophrenia

Background:Yoga therapy (YT) improves cognitive function in healthy individuals, but its impact on cognitive function among persons with schizophrenia (SZ) has not been investigated.Objective:To evaluate the adjunctive YT for cognitive domains impaired in SZ.Methods:Patients with SZ received YT or treatment as usual (TAU;n= 65,n= 23, respectively). Accuracy and speed for seven cognitive domains were assessed using a computerised neurocognitive battery (CNB), thus minimising observer bias. Separately, YT was evaluated among patients with bipolar I disorder (n= 40), major depressive disorder (n= 37) and cardiology outpatients (n= 68). All patients also received routine pharmacotherapy. Patients were not randomised to YT or TAU.Results:In comparison with the SZ/TAU group, the SZ/YT group showed significantly greater improvement with regard to measures of attention following corrections for multiple comparisons; the changes were more prominent among the men. In the other diagnostic groups, differing patterns of improvements were noted with small-to-medium effect sizes.Conclusions:Our initial analyses suggest nominally significant improvement in cognitive function in SZ with adjunctive therapies such as YT. The magnitude of the change varies by cognitive domain and may also vary by diagnostic group.

scholarly journals Acute Effects of Salvia Supplementation on Cognitive Function in Athletes During a Fatiguing Cycling Exercise: A Randomized Cross-Over, Placebo-Controlled, and Double-Blind Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Nicolas Babault ◽  
Ahmad Noureddine ◽  
Nicolas Amiez ◽  
Damien Guillemet ◽  
Carole Cometti
Keyword(s):  
Heart Rate ◽  
Reaction Time ◽  
Cognitive Function ◽  
Stroop Task ◽  
Perceived Exertion ◽  
Digit Span ◽  
Acute Effects ◽  
Warm Up ◽  
Positive Effects ◽  
Fatiguing Exercise

Background:Salvia (sage) supplementation has been shown to improve the cognition function in healthy individuals or patients (e.g., attention, memory). To date, no study has explored its relevancy in the context of sporting performance. The aim of this study was to explore the acute effects of a combination of Salvia officinalis and Salvia lavandulaefolia on cognitive function in athletes performing a fatiguing cycling task.Methods: Twenty-six volunteers were included in this cross-over, randomized, double-bind vs. placebo trial. Two hours before the two experimental sessions (here called SAGE and PLACEBO), volunteers randomly received a supplementation of sage or placebo. During each experimental session, participants were tested at four occasions while cycling during a warm-up, in the middle and at the end of a fatiguing task and after a short 5-min recovery. Tests included a Stroop task, a simple reaction time task, and a backward digit span memory task. Heart rate and rating of perceived exertion (RPE) were also measured at the beginning of the four test sessions.Results: Heart rate was significantly greater during the fatiguing exercise than during warm-up and recovery (P < 0.001) without any supplementation effect. RPE was greater during the fatiguing exercise than during warm-up and recovery (P < 0.001). Moreover, RPE was significantly lower during the SAGE session as compared to PLACEBO (P = 0.002). Reaction time was not altered during the exercise but was significantly shorter with SAGE as compared to PLACEBO (P = 0.023). The Stroop task only revealed significantly longer reaction time during warm-up as compared to recovery (P = 0.02) independently of the supplementation. The digit span memory test revealed a significant greater span score with SAGE as compared to PLACEBO (P = 0.044).Conclusion: The combination of Salvia improved the cognitive functions (perceived exertion, working memory, and reaction time). The positive effects were obtained in fresh condition and were maintained with fatigue.

scholarly journals How does cognitive function measured by the reaction time and critical flicker fusion frequency correlate with the academic performance of students?

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Archana Prabu Kumar ◽  
Abirami Omprakash ◽  
Maheshkumar Kuppusamy ◽  
Maruthy K.N. ◽  
Sathiyasekaran B.W.C. ◽  
...  
Keyword(s):  
Academic Performance ◽  
Reaction Time ◽  
Cognitive Function ◽  
Undergraduate Students ◽  
Cross Sectional Study ◽  
Female Students ◽  
Cross Sectional ◽  
Flicker Fusion Frequency ◽  
Fusion Frequency ◽  
And Gender

Abstract Background The reaction time (RT) is “the time taken for the appearance of rapid voluntary reaction by an individual following a stimulus, either auditory or visual” and the Critical Flickering Fusion Frequency (CFFF) is “the rate at which successively presented light stimuli appear to be steady and continuous”. RT and CFFF are commonly used for the assessment of cognitive functions that are known to influence academic performance. However, data about the exact correlation between these are scarce, particularly in India. This research aimed to study the association between visual RT (VRT), auditory RT (ART) and CFFF and their impact on the academic performance of undergraduate students. Methods This cross-sectional study was conducted on 700 students of Faculty of Medicine and Dentistry at a private medical university in South India, during the period from 2015 to 2017. The VRT, ART and CFFF were evaluated, and the best out of three subsequent attempts was recorded. The mean score (in percentage) of the three best marks out of the five internal assessments for the course during each academic year was considered for analysis. The association between the different cognitive tests and the average academic performance was analysed. Results Female students had faster VRT (n = 345, mean = 243.97, SD = 83.87) than male students (n = 273, mean = 274.86, SD = 96.97) (p = 0.001). VRT and ART had a moderate negative correlation with academic performance (for ART, r = − 0.42, p < 0.001; for VRT; r = − 0.40, p < 0.001). CFFF had a very weak positive correlation with academic performance (r = 0.19, p = 0.01). The only independent predictors of academic performance were RT and gender (Adjusted R2 = 0.11). Conclusion Although there is a correlation between CFFF and cognitive function, our study showed only a weak correlation between CFFF and academic performance. Female students had faster RTs, and gender was an independent predictor of academic performance. Rather, students with faster RTs appear to have an advantage in academic performance.

scholarly journals Prospective Associations of Erythrocyte Composition and Dietary Intake of n-3 and n-6 PUFA with Measures of Cognitive Function

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1253 ◽  
Author(s):  
Sherman Bigornia ◽  
Tammy Scott ◽  
William Harris ◽  
Katherine Tucker
Keyword(s):  
Cognitive Impairment ◽  
Executive Function ◽  
Cognitive Function ◽  
Dietary Intake ◽  
Puerto Rican ◽  
Cognitive Domain ◽  
Health Study ◽  
Individual Species ◽  
Dietary Pufa ◽  
The Impact

Polyunsaturated fatty acid (PUFA) consumption is recommended as part of a healthy diet, but evidence of the impact of individual species and biological concentrations on cognitive function is limited. We examined prospective associations of PUFA erythrocyte composition and dietary intake with measures of cognitive function among participants of the Boston Puerto Rican Health Study (aged 57 years). Erythrocyte and dietary PUFA composition were ascertained at baseline and associated with 2-year scores on the Mini-Mental State Exam (MMSE) (n = 1032) and cognitive domain patterns derived from a battery of tests (n = 865), as well as with incidence of cognitive impairment. Erythrocyte and dietary n-3 PUFA were not significantly associated with MMSE score. However, total erythrocyte and dietary n-3 very-long-chain fatty acids (VLCFA), and intake of individual species, were associated with better executive function (P-trend < 0.05, for all). There was evidence that greater erythrocyte n-6 eicosadienoic acid concentration was associated with lower MMSE and executive function scores (P-trend = 0.02). Only erythrocyte arachidonic acid (ARA) concentration predicted cognitive impairment (Odds Ratio = 1.26; P = 0.01). Among Puerto Rican adults, we found that n-3 VLCFA consumption may beneficially impact executive function. Further, these findings provide some evidence that n-6 metabolism favoring greater ARA tissue incorporation, but not necessarily dietary intake, could increase the risk of cognitive impairment.

scholarly journals Relationship Between Dietary Lutein and Cognition in an Older Adult Population (P14-030-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Krystle Zuniga ◽  
Alexandria Turner ◽  
Nicholas Bishop
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Older Adult ◽  
Verbal Memory ◽  
Adult Population ◽  
Panel Study ◽  
Community Dwelling ◽  
Leafy Vegetables ◽  
Cognitive Domain ◽  
Word Recall

Abstract Objectives The dietary carotenoid lutein accumulates in the brain, and lutein supplementation has been demonstrated to improve cognitive function in older adults. The purpose of the study was to examine the association between dietary lutein intake and cognitive function in a recent and representative sample of the older adult U.S. population. Additionally, we aimed to identify the major contributors to dietary lutein intake in older adults. Methods Observations were drawn from the 2012 Health and Retirement Study (HRS), a nationally-representative panel study of older U.S. adults, and the 2013 Health Care and Nutrition Study (HCNS), which assessed dietary intake via food frequency questionnaire in a subsample of HRS respondents. The analytic sample included 7045 respondents age 50 and older. Cognitive function was evaluated on the cognitive domain of episodic verbal memory, assessed using immediate word recall (IWR) and delayed word recall (DWR). Quartiles of lutein intake were calculated then used to compare IWR and DWR scores in 2012. Descriptive statistics and bivariate comparisons were adjusted for the complex survey design of the HRS and HCNS with results representative of community-dwelling older Americans in 2013. Results The average age of the sample was 65.6 ± 10.3 years old. Leafy vegetables, cruciferous vegetables, dark yellow vegetables, eggs, fruit and other vegetables were significant predictors of dietary lutein intake. Lutein intake was significantly different between quartiles (P < 0.001) with lutein intakes of 720 ± 231 ug/day (Q1), 1468 ± 229 ug/day (Q2), 2394 ± 324 ug/day (Q3), and 5632 ± 3029 ug/day (Q4). Quartiles 3 and 4 had significantly higher IWR and DWR scores than quartiles 1 and 2 (P < 0.001). Conclusions Older adults may benefit from higher lutein intake through consumption of various vegetables, fruits, and eggs, as lutein may specifically protect episodic memory. Further research is needed to identify the mechanism of lutein's cognitive benefits. Funding Sources American Egg Board/Egg Nutrition Center.

scholarly journals The Effects of High-Intensity Interval Exercise and Hypoxia on Cognition in Sedentary Young Adults

Medicina ◽  
2019 ◽  
Vol 55 (2) ◽  
pp. 43 ◽  
Author(s):  
Shengyan Sun ◽  
Paul D. Loprinzi ◽  
Hongwei Guan ◽  
Liye Zou ◽  
Zhaowei Kong ◽  
...  
Keyword(s):  
Reaction Time ◽  
Cognitive Function ◽  
High Intensity ◽  
Cognitive Task ◽  
Response Accuracy ◽  
Acute Bout ◽  
Moderate Hypoxia ◽  
Interval Exercise ◽  
Hypoxic Conditions ◽  
High Intensity Interval

Background and Objectives: Limited research has evaluated the effects of acute exercise on cognition under different conditions of inspired oxygenation. Thus, the purpose of this study was to examine the effects of high-intensity interval exercise (HIE) under normoxia (inspired fraction of oxygen (FIO2): 0.209) and moderate hypoxia (FIO2: 0.154) on cognitive function. Design: A single-blinded cross-over design was used to observe the main effects of exercise and oxygen level, and interaction effects on cognitive task performance. Methods: Twenty inactive adults (10 males and 10 females, 19–27 years old) performed a cognitive task (i.e., the Go/No-Go task) before and immediately after an acute bout of HIE under normoxic and hypoxic conditions. The HIE comprised 10 repetitions of 6 s high-intensity cycling against 7.5% body weight interspersed with 30 s passive recovery. Heart rate, peripheral oxygen saturation (SpO2) and rating of perceived exertion were monitored. Results: The acute bout of HIE did not affect the reaction time (p = 0.204, η2 = 0.083) but the accuracy rate decreased significantly after HIE under both normoxic and hypoxic conditions (p = 0.001, η2 = 0.467). Moreover, moderate hypoxia had no influence either on reaction time (p = 0.782, η2 = 0.004) or response accuracy (p = 0.972, η2 < 0.001). Conclusions: These results indicate that an acute session of HIE may impair response accuracy immediately post-HIE, without sacrificing reaction time. Meanwhile moderate hypoxia was found to have no adverse effect on cognitive function in inactive young adults, at least in the present study.

scholarly journals Cognitive impairment as a function of sleep quality and gender

2019 ◽  
pp. 4
Author(s):  
R. Akhil ◽  
B.P. Nair
Keyword(s):  
Working Memory ◽  
Reaction Time ◽  
Sleep Quality ◽  
Sustained Attention ◽  
Divided Attention ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
Vigilance Test ◽  
And Gender ◽  
Good Sleep

Background: The study aims at finding whether there is any significant difference between sub-groups classified on the basis of sleep quality (good sleep quality and poor sleep quality) and gender in the performance of various cognitive functioning tests like Visual N Back Test (N Back 1and N Back 2 test) for working memory, Triad test for divided attention, Digit Vigilance Test for sustained attention and Reaction time test (simple reaction time and choice reaction time). Materials and methods: The sample consisted of 30 participants, both males (N=13) and females (N=17) in the age range between 18 to 30 years, randomly drawn from Thiruvananthapuram and Kollam districts of Kerala. The participants of the study are screened and categorized into two groups of 15 members each on the basis of the scores obtained in the Pittsburgh Sleep Quality Index (PSQI). t-test and two-way ANOVA were performed to test the significance of the hypotheses. Results: The results showed that the participants with poor sleep quality significantly differed from those with good sleep quality and committed more number of errors in the triad test of divided attention and took more time and committed more errors in the completion of the digit vigilance test of sustained attention. Conclusion: A gender advantage favoring females was seen on the test of working memory, test for sustained attention and the test for choice reaction time. An interaction between sleep quality and gender was noticed only on the test of divided attention. It was seen that males with poor sleep quality are more impaired in divided attention tasks than females with poor sleep quality.

Divided attention in a reaction time index of traffic sign perception

Ergonomics ◽  
1981 ◽  
Vol 24 (2) ◽  
pp. 111-124 ◽  
Author(s):  
Frank J. Testin ◽  
Robert E. Dewar1
Keyword(s):  
Reaction Time ◽  
Divided Attention ◽  
Traffic Sign ◽  
Time Index

Effect of Bhramari pranayama practice on simple reaction time in healthy adolescents – a randomized control trial

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Maheshkumar Kuppusamy ◽  
Dilara Kamaldeen ◽  
Ravishankar Pitani ◽  
Julius Amaldas ◽  
Padmavathi Ramasamy ◽  
...  
Keyword(s):  
Reaction Time ◽  
Cognitive Function ◽  
Simple Reaction Time ◽  
Control Group ◽  
Visual Reaction Time ◽  
Before And After ◽  
Visual Reaction ◽  
Auditory Reaction Time ◽  
Randomized Control ◽  
Apparently Healthy

AbstractObjectivesThe improvement in the/reaction time is important, as it is an indicator of cognitive function. Therefore, there is a need, especially for adolescents in the form of techniques or courses that can improve the reaction time. Yoga was found to cause a better improvement in the health of the individuals. The present study intended to show the effects of Bhramari pranayama (Bhr.P) on reaction time in the healthy adolescents.MethodsOf the 730 potential subjects screened, 520 apparently healthy adolescents randomly assigned to either the Bhr.P group (n-260) or control group (n-260). Bhr.P group practiced the bhramari pranayama for 3 days in a week for 6 months. The Auditory Reaction Time (ART) and the Visual Reaction Time (VRT) were assessed before and after Bhr.P pranayama practice.ResultsBhr.P group shows significant shortening of response time in both VRT (from 267.13 ± 52.65 to 249.87 ± 39.41 ms) and ART (from 237.42 ± 48.12 to 227.91 ± 34.60 ms) after 6 months of Bhr.P practice. In control group subjects, no such significant changes were found (p > 0.05).ConclusionsShortening of RT implies an improvement in the information processing and reflexes. This beneficial effect of Bhr.P on reaction time can be used for improving cognitive function in the adolescents for their academic performances.

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