scholarly journals Effects of Short-term Low- to Moderate- Dose Glucocorticoids on Immuno-inflammatory Indicators and Prognosis of Patients With Regular and Severe COVID-19: A Retrospective Cohort Study

2020 ◽  
Author(s):  
Jing Zhang ◽  
Yi Kang ◽  
Hai-Bo Wang ◽  
Hai-Yang Liu ◽  
Ya-Nan Qi ◽  
...  
Keyword(s):  
Retrospective Cohort ◽  
Control Group ◽  
C Reactive Protein ◽  
Moderate Dose ◽  
Short Term ◽  
Blood Examination ◽  
Reactive Protein ◽  
The Difference ◽  
And Control ◽  
Severe Type

Abstract Background: To explore the effects of short-term low- to moderate- dose glucocorticoids on the immune-inflammatory indicators and 28-d prognoses of patients with regular or severe coronavirus disease 2019 (COVID-19).Methods: The clinical data and laboratorial examination results of 66 patients with regular or severe type of COVID-19 that treated in Henan Provincial People’s Hospital and Nanyang Central Hospital between January 20 and February 14, 2020 were retrospectively analyzed. Here, 36 patients that had been treated with glucocorticoids were categorized in the glucocorticoids group (GC group), while the other 30 patients that had not been treated with glucocorticoids were categorized in the control group.Results: The immune-inflammatory indicators and prognoses of the patients in the two groups were compared. The sex, age, clinical types, and complications were not significantly different between the two groups (all P>0.05). After hospitalization, 33.3% and 6.7% of the patients in the GC group and control group were with chest distress, respectively, and the difference was statistically significant (P=0.019). The duration of fever was also significantly different between the two groups (6.91 ± 4.41 vs. 9.21 ± 4.46 days, P=0.036), but the blood examination results within 24 h after hospitalization were not significantly different between the two groups (all P>0.05). The C-reactive protein (CRP) and Interleukin-6 (IL-6) levels were lower in the GC group than control group on day 7 (P=0.012, P=0.035) but were not significantly different between the two groups on day 14. The CRP and IL-6 levels were significantly reduced after glucocorticoids treatment on day 3, 5 and 7 (all P<0.05) in GC group. The median time of hospital stay, and 28-d prognoses were not significantly different between the two groups (P=0.080, P>0.999).Conclusions: Glucocorticoids could decrease the levels of inflammatory indicators, but did not significantly influence other immune-related indicators and 28-d prognoses.

scholarly journals Studying the Role of C-Reactive Protein in Patients with Sleeve Gastrectomy in Baghdad

2021 ◽  
Vol 3 (1) ◽  
pp. 55-60
Author(s):  
Mohammed Abbas Fadil ◽  
Raya Ezat Maroof ◽  
Moayed Abbas Fadil
Keyword(s):  
Sleeve Gastrectomy ◽  
Healthy Person ◽  
Control Group ◽  
C Reactive Protein ◽  
Serum Samples ◽  
Reactive Protein ◽  
Medical City ◽  
Healthy Control ◽  
And Control

Obesity and severe obesity are increasing serious health problems with an epidemic percentage in most countries. In Sleeve gastrectomy, a part of the stomach structure is removed, limiting its capacity by about two to three. A total of thirty blood samples were collected from patients with obesity and the result was compared with healthy person throughout the time from November 2019 to September 2020. Before sleeve gastrectomy and after more than 6 months of sleeve surgery, the sample was collected from the Medical City/Baghdad Teaching Hospital, the withdrawal was again taken at home to have pre and post sleeve gastrectomy, Patient age ranged between [20-46] years for obese patients and healthy control. Then the serum samples were obtained from patients and control group to screen for C-reactive protein by agglutination method. The result of the present study found that the positivity of CRP in pre-operation is higher than that of post-operative with high significance [P<0.005].

scholarly journals C – reactive protein in saliva of non-smoking patients with periodontitis (a pilot study)

2021 ◽  
Author(s):  
Zerina Hadžić ◽  
Ivan Puhar
Keyword(s):  
Pilot Study ◽  
Test Group ◽  
Periodontal Therapy ◽  
Control Group ◽  
C Reactive Protein ◽  
Inflammatory Biomarker ◽  
Reactive Protein ◽  
Before And After ◽  
Oral Hygiene Instructions ◽  
And Control

Introduction: C-reactive Protein (CRP) as an inflammatory biomarker can be easily determined in saliva, but the values of salivary CRP in periodontitis are not well-studied. The aim of this study was to analyze and determine the values of salivary CRP in non-smokers with periodontitis stage 3 or 4 before and after supragingival and subgingival full-mouth periodontal therapy.Methods: Standard periodontal parameters and saliva samples were collected in 12 non-smoking patients. Patients in the test group (n = 6) underwent supragingival and subgingival full-mouth periodontal therapy, and the control group (n = 6) received only supragingival full-mouth therapy. Both groups received the same oral hygiene instructions in addition to therapy. After 3 months, re-registration of periodontal parameters and re-sampling of saliva for analysis of salivary CRP were done for both groups.Results: Statistical analysis revealed large differences in the values of clinical periodontal parameters and CRP levels in the test group after therapy. Values of salivary CRP in the test and control groups were lower 3 months the therapy; however, the results were not statistically significant. The correlation of clinical periodontal parameters and salivary CRP varied in both groups.Conclusion: Our pilot study reveals decreased concentrations of salivary C-reactive protein in non-smoking patients following non-surgical periodontal therapy. Further studies are needed to prove the reliability of salivary CRP as a biomarker for periodontitis.

Plasma Concentrations of C-Reactive Protein and Fibrinogen in Ischaemic Stroke

2002 ◽  
Vol 30 (6) ◽  
pp. 591-596 ◽  
Author(s):  
İ İyigün ◽  
Y Bakirci
Keyword(s):  
Ischaemic Stroke ◽  
Cerebral Artery ◽  
Plasma Concentrations ◽  
Control Group ◽  
C Reactive Protein ◽  
Arterial Lesion ◽  
Reactive Protein ◽  
The Difference ◽  
Unconscious Patients ◽  
The Relationship

This study investigated how fibrinogen and C-reactive protein (CRP) levels change in response to neural damage occurring after ischaemia, and the relationship between the distribution of the arterial lesion, the disease prognosis and the levels of these substances. Fibrinogen and CRP levels were measured in blood samples obtained from 83 patients admitted to hospital within 72 h of a first ischaemic stroke. The patients were evaluated clinically with the Glasgow Outcome Scale (GOS), and results were compared with 43 age-matched controls. The fibrinogen and CRP levels in unconscious patients with hemiparesis or hemiplegia were higher than those in conscious hemiplegic patients. Also, the difference in GOS values between the unconscious patients with hemiparesis or hemiplegia and conscious patients with hemiparesis or hemiplegia was statistically significant. Patients with large infarcts in the median cerebral artery and anterior cerebral artery had higher fibrinogen and CRP concentrations than the control group. In conclusion, fibrinogen and CRP may be important measures for determining the prognosis and outcome in patients following ischaemic stroke.

scholarly journals The Effect of Eight Weeks of Massage on Blood Pressure, Heart Rate and C-Reactive Protein in Women With Hypertension

2020 ◽  
Vol 23 (3) ◽  
pp. 398-411
Author(s):  
Shahnaz Shahrjerdi ◽  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Control Group ◽  
Common Disease ◽  
Medical Sciences ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Massage Group ◽  
Quasi Experimental ◽  
And Control

Background and Aim: Hypertension is a common disease and universal that can cause cardiovascular disease and kidney damage. The purpose of this study was to determine the effect of an eight-weeks massage on blood pressure (systolic and diastolic), heart rate and C-reactive protein in women with hypertension.  Methods & Materials: In this quasi-experimental study, 44 volunteer women with Mean±SD age of 42.12±5.31years were selected from women referred to Arak Oil Company specialized polyclinic with hypertension. Four women excluded from the study for some reason, and the rest were divided into experimental and control groups. In massage group massage was done for three sessions per week, 45-60 minutes in each session, on the back and upper limbs for eight weeks. Data analysis was conducted using dependent and independent t-test by SPSS V. 25 statistical software at the significant level of (P≤0.05). Ethical Considerations: This study (Code: 92-160-26) was approved in Research Ethics Committee of Arak University of Medical Sciences. Results: The results showed that eight weeks of massage reduced blood pressure (P=0.001), the heart rate (P=0.001), and C-reactive protein (P=0.001) in women with hypertension compared to the control group (P=0.62). Conclusion: The findings of this study showed that massage for eight weeks is an efficient and appropriate method to improve systolic and diastolic blood pressure, heart rate, and C-reactive protein in patients with hypertension.

scholarly journals Ringworm: Evaluation of C-reactive Protein and Lipid Profile as well as Their Correlation with the Patients Age and Body Mass Index

2020 ◽  
Vol 19 (4) ◽  
pp. 673-677
Author(s):  
Md Shafiul Hossen ◽  
Auditi Kar ◽  
Hasan Moinul Haque
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol Level ◽  
Medical Science ◽  
Control Group ◽  
Healthy Individuals ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Significant Difference ◽  
Serum Crp ◽  
And Control

Objectives: Ringworm is a common cutaneous fungal disease with worldwide distribution.It may lead to the abnormal c-reactive protein levels and metabolism of lipid. Thus this study has been designed for determining serum CRP and also evaluating the Lipid profile in patients associated with ringworm. Materials and methods: This study recruited 25 patients with ringworm (cases) and 25 healthy individuals (controls). A questionnaire of personal characteristics was completed for each patient and control. Inflammatory marker (CRP) and Serum lipid profile (total, lowdensity lipoprotein (LDL), high-density lipoprotein (HDL) cholesterol and triglyceride) was recorded for each case and control. The test of significance was applied for statistical analysis. Results and discussion: The mean serum CRP were 1.608±0.14 and 0.648±0.03 mg/dl and total cholesterol level were 175.09±3.26 and 182.09±3.01 mg/dl in ringworm patients and control subject respectively. It was also observed that the serum TG; HDL; LDL levels were 131.76±3.07 and 139.84±3.47 mg/dl; 80.79±1.79 and 73.35±4.14 mg/dl; 67.95±4.64 and 86.55±3.70 mg/dl in patients and control group respectively. The value of CRP was significantly increased in patients compared to control group (p <0.05). There was no significant difference of lipid profile study between patients and control Conclusion: Findings of this study indicate increased concentrations of CRP in patients affected to ringworm and its role in this infection. Patients should thus be routinely screened for such abnormalities Probably observation of lipid profile in healthy individuals in compare with patients group indicates that it has no relationship in case of ringworm. Bangladesh Journal of Medical Science Vol.19(4) 2020 p.673-677

scholarly journals Association of C-reactive protein and Interleukin-6 single nucleotide polymorphisms with preterm labour: results of a pilot study

2021 ◽  
Author(s):  
Akira Sato ◽  
Hiroshi Miura ◽  
Yohei Onodera ◽  
Hiromitu Shirasawa ◽  
Saeko Kameyama ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Preterm Labour ◽  
Normal Pregnancy ◽  
Cervical Length ◽  
Control Group ◽  
Nucleotide Polymorphisms ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Pcr Rflp ◽  
And Control

Preterm labour (PTL) can be described as an inflammatory event. C-reactive protein (CRP) and Interleukin-6 (IL-6) are key members of the innate immune response that play major roles in inflammation. The main objective of this case-control study was to determine the association of specific CRP and IL-6 polymorphisms with PTL. The study was carried out in a total of 31 Japanese women with PTL and 28 control women with normal pregnancy. Four SNPs in the CRP gene (rs1800947, rs3091244, rs2794521, and rs3093059) and two SNPs in the IL-6 gene (rs2097677 and rs1800795) were genotyped using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Biochemical parameters were assayed and cervical length measurements were performed with ultrasound sonography. There were no significant differences in inflammatory markers, including white blood cell count, CRP, neutrophil elastase in cervical mucous, and foetal fibronectin in vaginal discharge, between the PTL and control groups. The frequency of rs1800947 minor allele (C) was significantly higher in the PTL group than in the control group. This finding has not been previously reported. We suggest that mutations in rs1800947 may lead to PTL. Thus, the rs1800947 SNP may be useful as a genetic marker for PTL risk assessment in pregnant women.

scholarly journals Apolipoproteins: Good Markers for Cardiovacular Risk in Patients with Chronic Kidney Disease and Dyslipidemia

2014 ◽  
Vol 21 (3) ◽  
pp. 185-191 ◽  
Author(s):  
Mirela - Nicoleta Tudor ◽  
Adina Mitrea ◽  
Simona Georgiana Popa ◽  
Sorin Zaharie ◽  
Maria Moţa ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Estimated Glomerular Filtration Rate ◽  
Control Group ◽  
C Reactive Protein ◽  
High Cardiovascular Risk ◽  
Apo B ◽  
Reactive Protein ◽  
And Control

AbstractBackground and aims. Dyslipidemia (DLP) is a common complication of chronic kidney disease (CKD) and may accelerate its progression. Circulating lipoproteins and their constituent proteins, apolipoproteins, are risk factors for CKD and cardiovascular diseases (CVD). The aim of the study was to determine whether there is a correlation between apolipoproteins and estimated glomerular filtration rate (eGFR) or between apolipoproteins and anthropometrical and laboratory parameters or between evaluated cardiovascular risk (CV) and dyslipidemia/CKD. Material and methods. We performed a study on 51 subjects from the Nephrology Department of Emergency Clinical County Hospital of Craiova, from November 2011 to July 2013. Results. We found statistically significant correlations between eGFR and Apo A1. Also we found a linear correlation between C-reactive protein (CRP) and Apo B. When we evaluated the CV risk using CRP, we found statistically significant differences between the groups (CKD and DLP, only CKD, only DLP and control group), patients with CKD and DLP showing the highest levels of CRP. Conclusions. Elevated levels of Apo A1 are associated with a low rate of CKD. DLP and chronic inflammation play an important role in the progression of CKD. Patients with CKD and DLP had a high cardiovascular risk.

scholarly journals Serum P-Cresyl Sulfate Is a Predictor of Central Arterial Stiffness in Patients on Maintenance Hemodialysis

Toxins ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 10 ◽  
Author(s):  
Yu-Hsien Lai ◽  
Chih-Hsien Wang ◽  
Chiu-Huang Kuo ◽  
Yu-Li Lin ◽  
Jen-Pi Tsai ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Area Under The Curve ◽  
Maintenance Hemodialysis ◽  
Control Group ◽  
Liquid Chromatography Mass Spectrometry ◽  
C Reactive Protein ◽  
Optimal Cutoff ◽  
Reactive Protein ◽  
And Control ◽  
The Relationship

Arterial stiffness (AS) has an important impact on the outcomes of patients on hemodialysis (HD), and p-cresyl sulfate (PC) can mediate the process of vascular damage. We aimed to investigate the relationship between carotid–femoral pulse wave velocity (cfPWV) and the level of PCs in HD patients. Serum PCs were quantified using liquid chromatography mass spectrometry. Patients who were on standard HD for more than 3 months were enrolled and categorized according to the cfPWV into the high AS (>10 m/s) and control (≤10 m/s) groups. Forty-nine (41.5%) patients belonged to the high AS group and had a higher incidence of diabetes mellitus (DM) and increased systolic blood pressure, serum C-reactive protein, and PC levels but had lower creatinine, compared with those in the control group. In HD patients, the risk for developing high AS increased in the presence of DM (OR 4.147, 95% confidence interval (CI) 1.497–11.491) and high PCs (OR 1.067, 95% CI 1.002–1.136). Having DM (r = 0.446) and high PC level (r = 0.174) were positively associated with cfPWV. The most optimal cutoff value of PC for predicting AS was 18.99 mg/L (area under the curve 0.661, 95% CI 0.568–0.746). We concluded that DM and PCs were promising predictors of high AS in patients on maintenance HD.

scholarly journals Effects of Single Bout and Short Term Aerobic Exercise on C-Reactive Protein in Type-2 Diabetes Patients: A Pilot Study

2020 ◽  
Vol 61 (1) ◽  
pp. 31-42
Author(s):  
C. I. Ezema ◽  
M. C. Nweke ◽  
C. N. Amarachukwu ◽  
C. Obiekwe ◽  
C. I. Okafor ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Aerobic Exercise ◽  
C Reactive Protein ◽  
Control Groups ◽  
Short Term ◽  
Reactive Protein ◽  
Single Bout ◽  
And Control ◽  
Diabetes Patients

Type-2 diabetes is a leading risk for cardiovascular diseases and events due to ease of develop­ment of atherosclerosis in people with type-diabetes. Chronic inflammation is a major driver of atherosclerosis in type-2 diabetes and it has been linked to elevated C-reactive protein (CRP) level. The objective of this study was to determine whether CRP is amenable to aerobic exercise. A total of 40 adults diagnosed with type-2 diabetes patients were sampled randomly, and later, conveniently allocated into exercise and control groups. All the subjects were on the diabetes exchange diet as recommended by their Dieticians. Results show that the glucose level of the subjects of this study was fairly under control ((glycated haemoglobin (HbA1c) = 0.80±0.11% for each of the group)). A weak negative correlation was found between ex­ercise-induced reductions in CRP and HbA1c (r = -0.345; p = 0.029). Significant (p < 0.05) difference in CRP was found between study and control groups following single bout (30 min) aerobic exercise, however, no significant (p > 0.05) difference in CRP was found between study and control groups after 8-weeks. Single bout or short-term aerobic exercises does not reduce CRP in people with fairly controlled type-2 diabetes mellitus.

Effect of Electroacupuncture on the Inflammatory Response in Patients with Acute Pancreatitis: An Exploratory Study

2015 ◽  
Vol 33 (2) ◽  
pp. 115-120 ◽  
Author(s):  
Shi-Feng Zhu ◽  
Hui Guo ◽  
Rong-Rong Zhang ◽  
Yumei Zhang ◽  
Juan Li ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Inflammatory Responses ◽  
Length Of Hospital Stay ◽  
Control Group ◽  
Serum Concentrations ◽  
C Reactive Protein ◽  
Control Groups ◽  
Reactive Protein ◽  
Registration Number ◽  
And Control

Objectives To examine the effects of electroacupuncture (EA) on inflammatory responses in patients with acute pancreatitis (AP). Methods Eighty patients with mild or severe AP were randomly allocated to a control group or an EA group. All patients were managed conservatively. In addition, the EA group received acupuncture for 30 min per day for 7 days at bilateral points ST36, LI4, TE6, ST37 and LR3. Interleukin (IL)-6, IL-10 and C-reactive protein (CRP) levels were measured on admission and on day 7. The time to re-feeding and length of stay in hospital were also recorded. Results A total of 58 patients provided complete data. The characteristics of the patients in the EA and control groups were similar. After 7 days the serum concentrations of IL-10 were higher in the EA group than in the control group (mild AP: 6.2±1.2 vs 5.2±0.9 pg/mL, p<0.05; severe AP: 14.9±7.8 vs 7.9±6.3 pg/mL, p<0.05). For patients with severe AP, the CRP level in the EA group was lower than in the control group (p<0.05). Conclusions EA may reduce the severity of AP by inducing anti-inflammatory effects and reducing the time to re-feeding; however, it did not reduce the length of hospital stay. Trial Registration Number ChiCTR-TRC-13003572.

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