Standardised 3D-CT Lung Volumes for Patients with Idiopathic Pulmonary Fibrosis

Abstract Background: The assessment of lung physiology via pulmonary function tests (PFTs) is essential for patients with idiopathic pulmonary fibrosis (IPF). However, PFTs require active participation, which can be challenging for patients with severe respiratory failure, such as during acute exacerbations (AE) of IPF. Recently advances enabled to re-construct of 3-dimensional computed-tomography (3D-CT) images. Methods: This is a retrospective multi-center cohort study. This study established a standardisation method and quantitative analysis of lung volume (LV) based on anthropometry using three-dimensional computed tomography (3D-CT) images. The standardised 3D-CT LV in patients with IPF at diagnosis (n=140) and during AE (cohort1; n=61 and cohort2; n=50) and those of controls (n=53) were measured. Results: The standardised 3D-CT LVs at IPF diagnosis were less than those of control patients, especially in the lower lung lobes. The standardised 3D-CT LVs were correlated with forced vital capacity (FVC) and validated using the modified Gender-Age-Physiology (GAP) index. The standardised 3D-CT LVs at IPF diagnosis were independently associated with prognosis. During AE, PFTs were difficult to perform, 3D-CT analyses revealed reduced lung capacity in both the upper and lower lobes compared to those obtained at diagnosis. Lower standardised 3D-CT LVs during AE were independently associated with worse outcomes in independent two cohorts. Particularly, volume loss in the upper lobe at AE had prognostic values.Conclusion: A novel image quantification method for assessing pulmonary physiology using standardised 3D-CT-derived LVs was developed. This method successfully predicts mortality in patients with IPF and AE of IPF, and may be a useful alternative to PFTs when PFTs cannot be performed.

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Prognosis of pulmonary fibrosis presenting with a usual interstitial pneumonia pattern on computed tomography in patients with myeloperoxidase anti-neutrophil cytoplasmic antibody-related nephritis: a retrospective single-center study

BMC Pulmonary Medicine ◽

10.1186/s12890-019-0969-5 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Toshikazu Watanabe ◽

Tomoyuki Minezawa ◽

Midori Hasegawa ◽

Yasuhiro Goto ◽

Takuya Okamura ◽

...

Keyword(s):

Computed Tomography ◽

Pulmonary Fibrosis ◽

Interstitial Pneumonia ◽

Lung Volume ◽

Lung Fibrosis ◽

Usual Interstitial Pneumonia ◽

Three Dimensional ◽

3D Ct ◽

Antifibrotic Therapy ◽

Significant Difference

Abstract Background Myeloperoxidase anti-neutrophil cytoplasmic antibody-related nephritis (MPO-ANCA nephritis) is occasionally accompanied by lung abnormalities such as pulmonary fibrosis. However, the clinical features of pulmonary fibrosis in patients with MPO-ANCA nephritis have not been well documented. This study was performed to compare the prognosis of a usual interstitial pneumonia (UIP) pattern of lung fibrosis in patients with MPO-ANCA nephritis with the prognosis of idiopathic pulmonary fibrosis (IPF). Methods We retrospectively reviewed the medical records of 126 patients with MPO-ANCA nephritis and identified 31 with a UIP pattern of lung fibrosis on high-resolution or thin-slice computed tomography (CT). We compared the characteristics and prognosis of these patients with those of 32 patients with IPF. In 18 patients from both groups, we assessed and compared the decline in lung volume over time using three-dimensional (3D) CT images reconstructed from thin-section CT data. Results The numbers of male and female patients were nearly equal among patients with MPO-ANCA nephritis exhibiting a UIP pattern; in contrast, significant male dominancy was observed among patients with IPF (p = 0.0021). Significantly fewer smokers were present among the patients with MPO-ANCA nephritis with a UIP pattern than among those with IPF (p = 0.0062). There was no significant difference in the median survival time between patients with MPO-ANCA nephritis with a UIP pattern (50.8 months) and IPF (55.8 months; p = 0.65). All patients with IPF in this cohort received antifibrotic therapy (pirfenidone or nintedanib). Almost half of the deaths that occurred in patients with MPO-ANCA nephritis with a UIP pattern were caused by non-respiratory-related events, whereas most deaths in patients with IPF were caused by respiratory failure such as acute exacerbation. In the 3D CT lung volume analyses, the rate of decline in lung volume was equivalent in both groups. Conclusions MPO-ANCA nephritis with a UIP pattern on CT may have an unfavorable prognosis equivalent to that of IPF with a UIP pattern treated with antifibrotic agents.

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Multicenter study of quantitative computed tomography analysis using a computer-aided three-dimensional system in patients with idiopathic pulmonary fibrosis

Japanese Journal of Radiology ◽

10.1007/s11604-015-0496-0 ◽

2015 ◽

Vol 34 (1) ◽

pp. 16-27 ◽

Cited By ~ 9

Author(s):

Tae Iwasawa ◽

Tetsu Kanauchi ◽

Toshiko Hoshi ◽

Takashi Ogura ◽

Tomohisa Baba ◽

...

Keyword(s):

Computed Tomography ◽

Idiopathic Pulmonary Fibrosis ◽

Pulmonary Fibrosis ◽

Multicenter Study ◽

Quantitative Computed Tomography ◽

Three Dimensional ◽

Dimensional System ◽

Computer Aided ◽

Three Dimensional System ◽

Tomography Analysis

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Motion Analysis of the Trapeziometacarpal Joint Using Three-dimensional Computed Tomography

The Journal of Hand Surgery (Asian-Pacific Volume) ◽

10.1142/s2424835516500120 ◽

2016 ◽

Vol 21 (01) ◽

pp. 78-84 ◽

Cited By ~ 1

Author(s):

Tetsuya Kimura ◽

Hiroaki Takai ◽

Tatsuo Azuma ◽

Koichi Sairyo

Keyword(s):

Computed Tomography ◽

Range Of Motion ◽

Three Dimensional ◽

Ct Images ◽

Metacarpal Bone ◽

Joint Surface ◽

3D Ct ◽

Trapeziometacarpal Joint ◽

Wide Range ◽

Contact Surfaces

Background: Zancolli theorized that the first metacarpal bone axially rotates on the semispheroidal part of the trapezium, which is controlled by ligaments. This study used three-dimensional computed tomography (3D-CT) to describe the motion of the first metacarpal bone on the trapezium. Methods: 3D-CT images were taken of the left hand of 30 healthy volunteers (mean age [Formula: see text] years, 15 men and 15 women). They were divided into five groups: radial abduction, retroposition, adduction, palmar abduction, and opposition. The range of motion of radial abduction and palmar abduction of the trapeziometacarpal joint was measured from the first metacarpal bone to the second metacarpal bone. The range of motion of pronation was measured following Cheema's method. The main contacts of the joint surface of trapezium and the first metacarpal bone were determined on the 3D-CT images. Results: Pronation of the trapeziometacarpal joint was [Formula: see text] in radial abduction, [Formula: see text] in retroposition, [Formula: see text] in adduction, [Formula: see text] in palmar abduction, and [Formula: see text] in opposition. Radial abduction was [Formula: see text] in radial abduction, [Formula: see text] in retroposition, [Formula: see text] in adduction, [Formula: see text] in palmar abduction, and [Formula: see text] in opposition. Palmar abduction was [Formula: see text] in radial abduction, [Formula: see text] in retroposition, [Formula: see text] in adduction, [Formula: see text] in palmar abduction, and [Formula: see text] in opposition. The contact surfaces of the trapezium and the first metacarpal bone were dorsal and ulnar in radial abduction, radial and ulnar in retroposition, and volar-ulnar and volarradial in opposition, respectively, while they were both central in adduction and both radial in palmar abduction. Conclusions: The range of motion of the trapeziometacarpal joint was 44° for radial abduction/adduction, 48° for palmar abduction/adduction, and 57° for pronation/supination. The varying contact surfaces of the trapezium and the first metacarpal bone enabled a wide range of motion.

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Alterations in Plasma miR-21, miR-590, miR-192 and miR-215 in Patients with Idiopathic Pulmonary Fibrosis and Their Clinical Importance

10.21203/rs.3.rs-471899/v1 ◽

2021 ◽

Author(s):

Hulya Dirol ◽

Aslı Toylu ◽

Aliye Candan Ogus ◽

Aykut Cilli ◽

Omer Ozbudak ◽

...

Keyword(s):

Idiopathic Pulmonary Fibrosis ◽

Pulmonary Fibrosis ◽

Plasma Levels ◽

Pulmonary Function Tests ◽

Clinical Importance ◽

Cross Sectional Study ◽

Cross Sectional ◽

Pulmonary Physiology ◽

Significant Difference ◽

And Control

Abstract Background: It is well-established that microRNAs (miRNAs) have regulatory roles in the fibrotic processes of various tissues. Studies revealed that some miRNAs play a pivotal role in the development of idiopathic pulmonary fibrosis (IPF). Methods: In this single-center, cross-sectional study, the plasma levels of miR-21, miR-590, miR-192, and miR-215 in IPF (n=88) and the control (n=20) group were investigated using real-time PCR. The pulmonary function tests and the plasma sampling of participants were carried out simultaneously. Patients were grouped according to age, forced vital capacity, diffusing capacity for carbon monoxide (DLCO), and the Gender-Age-pulmonary Physiology (GAP) score. The expression levels of the target miRNAs between these clinical subgroups were compared.Results: The IPF and control groups were similar in terms of gender and age. The mean plasma miR-21 and miR-590 levels in IPF were significantly higher than in the control (p<0.0001, p<0.0001, respectively). There was no significant difference in miR-192 and miR-215 levels between the groups. While miR-21 and miR-590 correlated positively with age (p=0.041, p=0.007, respectively), miR-192 and miR-215 displayed a negative correlation with age (p=0.0002, p<0.0001, respectively). MiR-192 and miR-215 increased as the GAP score decreased and miR-192 level in patients with honeycombing was significantly lower than in those without honeycombing (p=0.003).Conclusions: Our results suggest that higher plasma levels of miR-21 and miR-590 were related to the presence of IPF. While all target miRNAs correlated with age, the miR-21 and miR-590 were associated with DLCO, and miR-192 and miR-215 were associated with GAP score and honeycombing.

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Three-Dimensional Reconstruction Algorithm of Computed Tomography Imaging for Surgical Treatment and Rapid Rehabilitation Nursing of Renal Cell Carcinoma

Scientific Programming ◽

10.1155/2021/9948656 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Lijun Wang ◽

Haiyan Lin ◽

Hong Zheng ◽

Yuying Jiang

Keyword(s):

Computed Tomography ◽

3D Reconstruction ◽

Renal Cell ◽

Three Dimensional ◽

Life Quality ◽

Reconstruction Algorithm ◽

Nursing Intervention ◽

Ct Images ◽

3D Ct ◽

Self Rating

This study was carried out to explore the promotion role of computed tomography (CT) imaging three-dimensional (3D) reconstruction technology and rapid rehabilitation nursing intervention (RRNI) in the treatment of patients with renal cell cancer (RCC) laparoscopic radical nephrectomy (LRN) in view of the patient’s condition. 98 RCC patients who were admitted to the hospital from July 2019 to July 2020 were selected as the research subjects, and all patients underwent the LRN and the RRIN. Of which, 46 RCC patients were scanned with CT images (regarded as the CT group), and 46 RCC patients were scanned with CT images based on 3D reconstruction algorithms (regarded as the 3D CT group). The clinical efficacy and the life quality, pain degree, and adverse mood changes before and after the RRN were analyzed and compared. The results showed that the surgery time in the 3D CT group and the CT group was 130.2 ± 42.8 minutes and 162.4 ± 38.5 minutes, respectively ( P < 0.05 ). The recurrence rate of RCC in both groups was 0%. The estimated blood loss in the 3D CT group and the CT group was 93.6 ± 35.5 mL and 90.3 ± 40.2 mL, respectively; the complication rate in the 3D CT and CT group was 5% and 12%, respectively; the hospital stay in the 3D CT and CT group was 12.5 ± 4.7 days and 12.1 ± 3.2 days, respectively, which had no statistical significance ( P > 0.05 ). The scores of visual analogue scale (VAS), 36-Item Short-Form Health Survey (SF-36), self-rating depression scale (SDS), and self-rating anxiety scale (SAS) of patients in the two groups were statistically significant ( P < 0.05 ). It indicated that CT images based on the 3D reconstruction algorithm could be applied in LRN of RCC patients to shorten the surgery time and improve the surgical effect, and implementation of the RRN could relieve the adverse mood of RCC patients and effectively improve their life quality.

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Comparison between Three-Dimensional and Triplanar Computed Tomography Imaging of the Frontal Recess

American Journal of Rhinology and Allergy ◽

10.2500/ajra.2009.23.3350 ◽

2009 ◽

Vol 23 (5) ◽

pp. 502-505 ◽

Cited By ~ 7

Author(s):

Seth J. Isaacs ◽

Parul Goyal

Keyword(s):

Computed Tomography ◽

Frontal Sinus ◽

Three Dimensional ◽

Surgical Techniques ◽

Ct Images ◽

Outflow Tract ◽

Sinus Surgery ◽

3D Ct ◽

Sinus Disease ◽

Frontal Recess

Background Despite advances in endoscopic surgical techniques, management of frontal sinus disease remains challenging. Much of this is related to the complex nature of frontal recess anatomy. A thorough understanding of frontal recess anatomy is paramount for the safety and success of frontal sinus surgery. Three-dimensional (3D) computed tomography (CT) may allow surgeons to obtain a more complete preoperative assessment of frontal recess anatomy. The purpose of this study was to determine if reconstructed 3D CT images as an adjunct to conventional triplanar imaging provide additional information regarding the frontal recess anatomy. Methods A prospective study was performed. Two otolaryngologists reviewed the CT scans of 25 patients referred for routine paranasal sinus disease. The findings from review of the triplanar CT images were compared with the findings from review of the 3D reconstructions. Each study was assessed for (1) frontoethmoidal cells, (2) agger nasi cell, (3) subrabullar and frontal bullar cells, (4) intersinus septal cell, (5) superior uncinate process attachment site, and (6) and frontal sinus outflow tract. The examiners rated the usefulness of each study to identify each of the aforementioned anatomic subsites using a modified 5-point Likert scale. Results Intersinus septal cells, supraorbital ethmoid cells, and the anterior–posterior dimension of the frontal sinus outflow tract were better defined on the reconstructed 3D CT images. Conclusion Three-dimensional CT is a useful adjunct to the conventional triplanar studies for the evaluation of frontal sinus and recess anatomy. This technique can define certain anatomic variants more effectively than 2D multiplanar reconstructed images.

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Visualization of torn anterior cruciate ligament using 3-dimensional computed tomography

Orthopedic Reviews ◽

10.4081/or.2013.e22 ◽

2013 ◽

Vol 5 (3) ◽

pp. 22 ◽

Cited By ~ 1

Author(s):

Hiroaki Uozumi ◽

Toshimi Aizawa ◽

Takehiko Sugita ◽

Tomonori Kunii ◽

Shun Abe ◽

...

Keyword(s):

Computed Tomography ◽

Anterior Cruciate Ligament ◽

Acl Reconstruction ◽

Cruciate Ligament ◽

Three Dimensional ◽

Lateral Wall ◽

Ct Images ◽

Reconstruction Technique ◽

3D Ct ◽

Anterior Cruciate

Recently, a remnant-preserving anterior cruciate ligament (ACL) reconstruction technique has been developed. However, the pre-operative condition of remnant ACL is occasionally difficult to evaluate by magnetic resonance imaging. The purpose of this study is to evaluate the accuracy of pre-operative visualization of remnant ACL using three-dimensional computed tomography (3D-CT). The remnant ACL in 25 patients was examined by 3D-CT before ACL reconstruction surgery. Findings on 3D-CT images and arthroscopy were compared. The 3D-CT images were classified into 4 groups: Group A, remnant fibers attached to the posterior cruciate ligament (PCL); Group B, those located between the PCL and the lateral wall; Group C, those attached to the lateral wall; and Group D, no identifiable remnant fibers on the tibial side. These groups were made up of 4, 3, 9 and 9 patients, respectively. Findings on 3D-CT images were identical to those during arthroscopy in 20 of 25 cases (80%). Remnant ACL can be accurately evaluated using 3D-CT in 80% of cases of torn ACL. This novel method is a useful technique for pre-operative assessment of remnant ACL.

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Clinicoserological features of antisynthetase syndrome (ASyS)-associated interstitial lung disease presenting to respiratory services: comparison with idiopathic pulmonary fibrosis and ASyS diagnosed in rheumatology services

BMJ Open Respiratory Research ◽

10.1136/bmjresp-2020-000829 ◽

2021 ◽

Vol 8 (1) ◽

pp. e000829

Author(s):

Shaney L Barratt ◽

Havra H Adamali ◽

Caroline Cotton ◽

Ben Mulhearn ◽

Hina Iftikhar ◽

...

Keyword(s):

Interstitial Lung Disease ◽

Idiopathic Pulmonary Fibrosis ◽

Pulmonary Fibrosis ◽

Lung Disease ◽

Trna Synthetase ◽

Musculoskeletal Symptoms ◽

Antisynthetase Syndrome ◽

Cytoplasmic Staining ◽

Phenotypic Differences ◽

Lung Physiology

IntroductionAntisynthetase syndrome (ASyS) is a rare autoimmune connective tissue disease (CTD), associated with autoantibodies targeting tRNA synthetase enzymes, that can present to respiratory (interstitial lung disease (ILD)) or rheumatology (myositis, inflammatory arthritis and systemic features) services. The therapeutic management of CTD-associated ILD and idiopathic pulmonary fibrosis (IPF) differs widely, thus accurate diagnosis is essential.MethodsWe undertook a retrospective, multicentre observational cohort study designed to (1) evaluate differences between ASyS-associated ILD with IPF, (2) phenotypic differences in patients with ASyS-ILD presenting to respiratory versus rheumatology services, (3) differences in outcomes between ASySassociated with Jo-1 versus non-Jo-1 autoantibodies and (4) compare long-term outcomes between these groups.ResultsWe identified 76 patients with ASyS-ILD and 78 with IPF. Patients with ASyS were younger at presentation (57 vs 77 years, p<0.001) with a female predominance (57% vs 33%, p=0.006) compared with IPF. Cytoplasmic staining on indirect immunofluorescence was a differentiating factor between ASyS and IPF (71% vs 0%, p<0.0001). Patients with ASyS presenting initially to respiratory services (n=52) had a higher prevalence of ASyS non-Jo-1 antibodies and significantly fewer musculoskeletal symptoms/biochemical evidence of myositis, compared with those presenting to rheumatology services (p<0.05), although lung physiology was similar in both groups. There were no differences in high-resolution CT appearances or outcomes in those with Jo-1 versus non-Jo-1 ASyS-ILD.ConclusionsExtended autoimmune serology is needed to evaluate for ASyS autoantibodies in patients presenting with ILD, particularly in younger female patients. Musculoskeletal involvement is common in ASyS (typically Jo-1 autoantibodies) presenting to rheumatology but the burden of ILD is similar to those presenting to respiratory medicine.

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Automated computed tomography quantification of fibrosis predicts prognosis in combined pulmonary fibrosis and emphysema in a real-world setting: a single-centre, retrospective study

Respiratory Research ◽

10.1186/s12931-020-01545-3 ◽

2020 ◽

Vol 21 (1) ◽

Author(s):

Masahiro Nemoto ◽

Yuichiro Nei ◽

Brian Bartholmai ◽

Kazuki Yoshida ◽

Hiroki Matsui ◽

...

Keyword(s):

Computed Tomography ◽

Retrospective Study ◽

Pulmonary Fibrosis ◽

Acute Exacerbation ◽

Real World ◽

Medical Center ◽

Pulmonary Function Tests ◽

Quantitative Computed Tomography ◽

Single Centre ◽

Real World Setting

Abstract Background Combined pulmonary fibrosis and emphysema (CPFE) is a heterogeneous clinico-radiological syndrome without a consensus definition. There are limited data on the relation between the amount of parenchymal fibrosis and prognosis. In this study, we assessed the prognostic implications of the extent of fibrosis assessed by an automated quantitative computed tomography (CT) technique and the radiological and functional change over time in patients with a broad spectrum of fibrotic interstitial lung diseases (ILDs) encountered in a real-world setting. Methods We conducted a single-centre, retrospective study of 228 consecutive patients with CPFE, encountered from 2007 to 2015 at Kameda Medical Center, Chiba, Japan. We investigated the prognostic value of automated CT fibrosis quantification and the subsequent course of CPFE. Results Among 228 patients with CPFE, 89 had fibrosis affecting < 5% of their lungs, 54 had 5 to < 10% fibrosis, and 85 had ≥ 10% fibrosis at the time of diagnosis. Lower volume of fibrosis correlated with lower rates of mortality and acute exacerbation (p < 0.001). In particular, among those with < 5% fibrosis, only 4.5% died and none experienced acute exacerbation during follow-up, whereas 57.6% and 29.4% of those with ≥ 10% fibrosis experienced death and acute exacerbation, respectively. Although, the ≥ 10% fibrosis group had the poorest overall survival as well as the highest incidence of acute exacerbation, the incidence of decline in pulmonary function tests, change per year in total lung volume, and progression of fibrosis on chest CT was highest in the 5 to < 10% fibrosis group. The Cox proportional hazard model for CPFE progression (defined by composite criteria of death, acute exacerbation, and decline in forced vital capacity or diffusing capacity) showed fibrosis proportion was a risk factor independent of age, sex, smoking pack-years, the Charlson Comorbidity Index, lung cancer, connective tissue disease, and idiopathic pulmonary fibrosis. Conclusions Less severe (< 5%) fibrosis at baseline was associated with disease stability and better prognosis compared to more severe fibrosis in CPFE occurring with fibrotic ILDs. Further studies including a validation cohort will be needed. Trial Registration Retrospectively registered.

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