scholarly journals Metabolomics Profile in Acute Respiratory Distress Syndrome By Nuclear Magnetic Resonance Spectroscopy In Patients With Community-Acquired Pneumonia

2021 ◽  
Author(s):  
Yongqin Yan ◽  
Jianuo Chen ◽  
Qian Liang ◽  
Hong Zheng ◽  
Yiru Ye ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Acute Respiratory Distress Syndrome ◽  
Nmr Spectroscopy ◽  
Treatment Efficacy ◽  
Distress Syndrome ◽  
Community Acquired Pneumonia ◽  
Early Prediction ◽  
Urine Metabolites ◽  
Serum Metabolites ◽  
Serum And Urine

Abstract Background: Acute respiratory distress syndrome (ARDS) is a challenging clinical problem. To date, no standardized diagnostic biomarker has been validated for community-acquired pneumonia (CAP)-induced ARDS. An integrated analysis of changes in the metabolic profile could help detect biomarkers for early prediction of ARDS development and evaluation of treatment efficacy.Methods: A total of 88 patients were enrolled for the final analysis and divided into two groups: the ARDS group (n = 43) and the no-ARDS group (n = 45). We examined differences in serum and urine metabolites and explored dynamic changes with nuclear magnetic resonance (NMR) spectroscopy.Results: A total of 20 serum and 42 urine metabolites were identified using NMR spectroscopy. Serum metabolites, including leucine, 3-hydroxybutyrate, lactate, acetone, citrate, and choline, and urine metabolites, including creatine and creatinine, could distinguish patients with CAP with and without ARDS, with areas under the receiver operating characteristic curve (AUC) values of 0.790 and 0.747, respectively. The treatment efficacy of patients with ARDS was achieved at an AUC of 0.862 with serum metabolites 3-hydroxybutyrate, lactate, acetone, acetoacetate, citrate, and choline, and of 0.691 with urine metabolites taurine and glucose. The treatment efficacy of patients without ARDS was achieved at an AUC of 0.845 with serum metabolites alanine, acetate, acetoacetate, glutamine, creatine, and glucose and 0.891 with urine metabolites choline, tryptamine, and 3-indoxyl sulfate. We also proposed a combined biomarker of associated serum and urine metabolites to predict ARDS in patients with CAP (AUC = 0.865) and evaluate treatment efficacy for patients with and without ARDS (AUC = 0.921 and 0.893, respectively).Conclusions: Serum and urine analyses showed that metabolomics provides potential circulatory markers for early prediction and evaluation of treatment efficacy in patients with CAP with and without ARDS.

scholarly journals Supervised machine learning for the early prediction of acute respiratory distress syndrome (ARDS)

2020 ◽  
Vol 60 ◽  
pp. 96-102 ◽  
Author(s):  
Sidney Le ◽  
Emily Pellegrini ◽  
Abigail Green-Saxena ◽  
Charlotte Summers ◽  
Jana Hoffman ◽  
...  
Keyword(s):  
Machine Learning ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Supervised Machine Learning ◽  
Early Prediction

Differential Characteristics of Patients With Mild Acute Respiratory Distress Syndrome Due to Community-Acquired Pneumonia Admitted to ICU

CHEST Journal ◽  
2014 ◽  
Vol 145 (3) ◽  
pp. 176A
Author(s):  
Laura Novella ◽  
Francisco Sanz ◽  
Estrella Fernández-Fabrellas ◽  
Ángela Cervera ◽  
Maria Luisa Briones ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Community Acquired Pneumonia

scholarly journals Severe Community-Acquired Pneumonia due to Acinetobacter baumannii in North America: Case Report and Review of the Literature

2018 ◽  
Vol 5 (3) ◽  
Author(s):  
David P Serota ◽  
Mary Elizabeth Sexton ◽  
Colleen S Kraft ◽  
Federico Palacio
Keyword(s):  
Risk Factors ◽  
Septic Shock ◽  
Acute Respiratory Distress Syndrome ◽  
Case Report ◽  
North America ◽  
Acinetobacter Baumannii ◽  
Distress Syndrome ◽  
Community Acquired Pneumonia ◽  
Review Of The Literature ◽  
Severe Community Acquired Pneumonia

Abstract Acinetobacter baumannii is a rare but emerging cause of fulminant community-acquired pneumonia (CAP-AB). We describe a patient from a rural area who developed acute respiratory distress syndrome and septic shock. We describe risk factors and characteristics of this syndrome and review published cases of CAP-AB from North America.

scholarly journals Cepacia Syndrome in a Non-Cystic Fibrosis Patient

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Naomi Hauser ◽  
Jose Orsini
Keyword(s):  
Cystic Fibrosis ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Failure ◽  
Burkholderia Cepacia ◽  
Distress Syndrome ◽  
Tracheal Aspirate ◽  
Lung Infection ◽  
Community Acquired Pneumonia ◽  
Blood Cultures ◽  
Necrotizing Pneumonia

Burkholderia(formerlyPseudomonas)cepaciacomplex is a known serious threat to patients with cystic fibrosis, in whom it has the potential to cause the fatal combination of necrotizing pneumonia, worsening respiratory failure, and bacteremia, known as Cepacia syndrome. The potential for this pathogen to infect non-cystic fibrosis patients is limited and its epidemiology is poorly understood. Previously reported cases of severeBurkholderia cepaciacomplex lung infection in immunocompetent hosts include pneumonia, bronchiectasis, pyopneumothorax, and cavitary lesions. We present a case of a 64-year-old man withStreptococcus pneumoniaecommunity-acquired pneumonia whose hospital course was complicated by developing cavitary lung lesions, bacteremia, and acute respiratory distress syndrome. Repeated tracheal aspirate and blood cultures grewBurkholderia cepacia. Our case appears to be the first report of Cepacia syndrome in a patient without cystic fibrosis. This report raises concern regarding the potential severity of pulmonaryBurkholderia cepaciacomplex infection and the need to broaden clinicians’ suspicion for Cepacia syndrome. A framework to help diagnose and treat infected non-cystic fibrosis individuals may be useful.

Therapeutic hypothermia as an adjunct to extracorporeal membrane oxygenation for acute respiratory distress and refractory hypoxemia

Perfusion ◽  
2019 ◽  
Vol 34 (5) ◽  
pp. 422-424 ◽  
Author(s):  
Jessica G Y Luc ◽  
Steven R Meyer ◽  
William J Murtha ◽  
Gurmeet Singh
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Extracorporeal Membrane Oxygenation ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Therapeutic Hypothermia ◽  
Distress Syndrome ◽  
Community Acquired Pneumonia ◽  
Successful Management ◽  
Membrane Oxygenation ◽  
Refractory Hypoxemia

Legionella community–acquired pneumonia necessitating veno-venous extracorporeal membrane oxygenation for severe acute respiratory distress syndrome has been reported in adults. However, few options remain in cases of refractory hypoxemia on veno-venous extracorporeal membrane oxygenation. Herein, we describe adjunctive extended therapeutic hypothermia for refractory hypoxemia despite veno-venous extracorporeal membrane oxygenation for successful management of severe acute respiratory distress syndrome secondary to Legionella.

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