Effect of thyroid dysfunction on hematological profiles at Menelik II Referral Hospital, Addis Ababa, Ethiopia

Abstract Background Thyroid hormones have a crucial role in the metabolism, production, and proliferation of blood cells. So the current study aimed to assess the hematological profile of patients with thyroid dysfunction. Methods A comparative prospective study was conducted from June to September 2021; on a total of 360 participants (120 health groups and 240 patients with thyroid dysfunction. 10 ml of venous blood samples were collected and separated into two test tubes (in the SST tube used for measurement of TSH, T3, and T4, and sample in the EDTA tubes was used for CBC analysis). The analysis was done by using SPPS software. Finally, the result was interpreted by using chi-square, Pearson's correlation, and multivariate logistic regression. The level of statistical significance was set at a 95% confidence and P-value is less than 0.05 was considered clinically significant. Results Out of 360 study participants (120 (33.33%) hypothyroidism, 120 (33.33%) hyperthyroidism, and 120 (33.33%) healthy controls); 195 (54.2%) were female, 150 (41.7%) were in the age range of 25-44 years. The finding indicated a statistically significant decrease in RBC, Hgb, HCT, MCV, PLT, MCH, MCHC, MPV, and a significantly increased valve in RDW, WBC, and NEU% in both types of thyroid dysfunction compared to control groups (p-value <0.05). Finding of MON%, EOS% and BAS% did not show significant differences between the groups (p-value >0.05). Conclusion The finding showed that thyroid dysfunction has a significant effect on RBCs, Hgb, HCT, MCV MCHC, MCH, WBC, neutrophils, PLT count, and MPV findings (p<0.05). But no show significant effect on monocyte, eosinophil and basophils (p-value > 0.05).

Download Full-text

ULTRASOUND PREDICTABILITY OF LOWER UTERINE SEGMENT CESAREAN SECTION SCAR THICKNESS

10.36106/ijsr/3520656 ◽

2020 ◽

pp. 9-11

Author(s):

Madhu Kumari ◽

Kumari Bibha ◽

Abha Sinha ◽

Debarshi Jana

Keyword(s):

Cesarean Section ◽

Gestational Age ◽

Statistical Significance ◽

P Value ◽

Chi Square ◽

Medical College ◽

Chi Square Test ◽

Uterine Scar ◽

Age Range ◽

The Given

Objective: The objective of this study is to find out association between scar thickness, assessed sonographically, and intraoperative findings (IOF). Study Design: Descriptive study. Place and Duration of Study: Department of Obstetrics and Gynecology, Sri Krishna Medical College and Hospital, Muzaffarpur, Bihar from June 2019 to May 2020. Methodology: A total of 70 pregnant patients were included in this study. Transabdominal ultrasound was done for scarred uteri. Sonographic findings were co-related with introperative findings. All the given data were entered on SPSS version 23. Age was expressed as mean ± SD. Parity, gestational age, and interval between cesarean sections were expressed as frequencies with percentages. Statistical analysis was done by using Chi-square test for categorical data for association between sonographic scar thickness and intraoperative findings. The statistical significance was set at p-value <0.05. Results: The age range of the patients was 20- 36 years with a mean of 27.91 ±3.690 years. Gestational age at the time of cesarean section was between 27-40 weeks of gestation with a mean of 37 ±2.126 weeks. The interval from previous cesarean was 10 months at the minimum, and 6 years at the maximum with a mean of 2.29 ±1.0 months. Mean scar thickness was 2.5 mm. Association between scar thickness (<1-3 mm) and intaoperative findings of dehiscence and rupture showed a p-value of <0.001. Conclusion: Sonographic assessment of a uterine scar has a practical application to determine the thickness of previous scar, and assess its integrity.

Download Full-text

Small dose of ephedrine for prevention of hypotension following propofol and fentanyl administration during induction of general anesthesia

Annals of African Medical Research ◽

10.4081/aamr.2020.126 ◽

2021 ◽

Vol 3 (2) ◽

Author(s):

Gamal Ejaimi ◽

Abla Saab ◽

Sittelnissa Ahmed ◽

Areeg Ahmed ◽

Hussain Abujamilah ◽

...

Keyword(s):

General Anesthesia ◽

Small Dose ◽

Elective Surgery ◽

Statistical Significance ◽

Control Group ◽

P Value ◽

Chi Square ◽

Arterial Blood ◽

Chi Square Test ◽

Study Participants

Induction of general anesthesia with propofol and fentanyl could result in hypotension and bradycardia. Various methods are being used to prevent these adverse effects. The aim of our study was to assess the efficacy and safety of a small dose of ephedrine in prevention of hypotension following administration of propofol and fentanyl. This prospective, randomized, comparative study was conducted among a total of 50 patients, both genders, age 18 years up to 60 years with ASA grade Ι and ΙΙ and some of class ΙΙΙ, presented for elective surgery under general anesthesia. Patients were randomly allocated into one of two groups (25 patients in each): CG (the control group), which received propofol in a dose of 2 mg/kg, intravenously, over 20–30 s mixed with 2 mL normal saline: and EphG (Ephedrine group), while received propofol in a dose of 2 mg/kg, intravenously, over 20–30 s mixed with 2 mL of ephedrine (10 mg). The Mean Arterial Blood Pressure (MAP) and Heart Rate (HR) were recorded before induction and then every 1 min up to 6 min after induction. The categorical data are presented as a number and percentage and were subjected to Fisher’s exact or Chi-square test for analysis. The statistical significance was p≤0.05. The significant differences in HR were observed in the 3rd,4th, and 5th minutes with P-value, 0.018, 0.000, 0.000, respectively. However, no patient in the study participants had bradycardia. The significant differences in MAP were observed in the 2nd, 3rd,4th, and 5th minutes with P-value, 0.035, 0.000, 0.000, and 0.000, respectively. The percentage of patient in CG who developed hypotension in the 3rd and 4th is 44% and 32% compared to 8% and 0% in EphG, with significant differences (P-value 0.004 and 0.002, respectively). Administration of small dose of ephedrine with propofol could attenuate propofol/fentanyl hypotensive and bradycardic effects.

Download Full-text

Social determinants of telemedicine utilization in ambulatory cardiovascular patients during the COVID-19 pandemic

European Heart Journal - Digital Health ◽

10.1093/ehjdh/ztab039 ◽

2021 ◽

Author(s):

Kemar J Brown ◽

Njambi Mathenge ◽

Daniela Crousillat ◽

Jaclyn Pagliaro ◽

Connor Grady ◽

...

Keyword(s):

Statistical Significance ◽

The Elderly ◽

P Value ◽

Chi Square ◽

Cardiovascular Patients ◽

Baseline Characteristics ◽

Racial Ethnic ◽

Cardiovascular Care ◽

Zip Code ◽

Hispanic White

Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has resulted in the rapid uptake of telemedicine (TM) for routine cardiovascular care. Objectives To examine the predictors of TM utilization among ambulatory cardiology patients during the COVID-19 pandemic. Methods In this single centre retrospective study, all ambulatory cardiovascular encounters occurring between March 16th - June 19th, 2020 were assessed. Baseline characteristics by visit type (in-person, TM-phone, TM-video) were compared using Chi-square and student t-tests, with statistical significance defined by p value < 0.05. Multivariate logistic regression was used to explore the predictors of TM versus in-person care. Results 8446 patients (86% Non-Hispanic White, 42% female, median age 66.8 +/- 15.2 years) completed an ambulatory cardiovascular visit during the study period. TM-phone (n = 4,981, 61.5%) was the primary mode of ambulatory care followed by TM-video (n = 2693, 33.2%). Non-Hispanic Black race (OR 0.56; 95% CI: 0.35 - 0.94, p-value=0.02), Hispanic ethnicity (OR 0.53; 95% CI: 0.29 - 0.98, p = 0.04), public insurance (Medicaid OR 0.50; 95% CI:0.32 – 0.79, p = 0.003, Medicare OR 0.65; 95% CI: 0.47– 0.89, p = 0.009), zip-code linked median household income (MHI) of <$75,000, age >85 years, and patients with a diagnosis of heart failure were associated with reduced access to TM-video encounters and a higher likelihood of in-person care. Conclusions Significant disparities in TM-video access for ambulatory cardiovascular care exist among the elderly, lower income, as well as Black and Hispanic racial/ethnic groups.

Download Full-text

Characteristics, Treatment, and Prognosis of Cracked Teeth: A Comparison with Data from 10 Years Ago

European Journal of Dentistry ◽

10.1055/s-0041-1728842 ◽

2021 ◽

Author(s):

Tae Yeon Lee ◽

Sung Eun Yang ◽

Hye Min Kim ◽

Min Joo Kye

Keyword(s):

Root Canal ◽

Statistical Significance ◽

Treatment Method ◽

Root Canal Treatment ◽

Periodontal Pocket ◽

P Value ◽

Chi Square ◽

Pocket Depth ◽

Persistent Symptoms ◽

Probing Depth

Abstract Objectives The purpose of this study was to analyze and to compare retrospectively the characteristics, the treatment process, and the prognosis of cracked teeth by comparing recent data with data from 10 years ago. Materials and Methods Sixty-eight cracked teeth from March 2009 to June 2010 (2009 data) and 185 cracked teeth from March 2019 to June 2020 (2019 data) were analyzed. The characteristics of cracked teeth and the treatment method depending on probing depth, caries, and symptoms, and prognosis depending on pocket depth and apical lesions were analyzed using R version 3.3.3 (R Foundation for Statistical Computing, Vienna, Austria) and T&F version 3.0 (YooJin BioSoft, Korea). To compare proportions, the two-sample proportion test was performed. The distribution of proportions within the samples from 2009 and 2019 data was analyzed using the Chi-square test or binomial test. A p-value <0.05 was considered to indicate statistical significance. Results Significantly fewer cracked teeth received root canal treatment before crown in 2019 than in 2009 (p = 0.032). In both 2009 and 2019, symptomatic cracked teeth and those with deep periodontal pockets (>6 mm) were significantly more likely to receive root canal treatment. In both years, cracked teeth with a probing depth less than 6 mm or without an apical lesion were significantly more likely to be asymptomatic at 3-month and 6-month follow-ups (p < 0.001). Conclusion Cracked teeth with a deep periodontal pocket or symptoms had a higher likelihood of endodontic treatment, and the presence of a deep periodontal pocket or apical lesion was associated with a higher risk of persistent symptoms. Therefore, clinicians should consider these factors when planning treatment and predicting patients’ prognosis.

Download Full-text

Role of susceptibility weighted imaging (SWI) in assessment of intra axial brain neoplasms in adults

QJM ◽

10.1093/qjmed/hcab106.056 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Pasant Mohamed Abo-Elhoda Darwish Mohamed Abo-Elhoda ◽

Hesham Mahmoud Ahmed Mansour ◽

Yosra Abdelzaher Abdullah ◽

Eman Ahmed Fouad Darwish

Keyword(s):

Brain Neoplasms ◽

Tumor Size ◽

Venous Blood ◽

Brain Parenchyma ◽

P Value ◽

Susceptibility Weighted Imaging ◽

Low Grade ◽

Chi Square ◽

Cross Sectional

Abstract Background Susceptibility weighted imaging (SWI) is a 3D gradient-echo MR technique that is based on blood oxygen level dependent (BOLD) induced phase effects between the venous blood and the surrounding brain parenchyma. SW-MR imaging allows for noninvasive visualization of small veins at submillimeter resolution and, therefore, is used to depict venous architecture in brain lesions. The extreme sensitivity of SWI for the detection of neovascularity (venous blood), haemorrhage, and calcification has been an indispensable tool for characterization of the internal architecture of brain tumours. Objectives Is to evaluate the role of Susceptibility weighted imaging in assessment of adults Intra axial brain Neoplasms, and its ability to characterize them into high and low grade lesions in comparison to histopathology which will be used as gold standard. Methods A cross sectional study including 31 patients suspecting intracranial brain neoplasm radiologically and clinically, conducted at Private center, the patients were investigated using Siemens machine Magnetom Skyra 3T, the period was between January 2018 till the end of June 2019 . Results Our study included 31 patients. Including 15 female and 16 male patients, with the patient’s age ranging from 20 to 68 years old with median 48 years old ranging from 35.75 (25% percentile) to 58.75 (75% percentile). Among total cases, there were 8 patients with grade 2 glioma, 10 patients with grade 3 glioma and 6 patients with grade 4 glioma, 2 patients with lymphoma and 5 patients with brain metastasis (1 lung cancer and 4 breast cancer). All the patients were evaluated with MRI including SWI sequence with special comment on the number of the intratumoral susceptibility signal (ITSS), the size of the ITSS, its morphology as well as the ratio of the ITSS to the tumor size, which were then correlated with the patient histopathological results obtained later. The study revealed that the best parameter to accurately grade the tumor is the number of ITSS within the lesion with P value 0.001, followed by the size of the ITSS with P value 0.002 and Pearson Chi-Square value equals 20.6, while the lowest one was the ratio of the ITSS to the tumor size with P value 0.002 Pearson Chi-Square value equals 17.3. Our study showed that the morphology alone was not able to accurately grade the tumor with P value 0.007 ( Not significant) Conclusion SWI using 3T MR system provides quite useful information for preoperative tumor grading. There seems to be a strong correlation between pathological grading and that assessed with SWI.

Download Full-text

Gloves Perforations in Minor Oral Surgical Procedures: A Comparison of Latex and Nitrile Gloves

Journal of The Pakistan Dental Association ◽

10.25301/jpda.302.103 ◽

2021 ◽

Vol 30 (02) ◽

pp. 103-106

Author(s):

Ajeet Kumar ◽

◽

Naveed Iqbal ◽

Javaria Farooq ◽

Saad Uddin Siddiqui

Keyword(s):

Local Anesthesia ◽

Surgical Procedures ◽

Statistical Significance ◽

Descriptive Analysis ◽

P Value ◽

Dominant Hand ◽

Chi Square ◽

Oral Surgical Procedures ◽

Latex Gloves ◽

Chi Square Test

OBJECTIVE: This study was performed to compare incidence of perforations in Latex and Nitrile examination gloves during Minor Oral surgical procedures performed under local anesthesia. METHODOLOGY: 100 pairs of latex and 100 pairs of Nitrile examination gloves where used to perform 200 minor oral surgical procedures under local anesthesia. After completion of every minor oral surgical procedure each gloves was examined by Water Inflation method to observe presence or absence of Perforations. A data sheet was used to collect data including type of Gloves used (Latex or Nitrile) presence of perforations, sites of perforations and nature of minor oral surgical procedures. Data was entered and analyzed using SPSS version 20. Descriptive analysis was conducted to calculate frequency and percentages of Number and sites of perforations for both Nitrile and latex examination gloves. Chi Square test was used to find out statistical significance of difference of perforations rate between Nitrile and Latex gloves. P value of < 0.05 was considered significant. RESULTS: Out of 200 latex gloves 23 (11.5) had 29 perforations whereas out of total 200 Nitrile gloves 28 (14%) had 22 perforations. Nitrile gloves had a statistically significant higher rate of perforations as compared to Latex gloves. (P value 0.043). For both Nitrile and Latex gloves left non dominant hand had highest frequency of perforations Latex 18 (81.81%) perforations and Nitrile 18(62.06%). Index finger and thumb were most frequent sites of perforations in both Latex and Nitrile gloves. CONCLUSION: Gloves perforations were more common in Nitrile examination gloves however total number of perforations was more in Latex examination gloves.

Download Full-text

Incidences of Root Microcracks Caused by Hand and Rotary File System at Different Lengths

International Healthcare Research Journal ◽

10.26440/ihrj/0309.12004 ◽

2019 ◽

Vol 3 (9) ◽

pp. 283-289

Author(s):

Shuchi Sukul ◽

Goldy Rathee ◽

Parimal Anand ◽

Sakshi Kataria ◽

Pratibha Taneja

Keyword(s):

File System ◽

Statistical Significance ◽

File Systems ◽

In Vitro Study ◽

Root Surface ◽

P Value ◽

Chi Square ◽

Chi Square Test ◽

Group B

OBJECTIVES: The present research was conducted to assess incidences of root microcracks caused by hand and rotary file system at different lengths MATERIAL AND METHODS: This in-vitro study was undertaken to assess incidence of root microcracks caused by hand and rotary file system at different lengths In total, 100 the mandibular premolar with straight roots determined with intact, fully formed apices were taken. Samples were randomly distributed into 5 groups based on the file system used: a) Group A: Control, b) Group B: Reciproc, c) Group C: WaveOne, d) Group D: One Shape and e) Group E: ProTaper. Pearson Chi-square test was used to determine the differences between groups. The dentinal defects were expressed as percentage of samples with microcracks in each group. Level of statistical significance was set at p-value less than 0.05. RESULTS: The chi square test was used to compare the Distribution of the number of teeth in which cracks were observed on the horizontal sections. It was found to be significant with group ProTaper showing maximum cracks at 3,6,9 mm level as compared to other file systemCONCLUSION: Nickel-titanium instruments causes cracks on the apical root surface or in the root canal wall. ProTaper causes maximum dentinal cracks as compared to other file systems

Download Full-text

Neonatal and Maternal Outcomes in Spontaneously-Conceived Twin Pregnancies According to Mode of Delivery

Folia Medica ◽

10.3897/folmed.62.e49276 ◽

2020 ◽

Vol 62 (3) ◽

pp. 468-476

Author(s):

Samantha Mc Kenzie Stancu ◽

Manuela Cristina Russu

Keyword(s):

Neonatal Intensive Care ◽

Statistical Significance ◽

Mode Of Delivery ◽

Statistical Correlation ◽

P Value ◽

Maternal Outcomes ◽

Chi Square ◽

Chi Square Test ◽

Nicu Admission ◽

Twin Pregnancies

Introduction: Appropriate intrapartum conduct in a twin delivery remains a challenging aspect of obstetric practice. The objective of this study was to compare neonatal and maternal outcomes in twin pregnancies according to mode of delivery.  Materials and methods: This is a single centre retrospective cohort study of all consecutive spontaneously-conceived twin deliver-ies (≥ 24 weeks, estimated fetal weight ≥ 500 grams) over a nine-year period between 01/01/2007 - 31/12/2016 at a tertiary-level centre. Neonatal outcomes included survival, APGAR score, prematurity-associated pathology (PAP), admission to the neonatal intensive care unit (NICU) and length of stay (LOS). Maternal outcomes included postpartum complications and LOS. Statistical analysis comprised Chi-square test with subsequent p-value and odds-ratio with 95% confidence interval. Statistical significance was set at p<0.05. Results: A total of 173 consecutive women with spontaneously-conceived twin deliveries were enrolled in this study, 129 (74.6%) women delivered by caesarean section (CS). The success rate of vaginal delivery (VD) was 93.6% (44/47). A strong statistical correlation was identified between CS and NICU admission; 53.2% vs. 1.5% (p=0.0001). Neonatal LOS in the NICU was significantly longer in the CS group. Prematurity-associated pathology (PAP) was noted in 75 pairs of twins (75/173); 61 pairs were delivered by CS, bearing strong statistical significance (p<0.0001). Postpartum complications occurred in 14.7% of CS compared to 13.6% of VDs.  Conclusion: Neonates delivered by CS had a higher rate of PAP, NICU admission, lower birth weight and longer LOS. This study showed that VD is safe, especially when the first twin is in cephalic presentation

Download Full-text

Estado nutricional e desfechos clínicos em pacientes críticos internados em hospital universitário

Abr-Jun - Braspen Journal ◽

10.37111/braspenj.2019344009 ◽

2020 ◽

Vol 34 (4) ◽

pp. 361-366

Author(s):

Edcleide Oliveira dos Santos Olinto ◽

Gina Araújo Martins Feitosa ◽

Izaura Odir Lima Gomes da Costa ◽

Janine Maciel Barbosa ◽

Ericka Vilar Bôtto Targino ◽

...

Keyword(s):

Body Mass ◽

Statistical Significance ◽

Strong Relationship ◽

The Body ◽

University Hospital ◽

Nutritional Risk ◽

World Health ◽

P Value ◽

Chi Square ◽

Length Of Hospitalization

Introduction: There is a strong relationship between malnutrition and increased length of hospitalization and morbidity and mortality. Studies have shown that malnourished patients can have up to twenty times more complications than eutrophic ones. In critically ill patients, there is a tendency to catabolism, resulting in the loss of lean body mass, which when it reaches 40% is usually lethal. Methods: A quantitative, descriptive study was conducted on adults from both genders, admitted to the intensive care unit (ICU) of a university hospital, from March to December 2018. The following variables were collected from the evaluation and nutritional records: length of hospitalization in the ICU, date of discharge or death, nutritional risk through specific screening, height, weight and arm circumference (AC). For the screening, the Nutric score was used. For the nutritional evaluation, the body mass index (BMI) and AC indicators and the classifications recommended by the World Health Organization (2004) and Blackburn and Thornton (1979) were used. After collecting the data, they were analyzed in the Statistical Package for Social Sciences (SPSS) 13.0 and for the association of the variables the Chi-square test was used, considering statistical difference when the p value <0.05. Results: The sample consisted of 116 patients, mostly female (53.4%) whose median age was 46 years (interquartile range IQR 31-53). Regarding the frequency of nutritional risk, most patients (61.5%) had a low score. There was an important frequency of malnutrition, according to the AC indicator (73%), although BMI (43.5%) showed eutrophy. Even though most patients had low nutritional risk, those with high nutritional risk (38.5%) had a higher tendency to mortality, however, not statistically confirmed (p> 0.05). There was also a tendency of association between death and malnutrition, although no statistical significance was shown(p> 0.05). Conclusion: Patients at nutritional risk and/or malnutrition appear to be vulnerable to worse clinical outcomes.

Download Full-text

Prevalence of Allergic Rhinitis in Children with Adenotonsillar Hypertrophy Referred to Imam Khomeini Hospital of Ahvaz from 2019 to 2020

Jundishapur Journal of Chronic Disease Care ◽

10.5812/jjcdc.114620 ◽

2021 ◽

Vol 10 (2) ◽

Author(s):

Soheila Nikakhlagh ◽

Shohreh Norouzi ◽

Nader Saki ◽

Mohammad Bagher Bakhshipour

Keyword(s):

Allergic Rhinitis ◽

Strong Association ◽

Allergic Diseases ◽

P Value ◽

Chi Square ◽

Exact Test ◽

Adenotonsillar Hypertrophy ◽

Chi Square Test ◽

Main Components ◽

Age Range

Background: Allergic diseases are among the most common chronic conditions in pediatrics. Objectives: This study aimed to evaluate the relative frequency of allergic rhinitis (AR) in children with adenotonsillar hypertrophy. Methods: In this descriptive study, 175 patients with adenotonsillar hypertrophy referred to the Imam Khomeini hospital of Ahvaz from March 2019 to March 2020 were enrolled. Allergic rhinitis was diagnosed based on the Score for AR (SFAR) questionnaire. The questionnaire, including the expert-designed SFAR, has eight main components that evaluate eight quantitative features of AR, and each was designated with a specific weighted score based on previous clinical studies. The total score could vary from 0 to 16. Frequency and percentage were used to describe the data. The chi-square test and Fisher's exact test were used to analyze the data. Results: One hundred seventy-five patients with adenotonsillar hypertrophy in the age range of 1 to 17 years were studied. Ninety-one patients (52%) were male, and 84 patients (48%) were female. Based on the score obtained from the questionnaire, 146 patients (83.4%) had a score of less than seven, indicating susceptibility to AR. Twenty-nine patients (16.6%) had a score equal to or higher than 7, confirming the diagnosis of AR. The Chi-square test showed that AR was significantly associated with all the components of the questionnaire, except for cigarette smoking (P-value < 0.001). Conclusions: This study showed the strong association of AR with some demographic factors. Allergic rhinitis could potentially increase the risk of adenotonsillar hypertrophy in children.

Download Full-text