scholarly journals Outbreak of peracute Glässer’s disease in suckling piglets in a self-recruiting high health farrow to grower herd: A Case report

2020 ◽  
Author(s):  
Odd Magne Karlsen
Keyword(s):  
Room Temperature ◽  
Management Practices ◽  
Histopathological Examination ◽  
Bacteriological Examination ◽  
Case Presentation ◽  
Procaine Penicillin ◽  
Glässer’S Disease ◽  
Suckling Piglets ◽  
Poor Ventilation ◽  
Glasser's Disease

Abstract BackgroundGlässer’s disease is caused by a bacterial infection where the causative agent is Glaesserella parasuis and is of rising concern in Norwegian high health pig herds. Different factors can trigger the onset of Glässer’s disease, including management practices such as unstable room temperature, poor ventilation or impaired immunity. Outbreaks of peracute Glässer’s disease in suckling piglets are rarely described. Case presentationIn a high health, farrow to grower pig herd 270 suckling piglets out of 920 died in a peracute to acute manner during a 20-day period. Post-mortem examinations revealed findings consistent with congestion and oedema and histopathological examination found no signs of inflammation or intravascular microthrombi. Bacteriological examination detected G. parasuis in relevant tissues. Emesis in half of the piglets and central nervous signs in a few was found after first intramuscular injection of procaine penicillin. Anaemia, poor temperature regulation in the farrowing unit and poor hygiene were factors contributing to the disease outbreak.ConclusionsIn the present case, it was concluded that an outbreak with high mortality and predominantly peracute to acute clinical disease in 3-5 week old suckling piglets was caused by Glässer’s disease (G. parasuis).

scholarly journals First report of urinary tract infection caused by Comamonas kerstersii in a goat

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Silvia Pavone ◽  
Roberto Rinoldo ◽  
Elisa Albini ◽  
Alessandro Fiorucci ◽  
Biagio Caponi ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Histopathological Examination ◽  
Severe Depression ◽  
Renal Infarction ◽  
Case Presentation ◽  
First Report ◽  
Flight Mass Spectrometry ◽  
Abdominal Organs

Abstract Background Comamonas kerstersii is rarely associated with infections in humans and has never been reported in animals until now. Case presentation Herein, we describe a case of urinary tract infection caused by C. kerstersii in a young goat. A seven-month-old male goat showed lethargy, generalised weakness and anorexia and in the last hours before its death, severe depression, slight abdominal distention, ruminal stasis, and sternal recumbency. Grossly, multifocal haemorrhages in different organs and tissues, subcutaneous oedema and hydrocele, serous fluid with scattered fibrin deposition on the serosa of the abdominal organs and severe pyelonephritis with multifocal renal infarction were detected. Histopathological examination confirmed severe chronic active pyelonephritis with renal infarcts, multi-organ vasculitis and thrombosis suggestive of an infectious diseases of bacterial origin. The bacterium was identified using routine methods, matrix assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF-MS), and sequencing of the gyrB gene. Conclusions To the best of our knowledge, this is the first report of C. kerstersii infection in animals (goat). Our findings support the possibility of C. kerstersii isolation from extraintestinal sites and suggest this organism as a possible cause of urinary tract infection.

scholarly journals Melanosis coli in a peritoneal dialysis patient: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Nor Fadhlina Zakaria ◽  
Nurul Izah Ahmad ◽  
Elmina Mokhtar ◽  
Wan Zul Haikal Hafiz Wan Zukiman ◽  
Anim Md Shah
Keyword(s):  
Peritoneal Dialysis ◽  
Chronic Diarrhea ◽  
Histopathological Examination ◽  
Hypovolemic Shock ◽  
Peritoneal Dialysis Patient ◽  
Electrolyte Imbalance ◽  
Case Presentation ◽  
Melanosis Coli ◽  
Life Threatening ◽  
Black Discoloration

Abstract Background Patients who undergo peritoneal dialysis (PD) are at risk of gut bacteria translocation leading to peritonitis when there is chronic diarrhea. Chronic diarrhea is defined as any course of diarrhea that lasts at least 4 weeks, which can be continuous or intermittent. Chronic diarrhea of any duration may cause dehydration, electrolyte imbalance, and life-threatening hypovolemic shock. In PD patients, excessive ultrafiltration from the exchanges, combined with severe gastrointestinal loss, may cause hypovolemic shock, electrolyte imbalance, and metabolic acidosis. There are multiple causes of chronic diarrhea in PD patients including infective causes, mitotic lesions, and rarely the regular and excessive use of laxatives, which is a diagnosis of exclusion. Case presentation We report a case of Melanau lady with chronic diarrhea secondary to laxative usage in a patient being treated with automated peritoneal dialysis (APD). The patient went into hypovolemic shock, but luckily did not contract peritonitis. A colonoscopy revealed brown to black discoloration of the colon, a feature suggestive of melanosis coli. A biopsy of the intestine further confirmed the diagnosis by histopathological examination. Withdrawal of laxatives and the introduction of probiotics improved the symptoms tremendously. Conclusions The chronic use of laxatives in PD patients can potentially lead to a devastating problem; thus, the management team must monitor treatment commencement appropriately.

STUDIES OF PENICILLIN IN PEDIATRICS

PEDIATRICS ◽  
1950 ◽  
Vol 5 (4) ◽  
pp. 664-671
Author(s):  
B. M. KAGAN ◽  
M. NIERENBERG ◽  
D. GOLDBERG ◽  
A. MILZER
Keyword(s):  
Intramuscular Injection ◽  
Room Temperature ◽  
Serum Levels ◽  
Sesame Oil ◽  
Peanut Oil ◽  
Penicillin G ◽  
Procaine Penicillin ◽  
Pertinent Data ◽  
Significant Difference ◽  
Pediatric Use

Table I summarizes most of the pertinent data in this report on the serum penicillin concentrations 12 and 24 hours after intramuscular injection of K penicillin G in peanut oil and beeswax, which is fluid at room temperature, and of three different procaine penicillin preparations. These three preparations are procaine penicillin G in sesame oil, procaine penicillin G in peanut oil with 2% aluminum monostearate, and procaine penicillin G in water with Na-carboxymethylcellulose. When they were given in a dosage of 8000 u./lb. to infants and children, weighing between 4.5 and 18.0 kg., there was no statistically significant difference in the serum levels obtained. A dosage schedule for these preparations is suggested for pediatric use. The aqueous preparation offers some advantages which are discussed. Experiences are reported which emphasize the necessity of avoiding intravenous administration of all these preparations.

scholarly journals Protective Efficacy of an Inactive Vaccine Based on the LY02 Isolate against AcuteHaemophilus parasuisInfection in Piglets

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Xiao-Hua Li ◽  
Guo-Zhen Zhao ◽  
Long-Xin Qiu ◽  
Ai-Ling Dai ◽  
Wang-Wei Wu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Protective Immunity ◽  
Protective Efficacy ◽  
Haemophilus Parasuis ◽  
Fujian Province ◽  
Cellular Immune Responses ◽  
Glässer’S Disease ◽  
Potential Vaccine ◽  
Cellular Immune ◽  
Glasser's Disease

Haemophilus parasuiscan cause Glässer’s disease characterized by fibrinous polyserositis, polyarthritis, and meningitis. The current prevention of Glässer’s disease is mainly based on the inactive vaccines; however, the protective efficacy usually fails in heterogeneous or homologous challenges. Here, the predominant lineage ofH. parasuis(LY02 strain) in Fujian province, China, characterized as serovar 5, was used to evaluate the protective immunity against acuteH. parasuisinfection in piglets after inactivation. Following challenging withH. parasuis,only mild lesions in the pigs immunized with the killed vaccine were observed, whereas the typical symptoms of Glässer’s disease presented in the nonimmunized piglets. A strong IgG immune response was induced by the inactive vaccine. CD4+and CD8+T lymphocyte levels were increased, indicating the potent cellular immune responses were elicited. The significantly high levels of IL-2, IL-4, TGF-β, and IFN-γin sera from pigs immunized with this killed vaccine suggested that the mixed Th1 and Th2 immune responses were induced, associated with the high protection againstH. parasuisinfection compared to the nonimmunized animals. This study indicated that the inactivated LY02 strain ofH. parasuiscould serve as a potential vaccine candidate to prevent the prevalence ofH. parasuisin Fujian province, China.

GLASSER'S DISEASE OF SWINE

1947 ◽  
Vol 23 (4) ◽  
pp. 91-94 ◽  
Author(s):  
A. K. Sutherland ◽  
G. C. Simmons
Keyword(s):  
Glässer’S Disease ◽  
Glasser's Disease

scholarly journals Two different clinical forms of squamous cell carcinoma (SCC) in the perineum and vulva of two mares

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Andrzej Raś ◽  
Iwona Otrocka-Domagała ◽  
Małgorzata Raś-Noryńska
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Ultrasound Examination ◽  
Histopathological Examination ◽  
Reproductive Organs ◽  
Malignant Neoplasms ◽  
Surgical Removal ◽  
Chemotherapy Treatment ◽  
Case Presentation

Abstract Background Genital malignant neoplasms in mares are relatively rare. The treatment involve surgical removal of the tumour masses, chemotherapy or both. Case presentation Two elderly warmblood mares, aged 16 and 20 were presented in University Clinic with the lumpy lesions at the region of perineum and left labia. Surgical removals of tumour masses were performed on standing animals. Removed tissues were subjected to histopathological examination which confirmed SCC. Conclusions Clinical and ultrasound examination of reproductive organs in both mares showed no inflammatory or neoplastic changes. Both mares healed within 2 weeks after surgery and showed no signs of tumour recurrence for the following year despite no chemotherapy treatment.

scholarly journals Update on Glässer’s disease: How to control the disease under restrictive use of antimicrobials

2020 ◽  
Vol 242 ◽  
pp. 108595 ◽  
Author(s):  
Mar Costa-Hurtado ◽  
Emili Barba-Vidal ◽  
Jaime Maldonado ◽  
Virginia Aragon
Keyword(s):  
Glässer’S Disease ◽  
Glasser's Disease

scholarly journals Primary epithelioid rhabdomyosarcoma of the stomach: a case report and review of literature

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Yangkun Wang ◽  
Pei Guo ◽  
Zhishang Zhang ◽  
Runde Jiang ◽  
Zuguo Li
Keyword(s):  
Tumor Cells ◽  
Unusual Case ◽  
Histopathological Examination ◽  
Gastroesophageal Junction ◽  
Rare Tumor ◽  
Review Of Literature ◽  
Ki 67 ◽  
Case Presentation ◽  
Cytoplasmic Content ◽  
Mitotic Figures

Abstract Background Epithelioid rhabdomyosarcoma is a rare tumor that generally occurs in the bladder, the parotid gland, or the skin of the neck. We describe an unusual case of primary epithelioid rhabdomyosarcoma of the stomach and review the literature. Case presentation A 64-year-old woman presented with a lesion at the gastroesophageal junction. Histopathological examination showed irregularly sized round cells with low cytoplasmic content and eccentric nuclei. Mitotic figures were present. Fibrovascular septa and areas of necrosis were observed between tumor cells. Tumor cells were strongly positive for MyoD1, desmin, and myogenin, and weakly positive for actin, CD56, and PGP9.5. The ki-67 index was ≥90%. Conclusions Primary epithelioid rhabdomyosarcoma of the stomach is extremely rare. Better awareness of this entity is necessary for early diagnosis and treatment.

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