Correlation Between CCND1 Gene Polymorphism and Genetic Susceptibility to Gastric Cancer in Chinese Population

2020 ◽  
Author(s):  
Huiwen Pan ◽  
Xuyu Gu ◽  
Chen Zou ◽  
Keping Chen ◽  
Yu Fan
Keyword(s):  
Gastric Cancer ◽  
Gene Polymorphism ◽  
Case Control Study ◽  
Control Groups ◽  
Ccnd1 Gene ◽  
Significant Difference ◽  
And Control ◽  
The Relationship ◽  
Normal Controls ◽  
Control Study

Abstract Objective: The relationship between Cyclin D1 gene (CCND1) rs9344 polymorphism and susceptibility to gastric cancer (GC) is investigated.Methods: In a case-control study, we selected 577 cases of GC from The People's Hospital Affiliated to Jiangsu University in China along with 678 normal controls. Blood DNA was extracted and PCR amplified, gene polymorphism was determined using Snapshot method.Results: Analysis reveals significant difference in smoking between GC and control groups (P=0.006), however, not on polymorphism (P＞0.05). Conclusion: Smoking is associated with gastric cancer, whereas CCND1 rs9344 polymorphism does not implicate susceptibility of gastric cancer.

scholarly journals Association of Genetic Polymorphisms in FOXA1 with the Progression of Genetic Susceptibility to Gastric Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Guo-wen Ding ◽  
Xu-yu Gu ◽  
Zhe Dai ◽  
Hui-wen Pan ◽  
Xiao-yan Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Target Gene ◽  
Case Control Study ◽  
Control Group ◽  
Case Group ◽  
Significant Difference ◽  
Drinking Status ◽  
And Control ◽  
The Relationship ◽  
Control Study

Objective. To investigate the relationship between polymorphism of FOXA1 gene rs12894364 and rs7144658 and susceptibility to gastric cancer. Methods. A case-control study was conducted to select 577 cases of primary gastric cancer and 678 cases of normal control. We extracted whole blood genomic DNA and amplified the target gene fragment by PCR. The genotyping and allele was tested through a snapshot method. Results. There was no significant difference in the frequency distribution of genotype between the case group and control group (P>0.05). Stratified analyses showed the SNPs were not correlated with the susceptibility of GC according to different age, gender, cigarette smoking, and alcohol drinking status. Conclusion. There is no significant correlation between the polymorphisms of FOXA1 gene rs12894364 and rs7144658 and the risk of gastric cancer.

Dietary diversity score is inversely related to the risk of polycystic ovary syndrome in Tehranian women: a case-control study

2021 ◽  
pp. 1-6
Author(s):  
Sahel Soodi ◽  
Seyed Ali Keshavarz ◽  
Sedighe Hosseini ◽  
Behnood Abbasi
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Case Control Study ◽  
Dietary Diversity ◽  
Polycystic Ovary ◽  
Case Control ◽  
Control Groups ◽  
Ovary Syndrome ◽  
And Control ◽  
The Relationship ◽  
Control Study

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age and is affected by various dietary factors. Therefore, this study aimed to investigate the relationship between dietary diversity score (DDS) and the risk of PCOS. Our case-control study was conducted in the summer and autumn of 2019 in Taleghani and Arash hospitals in Tehran, Iran. A total of 494 participants (203 cases and 291 controls) were included in the study. Thereafter, their demographic information, dietary intake, and anthropometric and physical activity assessments were gathered. A validated semi-quantitative food frequency questionnaire was then used to calculate the DDS by scoring 5 food groups. To evaluate the risk of PCOS in association with DDS, the subjects were categorized based on the quartile cut-off points of the DDS. The mean ± SD age of the participants in both the case and control groups was 28.98 ± 5.43 and 30.15 ± 6.21 years, while mean ± SD body mass index was 25.74 ± 5.44 and 23.65 ± 3.90 kg/m2, respectively. The comparison between the case and control groups indicated that total DDS was 5.19 ± 1.19 for the cases and 5.51 ± 1.19 for the controls. The comparison of DDS in the highest versus the lowest quartiles showed a decreased risk of PCOS (p < 0.05). We demonstrated an inverse association between DDS and PCOS compared with the control group. Furthermore, a higher DDS was significantly associated with a lower risk of PCOS (odds ratio = 0.40). Novelty: This is the first investigation on the relationship between DDS and PCOS. Results depicted an inverse relationship between DDS and PCOS.

Hair nicotine concentration of cats with gastrointestinal lymphoma and unaffected control cases

2020 ◽  
Vol 186 (13) ◽  
pp. 414-414 ◽  
Author(s):  
Victoria Smith ◽  
Clare Knottenbelt ◽  
David Watson ◽  
Dominic J Mellor ◽  
Alexandra Guillen Martinez ◽  
...  
Keyword(s):  
Case Control Study ◽  
Control Group ◽  
Gastrointestinal Lymphoma ◽  
Control Groups ◽  
Nicotine Concentration ◽  
Hair Samples ◽  
Significant Difference ◽  
Unaffected Control ◽  
And Control ◽  
Control Study

BackgroundA previous study showed an association between owner-reported exposure to environmental tobacco smoke (ETS) and lymphoma in cats. This study aimed to investigate the association between ETS exposure and gastrointestinal lymphoma in cats, using hair nicotine concentration (HNC) as a biomarker.MethodsThis was a prospective, multi-centre, case–control study. Gastrointestinal lymphoma was diagnosed on cytology or histopathology. Hair samples were obtained from 35 cats with gastrointestinal lymphoma and 32 controls. Nicotine was extracted from hair by sonification in methanol followed by hydrophilic interaction chromatography with mass spectrometry. Non-parametric tests were used.ResultsThe median HNC of the gastrointestinal lymphoma and control groups was not significantly different (0.030 ng/mg and 0.029 ng/mg, respectively, p=0.46). When the HNC of all 67 cats was rank ordered and divided into quartiles, there was no significant difference in the proportion of lymphoma cases or controls within these groups (p=0.63). The percentage of cats with an HNC≥0.1 ng/mg was higher for the lymphoma group (22.9%) than the control group (15.6%) but failed to reach significance (p=0.45).ConclusionA significant association was not identified between HNC (a biomarker for ETS) and gastrointestinal lymphoma in cats; however, an association may exist and further studies are therefore required.

scholarly journals Assesment of Endometrial Vascularization with Immunohistochemical CD34 Assay in Recurrent Pregnancy Loss: A Case Control Study

2017 ◽  
pp. 1
Author(s):  
Emine Aydın ◽  
Taner Usta
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Case Control Study ◽  
Transmembrane Protein ◽  
Vessel Diameter ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
And Control ◽  
Control Study

<p><strong>Objectives:</strong> We compared the endometrial vascularization in hysteroscopic endometrial samplings between recurrent pregnancy loss (RPL) and control group.</p><p><strong>Study Design:</strong> We prospectively evaluated hysteroscopic endometrial samplings from RPL and control groups. CD34 transmembrane protein was used for evaluating endometrial vascularization. The vascularization was assessed based on thickness of vessels, diameter of the largest vessel, and number of vessels per mm2 in CD34-stained slides.</p><p><strong>Results:</strong> There was no significant difference in demographic findings and vascularization, such as largest vessel diameter (p: 0.572), and number of vessels per mm2 (p: 0.982) between the two groups.</p><p><strong>Conclusion:</strong> The cycling endometrium is a highly angiogenic tissue and may play a role in the etiology of RPL. However, we find a weak relationship between endometrial vascularization and RPL.</p>

scholarly journals Prostate-specific antigen and (free prostate-specific antigen/ prostate-specific antigen) ratio in patients with Benign Prostatic Hyperplasia and Prostate Cancer

2020 ◽  
Vol 1 (01) ◽  
pp. 17-25
Author(s):  
Amal A. Hussein ◽  
Rayah S. Baban ◽  
Alaa G. Hussein
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Case Control Study ◽  
Specific Antigen ◽  
Control Group ◽  
Inverse Association ◽  
Control Groups ◽  
Significant Difference ◽  
And Control ◽  
Control Study

Background: Prostate cancer is one of the most common cancers in menworldwide. Many markers are suggested as markers of prostate cancer with differentspecificity and sensitivity.Objective : The present study’s main aim is to examine the possible utility ofprostate-specific antigen indices as markers of prostate cancer.Methods: A case-control study was conducted in the Department of Chemistry andBiochemistry, College of Medicine, Al- Nahrain University, Baghdad, Iraq from July2018 till March 2019, includes 84 subjects divided into three groups:Twenty Four patients with prostate cancer (PCA), thirty patients with benignprostatic hyperplasia (BPH) and thirty healthy subjects as a control group wereexamined in this study.Thirty healthy volunteer subjects were asked to be involved in this study as a controlgroup. Blood samples from these patients were collected before obtaining a prostaticbiopsy. Serum PSA, fPSA levels were quantified by the ELISA technique.Results: PSA cut-off value was found to be more than 9.57 ng/ml for Prostate Cancerpatients, values range between 3.17 - 9.57 ng/ml for BPH patients and cut-off valuefor control was found to be less than 3.17 ng/ml, while serum (fPSA/PSA) % cut-offvalue was less than 11.1% for Prostate Cancer patients, values range between 11.1% -31 % for BPH patients, and cut-off value was greater than 31% for the control group.Conclusion: There is a highly significant difference in serum PSA levels and(fPSA/PSA)% between the prostate cancer and control groups. Body mass indexshowed an inverse association with the risk of prostate cancer.

scholarly journals Assessment of Regulatory T Cells in Childhood Immune Thrombocytopenic Purpura

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Karina L. M. Mazzucco ◽  
Lauro M. Junior ◽  
Natália E. Lemos ◽  
Andréa Wieck ◽  
Annelise Pezzi ◽  
...  
Keyword(s):  
T Cells ◽  
Case Control Study ◽  
Treg Cells ◽  
Healthy Controls ◽  
Newly Diagnosed ◽  
Control Groups ◽  
Platelet Counts ◽  
Significant Difference ◽  
And Control ◽  
Control Study

This study had the objective to assess the frequency of Tregs in children newly diagnosed with ITP and ascertain whether an association exists between Tregs and platelet counts, by means of a comparison with healthy controls. This case-control study included 19 patients newly diagnosed with ITP—whose blood samples were collected at four points in time: before any therapy and 1, 3, and 6 months after diagnosis—and 19 healthy controls. Tregs (CD4+ CD25+Foxp3 T cells) were evaluated by flow cytometry. There was a statistically significant difference in platelet count between the case and control groups. There were no significant differences in Treg counts between cases and controls at any point during the course of the study and no difference in Treg counts between the chronic and nonchronic groups and no significant correlation between Tregs and platelet counts in the case and control groups. The findings of this study did not show any statistically significant correlation between Tregs and number of platelets in the case and control groups. Treg cells did not play a role in the regulation of autoimmunity in children with ITP.

scholarly journals Association Between Serum Cadmium and Arsenic Levels with Bladder Cancer: A Case-control Study

2021 ◽  
Vol 14 (7) ◽  
Author(s):  
Vahid Moazed ◽  
Elham Jafari ◽  
Mohammad Reza Ebadzadeh ◽  
Amin Pourzare ◽  
Hamid Reza Gharehchahi ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Regression Models ◽  
Case Control Study ◽  
Case Control ◽  
P Value ◽  
Control Groups ◽  
Significant Difference ◽  
The Mean ◽  
And Control ◽  
Control Study

Background: Bladder cancer is the second most common cancer of the genitourinary system and the eighth cause of cancer death. In addition to known risk factors such as smoking and urinary stones, trace elements are also effective in causing bladder cancer and other cancers. Objectives: This study was conducted to determine the association between bladder cancer and the carcinogens cadmium and arsenic. Methods: This case-control study was conducted on 40 patients with bladder cancer admitted to Shahid Bahonar Hospital and a control group of 40 healthy individuals in Kerman, Iran, in 2018. The serum levels of arsenic and cadmium were measured by atomic absorptiometry. The paired t-test and chi-square tests were employed to assess the difference between cases and controls groups. An unadjusted and 2 multivariable conditional regression models were separately adjusted on sex, family cancer history, residence, occupation, and smoking and were used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) to assess the association between arsenic and cadmium levels and bladder cancer. The statistical software SPSS version 26 and R software version 3.6.3 were used to perform the statistical analyses. Results: The mean cadmium level was 2.99 ± 1.45 and 2.59 ± 0.46 in the case and control groups, respectively, with no statistically significant difference between the groups (P = 0.100). The mean arsenic level was 2.12 ± 1.04 and 1.43 ± 0.73 in the case and control groups, respectively, demonstrating a statistically significant difference between the groups (P = 0.001). Unadjusted and adjusted conditional logistic regression models indicated significant association between arsenic levels and bladder cancer (unadjusted: odds ratio (OR) (95% CI): 0.66 (0.46 - 0.94), P-value = 0.022; adjusted: OR (95% CI): 0.64 (0.44 - 0.92), P-value = 0.018). Conclusions: Overall, cadmium and arsenic levels are higher in patients with bladder cancer, with a statistically significant difference for arsenic. However, these elements are not interrelated and are not related to other factors.

scholarly journals The Relationship between Lateral Nasal Wall Collapse and Nasal Obstruction, a case-control study

2021 ◽  
Author(s):  
Yong Ju Jang ◽  
Mi Rye Bae ◽  
Woo Ri Choi
Keyword(s):  
Nasal Obstruction ◽  
Case Control Study ◽  
Lateral Nasal Wall ◽  
Skin Thickness ◽  
Nasal Valve ◽  
Control Groups ◽  
And Control ◽  
The Relationship ◽  
Valve Angle ◽  
Control Study

Objectives In clinical practice, lateral nasal wall collapse during forced inspiration is widely regarded as a sign of nasal obstruction or criterion indicating nasal valve surgery. This study aims to evaluate the relationship between the degree of lateral nasal wall collapse and subjective nasal obstruction. Design Case-Control study Setting Tertiary centre hospital Participants Case group consisted of 24 patients who had been diagnosed with a deviated nasal septum or nasal valve stenosis. Control group consisted of 27 volunteers with no nasal obstruction symptoms and no septal deviation on nasal endoscopy. Main outcome measures Lateral nasal wall collapse is determined by the degree of lateral nasal wall triangle (LNWT) area reduction on frontal view during forced inspiration compared to quiet inspiration. LNWT area ratio of the patient and control groups was compared. The relationship between the lateral nasal wall collapse and clinical factors including symptom scores, nasal valve angles, skin thickness were evaluated. Results The average LNWT area ratio of the patient (n=24) and control groups (n=27) was 0.96 and 0.83 respectively (p=0.001). Symptom score (NOSE and VAS) is not related to the degree of lateral nasal wall collapse. Moreover, nasal valve angle and skin thickness were also not related to the degree of lateral nasal wall collapse. In 14 of the 19 patients, the more obstructed side corresponded to the side of narrower nasal valve angle, and 5 were not. Conclusion Lateral nasal wall collapse is not related to a patients’ nasal obstruction.

scholarly journals Salivary Atopy Biomarkers in Patients with Geographic Tongue

2021 ◽  
Author(s):  
Leila Farhad-Mollashahi ◽  
Zohreh Dalirsani ◽  
Marieh Honarmand ◽  
Saeedeh Salimi ◽  
Soudeh Shahabi Nezhad
Keyword(s):  
Immunoglobulin E ◽  
Dorsal Surface ◽  
Control Groups ◽  
Cationic Protein ◽  
Significance Level ◽  
Significant Difference ◽  
Unstimulated Saliva ◽  
And Control ◽  
The Relationship ◽  
Control Study

Abstract Objectives Geographic tongue is the mucositis of the dorsal surface of the tongue with no definite etiology, although it may be associated with atopic conditions. In this study, the salivary immunoglobulin E (IgE) and eosinophilic cationic protein (ECP) levels were assessed in patients with geographic tongue to examine the relationship between this condition and allergy-related biomarkers. Materials and Methods In this case-control study, unstimulated saliva was collected from 45 geographic tongue patients and 45 controls, and the salivary IgE and ECP levels were assessed. The data were analyzed with SPSS 20.0 using the Mann–Whitney test with a significance level of p < 0.05. Results The salivary IgE level in the case and control groups was 123.76 ± 8.1 and 74.34 ± 6.2 IU/mL, respectively, and the salivary ECP level was 9.4 ± 6.0 and 7.6 ± 3.2 ng/mL, respectively. There was a statistically significant difference between the two groups in terms of salivary IgE (p = 0.007) and ECP (p = 0.001) levels. Conclusion Salivary IgE and ECP levels increase in patients with geographic tongue. They can, therefore, be used for the initial diagnostic workup and to investigate the possible association of geographic tongue with allergic reactions.

scholarly journals Chronic Urinary Infection in Overactive Bladder Syndrome: A Prospective, Blinded Case Control Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Zainab Khan ◽  
Gareth D. Healey ◽  
Roberta Paravati ◽  
Nidhika Berry ◽  
Eugene Rees ◽  
...  
Keyword(s):  
Overactive Bladder ◽  
Case Control Study ◽  
Case Control ◽  
Routine Laboratory ◽  
Clinical Infection ◽  
Control Groups ◽  
Significant Difference ◽  
Laboratory Cultures ◽  
And Control ◽  
Control Study

ObjectivesTo investigate whether women with overactive bladder (OAB) symptoms and no evidence of clinical infection by conventional clean-catch midstream urine cultures have alternative indicators of sub-clinical infection.Patients/Subjects, Materials &amp; MethodsThe study was a prospective, blinded case-control study with 147 participants recruited, including 73 OAB patients and 74 controls. The OAB group comprised female patients of at least 18 years of age who presented with OAB symptoms for more than 3 months. Clean-catch midstream urine samples were examined for pyuria by microscopy; subjected to routine and enhanced microbiological cultures and examined for the presence of 10 different cytokines, chemokines, and prostaglandins by ELISA.ResultsThe mean age and BMI of participants in both groups were similar. No significant difference in the number of women with pyuria was observed between OAB and control groups (p = 0.651). Routine laboratory cultures were positive in three (4%) of women in the OAB group, whereas the enhanced cultures isolated bacteria in 17 (23.2%) of the OAB patients. In the control group, no positive cultures were observed using routine laboratory cultures, whereas enhanced culture isolated bacteria in 8 (10.8%) patients. No significant differences were observed in the concentrations of PGE2, PGF2α, MCP-1, sCD40L, MIP-1β, IL12p70/p40, IL12/IL-23p40, IL-5, EGF and GRO-α between the OAB and control groups.ConclusionsPatients with OAB symptoms have significant bacterial growth on enhanced culture of the urine, which is often not detectable through routine culture, suggesting a subclinical infection. Enhanced culture techniques should therefore be used routinely for the effective diagnosis and management of OAB.

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