scholarly journals Multiple Myeloma and Physical Activity

2020 ◽  
Author(s):  
Catherine Shin Yee Lecat ◽  
Abigail Fisher ◽  
Orla McCourt ◽  
Joanne Land ◽  
Kwee Yong
Keyword(s):  
Physical Activity ◽  
Multiple Myeloma ◽  
Bone Destruction ◽  
Evaluation Study ◽  
Service Evaluation ◽  
Psychosocial Wellbeing ◽  
Risk Of Injury ◽  
High Incidence ◽  
To Receive

Abstract Objective: With improved survival in multiple myeloma, survivors face the challenge of maintaining their premorbid levels of physical and psychosocial wellbeing. Physical activity (PA) has been shown to improve quality of life (QoL) in cancer patients with some evidence in MM. Due to the high incidence of bone destruction, PA may be perceived as introducing risk of injury. This service evaluation study aimed to determine MM patients’ exercise levels, their perception of PA, and to explore correlations with QoL. Results: MM outpatients were given a questionnaire to complete. Of the 65 respondents, 75% would like to increase PA level. Weakness, fatigue and pain were the most commonly perceived barriers to PA. 59% would like to receive PA advice. Only 25% were deemed active based on the Godin leisure-time exercise questionnaire score, with 39% deemed insufficiently active. Our respondents had lower mean FACT-G and FACIT-F scores compared to scores from general population, suggesting a lower QoL. Finally, there was a significant positive correlation between the GLTEQ score and the FACT-G score (p < 0.001). Results highlight an unmet exercise need in MM patients. Current practice should be reviewed to develop a more holistic care model that incorporates tailored exercise advice or programme.

scholarly journals Multiple myeloma and physical activity

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Catherine S. Y. Lecat ◽  
Orla McCourt ◽  
Joanne Land ◽  
Kwee Yong ◽  
Abigail Fisher
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Multiple Myeloma ◽  
Functional Assessment ◽  
Chronic Illness Therapy ◽  
Physical Activity Advice ◽  
Related Quality ◽  
Health Related ◽  
To Receive

Abstract Objective Physical activity has been shown to improve quality of life in cancer patients with some evidence in multiple myeloma. This study aimed to determine myeloma patients’ exercise levels, their perception of physical activity, and to explore correlations with quality of life. Myeloma outpatients were invited to complete a number of questionnaires, including the Godin leisure-time exercise questionnaire (GLTEQ) to determine their exercise levels, the Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire to assess health related quality of life, and the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) questionnaire to assess fatigue. Results Of the 65 respondents, 75% would like to increase their exercise level. Weakness, fatigue and pain were the most commonly perceived barriers to physical activity. 59% would like to receive physical activity advice. Only 25% were deemed active based on their GLTEQ scores. Finally, there was a significant positive correlation between the GLTEQ score and the FACT-G score (p < 0.001). Results highlight an unmet exercise need in myeloma patients. Current practice should be reviewed to develop a more holistic care model that incorporates tailored exercise advice or programme.

scholarly journals Current approaches to supportive care in multiple myeloma

2011 ◽  
Vol 139 (suppl. 2) ◽  
pp. 123-128
Author(s):  
Nenad Govedarovic ◽  
Tomislav Vukicevic
Keyword(s):  
Multiple Myeloma ◽  
Chronic Condition ◽  
Malignant Disease ◽  
Plasma Cells ◽  
Supportive Therapy ◽  
Bone Destruction ◽  
Monoclonal Protein ◽  
Blood Disease ◽  
Skeletal Disease

Myeloma multiplex is a malignant blood disease in which monoclonal expansion of malignant plasma cells occurs, together with hyperproduction of monoclonal protein,as well as impairment of normal haematopoiesis. Specific features of myeloma include bone destruction, renal failure and immunologic deficiency which decreases the overall quality of the patient?s life. Thus, prevention and supportive therapy of skeletal disease, anaemia, pain, nausea, infection and hypercalcemia, represent the essential part of therapy in myeloma patients. Improvements achieved in the specific haematological treatment, including supportive measures of complications of multiple myeloma, previously defined as incurable malignant disease, results in the improvement of the overall survival and the quality of life of these patients, thus qualifing multiple myeloma into a chronic condition.

Melphalan and prednisone plus thalidomide or placebo in elderly patients with multiple myeloma

Blood ◽  
2010 ◽  
Vol 116 (9) ◽  
pp. 1405-1412 ◽  
Author(s):  
Anders Waage ◽  
Peter Gimsing ◽  
Peter Fayers ◽  
Niels Abildgaard ◽  
Lucia Ahlberg ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Partial Response ◽  
Controlled Study ◽  
Plateau Phase ◽  
Life Outcomes ◽  
Double Blind ◽  
Skin Reactions ◽  
Significant Difference ◽  
To Receive

Abstract In this double-blind, placebo-controlled study, 363 patients with untreated multiple myeloma were randomized to receive either melphalan-prednisone and thalidomide (MPT) or melphalan-prednisone and placebo (MP). The dose of melphalan was 0.25 mg/kg and prednisone was 100 mg given daily for 4 days every 6 weeks until plateau phase. The dose of thalidomide/placebo was escalated to 400 mg daily until plateau phase and thereafter reduced to 200 mg daily until progression. A total of 357 patients were analyzed. Partial response was 34% and 33%, and very good partial response or better was 23% and 7% in the MPT and MP arms, respectively (P < .001). There was no significant difference in progression-free or overall survival, with median survival being 29 months in the MPT arm and 32 months in the MP arm. Most quality of life outcomes improved equally in both arms, apart from constipation, which was markedly increased in the MPT arm. Constipation, neuropathy, nonneuropathy neurologic toxicity, and skin reactions were significantly more frequent in the MPT arm. The number of thromboembolic events was equal in the 2 treatment arms. In conclusion, MPT had a significant antimyeloma effect, but this did not translate into improved survival. This trial was registered at www.clinicaltrials.gov as #NCT00218855.

scholarly journals Prediction and injury risk based on movement patterns and flexibility in a 6-month prospective study among physically active adults

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11399
Author(s):  
Dawid Koźlenia ◽  
Jarosław Domaradzki
Keyword(s):  
Physical Activity ◽  
Injury Risk ◽  
Movement Patterns ◽  
Physically Active ◽  
Injury Prediction ◽  
Risk Of Injury ◽  
Quality Movement ◽  
Quality Of Movement ◽  
Active Adults

Background Physical activity has many health benefits but also carries a risk of injury. Some universal factors are connected with an increased risk regardless of the type of sport. Identifying these factors may help predict injuries and aid in their prevention. Aim The aim of this study is to determine the level of injury risk and the accuracy of injury prediction during a prospective 6-month period based on the quality of movement patterns and level of flexibility among average physically active young adults. Material and Methods A group of 123 young, physically active adults were recruited for this study. The International Physical Activity Questionnaire (IPAQ) was used to determine their level of physical activity. The author’s own Injury History Questionnaire (IHQ) was used to retrospectively collect injury data from the 12 months before the study and prospectively collect data during the six month observation period. The Functional Movement Screen (FMS) test was conducted to assess the movement patterns quality and a sit-and-reach test was conducted to measure lower back and hamstrings flexibility. Results Low-quaility movement patterns (14≥ FMS) increased the injury risk level sevenfold. A level of flexibility reduced by one cm increased the risk of injury by 6%. Previous injuries also increased the risk of injury reccurence 6.4 times. Predicting injury occurrence based on the quality of movement patterns allows for an accuracy of 73%, whereas flexibility allows for a 41% accuracy. The simultaneous use of these two factors did not improve injury prediction accuracy. Conclusion The risk of an injury increases with low-quality movement patterns, a low level of flexibility, and previous injuries. Preventative strategies should include shaping high-quality movement patterns, the right level of flexibility, and the full healing of injuries before resuming activities. The quality of movement patterns is an accurate predictor of injury risk, but lower back and hamstrings flexibility is not a reliable predictor of injury.

scholarly journals SPORTS SPECIALIZED YOUTH ATHLETES EXHIBIT LOWER RISK QUALITY OF MOTION THAN NON-SPECIALIZED ADOLESCENTS

2021 ◽  
Vol 9 (7_suppl3) ◽  
pp. 2325967121S0007
Author(s):  
Madison R. Heath ◽  
Joseph Janosky ◽  
Angelo Pegno ◽  
Jonathan M. Schachne ◽  
Peter D. Fabricant
Keyword(s):  
Physical Activity ◽  
Acute Injury ◽  
Activity Levels ◽  
Healthy Children ◽  
Maximum Score ◽  
Youth Athletes ◽  
Risk Of Injury ◽  
Quality Of Motion ◽  
The Mean

Background: Quality of motion and neuromuscular balance are noted predictors of acute injury risk. Early sports specialization and extremely high activity levels have been linked to high risk of injury, especially overuse injury. Purpose: The purpose of this study is to investigate for any relationships between quality of physical movement, quantity of physical activity, and degree of sports specialization in a healthy cohort of children and adolescents. Methods: Healthy children between the ages 10 and 18 completed the HSS Pedi-FABS to assess quantity of physical activity and the Jayanthi scale to assess degree of sports specialization. Quality of motion was assessed using motion analysis sensors (DorsaVi, Kew, Australia) during 5 repetitions of 4 different jumping and squatting motions (Table 1). For each repetition, one point was given for low risk of injury anterior or medial/lateral motion, for a maximum score of 2 per leg. Quality of motion scores were summed for a maximum score of 100 per participant. Specialization level was dichotomized as high specialization with a Jayanthi scale score of 2 or 3 and low specialization with a score of 1 or 2. Independent samples t-tests were used to compare high vs. low specialization participants on physical activity quantity and overall quality of motion. A Pearson correlation was used to determine the relationship between quantity of physical activity and quality of motion. Results: Final analyses included 147 participants (72% male) with a mean age of 13.4 ± 2.2 years. For the entire cohort, the mean Pedi-FABS score was 22.9 ± 6.8, the mean quality score was 25.5 ± 13.5 and 73% were highly specialized. Participants that were highly specialized displayed low risk motion more frequently than participants with low sport specialization (27.6 ± 14.0 vs 19.8 ± 10.1, p < 0.01; Table 2). Highly specialized participants had significantly higher activity levels (24.6 ± 5.9 vs 18.1 ± 6.9, p < 0.001). Additionally, quality of motion was moderately correlated with physical activity level (r = 0.349, p < 0.001). Conclusion: Overall quality of motion as in jump-landing tasks in healthy children was better in highly specialized participants. Taken together with existing literature, although early specialization may put young athletes at risk for overuse injuries, highly sports specialized youth athletes may be at lower risk for acute injury. Future research should explore associations between sports specialization, physical activity, save movement patterns, and athletic injuries. [Table: see text][Table: see text]

scholarly journals Physical Exercise Moderates the Effects of Disability on Depression in People with Multiple Sclerosis during the Covid-19 Outbreak

2021 ◽  
Vol 10 (6) ◽  
pp. 1234
Author(s):  
Antonio Carotenuto ◽  
Cristiano Scandurra ◽  
Teresa Costabile ◽  
Luigi Lavorgna ◽  
Giovanna Borriello ◽  
...  
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Physical Exercise ◽  
Physical Disability ◽  
Psychosocial Wellbeing ◽  
Interaction Plot ◽  
Post Hoc ◽  
Moderating Role

Physical disability impacts psychosocial wellbeing in people with multiple sclerosis. However, the role of physical activity in this context is still debated. By taking advantage of a previous survey, conducted online from 22 April to 7 May 2020, we performed a post-hoc analysis with the aim to assess the associations between disability, physical exercise, and mental health in multiple sclerosis. We retrieved the following data: (i) sociodemographic information, (ii) changes in lifestyle (including exercise), (iii) physical disability, as measured with the Patient-Determined Disease Steps scale, and (iv) anxiety feelings and depressive symptoms assessed via the items included in the Quality of Life in Neurological Disorders measurement system. Examination of the interaction plot showed that the effect of disability on depression, but not on anxious symptoms, was significant for all levels of physical exercise (low: b = 1.22, 95% C.I. 0.85, 1.58, p < 0.001; moderate: b = 0.95, 95% C.I. 0.66, 1.24, p < 0.001; and high: b = 0.68, 95% C.I. 0.24, 1.13, p = 0.003). Based on these data, we can conclude that disability significantly impacted depression during the COVID-19 pandemic, with physical activity playing a moderating role. Our results suggest that favoring exercise in multiple sclerosis (MS) would ameliorate psychological wellbeing regardless of the level of physical disability.

Exploring the physical and psychosocial benefits of yoga for adults with intellectual and developmental disabilities

2019 ◽  
Vol 18 (4) ◽  
pp. 38-48
Author(s):  
Brandi M. Crowe, PhD, LRT/CTRS ◽  
Claire K. Allison, MS, LRT/CTRS ◽  
Marieke Van Puymbroeck, PhD, CTRS, FDRT ◽  
Em V. Adams, MS, CTRS ◽  
Arlene A. Schmid, PhD, OTR, FAOTA
Keyword(s):  
Physical Activity ◽  
Developmental Disabilities ◽  
Physical Functioning ◽  
Psychosocial Health ◽  
Future Research ◽  
Intellectual And Developmental Disabilities ◽  
Psychosocial Wellbeing ◽  
Body Strength ◽  
Psychosocial Benefits

Individuals with intellectual and developmental disabilities (IDD) often experience negative physical and psychosocial health outcomes that may result in lower levels of engagement in physical activity and decreased quality of life. Physical activity, such as yoga, may improve physical functioning and psychosocial wellbeing among individuals with IDD. There is a lack of published research that evaluates outcomes of yoga participation for individuals with IDD. Thus, the purpose of this multimethod study was to explore the influence of yoga participation on the physical functioning and psychosocial wellbeing of adults with IDD. Eleven adults with IDD engaged in 12, 60-minute yoga sessions for 7 weeks. Results indicated significant improvements in participants’ lower body strength and endurance, and their interest and enjoyment as motivation for participating in physical activity. Findings suggest that yoga has the potential to improve physical functioning and psychosocial wellbeing among adults with IDD. Recommendations for future research are included.

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