Clinical Features of B. Cereus Sepsis in Premature Neonates
Abstract Background: To analyze the clinical characteristics and prognosis of bacillus cereus sepsis in premature neonates.Method: Retrospectively analyze the data of 8 premature neonates of bacillus cereus sepsis in Shanghai Children’s Hospital from January 2015 to December 2019, where clinical information is collected from patients’ medical records and charts, information of neurodevelopment is collected for patients from follow-up visits at corrected age of 6 months and 12 months.Results: 8 premature neonates of bacillus cereus sepsis were identified, among which 5 cases developed meningitis, abnormal Cerebral MRI images were seen in 5 cases. After empirical antibiotic treatment with Meropenem and Vancomycin, 1 patient died, 7 patients survived to discharge. Follow-up visits discovered that 1 patient developed hydrocephalus and showed severely delayed neurodevelopment, 2 patients had mild neurodevelopmental delay, and neurodevelopment was basically normal in other 4 patients. Conclusions: Bacillus cereus infection can cause severe nervous system complications, and affect neurodevelopmental outcome. Empirical antibiotic treatment with Meropenem and Vancomycin is proven effective.