scholarly journals Characterization and eradication of the high concentration infection source of oral segment of Candida by infection examination diagnosis system

2021 ◽  
Author(s):  
Yuusuke Nonomura
Keyword(s):  
Pathogenic Fungus ◽  
Diagnostic System ◽  
Japanese Patients ◽  
Diffusion Field ◽  
High Concentration ◽  
Living Body ◽  
Measurement Analysis ◽  
Time Space ◽  
Field Diffusion ◽  
Infection Source

Abstract Purpose: Candida albicans (CA) is a major pathogenic fungus that causes a critical infection and life-threatening disease. Currently, during the treatment of COVID-19 (in ICU), invasive Candidiasis and Candida colonization should be prevented to avoid the increase, in mortality, in SAPSII, and in length of stay. Our aim was to characterize and analyze the infection of CA for eradication. Methods: We characterized and analyzed the infection source and infection field which are carrier field, diffusion field, and spread field, by using a new infection examination (diagnostic) system (IEDS) comprising a new dental formula (measurement analysis) medium (DFM) with time, space, and phase, and the simultaneous relative differential equations (C4RDE). Results: This study showed that CA was not an endogenous microorganism, but a fungus that infected teeth causing dental caries that was successfully eradicated from all teeth of 353 Japanese patients. Conclusion: Our methods help to eradicate the infection source, prevent critical infection, and reduce mortality. The IEDS is a powerful tool that can be applied for any infection easily. It is possible for the dentists to characterize CA by IEDS and eradicate CA from the oral cavity. IE(D)S will dramatically reduce the threat to the living body by pathogenic microorganisms.

scholarly journals Characterization and Eradication of The High Concentration Infection Source of Oral Segment of Candida By Infection Examination Diagnosis System

2021 ◽  
Author(s):  
Yuusuke Nonomura
Keyword(s):  
Candida Albicans ◽  
Oral Cavity ◽  
Pathogenic Fungus ◽  
Diagnostic System ◽  
Japanese Patients ◽  
Diffusion Field ◽  
Microbial Infection ◽  
High Concentration ◽  
Time Space ◽  
Infection Source

Abstract Purpose: Candida albicans (CA) is a major pathogenic fungus that causes a critical infection and life-threatening disease. During ventilator usage for the treatment of COVID-19-associated pneumonia, CA colonization of the airway should be prevented to avoid an increase in mortality. Our aim was to characterize and analyze the infection of Candida albicans (CA) for eradication.Methods: We characterized and analyzed the infection source and infection field which are carrier field, diffusion field, and spread field, by using a new infection examination (diagnostic) system (IEDS) comprising a new dental formula (measurement analysis) medium (DFM) with time, space, and phase, and the simultaneous relative differential equations (C4RDE).Results: This study showed that CA was not an endogenous microorganism, but a fungus that infected teeth causing dental caries that was successfully eradicated from all teeth of 353 Japanese patients (oral cavity segment). [In the first examination, the percentages of people with CA (+) was 40.5% (the DMFT: 62.8%) and CA(-) was 56.4% (the DMFT: 47.1%). The difference in DMFT was 15.7% (P<0.01)] (DMFT is decayed, missing, and filled tooth index).Conclusion: Our methods help to eradicate the infection source (IS), prevent critical infection, and reduce mortality. The IEDS is a powerful tool that can be applied for any microbial infection easily. It is possible for the dentists to characterize CA by IEDS and eradicate CA from the oral cavity.

scholarly journals Characterization and eradication of the high concentration infection source of oral segment of Candida by infection examination diagnosis system

2021 ◽  
Author(s):  
Yuusuke Nonomura
Keyword(s):  
Candida Albicans ◽  
Oral Cavity ◽  
Pathogenic Fungus ◽  
Diffusion Field ◽  
Correct Result ◽  
Microbial Infection ◽  
High Concentration ◽  
Statistical Research ◽  
Time Space ◽  
Infection Source

Abstract Purpose: Candida albicans (CA) is a major pathogenic fungus that causes a critical infection and life-threatening disease. Currently, during the treatment of COVID-19 (in ICU), invasive Candidiasis and Candida colonization should be prevented to avoid the increase, in mortality, in SAPSII, and in length of stay. Our aim was to characterize and analyze the infection of Candida albicans (CA) for eradication. Methods: We characterized and analyzed the infection source and infection field which are carrier field, diffusion field, and spread field, by using a new infection examination (diagnostic) system (IEDS) comprising a new dental formula (measurement analysis) medium (DFM) with time, space, and phase, and the simultaneous relative differential equations (C4RDE).Results: This study showed that CA was not an endogenous microorganism, but a fungus that infected teeth causing dental caries that was successfully eradicated from all teeth of 353 Japanese patients (oral cavity segment). [In the first examination, the percentages of people with CA (+) was 40.5% (the DMFT: 62.8%) and CA(-) was 56.4% (the DMFT: 47.1%). The difference in DMFT was 15.7% (P<0.01)] (DMFT is decayed, missing, and filled tooth index).Conclusion: Eradication of the infection source (IS) of the oral segment(s) and breaking the infection chain (IC) by IE(D)S will dramatically reduce the threat to the living body by pathogenic microorganisms. And, our methods help to eradicate the infection source (IS), prevent critical infection, and reduce mortality. The IEDS is a powerful tool that can be applied for any microbial infection easily. It is possible for the dentists to characterize CA by IEDS and eradicate CA from the oral cavity. Moreover, CA must consider the phase of the space-time of infection source, infection field, receptor field, resistance field, adhesive colony, fixed colony and infection chain. Moreover, CA must consider the phase of microorganisms. If they are neglected, the statistical research or the medical treatment etc., the study cannot obtain the correct result.

scholarly journals The stratigraphic evolution of a submarine channel: linking seafloor dynamics to depositional products

2020 ◽  
Vol 90 (7) ◽  
pp. 673-686
Author(s):  
Stephen M. Hubbard ◽  
Zane R. Jobe ◽  
Brian W. Romans ◽  
Jacob A. Covault ◽  
Zoltan Sylvester ◽  
...  
Keyword(s):  
Turbidity Currents ◽  
High Concentration ◽  
Bounding Surface ◽  
Cross Sectional ◽  
Genetic Link ◽  
Submarine Channel ◽  
Time Space ◽  
Stratigraphic Evolution ◽  
Geomorphic Surfaces ◽  
The Relationship

ABSTRACT We investigate the relationship between the cross-sectional geomorphic expression of a submarine channel as observed on the seafloor and the stratigraphic product of long-lived erosion, bypass, and sediment deposition. Specifically, by reconstructing the time–space evolution of an individual channel fill (i.e., channel element) exposed in outcrop, we establish a genetic link between thick-bedded channel-element-axis sandstone to thinly interbedded channel-element-margin deposits. Although the bounding surface between axis sandstone and margin thin beds is sharply defined, it is composed of a series of geomorphic surface segments of various ages; as such, the composite stratigraphic surface (∼ 17 m relief) was formed from numerous incision events that repeatedly sculpted the conduit. By demonstrating the origin of the stratigraphic surface, we conclude that geomorphic surfaces with 2–7 m of erosional relief were largely responsible for the observed intra-channel-element architecture (and ultimately, the composite 17-m-thick element). The widely documented channel element axis-to-margin architecture is a product of submarine-channel thalweg dynamics, primarily recording interactions between the seafloor and the basal high-concentration layers of channelized turbidity currents.

scholarly journals Characterizing the Xenoma of Vairimorpha necatrix Provides Insights Into the Most Efficient Mode of Microsporidian Proliferation

2021 ◽  
Vol 11 ◽  
Author(s):  
Tian Li ◽  
Zhuoya Fang ◽  
Qiang He ◽  
Chunxia Wang ◽  
Xianzhi Meng ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Muscle Cells ◽  
High Electron ◽  
Scanning Electronic Microscopy ◽  
High Concentration ◽  
Transmission Electron ◽  
Intracellular Parasites ◽  
Infection Source ◽  
High Level

Microsporidia are a group of obligated intracellular parasites that can infect nearly all vertebrates and invertebrates, including humans and economic animals. Microsporidian Vairimorpha necatrix is a natural pathogen of multiple insects and can massively proliferate by making tumor-like xenoma in host tissue. However, little is known about the subcellular structures of this xenoma and the proliferation features of the pathogens inside. Here, we characterized the V. necatrix xenoma produced in muscle cells of silkworm midgut. In result, the whitish xenoma was initially observed on the 12th day post infection on the outer surface of the midgut and later became larger and numerous. The observation by scanning electronic microscopy showed that the xenoma is mostly elliptical and spindle with dense pathogen-containing protrusions and spores on the surface, which were likely shedding off the xenoma through exocytosis and could be an infection source of other tissues. Demonstrated with transmission electron microscopy and fluorescent staining, the xenoma was enveloped by a monolayer membrane, and full of vesicle structures, mitochondria, and endoplasmic reticulum around parasites in development, suggesting that high level of energy and nutrients were produced to support the massive proliferation of the parasites. Multiple hypertrophic nuclei were found in one single xenoma, indicating that the cyst was probably formed by fusion of multiple muscle cells. Observed by fluorescence in situ hybridization, pathogens in the xenoma were in merongony, sporogony, and octosporogony, and mature stages. And mature spores were pushed to the center while vegetative pathogens were in the surface layer of the xenoma. The V. necatrix meront usually contained two to three nuclei, and sporont contained two nuclei and was wrapped by a thick membrane with high electron density. The V. necatrix sporogony produces two types of spores, the ordinary dikaryotic spore and unicellular octospores, the latter of which were smaller in size and packed in a sporophorous vesicle. In summary, V. necatrix xenoma is a specialized cyst likely formed by fusion of multiple muscle cells and provides high concentration of energy and nutrients with increased number of mitochondria and endoplasmic reticulum for the massive proliferation of pathogens inside.

Ritualized behavior in animals and humans: Time, space, and attention

2006 ◽  
Vol 29 (6) ◽  
pp. 616-617 ◽  
Author(s):  
David Eilam
Keyword(s):  
Obsessive Compulsive Disorder ◽  
High Concentration ◽  
Time And Space ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Time Space ◽  
Stereotyped Behaviors

A study of the organization of obsessive-compulsive disorder (OCD) rituals in time and space illuminates a postulated mechanism on shifting focus in action parsing, from mid-ranged actions to finer movements (gestures). Performance of OCD rituals also involves high concentration rather than the automated, less attended performance of rituals in normal and stereotyped behaviors in animals and humans.

Combining Advanced Data Analysis Methods for the Constitution of an Integrated Gas Turbine Condition Monitoring and Diagnostic System

2000 ◽  
Author(s):  
A. Tsalavoutas ◽  
N. Aretakis ◽  
K. Mathioudakis ◽  
A. Stamatis
Keyword(s):  
Gas Turbine ◽  
Diagnostic System ◽  
Data Consistency ◽  
Adaptive Performance ◽  
Diagnostic Systems ◽  
Measurement Analysis ◽  
On Line ◽  
Direct Data ◽  
Advanced Analysis ◽  
Industrial Gas Turbine

This paper presents principles for the constitution of gas turbine monitoring and diagnostic systems which: a. are integrated, namely manage all the tasks essential for achieving a diagnosis (measurement, analysis, interpretation, historical data management etc.) b. employ different kind of processing methods in order to cover an extensive range of engine conditions, including direct data evaluation and data consistency checks, thermodynamic analysis, vibration analysis. The requirements to be fulfilled by an industrial gas turbine monitoring system are briefly reviewed and ways to achieve them are discussed, indicating how they can be materialized by implementation of specific techniques. Techniques previously derived by the group of the authors are implemented, and the merits they offer when used in combination are discussed. Features of a system, materialized according to the principles discussed, into an operating industrial gas turbine is presented. On-line application of advanced analysis techniques, such as adaptive performance modeling is discussed, on the basis of observations of the collected data. Data collected from an engine operating in the field are presented to substantiate the matters discussed, and cases of successful fault identification are shown.

Cytomembrane Preservation in Tissue Dehydrated Only With Glutaraldehyde and Epon 812 Resin

1973 ◽  
Vol 31 ◽  
pp. 320-321
Author(s):  
Daniel C. Pease
Keyword(s):  
Diffraction Pattern ◽  
X Ray Diffraction ◽  
High Concentration ◽  
Unpublished Study ◽  
X Ray ◽  
Sectioned Material

A previous study demonstrated that tissue could be successfully infiltrated with 50% glutaraldehyde, and then subsequently polymerized with urea to create an embedment which retained cytomembrane lipids in sectioned material. As a result, the 180-190 Å periodicity characteristic of fresh, mammalian myelin was preserved in sections, as was a brilliant birefringence, and the capacity to bind OsO4 vapor in the hydrophobic bilayers. An associated (unpublished) study, carried out in co-operation with Drs. C.K. Akers and D.F. Parsons, demonstrated that the high concentration of glutaraldehyde (and urea) did not significantly alter the X-ray diffraction pattern of aldehyde-fixed, myelin. Thus, by itself, 50% glutaraldehyde has little effect upon cytomembrane systems and can be used with confidence for the first stages of dehydration.

Effects of carbamylcholine on chick embryo aggregate retina cell cultures

1988 ◽  
Vol 46 ◽  
pp. 350-351
Author(s):  
Glenn M. Cohen ◽  
Radharaman Ray
Keyword(s):  
Cell Cultures ◽  
Single Cells ◽  
Retinal Cell ◽  
Cell Aggregates ◽  
High Concentration ◽  
In Ovo ◽  
Sterile Culture ◽  
Retinal Tissue ◽  
Synaptic Junctions ◽  
And Control

Retinal,cell aggregates develop in culture in a pattern similar to the in ovo retina, forming neurites first and then synapses. In the present study, we continuously exposed chick retinal cell aggregates to a high concentration (1 mM) of carbamylcholine (carbachol), an acetylcholine (ACh) analog that resists hydrolysis by acetylcholinesterase (AChE). This situation is similar to organophosphorus anticholinesterase poisoning in which the ACh level is elevated at synaptic junctions due to inhibition of AChE, Our objective was to determine whether continuous carbachol exposure either damaged cholino- ceptive neurites, cell bodies, and synaptic elements of the aggregates or influenced (hastened or retarded) their development.The retinal tissue was isolated aseptically from 11 day embryonic White Leghorn chicks and then enzymatically (trypsin) and mechanically (trituration) dissociated into single cells. After washing the cells by repeated suspension and low (about 200 x G) centrifugation twice, aggregate cell cultures (about l0 cells/culture) were initiated in 1.5 ml medium (BME, GIBCO) in 35 mm sterile culture dishes and maintained as experimental (containing 10-3 M carbachol) and control specimens.

The Fine Structure of Phloem Cells

1985 ◽  
Vol 43 ◽  
pp. 632-635
Author(s):  
James Cronshaw
Keyword(s):  
Structural Studies ◽  
High Concentration ◽  
Long Distance ◽  
Phloem Tissue ◽  
Sieve Elements ◽  
Long Distance Transport ◽  
P Protein ◽  
Companion Cells ◽  
Electron Microscopical ◽  
Distance Transport

Long distance transport in plants takes place in phloem tissue which has characteristic cells, the sieve elements. At maturity these cells have sieve areas in their end walls with specialized perforations. They are associated with companion cells, parenchyma cells, and in some species, with transfer cells. The protoplast of the functioning sieve element contains a high concentration of sugar, and consequently a high hydrostatic pressure, which makes it extremely difficult to fix mature sieve elements for electron microscopical observation without the formation of surge artifacts. Despite many structural studies which have attempted to prevent surge artifacts, several features of mature sieve elements, such as the distribution of P-protein and the nature of the contents of the sieve area pores, remain controversial.

Tem analysis of multiple-energy arsenic implanted and Rta'd silicon

1987 ◽  
Vol 45 ◽  
pp. 246-247
Author(s):  
R.A. Herring
Keyword(s):  
Device Fabrication ◽  
High Concentration ◽  
Tem Analysis ◽  
Defect Clusters ◽  
High Fluences ◽  
Small Defect ◽  
Before And After ◽  
The Matrix ◽  
The Difference ◽  
Factor Type

Rapid thermal annealing (RTA) of ion-implanted Si is important for device fabrication. The defect structures of 2.5, 4.0, and 6.0 MeV As-implanted silicon irradiated to fluences of 2E14, 4E14, and 6E14, respectively, have been analyzed by electron diffraction both before and after RTA at 1100°C for 10 seconds. At such high fluences and energies the implanted As ions change the Si from crystalline to amorphous. Three distinct amorphous regions emerge due to the three implantation energies used (Fig. 1). The amorphous regions are separated from each other by crystalline Si (marked L1, L2, and L3 in Fig. 1) which contains a high concentration of small defect clusters. The small defect clusters were similar to what had been determined earlier as being amorphous zones since their contrast was principally of the structure-factor type that arises due to the difference in extinction distance between the matrix and damage regions.

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