Risk Factors for Severe Cases of Inpatients with COVID-19 in Henan Province, China: A Multicenter Retrospective Cohort Study

Abstract Rationale: Our pilot study suggested that coexisting cerebrovascular diseases on admission with respiratory rate greater than 24 breaths per min, and LDH greater than 245U/L may be risk factors for death among hospitalized COVID-19 patients in Henan province, China. Whether these risk factors are associated with severe illness in inpatiente with COVID-19 is yet unclear.Background: To explore risk factors associated with severe cases in hospitalized COVID-19 patients in Henan province, ChinaMethods: This study was a multicenter retrospective cohort study. A total of 112 patients with COVID-19 were admitted to Henan Provincial People's Hospital and Anyang Infectious Disease Hospital from February 3 to March 31, 2020. These patients were confirmed by SARS-CoV-2 nucleic acid test. Demographic, epidemiological, clinical and laboratory data, imaging changes, and definite severity typing of illness (severe cases or non-severe cases) were extracted from electronic medical records and compared between severe cases and non-severe cases. Univariate and multivariate logistic regression methods were used to explore the risk factors associated with in-hospital severe cases.Results: A total of 104 patients (55 from Henan Provincial People's Hospital and 57 from Anyang Infectious Disease Hospital) were included in this study, of whom 62 (59.6%) were non-severe cases and 42 (40.4%) were severe cases. Multivariate regression showed increasing odds of in-hospital severe cases associated with age ³65 years (odds ratio 6.535 [95% CI, 1.365-31.295]; p=0.019), coexisting diabetes (11.165 [1.142-109.172], p=0.038), cough (17.494 [2.971-102.995]; p=0.002), increased procalcitonin (0.05-0.25ng/L) (9.640 [2.162-42.982]; p=0.003) and LDH greater than 245U/L (11.040 [2.661-45.808]; p=0.001) on admission.Conclusions: Age ³65 years, coexisting diabetes, cough, increased PCT, and LDH greater than 245U/L on admission may be risk factors for severe cases among hospitalized COVID-19 patients in Henan Province, China.

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Characteristics, outcomes and risk factors for mortality of 522 167 patients hospitalised with COVID-19 in Brazil: a retrospective cohort study

BMJ Open ◽

10.1136/bmjopen-2021-049089 ◽

2021 ◽

Vol 11 (5) ◽

pp. e049089

Author(s):

Marcia C Castro ◽

Susie Gurzenda ◽

Eduardo Marques Macário ◽

Giovanny Vinícius A França

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Cox Proportional Hazards ◽

Secondary Outcome ◽

Hospital Death ◽

Factors Associated ◽

Icu Admission ◽

Hospitalised Patients

ObjectiveTo provide a comprehensive description of demographic, clinical and radiographic characteristics; treatment and case outcomes; and risk factors associated with in-hospital death of patients hospitalised with COVID-19 in Brazil.DesignRetrospective cohort study of hospitalised patients diagnosed with COVID-19.SettingData from all hospitals across Brazil.Participants522 167 hospitalised patients in Brazil by 14 December 2020 with severe acute respiratory illness, and a confirmed diagnosis for COVID-19.Primary and secondary outcome measuresPrevalence of symptoms and comorbidities was compared by clinical outcomes and intensive care unit (ICU) admission status. Survival was assessed using Kaplan Meier survival estimates. Risk factors associated with in-hospital death were evaluated with multivariable Cox proportional hazards regression.ResultsOf the 522 167 patients included in this study, 56.7% were discharged, 0.002% died of other causes, 30.7% died of causes associated with COVID-19 and 10.2% remained hospitalised. The median age of patients was 61 years (IQR, 47–73), and of non-survivors 71 years (IQR, 60–80); 292 570 patients (56.0%) were men. At least one comorbidity was present in 64.5% of patients and in 76.8% of non-survivors. From illness onset, the median times to hospital and ICU admission were 6 days (IQR, 3–9) and 7 days (IQR, 3–10), respectively; 15 days (IQR, 9–24) to death and 15 days (IQR, 11–20) to hospital discharge. Risk factors for in-hospital death included old age, Black/Brown ethnoracial self-classification, ICU admission, being male, living in the North and Northeast regions and various comorbidities. Age had the highest HRs of 5.51 (95% CI: 4.91 to 6.18) for patients≥80, compared with those ≤20.ConclusionsCharacteristics of patients and risk factors for in-hospital mortality highlight inequities of COVID-19 outcomes in Brazil. As the pandemic continues to unfold, targeted policies that address those inequities are needed to mitigate the unequal burden of COVID-19.

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Risk factors associated with increased discontinuation rate of trimethoprim–sulfamethoxazole used as a primary prophylaxis for Pneumocystis pneumonia: A retrospective cohort study

Pulmonary Pharmacology & Therapeutics ◽

10.1016/j.pupt.2021.101999 ◽

2021 ◽

Vol 67 ◽

pp. 101999

Author(s):

Toshihito Otani ◽

Kakuhiro Yamaguchi ◽

Shinjiro Sakamoto ◽

Yasushi Horimasu ◽

Takeshi Masuda ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Primary Prophylaxis ◽

Pneumocystis Pneumonia ◽

Discontinuation Rate ◽

Factors Associated

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Risk factors associated with pseudoaldosteronism in patients with chronic hepatitis: A retrospective cohort study

Basic & Clinical Pharmacology & Toxicology ◽

10.1111/bcpt.13178 ◽

2018 ◽

Vol 124 (5) ◽

pp. 607-614 ◽

Cited By ~ 3

Author(s):

Akihiro Komatsu ◽

Tetsuhiro Yoshino ◽

Takeshi Suzuki ◽

Tomonori Nakamura ◽

Takanori Kanai ◽

...

Keyword(s):

Risk Factors ◽

Chronic Hepatitis ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Hepatitis A ◽

Factors Associated

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Epidemiology of extended spectrum β-lactamase producing Enterobacter bacteremia in a brazilian hospital

Revista da Sociedade Brasileira de Medicina Tropical ◽

10.1590/s0037-86822010000400022 ◽

2010 ◽

Vol 43 (4) ◽

pp. 452-454 ◽

Cited By ~ 11

Author(s):

Felipe Francisco Tuon ◽

Leila Carolina Bianchet ◽

Sergio Ricardo Penteado-Filho

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Urinary Catheter ◽

Elective Surgery ◽

Survival Curve ◽

Factors Associated ◽

Extended Spectrum ◽

Length Of Hospitalization

INTRODUCTION: Enterobacter can be included in the group of extended spectrum β-lactamases (EBSL)-producing bacteria, though few studies exist evaluating risk factors associated with this microorganism. A retrospective cohort study was conducted to determine risk factors associated with ESBL-producing-Enterobacter and mortality METHODS: A retrospective cohort study with 58 bacteremia caused by ESBL-producing-Enterobacter (28 cases) and non-ESBL (30 cases) RESULTS: Risk factors associated with ESBL-Enterobacter were trauma, length of hospitalization, admission to the intensive care unit, urinary catheter and elective surgery (p< 0.05). The survival curves were similar for ESBL and non-ESBL CONCLUSIONS: ESBL-producing-Enterobacter bacteremia is prevalent and the survival curve was similar to non-ESBL-producing strains.

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Correction: Cazzoletti et al. Risk Factors Associated with Nursing Home COVID-19 Outbreaks: A Retrospective Cohort Study. Int. J. Environ. Res. Public Health 2021, 18, 8434

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph182413175 ◽

2021 ◽

Vol 18 (24) ◽

pp. 13175

Author(s):

Lucia Cazzoletti ◽

Maria Elisabetta Zanolin ◽

Ilaria Tocco Tussardi ◽

Mulubirhan Assefa Alemayohu ◽

Ernesto Zanetel ◽

...

Keyword(s):

Public Health ◽

Risk Factors ◽

Cohort Study ◽

Nursing Home ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Factors Associated

The authors would like to make the following corrections to this paper [...]

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Risk factors associated with acute respiratory distress syndrome in COVID-19 patients outside Wuhan: A double-center retrospective cohort study of 197 cases in Hunan, China

World Journal of Clinical Cases ◽

10.12998/wjcc.v9.i2.344 ◽

2021 ◽

Vol 9 (2) ◽

pp. 344-356

Author(s):

Xing-Sheng Hu ◽

Chun-Hong Hu ◽

Ping Zhong ◽

Ya-Jing Wen ◽

Xiang-Yu Chen

Keyword(s):

Risk Factors ◽

Acute Respiratory Distress Syndrome ◽

Cohort Study ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Distress Syndrome ◽

Factors Associated

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Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study

The Lancet Oncology ◽

10.1016/s1470-2045(20)30309-0 ◽

2020 ◽

Vol 21 (7) ◽

pp. 893-903 ◽

Cited By ~ 77

Author(s):

Jianbo Tian ◽

Xianglin Yuan ◽

Jun Xiao ◽

Qiang Zhong ◽

Chunguang Yang ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Disease Severity ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Clinical Characteristics ◽

Factors Associated ◽

Patients With Cancer

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Risk factors associated with morbidity and mortality outcomes of COVID-19 patients on the 28th day of the disease course: a retrospective cohort study in Bangladesh

Epidemiology and Infection ◽

10.1017/s0950268820002630 ◽

2020 ◽

Vol 148 ◽

Author(s):

M. Z. Islam ◽

B. K. Riaz ◽

A. N. M. S. Islam ◽

F. Khanam ◽

J. Akhter ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Mortality Risk ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Morbidity And Mortality ◽

Morbidity Rate ◽

Disease Course ◽

Factors Associated ◽

Morbidity Risk

Abstract Diverse risk factors intercede the outcomes of coronavirus disease 2019 (COVID-19). We conducted this retrospective cohort study with a cohort of 1016 COVID-19 patients diagnosed in May 2020 to identify the risk factors associated with morbidity and mortality outcomes. Data were collected by telephone-interview and reviewing records using a questionnaire and checklist. The study identified morbidity and mortality risk factors on the 28th day of the disease course. The majority of the patients were male (64.1%) and belonged to the age group 25–39 years (39.4%). Urban patients were higher in proportion than rural (69.3% vs. 30.7%). Major comorbidities included 35.0% diabetes mellitus (DM), 28.4% hypertension (HTN), 16.6% chronic obstructive pulmonary disease (COPD), and 7.8% coronary heart disease (CHD). The morbidity rate (not-cured) was 6.0%, and the mortality rate (non-survivor) was 2.5%. Morbidity risk factors included elderly (AOR = 2.56, 95% CI = 1.31–4.99), having comorbidity (AOR = 1.43, 95% CI = 0.83–2.47), and smokeless tobacco use (AOR = 2.17, 95% CI = 0.84–5.61). The morbidity risk was higher with COPD (RR = 2.68), chronic kidney disease (CKD) (RR = 3.33) and chronic liver disease (CLD) (RR = 3.99). Mortality risk factors included elderly (AOR = 7.56, 95% CI = 3.19–17.92), having comorbidity (AOR = 5.27, 95% CI = 1.88–14.79) and SLT use (AOR = 1.93, 95% CI = 0.50–7.46). The mortality risk was higher with COPD (RR = 7.30), DM (RR = 2.63), CHD (RR = 4.65), HTN (RR = 3.38), CKD (RR = 9.03), CLD (RR = 10.52) and malignant diseases (RR = 9.73). We must espouse programme interventions considering the morbidity and mortality risk factors to condense the aggressive outcomes of COVID-19.

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