scholarly journals Peri-implant cartilage and bone histological changes following treatment of focal osteochondral defects in the femoral head with polyether ether ketone implants versus cobalt chromium molybdenum alloy implants: assessment in a goat model

2020 ◽  
Author(s):  
Zhiguo Yuan ◽  
Wei Zhang ◽  
Xiangchao Meng ◽  
Jue Zhang ◽  
Teng TengLong ◽  
...  
Keyword(s):  
Femoral Head ◽  
Osteochondral Defect ◽  
Osteochondral Defects ◽  
Cobalt Chromium ◽  
Cocrmo Alloy ◽  
Polyether Ether Ketone ◽  
Histological Score ◽  
Ether Ketone ◽  
Cobalt Chromium Molybdenum

Abstract Objective: This study aimed to quantitatively investigate the peri-implant histology of applying defect-size polyether ether ketone (PEEK) implant for the treatment of localized osteochondral defects in the femoral head and compared it with cobalt chromium molybdenum (CoCrMo) alloy implant.Methods: A femoral head osteochondral defect model was created in the left hips of goats (n=12). Defects were randomly treated by immediate placement of a PEEK (n=6) or CoCrMo implant (n=6). The un-operated right hip joints served as a control. Goats were sacrificed at 12 weeks. Periprosthetic cartilage quality was semi-quantitatively analyzed macroscopically and microscopically. Implant osseointegration was measured by micro-CT and histomorphometry.Results: The modified macroscopic articular evaluation score in the PEEK group was lower than that in the CoCrMo group (p<0.05), and the histological score of the periprosthetic and acetabular cartilage in the PEEK group was lower than that in the CoCrMo group (P<0.05). The mean bone-implant contact for PEEK implants was comparable with that for CoCrMo alloy implants at 12 weeks.Conclusions: A PEEK implant for the treatment of local osteochondral defect in the femoral head demonstrated effective fixation and superior in vivo cartilage protection compared with an identical CoCrMo alloy implant.

scholarly journals Articular cartilage and bone changes following treatment of focal osteochondral defects in the femoral head with polyether ether ketone implants versus cobalt chromium molybdenum alloy implants: assessment in a goat model

2020 ◽  
Author(s):  
Zhiguo Yuan ◽  
Wei Zhang ◽  
Xiangchao Meng ◽  
Jue Zhang ◽  
Teng TengLong ◽  
...  
Keyword(s):  
Femoral Head ◽  
Osteochondral Defect ◽  
Osteochondral Defects ◽  
Cobalt Chromium ◽  
Hip Joints ◽  
Cocrmo Alloy ◽  
Polyether Ether Ketone ◽  
Ether Ketone ◽  
Cobalt Chromium Molybdenum

Abstract Objective : This study aimed to investigate the feasibility of applying defect-size polyether ether ketone (PEEK) implant for the treatment of localized osteochondral defects in the femoral head and compared it with cobalt chromium molybdenum (CoCrMo) alloy implant. Methods : A femoral head osteochondral defect model was created in the left hips of goats (n=12). Defects were randomly treated by immediate placement of a PEEK (n=6) or CoCrMo implant (n=6). The un-operated right hip joints served as a control. Goats were sacrificed at 12 weeks. The hip joints were evaluated by gross appearance, computed tomography (CT), and magnetic resonance imaging(MRI). Periprosthetic cartilage quality and the opposing cartilage (at the acetabular) quality were analyzed macroscopically and microscopically. Implant osseointegration was measured by micro-CT and histomorphometry. Results : Radiography revealed that all implants had good overall placement, without loosening of the implant. The modified macroscopic articular evaluation score in the PEEK group was lower than that in the CoCrMo group (p<0.05), and the histological score of the periprosthetic and acetabular cartilage in the PEEK group was lower than that in the CoCrMo group (P<0.05). The mean bone-implant contact for PEEK implants was comparable with that for CoCrMo alloy implants at 12 weeks. Conclusions : A PEEK implant for the treatment of local osteochondral defect in the femoral head demonstrated effective fixation and superior in vivo cartilage protection compared with an identical CoCrMo alloy implant.

scholarly journals Comparative study of some mechanical properties of cobalt chromium and polyether ether ketone thermoplastic removable partial denture clasps: an In-vitro Study

2020 ◽  
Vol 23 (3) ◽  
Author(s):  
Rady El-Baz ◽  
Mostafa Fayad ◽  
Mohamed Abas ◽  
Ahmed Shoieb ◽  
Mohammed Gad ◽  
...  
Keyword(s):  
Fatigue Resistance ◽  
Testing Machine ◽  
Mean Value ◽  
Cobalt Chromium ◽  
Thermoplastic Resin ◽  
Removable Partial Denture ◽  
Partial Denture ◽  
Polyether Ether Ketone ◽  
Group I ◽  
Ether Ketone

Objective: was to evaluate the retentive force, fatigue resistance and deformity of clasps made from two materials cobalt chromium and poly ether et her ketone (PEEK). Material and Methods: sixteen models were fabricated, each one having lower 1st molar. Models were divided into two groups according to materials, group I (GI) for cobalt chromium (Co-Cr) and group II (GII) for PEEK. Each testing models and its clasps were mounted inside universal testing machine, the retention was measured by applying withdrawal force to it by this machine at 5 mm/min. The Fatigue resistance is measured by the reduction in retention through repeated insertion and removal cycles using robot a chewing simulator. Removal and insertion cycling of clasps was carried out for 360, 730, 1080, 1,440,2,116 and 2,880 cycles (corresponding to 3,6,9,12, 18 and 24 months of simulated clinical use of a RPD) to simulate the fatigue resistance test. Deformity was measured before and after each cycling using a digital micrometer. Statistical analysis was done by 2-way-ANOVA test to detect significance effects of each variable. Results: Retention and fatigue resistance, after 360,730, 1080, 1,440,2,116 and 2,880 cycles totally the difference between Co-Cr and PEEK groups was statistically non-significant (P = 0.0980>0.05) where (Co-Cr > PEEK). Deformation results, regardless to evaluation time, Co-Cr group recorded statistically significant higher deformation mean value than PEEK group (P = 0.008<0.05). Regardless to material group, deformation mean value changed non significantly by time (P = 0.2882> 0.05). Conclusion: PEEK clasps (1.0 mm in cross section diameter) engage 0.50 mm undercut provide sufficient retention nearly similar that of Co-Cr clasps.KeywordsFlexible clasps; Polyether ether ketone, PEEK; Thermoplastic resin; Partial denture.

scholarly journals Repairing the Osteochondral Defect in Goat with the Tissue-Engineered Osteochondral Graft Preconstructed in a Double-Chamber Stirring Bioreactor

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Yang Pei ◽  
Jun-jun Fan ◽  
Xiao-qiang Zhang ◽  
Zhi-yong Zhang ◽  
Min Yu
Keyword(s):  
Mechanical Stimulation ◽  
Osteochondral Defect ◽  
Control Group ◽  
Osteochondral Defects ◽  
Reparative Effect ◽  
Group B ◽  
Better Than ◽  
Stimulation Of ◽  
Double Chamber

To investigate the reparative efficacy of tissue-engineered osteochondral (TEO) graft for repairing the osteochondral defect in goat, we designed a double-chamber stirring bioreactor to construct the bone and cartilage composites simultaneously in oneβ-TCP scaffold and observed the reparative effect in vivo. The osteochondral defects were created in goats and all the animals were divided into 3 groups randomly. In groups A, the defect was treated with the TEO which was cultured with mechanical stimulation of stir; in group B, the defect was treated with TEO which was cultured without mechanical stimulation of stir; in groups C, the defect was treated without TEO. At 12 weeks and 24 weeks after operation, the reparative effects in different groups were assessed and compared. The results indicated that the reparative effect of the TEO cultured in the bioreactor was better than the control group, and mechanical stimulation of stir could further improve the reparative effect. We provided a feasible and effective method to construct the TEO for treatment of osteochondral defect using autologous BMSCs and the double-chamber bioreactor.

scholarly journals In Vivo Study of Osteochondral Defect Regeneration Using Innovative Composite Calcium Phosphate Biocement in a Sheep Model

Materials ◽  
2021 ◽  
Vol 14 (16) ◽  
pp. 4471
Author(s):  
Lenka Kresakova ◽  
Jan Danko ◽  
Katarina Vdoviakova ◽  
Lubomir Medvecky ◽  
Zdenek Zert ◽  
...  
Keyword(s):  
Amino Acids ◽  
Calcium Phosphate ◽  
Osteochondral Defect ◽  
Articular Surface ◽  
Fibrous Tissue ◽  
Treated Group ◽  
Negative Control ◽  
Osteochondral Defects ◽  
Sheep Model

This study aimed to clarify the therapeutic effect and regenerative potential of the novel, amino acids-enriched acellular biocement (CAL) based on calcium phosphate on osteochondral defects in sheep. Eighteen sheep were divided into three groups, the treated group (osteochondral defects filled with a CAL biomaterial), the treated group with a biocement without amino acids (C cement), and the untreated group (spontaneous healing). Cartilages of all three groups were compared with natural cartilage (negative control). After six months, sheep were evaluated by gross appearance, histological staining, immunohistochemical staining, histological scores, X-ray, micro-CT, and MRI. Treatment of osteochondral defects by CAL resulted in efficient articular cartilage regeneration, with a predominant structural and histological characteristic of hyaline cartilage, contrary to fibrocartilage, fibrous tissue or disordered mixed tissue on untreated defect (p < 0.001, modified O’Driscoll score). MRI results of treated defects showed well-integrated and regenerated cartilage with similar signal intensity, regularity of the articular surface, and cartilage thickness with respect to adjacent native cartilage. We have demonstrated that the use of new biocement represents an effective solution for the successful treatment of osteochondral defects in a sheep animal model, can induce an endogenous regeneration of cartilage in situ, and provides several benefits for the design of future therapies supporting osteochondral defect healing.

The in vivo response to a novel Ti coating compared with polyether ether ketone: evaluation of the periphery and inner surfaces of an implant

2018 ◽  
Vol 18 (7) ◽  
pp. 1231-1240 ◽  
Author(s):  
William Robert Walsh ◽  
Matthew H. Pelletier ◽  
Chris Christou ◽  
Jiawei He ◽  
Frank Vizesi ◽  
...  
Keyword(s):  
Polyether Ether Ketone ◽  
Ether Ketone

scholarly journals Evaluation of the Grafting Efficacy of Active Biomolecules of Phosphatidylcholine and Type I Collagen on Polyether Ether Ketone: In Vitro and In Vivo

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2081
Author(s):  
Jian-Chih Chen ◽  
Chih-Hua Chen ◽  
Kai-Chi Chang ◽  
Shih-Ming Liu ◽  
Chia-Ling Ko ◽  
...  
Keyword(s):  
Type I Collagen ◽  
3D Structure ◽  
Orthopedic Implants ◽  
Type I ◽  
Polyether Ether Ketone ◽  
Hydrophilic Nature ◽  
Potential Alternative ◽  
Ether Ketone

Biomolecule grafting on polyether ether ketone (PEEK) was used to improve cell affinity caused by surface inertness. This study demonstrated the sequence-polished (P) and sulfonated (SA) PEEK modification to make a 3D structure, active biomolecule graftings through PEEK silylation (SA/SI) and then processed with phosphatidylcholine (with silylation of SA/SI/PC; without SA/PC) and type I collagen (COL I, with silylation of SA/SI/C; without SA/C). Different modified PEEKs were implanted for 4, 8, and 12 weeks for histology. Sulfonated PEEK of SA showed the surface roughness was significantly increased; after the silylation of SA/SI, the hydrophilic nature was remarkably improved. The biomolecules were effectively grafted through silylation, and the cells showed improved attachment after 1 h. Furthermore, the SA/SI/PC group showed good in vitro mineralization. The new bone tissues were integrated into the 3D porous structures of SA/SI/PC and SA/SI/C in vivo making PEEK a potential alternative to metals in orthopedic implants.

scholarly journals Influences of Different Implant Material Combinations on the Stress Distribution of the Foot Following Total Ankle Replacement: a Finite Element Analysis

2021 ◽  
Author(s):  
Jian Yu ◽  
Dahang Zhao ◽  
Wen-Ming Chen ◽  
Pengfei Chu ◽  
Shuo Wang ◽  
...  
Keyword(s):  
Finite Element ◽  
Articular Surface ◽  
Reaction Force ◽  
Total Ankle Replacement ◽  
Von Mises Stress ◽  
Cobalt Chromium ◽  
Polyether Ether Ketone ◽  
Implant Material ◽  
Ankle Replacement ◽  
Ether Ketone

Abstract Background A proper combination of implant materials for Total Ankle Replacement (TAR) may reduce stress at the implant and the foot. This study aimed to investigate the biomechanical influences for different implant material combinations using the finite element (FE) method. Methods A validated foot model was modified to simulate TAR with the INBONE II ankle system at the second peak ground reaction force. Six types of materials were used (Ceramic, cobalt–chromium–molybdenum alloy (CoCrMo), Titanium alloy (Ti6Al4V), carbon-fiber-reinforced Polyether-ether-ketone (CFR-PEEK), Polyether-ether-ketone (PEEK), and used ultra-high molecular weight polyethylene (UHMWPE)). Results The von Mises stress at the bearing articular surface decreased with implant stiffness. The combination of CFR-PEEK on UHMWPE presented the lowest stress of 14.82 MPa. A low implant stiffness of the talar component, rather than the bearing, relieved the stress at the resected surface of the talus. Conclusions Soft implant material provided a stress reduction at the bearing and adjacent bones. CFR-PEEK seemed to be a good alternative to implant metal components.

Sign in / Sign up

Export Citation Format

Share Document