The in vivo response to a novel Ti coating compared with polyether ether ketone: evaluation of the periphery and inner surfaces of an implant

2018 ◽  
Vol 18 (7) ◽  
pp. 1231-1240 ◽  
Author(s):  
William Robert Walsh ◽  
Matthew H. Pelletier ◽  
Chris Christou ◽  
Jiawei He ◽  
Frank Vizesi ◽  
...  
Keyword(s):  
Polyether Ether Ketone ◽  
Ether Ketone

scholarly journals Peri-implant cartilage and bone histological changes following treatment of focal osteochondral defects in the femoral head with polyether ether ketone implants versus cobalt chromium molybdenum alloy implants: assessment in a goat model

2020 ◽  
Author(s):  
Zhiguo Yuan ◽  
Wei Zhang ◽  
Xiangchao Meng ◽  
Jue Zhang ◽  
Teng TengLong ◽  
...  
Keyword(s):  
Femoral Head ◽  
Osteochondral Defect ◽  
Osteochondral Defects ◽  
Cobalt Chromium ◽  
Cocrmo Alloy ◽  
Polyether Ether Ketone ◽  
Histological Score ◽  
Ether Ketone ◽  
Cobalt Chromium Molybdenum

Abstract Objective: This study aimed to quantitatively investigate the peri-implant histology of applying defect-size polyether ether ketone (PEEK) implant for the treatment of localized osteochondral defects in the femoral head and compared it with cobalt chromium molybdenum (CoCrMo) alloy implant.Methods: A femoral head osteochondral defect model was created in the left hips of goats (n=12). Defects were randomly treated by immediate placement of a PEEK (n=6) or CoCrMo implant (n=6). The un-operated right hip joints served as a control. Goats were sacrificed at 12 weeks. Periprosthetic cartilage quality was semi-quantitatively analyzed macroscopically and microscopically. Implant osseointegration was measured by micro-CT and histomorphometry.Results: The modified macroscopic articular evaluation score in the PEEK group was lower than that in the CoCrMo group (p<0.05), and the histological score of the periprosthetic and acetabular cartilage in the PEEK group was lower than that in the CoCrMo group (P<0.05). The mean bone-implant contact for PEEK implants was comparable with that for CoCrMo alloy implants at 12 weeks.Conclusions: A PEEK implant for the treatment of local osteochondral defect in the femoral head demonstrated effective fixation and superior in vivo cartilage protection compared with an identical CoCrMo alloy implant.

scholarly journals Evaluation of the Grafting Efficacy of Active Biomolecules of Phosphatidylcholine and Type I Collagen on Polyether Ether Ketone: In Vitro and In Vivo

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2081
Author(s):  
Jian-Chih Chen ◽  
Chih-Hua Chen ◽  
Kai-Chi Chang ◽  
Shih-Ming Liu ◽  
Chia-Ling Ko ◽  
...  
Keyword(s):  
Type I Collagen ◽  
3D Structure ◽  
Orthopedic Implants ◽  
Type I ◽  
Polyether Ether Ketone ◽  
Hydrophilic Nature ◽  
Potential Alternative ◽  
Ether Ketone

Biomolecule grafting on polyether ether ketone (PEEK) was used to improve cell affinity caused by surface inertness. This study demonstrated the sequence-polished (P) and sulfonated (SA) PEEK modification to make a 3D structure, active biomolecule graftings through PEEK silylation (SA/SI) and then processed with phosphatidylcholine (with silylation of SA/SI/PC; without SA/PC) and type I collagen (COL I, with silylation of SA/SI/C; without SA/C). Different modified PEEKs were implanted for 4, 8, and 12 weeks for histology. Sulfonated PEEK of SA showed the surface roughness was significantly increased; after the silylation of SA/SI, the hydrophilic nature was remarkably improved. The biomolecules were effectively grafted through silylation, and the cells showed improved attachment after 1 h. Furthermore, the SA/SI/PC group showed good in vitro mineralization. The new bone tissues were integrated into the 3D porous structures of SA/SI/PC and SA/SI/C in vivo making PEEK a potential alternative to metals in orthopedic implants.

scholarly journals Transcatheter Decellularized Tissue-Engineered Heart Valve (dTEHV) Grown on Polyglycolic Acid (PGA) Scaffold Coated with P4HB Shows Improved Functionality over 52 Weeks due to Polyether-Ether-Ketone (PEEK) Insert

2018 ◽  
Vol 9 (4) ◽  
pp. 64 ◽  
Author(s):  
Leon Bruder ◽  
Hendrik Spriestersbach ◽  
Kerstin Brakmann ◽  
Valentin Stegner ◽  
Matthias Sigler ◽  
...  
Keyword(s):  
Heart Valve ◽  
Second Generation ◽  
Heart Defects ◽  
Polyglycolic Acid ◽  
Elastic Fibers ◽  
Polyether Ether Ketone ◽  
Tissue Engineered Heart Valve ◽  
Ether Ketone ◽  
Decellularized Tissue

Many congenital heart defects and degenerative valve diseases require replacement of heart valves in children and young adults. Transcatheter xenografts degenerate over time. Tissue engineering might help to overcome this limitation by providing valves with ability for self-repair. A transcatheter decellularized tissue-engineered heart valve (dTEHV) was developed using a polyglycolic acid (PGA) scaffold. A first prototype showed progressive regurgitation after 6 months in-vivo due to a suboptimal design and misguided remodeling process. A new geometry was developed accordingly with computational fluid dynamics (CFD) simulations and implemented by adding a polyether-ether-ketone (PEEK) insert to the bioreactor during cultivation. This lead to more belly-shaped leaflets with higher coaptation areas for this second generation dTEHV. Valve functionality assessed via angiography, intracardiac echocardiography, and MRI proved to be much better when compared the first generation dTEHV, with preserved functionality up to 52 weeks after implantation. Macroscopic findings showed no thrombi or signs of acute inflammation. For the second generation dTEHV, belly-shaped leaflets with soft and agile tissue-formation were seen after explantation. No excessive leaflet shortening occurred in the second generation dTEHV. Histological analysis showed complete engraftment of the dTEHV, with endothelialization of the leaflets and the graft wall. Leaflets consisted of collagenous tissue and some elastic fibers. Adaptive leaflet remodeling was visible in all implanted second generation dTEHV, and most importantly no fusion between leaflet and wall was found. Very few remnants of the PGA scaffold were detected even 52 weeks after implantation, with no influence on functionality. By adding a polyether-ether-ketone (PEEK) insert to the bioreactor construct, a new geometry of PGA-scaffold based dTEHV could be implemented. This resulted in very good valve function of the implanted dTEHV over a period of 52 weeks.

scholarly journals Articular cartilage and bone changes following treatment of focal osteochondral defects in the femoral head with polyether ether ketone implants versus cobalt chromium molybdenum alloy implants: assessment in a goat model

2020 ◽  
Author(s):  
Zhiguo Yuan ◽  
Wei Zhang ◽  
Xiangchao Meng ◽  
Jue Zhang ◽  
Teng TengLong ◽  
...  
Keyword(s):  
Femoral Head ◽  
Osteochondral Defect ◽  
Osteochondral Defects ◽  
Cobalt Chromium ◽  
Hip Joints ◽  
Cocrmo Alloy ◽  
Polyether Ether Ketone ◽  
Ether Ketone ◽  
Cobalt Chromium Molybdenum

Abstract Objective : This study aimed to investigate the feasibility of applying defect-size polyether ether ketone (PEEK) implant for the treatment of localized osteochondral defects in the femoral head and compared it with cobalt chromium molybdenum (CoCrMo) alloy implant. Methods : A femoral head osteochondral defect model was created in the left hips of goats (n=12). Defects were randomly treated by immediate placement of a PEEK (n=6) or CoCrMo implant (n=6). The un-operated right hip joints served as a control. Goats were sacrificed at 12 weeks. The hip joints were evaluated by gross appearance, computed tomography (CT), and magnetic resonance imaging(MRI). Periprosthetic cartilage quality and the opposing cartilage (at the acetabular) quality were analyzed macroscopically and microscopically. Implant osseointegration was measured by micro-CT and histomorphometry. Results : Radiography revealed that all implants had good overall placement, without loosening of the implant. The modified macroscopic articular evaluation score in the PEEK group was lower than that in the CoCrMo group (p<0.05), and the histological score of the periprosthetic and acetabular cartilage in the PEEK group was lower than that in the CoCrMo group (P<0.05). The mean bone-implant contact for PEEK implants was comparable with that for CoCrMo alloy implants at 12 weeks. Conclusions : A PEEK implant for the treatment of local osteochondral defect in the femoral head demonstrated effective fixation and superior in vivo cartilage protection compared with an identical CoCrMo alloy implant.

scholarly journals Graphene Reinforced Polyether Ether Ketone Nanocomposites for Bone Repair Applications

2020 ◽  
Author(s):  
Nan Jiang ◽  
Peijie Tan ◽  
Miaomiao He ◽  
dan Sun ◽  
Li Zhang ◽  
...  
Keyword(s):  
Mechanical Testing ◽  
Photoelectron Spectroscopy ◽  
Bone Repair ◽  
Early Stage ◽  
Angle Measurement ◽  
X Ray ◽  
Polyether Ether Ketone ◽  
Ether Ketone

To improve the performance of polyether ether ketone matrix (PEEK) in hard tissue repair and replacement applications, we fabricated graphene (G) reinforced PEEK with graded G concentrations (0.1%-5%) through injection molding. The mechanical properties, surface morphology, chemical composition and thermal stability of the composites have been characterized through universal mechanical testing, scanning electron microscopy, contact-angle measurement, transmission electron microscope, X-ray photoelectron spectroscopy, X-ray diffraction and thermal analysis system. The biocompatibility has been assessed in vitro and the bone repair function of the composite implant have been assessed in vivo using a rabbit mandibular bone defect model. Mechanical testing results suggest that the composite samples have compressive moduli similar to that of the natural bone. Although addition of G into PEEK does not significantly influence the composite tensile, flexural or compressive moduli, it can significantly enhance the ductility and toughness of the material. On the other hand, all G-reinforced PEEK implants demonstrated enhanced adhesion and differentiation of rat bone marrow stromal cells (BMSCs), with 5% G-PEEK showing the highest bioactivity among all samples. The in vivo osseointegration data further revealed that 5% G-PEEK has the best effect in promoting osseointegration and bone regeneration, in both early stage and late stage bone re-growth. Study shows that our G-reinforced PEEK-based implants provides a promising strategy for enhancing the performance of future regenerative bone implants.<br>

scholarly journals Three-Dimensionally-Printed Polyether-Ether-Ketone Implant with a Cross-Linked Structure and Acid-Etched Microporous Surface Promotes Integration with Soft Tissue

2019 ◽  
Vol 20 (15) ◽  
pp. 3811 ◽  
Author(s):  
Xiaoke Feng ◽  
Hao Yu ◽  
Huan Liu ◽  
Xiaonan Yu ◽  
Zhihong Feng ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Rabbit Model ◽  
Three Dimensional ◽  
Zealand White Rabbit ◽  
Adhesion Properties ◽  
Polyether Ether Ketone ◽  
Ether Ketone ◽  
Materials Used

Polyether-ether-ketone (peek) is one of the most common materials used for load-bearing orthopedic devices owing to its radiolucency and favorable mechanical properties. However, current smooth-surfaced peek implants can lead to fibrous capsule formation. To overcome this issue, here, peek specimens with well-defined internal cross-linked structures (macropore diameters of 1.0–2.0 mm) were fabricated using a three-dimensional (3D) printer, and an acid-etched microporous surface was achieved using injection-molding technology. The cell adhesion properties of smooth and microporous peek specimens was compared in vitro through a scanning electron microscope (SEM), and the soft tissue responses to the both microporous and cross-linked structure of different groups were determined in vivo using a New Zealand white rabbit model, and examined through histologic staining and separating test. The results showed that the acid-etched microporous surface promoted human skin fibroblasts (HSF) adherence, while internal cross-linked structure improved the ability of the peek specimen to form a mechanical combination with soft tissue, especially with the 1.5 mm porous specimen. The peek specimens with both the internal cross-linked structure and external acid-etched microporous surface could effectively promote the close integration of soft tissue and prevent formation of fibrous capsules, demonstrating the potential for clinical application in surgical repair.

scholarly journals Biological tribology properties of the modified polyether ether ketone composite materials

2020 ◽  
Vol 59 (1) ◽  
pp. 399-405
Author(s):  
Li Ning ◽  
Chen Deqiang ◽  
Gao Xiyan ◽  
Lu Lirong ◽  
Chen Weizeng
Keyword(s):  
Tribological Properties ◽  
Blood Compatibility ◽  
Biological Properties ◽  
Nano Particles ◽  
Orthopaedic Implant ◽  
In Vivo Experiments ◽  
Polyether Ether Ketone ◽  
Medical Materials ◽  
Ether Ketone

AbstractModification of poly-ether-ether-ketone (PEEK) to adapt to the biological properties of materials is currently the key point in the research of medical materials. The tribological properties and biocompatibility of the PEEK composites modified by carbon fiber (CF), potassium titanate whisker(PTW) and nano-particles were discussed in this paper. The results show the modified PEEK composites by a certain length to diameter ratio of CF show the best using effect in vivo experiments in good blood compatibility, which is suitable for orthopaedic implant materials. A large number of experiments show that the PEEK composites would be modified with a certain ratio of CF (about 30%wt.), whisker (about 15%wt.) and HA (about 5%wt.) particle with better biological tribological properties, more important value in medical research.

scholarly journals Graphene Reinforced Polyether Ether Ketone Nanocomposites for Bone Repair Applications

2020 ◽  
Author(s):  
Nan Jiang ◽  
Peijie Tan ◽  
Miaomiao He ◽  
dan Sun ◽  
Li Zhang ◽  
...  
Keyword(s):  
Mechanical Testing ◽  
Photoelectron Spectroscopy ◽  
Bone Repair ◽  
Early Stage ◽  
Angle Measurement ◽  
X Ray ◽  
Polyether Ether Ketone ◽  
Ether Ketone

To improve the performance of polyether ether ketone matrix (PEEK) in hard tissue repair and replacement applications, we fabricated graphene (G) reinforced PEEK with graded G concentrations (0.1%-5%) through injection molding. The mechanical properties, surface morphology, chemical composition and thermal stability of the composites have been characterized through universal mechanical testing, scanning electron microscopy, contact-angle measurement, transmission electron microscope, X-ray photoelectron spectroscopy, X-ray diffraction and thermal analysis system. The biocompatibility has been assessed in vitro and the bone repair function of the composite implant have been assessed in vivo using a rabbit mandibular bone defect model. Mechanical testing results suggest that the composite samples have compressive moduli similar to that of the natural bone. Although addition of G into PEEK does not significantly influence the composite tensile, flexural or compressive moduli, it can significantly enhance the ductility and toughness of the material. On the other hand, all G-reinforced PEEK implants demonstrated enhanced adhesion and differentiation of rat bone marrow stromal cells (BMSCs), with 5% G-PEEK showing the highest bioactivity among all samples. The in vivo osseointegration data further revealed that 5% G-PEEK has the best effect in promoting osseointegration and bone regeneration, in both early stage and late stage bone re-growth. Study shows that our G-reinforced PEEK-based implants provides a promising strategy for enhancing the performance of future regenerative bone implants.<br>

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