scholarly journals Liquid metal-tailored gluten network for protein-based e-skin

2021 ◽  
Author(s):  
Bin Chen ◽  
Yudong Cao ◽  
Zhuo Yan ◽  
Rui Liu ◽  
Yunjiao Zhao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Disulfide Bonds ◽  
Protein Structures ◽  
Three Dimensional ◽  
Driving Mechanism ◽  
Self Healing ◽  
Structure Rearrangement ◽  
Electronic Skin ◽  
Regulation Method ◽  
Human Motions

Abstract Designing electronic skin (e-skin) with proteins is a critical way to endow e-skin with biocompatibility, but engineering protein structures to achieve controllable mechanical properties and self-healing ability remains a challenge. Here, we develop a hybrid gluten network through the incorporation of an eutectic gallium indium alloy (EGaIn) to design a self-healable e-skin with improved mechanical properties. The intrinsic reversible disulfide bonds/sulfhydryl groups reconfiguration of gluten networks is explored as a driving mechanism to introduce EGaIn as chemical cross-linkers to create hierarchical sulphur bonds, thus inducing the secondary structure rearrangement of gluten to form additional β-sheets as physical cross-linkers. Remarkably, this strategy allows the gluten network to realize a synthetic material-like stretchability (>1600%) and to endure a three-dimensional strain change. The obtained e-skin is biocompatible and biodegradable, and can sense strain changes from different scale human motions. The protein network micro-regulation method paves the way for future skin-like protein-based e-skin.

Conservation of Amino Acids into Multiple Alignments Involved in Pairwise Interactions in Three-Dimensional Protein Structures

2003 ◽  
Vol 01 (03) ◽  
pp. 505-520 ◽  
Author(s):  
Mounir Errami ◽  
Christophe Geourjon ◽  
Gilbert Deléage
Keyword(s):  
Amino Acids ◽  
Disulfide Bonds ◽  
Hydrophobic Interactions ◽  
Protein Structures ◽  
Three Dimensional ◽  
Structural Features ◽  
Multiple Alignment ◽  
Salt Bridges ◽  
Multiple Alignments ◽  
Multiple Sequences

We present an original strategy, that involves a bioinformatic software structure, in order to perform an exhaustive and objective statistical analysis of three-dimensional structures of proteins. We establish the relationship between multiple sequences alignments and various structural features of proteins. We show that amino acids implied in disulfide bonds, salt bridges and hydrophobic interactions are particularly conserved. Effects of identity, global similarity within alignments, and accessibility of interactions have been studied. Furthermore, we point out that the more variable the sequences within a multiple alignment, the more informative the multiple alignment. The results support multiple alignments usefulness for predictions of structural features.

scholarly journals Simulated and Experimental Investigation of the Mechanical Properties and Solubility of 3D-Printed Capsules for Self-Healing Cement Composites

Materials ◽  
2021 ◽  
Vol 14 (16) ◽  
pp. 4578
Author(s):  
Se-Jin Choi ◽  
Ji-Hwan Kim ◽  
Hyojin Jeong ◽  
Ja-Sung Lee ◽  
Tae-Uk Lim ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Low Cost ◽  
Three Dimensional ◽  
Design Parameters ◽  
Poly Lactic Acid ◽  
Material Strength ◽  
Cement Composites ◽  
Self Healing ◽  
Term Performance ◽  
Printing Direction

In the concrete industry, various R&D efforts have been devoted to self-healing technology, which can maintain the long-term performance of concrete structures, which is important in terms of sustainable development. Cracks in cement composites occur and propagate because of various internal and external factors, reducing the composite’s stability. Interest in “self-healing” materials that can repair cracks has led researchers to embed self-healing capsules in cement composites. Overcoming the limitations of polymer capsules produced by chemical manufacturing methods, three-dimensional (3D) printing can produce capsules quickly and accurately and offers advantages such as high material strength, low cost, and the ability to fabricate capsules with complex geometries. We performed structural analysis simulations, experimentally evaluated the mechanical properties and solubility of poly(lactic acid) (PLA) capsules, and examined the effect of the capsule wall thickness and printing direction on cement composites embedded with these capsules. Thicker capsules withstood larger bursting loads, and the capsule rupture characteristics varied with the printing angle. Thus, the capsule design parameters must be optimized for different environments. Although the embedded capsules slightly reduced the compressive strength of the cement composites, the benefit of the encapsulated self-healing agent is expected to overcome this disadvantage.

Different rates of formation of secondary and tertiary structure during renaturation of urea-denatured human serum albumin

1989 ◽  
Vol 54 (9) ◽  
pp. 2542-2549 ◽  
Author(s):  
Josef Chmelík
Keyword(s):  
Protein Folding ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Disulfide Bonds ◽  
Tertiary Structure ◽  
Hydrophobic Interactions ◽  
Protein Structures ◽  
Three Dimensional ◽  
Comparison Of The Results

A comparison of the results of our polarimetric measurements with the polarographic experiments reported earlier shows that the restoration of the secondary structure during the renaturation of human serum albumin is a process which is faster than the formation of the tertiary structure. These results, which are in agreement with the data on the kinetic control of protein folding, are discussed from the viewpoint of the importance of the individual types of interactions which take place during the formation and stabilization of three-dimensional protein structures. We have been able to demonstrate the great importance of electrostatic and hydrophobic interactions which together with the disulfide bonds are essential for the reversibility of the denaturation phenomena. The discussion also shows the essential role which evolution processes play in the selection of the mode of protein folding.

scholarly journals Self-Healing Cellulose Nanocrystals-Containing Gels via Reshuffling of Thiuram Disulfide Bonds

Polymers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1392 ◽  
Author(s):  
Wenyan Li ◽  
Shengchang Lu ◽  
Mengchan Zhao ◽  
Xinxing Lin ◽  
Min Zhang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Visible Light ◽  
Cellulose Nanocrystals ◽  
Disulfide Bonds ◽  
Self Healing ◽  
Engineering Applications ◽  
Original Length ◽  
Highly Stretchable

Self-healing gels based on reshuffling disulfide bonds have attracted great attention due to their ability to restore structure and mechanical properties after damage. In this work, self-healing gels with different cellulose nanocrystals (CNC) contents were prepared by embedding the thiuram disulfide bonds into gels via polyaddition. By the reshuffling of thiuram disulfide bonds, the CNC-containing gels repair the crack and recover mechanical properties rapidly under visible light in air. The thiuram disulfide-functionalized gels with a CNC content of 2.2% are highly stretchable and can be stretched approximately 42.6 times of their original length. Our results provide useful approaches for the preparation of dynamic CNC-containing gels with implications in many related engineering applications.

Autonomous self-healing polyisoprene elastomers with high modulus and good toughness based on the synergy of dynamic ionic crosslinks and highly disordered crystals

2020 ◽  
Vol 11 (41) ◽  
pp. 6549-6558
Author(s):  
Yohei Miwa ◽  
Mayu Yamada ◽  
Yu Shinke ◽  
Shoichi Kutsumizu
Keyword(s):  
Mechanical Properties ◽  
Room Temperature ◽  
Self Healing ◽  
High Modulus ◽  
Disordered Crystals ◽  
Ionic Crosslinks

We designed a novel polyisoprene elastomer with high mechanical properties and autonomous self-healing capability at room temperature facilitated by the coexistence of dynamic ionic crosslinks and crystalline components that slowly reassembled.

Biotemplated facile synthesis of three‐dimensional micro/nanoporous tin oxide: improving the flammable and mechanical properties of flexible PVC

2019 ◽  
Vol 14 (8) ◽  
pp. 828-830 ◽  
Author(s):  
Weihua Meng ◽  
Weihong Wu ◽  
Weiwei Zhang ◽  
Luyao Cheng ◽  
Yunhong Jiao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tin Oxide ◽  
Three Dimensional ◽  
Facile Synthesis

Polypyrrole/PU hybrid hydrogels: electrically conductive and fast self-healing for the potential application in body-monitor sensor

2021 ◽  
Author(s):  
Zhanyu Jia ◽  
Guangyao Li ◽  
Juan Wang ◽  
shouhua Su ◽  
Jie Wen ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Electrical Conductivity ◽  
Potential Application ◽  
Self Healing ◽  
Electrically Conductive ◽  
Sensor Application ◽  
Hybrid Hydrogels ◽  
Health Monitor

Conductivity, self-healing and moderate mechanical properties are necessary for multifunctional hydrogels which have great potential in health-monitor sensor application. However, the combination of electrical conductivity, self-healing and good mechanical properties...

scholarly journals Is Dialdehyde Chitosan a Good Substance to Modify Physicochemical Properties of Biopolymeric Materials?

2021 ◽  
Vol 22 (7) ◽  
pp. 3391
Author(s):  
Sylwia Grabska-Zielińska ◽  
Alina Sionkowska ◽  
Ewa Olewnik-Kruszkowska ◽  
Katarzyna Reczyńska ◽  
Elżbieta Pamuła
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Physicochemical Properties ◽  
Silk Fibroin ◽  
Three Dimensional ◽  
Microscopy Imaging ◽  
Maximum Deformation ◽  
One Step ◽  
Chitosan Blends ◽  
Fourier Transfer Infrared Spectroscopy

The aim of this work was to compare physicochemical properties of three dimensional scaffolds based on silk fibroin, collagen and chitosan blends, cross-linked with dialdehyde starch (DAS) and dialdehyde chitosan (DAC). DAS was commercially available, while DAC was obtained by one-step synthesis. Structure and physicochemical properties of the materials were characterized using Fourier transfer infrared spectroscopy with attenuated total reflectance device (FTIR-ATR), swelling behavior and water content measurements, porosity and density observations, scanning electron microscopy imaging (SEM), mechanical properties evaluation and thermogravimetric analysis. Metabolic activity with AlamarBlue assay and live/dead fluorescence staining were performed to evaluate the cytocompatibility of the obtained materials with MG-63 osteoblast-like cells. The results showed that the properties of the scaffolds based on silk fibroin, collagen and chitosan can be modified by chemical cross-linking with DAS and DAC. It was found that DAS and DAC have different influence on the properties of biopolymeric scaffolds. Materials cross-linked with DAS were characterized by higher swelling ability (~4000% for DAS cross-linked materials; ~2500% for DAC cross-linked materials), they had lower density (Coll/CTS/30SF scaffold cross-linked with DAS: 21.8 ± 2.4 g/cm3; cross-linked with DAC: 14.6 ± 0.7 g/cm3) and lower mechanical properties (maximum deformation for DAC cross-linked scaffolds was about 69%; for DAS cross-linked scaffolds it was in the range of 12.67 ± 1.51% and 19.83 ± 1.30%) in comparison to materials cross-linked with DAC. Additionally, scaffolds cross-linked with DAS exhibited higher biocompatibility than those cross-linked with DAC. However, the obtained results showed that both types of scaffolds can provide the support required in regenerative medicine and tissue engineering. The scaffolds presented in the present work can be potentially used in bone tissue engineering to facilitate healing of small bone defects.

scholarly journals 3D Printing of High Viscosity Reinforced Silicone Elastomers

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2239
Author(s):  
Nicholas Rodriguez ◽  
Samantha Ruelas ◽  
Jean-Baptiste Forien ◽  
Nikola Dudukovic ◽  
Josh DeOtte ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
High Performance ◽  
New Technologies ◽  
Three Dimensional ◽  
High Viscosity ◽  
Layer By Layer ◽  
Silicone Elastomers ◽  
Uv Curable ◽  
Octet Truss ◽  
Tunable Mechanical Properties

Recent advances in additive manufacturing, specifically direct ink writing (DIW) and ink-jetting, have enabled the production of elastomeric silicone parts with deterministic control over the structure, shape, and mechanical properties. These new technologies offer rapid prototyping advantages and find applications in various fields, including biomedical devices, prosthetics, metamaterials, and soft robotics. Stereolithography (SLA) is a complementary approach with the ability to print with finer features and potentially higher throughput. However, all high-performance silicone elastomers are composites of polysiloxane networks reinforced with particulate filler, and consequently, silicone resins tend to have high viscosities (gel- or paste-like), which complicates or completely inhibits the layer-by-layer recoating process central to most SLA technologies. Herein, the design and build of a digital light projection SLA printer suitable for handling high-viscosity resins is demonstrated. Further, a series of UV-curable silicone resins with thiol-ene crosslinking and reinforced by a combination of fumed silica and MQ resins are also described. The resulting silicone elastomers are shown to have tunable mechanical properties, with 100–350% elongation and ultimate tensile strength from 1 to 2.5 MPa. Three-dimensional printed features of 0.4 mm were achieved, and complexity is demonstrated by octet-truss lattices that display negative stiffness.

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