Forensic Pathological Analysis of Death Due to Pulmonary Thromboembolism: a Retrospective Study Based on 145 Cases

Abstract Pulmonary thromboembolism (PTE) is a common cause of sudden unexpected death in forensic practice following deep vein thrombosis (DVT). It remains easy to overlook the special procedure used for the detection of PTE during autopsies; therefore, the relationship between PTE and the associated risk factors is in need of analysis. In the present study, 145 fatal cases of PTE found during autopsies performed from 2004 to 2019 at the Center of Forensic Investigation of China Medical University were retrospectively evaluated; the demographic data, risk factors, original location of DVT, and time interval from the formation of DVT to PTE were analyzed. In addition, the difference in lung-to-heart weight ratio between the PTE and disease-free accident groups was calculated with matching for gender and age. The 40–59 age group accounted for more than half of the total cases (51.03%). Immobilization, trauma or fracture (especially of the pelvis, femur, tibia, or fibula), surgery, pregnancy and cesarean section, mental disorders and the use of antipsychotics were the top 5 high-risk factors for fatal PTE. Among the victims, 92.9% (130/140) died within 60 days of the first exposure to risk factors. Most DVT were formed and shed in lower limb veins, especially popliteal veins and their branches, which caused 87.6% of the thrombi distributed in bilateral pulmonary arteries. No significant difference in the lung-to-heart weight ratio was found between the PTE and control groups. The present study provides valuable information for the prevention and treatment of thrombosis during clinical events and may also be important for alerting forensic examiners to conduct special PTE detection in cases with potential risk factors.

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Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat

Acta Cirurgica Brasileira ◽

10.1590/s0102-86502009000400002 ◽

2009 ◽

Vol 24 (4) ◽

pp. 251-255 ◽

Cited By ~ 1

Author(s):

Honório Sampaio Menezes ◽

Cláudio Galeano Zettler ◽

Alice Calone ◽

Jackson Borges Corrêa ◽

Carla Bartuscheck ◽

...

Keyword(s):

Body Weight ◽

Wistar Rats ◽

Weight Ratio ◽

Diabetic Rats ◽

Heart Weight ◽

Diabetic Rat ◽

Control Group ◽

Computer Assisted ◽

Significant Difference ◽

Levene Test

PURPOSE: To compare body weight and length, heart weight and length, heart-to-body weight ratio, glycemia, and morphometric cellular data of offspring of diabetic rats (ODR) and of normal rats (control). METHODS: Diabetes was induced in 3 pregnant Wistar rats, bearing 30 rats, on the 11th day after conception by intraperitoneal injection of 50 mg/kg of streptozotocin. Six normal pregnant Wistar rats, bearing 50 rats, made up the control group. Morphometric data were obtained using a scale for the weight, length, heart and body measurements. Morphometric cellular data were obtained by a computer assisted method applied to the measurements of myocytes. Statistical analysis utilized Student's t-test, ANOVA and Levene test. RESULTS: Control offspring had greater mean body weight and length than offspring of diabetic rats (p < 0.001). Heart weight and length and heart-to-body ratios of newborn rats differed between groups at birth (p < 0.001), but showed no difference at 21 days. Mean nuclei area and perimetric value of the myocytes decrees throughout the first 21 days of life (p < 0.01) in the diabetic group. CONCLUSIONS: Heart hypertrophy on the offspring of diabetic rats at birth was demonstrated by the significant difference between the groups. After the eleventh day, no difference was found, which confirmed regression of cardiomegaly. The significant difference between the first and the 21th day of life, for nuclei area feature, demonstrate regression of cardiac hypertrophy in the offspring of diabetic rats.

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Dietary Patterns and Oxidative Stress in a Population of Women with Breast Cancer in the North-Western Regions of Algeria (Saida and El-Bayadh)

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v10i6.4543 ◽

2020 ◽

Vol 10 (6) ◽

pp. 24-30

Author(s):

Noureddine Halla ◽

Kebir Boucherit ◽

Kadda Hachem ◽

Amouria Asmouni ◽

Hanane Derrab ◽

...

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Risk Factors ◽

Dietary Patterns ◽

Demographic Data ◽

The Body ◽

Cancer Risk Factors ◽

The North ◽

Significant Difference ◽

North Western

Objective: The aim of this work is the study of risk factors for breast cancer in a population of women in the north-western regions of Algeria (Saida and El-Bayadh) Methodology: A case-control study was carried out on 40 women including 20 cancerous women and 20 control women, in order to determine the dietary patterns and general characteristics of the population studied and to compare the hematological and biochemical parameters, and markers of oxidative/antioxidant status between control women and breast cancer women. Results: The results obtained show that there is no significant difference in the average age however the body mass index was significantly increased in cancer women, revealing overweight (p <0.05), compared to control women. The marital status of the target population is predominantly a married woman status and the level of education shows a relatively low level in breast cancer cases compared to women controls. The illiteracy rate is exceptionally high in cancer women compared to controls (35% versus 20%). In addition, the levels of glucose, creatinine, HDL and ALAT are similar between the two groups of women. The contents of urea, cholesterol, triglyceride, LDL, ASAT, malondialdehyde and uric acid are significantly increased in women with breast cancer compared to women controls. But the vitamin C content is significantly reduced in cancer women compared to control women. Conclusion: We conclude from this study that there is an association between breast cancer and lipid alteration, oxidative stress, age, increase in BMI, socio-demographic data, professional situation, age, means of menstruation and menopause, and ultimately the lifestyle. All these factors are risk factors for breast cancer in the region of Saida and El-Bayadh. Keywords: Breast Cancer, Risk Factors, Dietary Patterns, Oxidative Stress.

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Risk Factors Analysis of Pulmonary Cement Embolism during Percutaneous Vertebroplasty or Kyphoplasty for Osteoporotic Vertebral Compression Fracture.

10.21203/rs.3.rs-309630/v1 ◽

2021 ◽

Author(s):

Dexin Zou ◽

Shengjie Dong ◽

Wei Du ◽

Bing Sun ◽

Xifa Wu

Keyword(s):

Risk Factors ◽

Vertebral Compression Fracture ◽

Demographic Data ◽

Multiple Logistic Regression Analysis ◽

Compression Fracture ◽

Osteoporotic Vertebral Compression Fracture ◽

Increased Risk ◽

Significant Difference ◽

Cement Embolism ◽

Pulmonary Ct

Abstract Objective: The purpose of this research is to evaluate the risk factors and incidence of PCE during PKP or PVP for osteoporotic vertebral compression fracture (OVCF) based on postoperative computed tomography (CT).Methods: A total of 2344 patients who underwent PVP or PKP due to OVCF in our spine centre were analyzed retrospectively. According to the detection of postoperative pulmonary CT, the patients were divided into two groups: pulmonary cement embolism group (PCE group) and non pulmonary cement embolism group (NPCE group). Demographic data in both groups were compared using the χ2 test for qualitative data and the unpaired t test for quantitative data. Multiple logistic regression analysis was carried out to identify risk factors that were significantly related to the PCE resulting from cement leakage.Results: PCE was found in 34 patients (1.9% 34/1782) with pulmonary CT examination after operation. There was no statistically significant difference in the parameters such as age, gender, body mass index (BMI) and cement volume in the two groups. Patients with three or more involved vertebrae had a significantly increased risk to suffer from PCE than those with one involved vertebra (p=0.046 OR 2.412 [95% CI 1.017-5.722]). Patients who suffered thoracic fracture had a significantly increased risk to suffer from PCE than those suffered thoracolumbar fracture (p=0.001 OR 0.241 [95% CI 0.105-0.550]). And significantly increased PCE risk also was observed in thoracic fracture compared with Lumbar fracture patients (p=0.028 OR 0.094 [95% CI 0.114-0.779]). The risk of PCE within two weeks after fracture was significantly higher than that after two weeks of fracture (p=0.000 OR 0.178 [95% CI 0.074-0.429]). Patients who underwent PVP surgery had a significantly increased PCE risk than those underwent PKP surgery (p=0.001 OR 0.187 [95% CI 0.069-0.509])Conclusion: The real incidence of PCE is underestimated due to the lack of routine postoperative pulmonary imaging examination. The number of Involved vertebrae, fracture location, operation timing and operation methods are independent risk factors for PCE.

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Minimally Invasive Versus Open Surgery for Radical Hysterectomy Followed By Adjuvant Radiotherapy in Intermediate- or High-Risk Early-Stage Cancer of The Cervix: A Retrospective Study

10.21203/rs.3.rs-830000/v1 ◽

2021 ◽

Author(s):

Qi-ying Zhang ◽

Zi Liu ◽

Ya-li Wang ◽

Jing Zhang ◽

Wen Li ◽

...

Keyword(s):

Risk Factors ◽

Cervical Cancer ◽

High Risk ◽

Minimally Invasive ◽

Cancer Patients ◽

Radical Hysterectomy ◽

Early Stage ◽

Time Interval ◽

Significant Difference ◽

The Impact

Abstract Background Postoperative radiotherapy (RT) or chemoradiotherapy (CRT) improves outcomes of cervical cancer patients with risk factors. Minimally invasive surgery (MIS) has an inferior survival than open radical hysterectomy (ORH), however, the impact of MIS on postoperative RT remains uncertain. The study compared the impacts of MIS versus ORH on delivering of adjuvant RT or CRT for intermediate- or high-risk early-stage cervical cancer. Methods Data on stage IB1-IIA2 patients who underwent radical hysterectomy and postoperative RT/CRT in our institution, from 2014 to 2017, were retrospectively collected. Patients with high or intermediate-risk factors who met the Sedlis criteria received postoperative pelvic external beam radiotherapy (50Gy/25f) with platinum-based chemotherapy (0–6 cycles) according to guidelines. Disease-free survival (DFS) and overall survival (OS) were compared in the two surgical groups. Results One hundred and twenty-nine patients eligible for the study (68 in ORH; 61 in MIS groups) had similar clinicopathologic features except for the stage (highest in MIS was IB1; IIA1 in ORH) and presence of lymph vascular space invasion (higher in MIS group). The median time interval from surgery to chemotherapy and to RT was shorter in the MIS group. Three-year DFS and OS were similar in both groups. Further sub-analysis indicated that the DFS and OS in intermediate/high-risk groups had no significant difference. Cox-multivariate analyses found that tumor size > 4 cm and time interval from surgery to RT beyond seven weeks were adverse independent prognostic factors for DFS. Conclusions In early-stage (IB1-IIA2) cervical cancer patients with intermediate or high-risk factors who received postoperative RT or CRT, no matter they received ORH or MIS as their primary treatment, the DFS and OS had no significant difference, despite TI from surgery to postoperative adjuvant therapy being shorter in the MIS group than ORH.

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PO 8609 PREVALENCE AND RISK FACTORS FOR GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) DEFICIENCY IN TWO P. VIVAX MALARIA-ENDEMIC AREAS IN SUDAN

BMJ Global Health ◽

10.1136/bmjgh-2019-edc.164 ◽

2019 ◽

Vol 4 (Suppl 3) ◽

pp. A62.2-A62

Author(s):

Muzamil Mahdi Abdel Hamid ◽

Musab Albsheer ◽

Mohamed Muneer ◽

Lina Altinae ◽

Andrew A Lover

Keyword(s):

Risk Factors ◽

G6pd Deficiency ◽

Demographic Data ◽

Univariate Analysis ◽

G6pd Activity ◽

Radical Cure ◽

Major Health Problem ◽

Significant Difference ◽

Endemic Areas ◽

Glucose 6 Phosphate Dehydrogenase

BackgroundPlasmodium vivax malaria is a major health problem in Sudan and the parasite has become widely distributed in the recent years. The WHO recommends the use of primaquine as radical cure for liver dormant stage, the hypnozoite. However, prior its use, a test for Glucose-6-phosphate Dehydrogenase (G6PD) should be performed. The objective of the current study was to determine prevalence and risk factors for G6PD deficiency in two P. vivax malaria-endemic areas in Sudan.MethodsA cross-sectional study recruiting 557 subjects from two malaria-endemic areas in Sudan was conducted. Demographic data and blood samples were collected. G6PD activity was measured by spectrometry using SPINREACT enzymatic-UV kit.ResultsThe measured G6PD activities for both sites ranged from 0.6 to 37.7 U/g Hb, with a median value of 12.8 U/g Hb. There was a significant difference in enzyme activity by study site (p<0.001), but not by sex (p=0.91). Overall, across the two study sites, 22 (3.9%) is G6PDd (<30%). Prevalence of G6PDd (<30%) in Khartoum is 1.8% (4/230) compared to 4.8% (16/327) in New Hafla. In univariate analysis predictors of G6PDd were study site (odds ratio of G6PD activity <3.8, Khartoum relative to New Halfa=0.22 (95% CI: 0.08 to 0.66), p=0.006), and recent antibiotic use (OR=2.45 (95% CI: 1.1 to 5.5), p=0.027). In multivariate analysis, the only factor that was significant was the individual’s weight in kilograms, with an OR of 0.97 (95% CI 0.95 to 0.99, p=0.014).ConclusionG6PD deficiency is less prevalent among Sudanese population and this indicates that the use of primaquine for radical cure of P. vivax malaria is safe.

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Frequency and Risk Factors of Red Blood Cell Alloimmunization in Thalassemia Major Patients in Markazi province

Iranian Journal of Pediatric Hematology & Oncology ◽

10.18502/ijpho.v9i1.293 ◽

2019 ◽

Author(s):

Aziz Eghbali MD ◽

Roghaieh.Rahimi-Afzal MD ◽

Sarvenaz Mehrabi MD ◽

Seyed Amir Sanatkar MD ◽

Morteza Mousavi-Hasanzadeh MD

Keyword(s):

Risk Factors ◽

Blood Transfusion ◽

Genetic Disorders ◽

Demographic Data ◽

Thalassemia Major ◽

Blood Groups ◽

The Body ◽

Factors Associated ◽

Significant Difference ◽

The Mean

Background: Thalassemia is one of the most common genetic disorders throughout the world. Blood transfusion plays an important role in the treatment of thalassemia but it leads to numerous complications such as iron overload and alloimmunization. This study evaluated the frequency and risk factors associated with alloimmunization in thalassemia major patients living in Markazi province, Iran. Materials and Methods: In this descriptive study, 48 thalassemia major patients who underwent blood transfusion at Amirkabir hospital were included. Patients' demographic data were recorded using a questionnaire. In order to perform alloimmunization screening and autoantibody assessment, patients were referred to Tehran Blood Transfusion Organization Laboratory. Results: The current study was performed on 48 patients with thalassemia major,. The mean age of patients was 12.5 ± 8.3 years. Among patients 26 (54.16%) were male and 22 (45.83%) were female, 13 patients (27.08%) had alloantibodies. Among 48 patients, 19 (39.58%) had undergone splenectomy. The patients' age of the first blood transfusion ranged from 1 month to 14 months and the mean age of the first blood transfusion was 9.5 ± 7.08 months. The blood transfusion intervals in patients were from 21 days to 40 days and the blood volume received at each transfusion session was 10-15 cc/kg of the body weight. In the current study, the data analysis indicated no significant correlation between alloantibodies and RH phenotype (P=0.43), patients' gender (P=0.9), or blood groups (P=0.4); whereas, a significant correlation was found between alloantibodies and splenectomy (P=0.02) as an increase in the prevalence of alloantibodies was reported in splenectomised patients. Conclusion: No significant difference was found between the patients with and without alloantibodies in terms of the prevalence of Rh phenotype, gender, and blood groups. However, there was a significant difference between the patients with and without alloantibodies in terms of splenectomy. Key words: Allo-immunization, Risk factors, Thalassemia major

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EPIDEMIOLOGY AND RISK FACTORS OF SUDDEN DEATH DUE TO PULMONARY THROMBOEMBOLISM: A RETROSPECTIVE STUDY

CBU International Conference Proceedings ◽

10.12955/cbup.v7.1461 ◽

2019 ◽

Vol 7 ◽

pp. 817-823

Author(s):

Rokas Šimakauskas ◽

Martinas Baltuonis ◽

Sigitas Laima ◽

Sigitas Chmieliauskas ◽

Dmitrij Fomin ◽

...

Keyword(s):

Risk Factors ◽

Sudden Death ◽

Cardiac Hypertrophy ◽

Cause Of Death ◽

Pulmonary Thromboembolism ◽

Traumatic Event ◽

Subcutaneous Fat ◽

Distribution Patterns ◽

Unexpected Death ◽

Risk Of Death

Introduction. Pulmonary thromboembolism (PTE) is not an uncommon cause of sudden, unexpected death. Autopsy is the gold standard for cause of death determination in cases of suspected PTE. Mortality rates due to PTE are not estimated accurately. Objective. The aim of this study was to analyze distribution patterns and risk factors of sudden deaths due to PTE. Methods. Retrospective analysis of Lithuanian State Forensic Medicine Service autopsy data, period 2014-2018. A total of 4533 cases were reviewed; 80 cases met the criteria of immediate cause of death being PTE and were included in the study. PTE epidemiology, risk factors, clinical and pathoanatomical characteristics were described by reviewing scientific literature and statistical databases. Results. PTE as the cause of sudden death was diagnosed in 37(46.25%) men and 43(53.75%) women. Median age at the time of death was 62.8±17.2 years. Death occurred in hospital in 21(26.25%) cases. Trauma was the underlying cause of PTE in 11(13.75%) cases; 9(81.8%) patients were admitted to hospital after a traumatic event. Cardiac hypertrophy was observed in 70(87.5%) autopsies. Abdominal subcutaneous fat thickness was 4.08±2.64 cm in men and 5.35±2.69 cm in women. Deep vein thrombosis (DVT) was confirmed upon microscopic examination in all cases, being the underlying cause of death in 67(83.75%) cases. Conclusion. Sudden death due to PTE usually occurs at an older age and in absence of medical care. PTE is common after sustaining severe traumatic injuries which, when not immediately lethal, are managed in hospital. Cardiac hypertrophy and obesity may increase risk of death due to PTE. Undiagnosed and untreated DVT is often the underlying cause of sudden death due to PTE.

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Risk factors of overactive bladder syndrome and its relation to sexual function in menopausal women

Urologia Journal ◽

10.1177/0391560317750484 ◽

2018 ◽

Vol 85 (1) ◽

pp. 10-14 ◽

Cited By ~ 5

Author(s):

Sevil Hakimi ◽

Elham Aminian ◽

Sakineh Mohammad- Alizadeh Charandabi ◽

Parvin Bastani ◽

Marzieh Mohammadi

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Overactive Bladder ◽

Sexual Function ◽

Demographic Data ◽

Overactive Bladder Syndrome ◽

Or Education ◽

Menopausal Women ◽

Significant Difference

Background: Overactive bladder syndrome is a common and annoying complication worldwide that could negatively affect the quality of life of afflicted individuals. We aimed to determine the prevalence and risk factors of overactive bladder syndrome and its relation to sexual function in healthy menopausal women. Methods: This cross-sectional study was done on 340 women aged 45-60 years in Tabriz, northwest Iran, during 2015-2016. Data were collected using a demographic data questionnaire, the Overactive Bladder Syndrome Score, and the McCoy Female Sexuality Questionnaire. Results: Fifty-six (16.5%), 63 (18.5%), and 10 (2.9%) of the participating women had mild, moderate, and severe overactive bladder syndrome, respectively. Predictors of overactive bladder included: night sweats, central prolapse, episiotomy, varicose disease, illiteracy or education at the primary level, systolic blood pressure >140 mmHg and lack of physical activity. We found a significant difference between the women with and without overactive bladder with respect to the total score and sub-domain scores related to sex partner (p = 0.029) and sexual interest (p = 0.049). Conclusions: The prevalence of overactive bladder was quite high in this study. Since sexual dysfunction is not an easy topic to talk about and can affect women’s quality of life, physicians should consider talking about these issues besides urinary issues to all middle-aged women.

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PREVENTION OF RISK FACTORS OF CARDIOVASCULAR DISEASE IN NURSING

CBU International Conference Proceedings ◽

10.12955/cbup.v5.1057 ◽

2017 ◽

Vol 5 ◽

pp. 988-993

Author(s):

MĂˇria NovysedlĂˇkovĂˇ ◽

RĂłbert Ĺ eliga

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Demographic Data ◽

Organ Damage ◽

Empirical Survey ◽

Education Of Patients ◽

Preventive Check ◽

Significant Difference ◽

Males And Females ◽

The Difference

Introduction: Cardiovascular disease, in terms of its frequency, the severity of organ damage, and the consequences for the health of the population constitutes one of the most pressing problems of our population. The prevention of subsequent coronary events and the maintenance of physical functioning in such patients are a major challenge in preventive care. However, many patients opt for a change in their lifestyle, some with the support of a health professional.Objective: This empirical survey focuses on the knowledge of respondents about preventing cardiovascular disease. Statistical methods determine the differences between males and females in attending preventive check-ups, understanding and observing risk factors in their lifestyle, and having an interest in changing their lifestyle.Methods: The survey uses a non-standardized questionnaire. Apart from demographic data, the questionnaire had 10 items assessing the respondentâ€™s knowledge of risk factors for cardiovascular disease, 10 on lifestyle and attitudes to the change in lifestyle, and five regarding their interest in education about the subject. Exploratory data includes answers from 70 respondents, who were outpatients in a general practitionerâ€™s department. Of these, 32 are males (46.0%) and 38 are females (54.0%). Results of the survey are analyzed using the Chi-Squared test. Results: Fifty-four of the 70 respondents (55.7%; 20 males and 34 females) undertake preventive check-ups at the general practitionerâ€™s department at least once in two years. No significant differences present between males and females in attending preventive check-ups (Ď‡2 = 3.455; df = 1; P = 0.05) and in showing a willingness for a lifestyle change (Ď‡2 = 1.789; P = 0.05). However, based on the given data, a significant difference presents between males and females regarding proper regime observance (Ď‡2 = 18.651; df = 1; P = 0.05). For example, females know the observance of a healthy diet is necessary for preventing ischemic heart disease (Ď‡2 = 20.124; df = 1; P = 0.05).Conclusion: The study shows that the difference between males and females is significant regarding their understanding of risk factors related to lifestyle and proper regime observance. Thus, education could lead to reducing or eliminating such risk factors. Prevention of risk factors is complex and lifelong. Under conditions of the Slovak health service, registered nurses are responsible for the education of patients.

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Anterior Positioning Screw in Proximal Femoral Plating Restricts Posterior Tilt of Retroverted Femoral Neck Fractures: a Retrospective Cohort Study

10.21203/rs.3.rs-282853/v1 ◽

2021 ◽

Author(s):

Sheng-Bo Nie ◽

Jun-Feng Liu ◽

Jiang-Hua Zhu ◽

Zi-Fei Zhou ◽

Lei Zhang ◽

...

Keyword(s):

Risk Factors ◽

Femoral Neck ◽

Demographic Data ◽

Multivariable Analysis ◽

Femoral Neck Fractures ◽

Harris Hip Score ◽

Fixation Failure ◽

Significant Difference ◽

Posterior Tilt ◽

Posterior Comminution

Abstract Background: Preoperative posterior tilt is a risk factor for fixation failure in femoral neck fractures. This study aimed to evaluate the configuration of anterior positioning screw in proximal femoral plating in the treatment of retroverted femoral neck fractures in terms of resisting posterior tilt.Methods: We retrospectively analyzed patients with retroverted femoral neck fractures who were fixed by proximal femoral plating from January 2014 to August 2019. All patients were divided into two groups according to screw configuration: anterior long-threaded screw (ALTS, n = 36) and normally short-threaded screws (NTS, n = 46). Baseline characteristics were reviewed and radiological and clinical outcomes were analyzed. Logistic regression analysis was used to identify risk factors for developing posterior tilt.Results: Demographic data showed no significant difference. Increased posterior tilt was lower in the ALTS group (3.2°, 2.1 – 4.3°) than that in the NTS group (5.3°, 4.2 – 8.3°) (p < 0.001), and the percentage of people with > 5° of posterior tilt was also lower in the ALTS group (5, 13.9% vs. 24, 52.2%; p < 0.001). Femoral neck shortening (FNS) was lower in the ALTS group (3.1 (2.1 – 4.7) mm vs. 4.3 (3.1 – 6.3) mm, p = 0.003), though not statistically significant when using 5 mm as the cut-off value. Harris Hip Score in the ALTS group was higher than that in the NTS group (87.0, 84.0 – 90.0 vs. 82.0, 76.0 – 84.5; p < 0.001). Postoperative complications including delayed union, nonunion, and avascular necrosis were comparable between the groups. Multivariable analysis identified posterior comminution (OR 15.9, 95% CI 3.6 – 70.3, p < 0.001), suboptimal reduction quality (OR 12.0, 95% CI 2.6 – 56.1, p = 0.002), and NTS configuration (ref: ALTS configuration) (OR 21.9, 95% CI 4.1 – 116.4, p < 0.001) as risk factors for developing posterior tilt.Conclusions: Configuration of anterior positioning screw in proximal femoral plating provides better resistance against posterior tilt in the fixation of retroverted femoral neck fractures. Also, posterior comminution, suboptimal reduction, and NTS configuration (ref: ALTS) are risk factors for developing posterior tilt.Trial registration: Retrospectively registered.

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