scholarly journals Antibiotic resistance among the Lahu hill tribe people in northern Thailand: a cross-sectional study

2020 ◽  
Author(s):  
SOPHAPHAN INTAHPHUAK ◽  
TAWATCHAI APIDECHKUL ◽  
PATITA KUIPIAPHUM
Keyword(s):  
Public Health ◽  
Escherichia Coli ◽  
Drug Resistance ◽  
Antibiotic Resistance ◽  
Antibiotic Use ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hill Tribe ◽  
Antibiotic Drug

Abstract Background Antibiotic resistance is often reported and is of major concern as a public health problem. The hill tribe people in Thailand are considered populations vulnerable to antibiotic resistance due to their poor economic and educational status. The study aimed to estimate the prevalence of, the factors associated with, and the major species of bacteria involved in antibiotic drug resistance among the Lahu hill tribe people in northern Thailand. Methods A cross-sectional study was conducted to gather information from participants between March and September 2019. A validated questionnaire was used for data collection. Participants who presented an illness related to infectious diseases were eligible to participate in the study and were asked to obtain specific specimens. Antibiotic susceptibility was tested by the Kirbey-Bauer disk diffusion test. Chi-square tests and logistic regression were used to detect the associations between variables at the significance level of α = 0.05. Results A total of 240 participants were recruited into the study; 70.4% were females, 25.4% were aged 30–40 years. More than half worked in the agricultural sector (55.4%) and had an education level of less than primary school (45.8%). The majority had urinary tract infections (67.9%) with two major pathogenic species of the infection: Escherichia coli (12.8%) and Enterobacter cloacae (8.0%). The prevalence of antibiotic resistance was 16.0%. Escherichia coli and Klebsiella pneumoniae species were found to have multidrug resistance that was greater than that of other species, while ampicillin was found to have the greatest drug resistance. In the multivariate model, it was found that those who had poor knowledge of antibiotic use had a 2.56-fold greater chance (95% CI = 1.09–5.32) of having antibiotic resistance than did those who had good knowledge of antibiotic use, and those who had poor antibiotic use behaviors had a 1.79-fold greater chance (95% CI = 1.06–4.80) of having antibiotic resistance than did those who had good antibiotic use behaviors. Conclusion Effective public health interventions are urgently needed to reduce antibiotic drug resistance among the Lahu people by improving their knowledge and skills regarding the proper use of antibiotics and eventually minimizing antibiotic resistance.

scholarly journals Antibiotic resistance among the Lahu hill tribe people, northern Thailand: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sophaphan Intahphuak ◽  
Tawatchai Apidechkul ◽  
Patita Kuipiaphum
Keyword(s):  
Public Health ◽  
Escherichia Coli ◽  
Drug Resistance ◽  
Antibiotic Resistance ◽  
Antibiotic Use ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hill Tribe ◽  
The Hill

Abstract Background Antibiotic resistance is often reported and great concerned as one of public health problems especially people living with poverty in developing countries including Thailand. The hill tribe people is defined as vulnerable population for antibiotic resistance in Thailand due to poor economic and education status particularly the Lahu people who is the second greatest group of the hill tribe people in Thailand. The study aimed to estimate the prevalence, factors associated with, and typing major species of bacteria with antibiotic drugs resistance among the Lahu hill tribe people in northern Thailand. Methods A cross-sectional study was conducted to gather the information from the participants. A validated questionnaire was used for data collection. Participants who presented an illness related to infectious diseases were eligible to participate the study and were asked to obtain specific specimen; sputum, urine or stool. Antibiotic susceptibility was tested by Kirbey Bauer’s disc diffusion test. Chi-square and logistic regression were used to detect the associations between variables at the significant level of α = 0.05. Results A total of 240 participants were recruited into the study. The majority had urinary tract infection (67.9%) with two major pathogenic species of the infection; Escherichia coli (12.8%), and Enterobacter cloacae (8.0%). The prevalence of antibiotic resistance was 16.0%. Escherichia coli and Klebsiella pneumoniae species were found to have multidrug resistance that was greater than that of other species, while ampicillin was found to have the greatest drug resistance. It was found that those who had poor knowledge of antibiotic use had a 2.56-fold greater chance (95% CI = 1.09–5.32) of having antibiotic resistance than did those who had good knowledge of antibiotic use, and those who had poor antibiotic use behaviors had a 1.79-fold greater chance (95% CI = 1.06–4.80) of having antibiotic resistance than did those who had good antibiotic use behaviors. Conclusion Effective public health interventions are urgently needed to reduce antibiotic drug resistance among the Lahu people by improving their knowledge and skills regarding the proper use of antibiotics and eventually minimizing antibiotic resistance. Moreover, health care professionals should strictly follow the standard guideline to prescribe antibiotics.

scholarly journals Antibiotics stewardship in Ghana: a cross-sectional study of public knowledge, attitudes, and practices

2020 ◽  
Author(s):  
Tamara Jimah ◽  
Ama P. Fenny ◽  
Oladele Ogunseitan
Keyword(s):  
Antibiotic Resistance ◽  
Inappropriate Medication ◽  
Antibiotic Use ◽  
Antibiotic Consumption ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Attitudes And Practices ◽  
Individual Knowledge ◽  
Knowledge Attitudes And Practices

Abstract Background Antibiotic resistance is a major contributing factor to global morbidity and mortality and is associated with inappropriate medication use. However, the level of antibiotic consumption and knowledge about antibiotic resistance in Ghana is inadequately quantified. Our study identifies strategies for improved stewardship of antibiotics to prevent the proliferation of resistant pathogens by assessing the level of antibiotic knowledge, attitudes, and consumption behaviors by region, gender, age, and education in rural and urban Ghana. Methods A cross-sectional study was conducted in 12 communities in the urban Greater Accra and rural Upper West regions of Ghana. A questionnaire survey was administered to 400 individuals aged 18 years and older in selected locations during September-October 2018 to gather data on individual knowledge, attitudes, and practices concerning antibiotics and antibiotic resistance. Multivariate analysis was used to investigate the association between demographic characteristics and knowledge, attitudes, and related behaviors. Results Over 30% (125/400) had not received a doctor’s prescription during their last illness. Seventy percent (278/400) had taken at least one antibiotic in the year prior to the survey. The top five frequently used antibiotics were Amoxicillin , Amoxicillin-clavulanic acid , Ampicillin , Ciprofloxacin , and Metronidazole . Women and older adults had higher knowledge compared to their respective counterparts (p<0.01). Furthermore, prudent antibiotic use was significantly more prevalent in women than men (p<0.05). Although no regional differences were found in overall knowledge, compared to urban residents, individuals residing in rural settings exhibited higher knowledge about the ineffectiveness of antibiotics for viruses like the cold and HIV/AIDS (p<0.001). Two hundred and fifty-two (63%) respondents were unaware of antibiotic resistance. There was generally a low level of self-efficacy among participants regarding their role in preserving the effectiveness of antibiotics. Conclusion Antibiotic knowledge, attitudes, and use varied significantly across demographics, suggesting a context-specific approach to developing effective community interventions.

scholarly journals Public awareness regarding the use and resistance of antibiotics: A cross-sectional study among Nepalese adults in Kathmandu valley

2018 ◽  
Vol 6 (3) ◽  
pp. 96-101
Author(s):  
Satish Kumar Deo ◽  
Sita Rijal ◽  
Tulza K.C
Keyword(s):  
Antibiotic Resistance ◽  
Public Awareness ◽  
Study Finding ◽  
Antibiotic Use ◽  
Cross Sectional Study ◽  
Public Health Issue ◽  
Sectional Study ◽  
Cross Sectional ◽  
Interview Method ◽  
Drug Classes

Background: Antibiotics are considered to be among the most commonly sold drug classes globally. Antibiotic resistance is a recognized public health issue at the local, national and global levels.Objectives: The aim of this study was to identify awareness of general public regarding the use and resistance of antibiotics.Methodology: A descriptive cross-sectional study was conducted in Kathmandu in November 2016 using a quantitative questionnaire among 120 adult people aged 20–60 years. Convenience sampling method was used and information on use of antibiotics and resistance was obtained using semi-structured questionnaire through interview method. Descriptive statistics was done to describe the respondent’s level of awareness regarding use of antibiotics and resistance.Results: Among the total respondents, majority had incorrect awareness as regards to action, reasons for using antibiotics, possible side effects of the antibiotic. Seventy one percent of the respondents had not heard about antibiotic resistance. The study finding showed that about 66.7% of the participants had inadequate awareness towards use and resistance of antibiotics.Conclusion: The findings demonstrate that the overall awareness on antibiotic use and resistance is poorly understood among our respondents. This information can be utilized in future educational and antibiotic resistance awareness raising campaigns.

scholarly journals KONTAMINASI BAKTERI ESCHERISCIA COLI PADA BOTOL SUSU BALITA DENGAN KEJADIAN DIARE PADA BALITA

2020 ◽  
pp. 22-30
Author(s):  
Andi Sani ◽  
Sartika Sartika ◽  
Inka Anugrah
Keyword(s):  
Public Health ◽  
Escherichia Coli ◽  
Health Center ◽  
Random Sampling ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Children Under Five ◽  
Public Health Center ◽  
Under Five

Kasus diare terus meningkat di Kota Makassar sebanyak 23.334 kasus ditahun 2016. Balita menjadi kelompok yang rentan terhadap diare. Penelitian ini bertujuan mengetahui kontaminasi bakteri Escherichia coli pada botol susu dengan kejadian diare pada balita di wilayah kerja Puskesmas Kaluku Bodoa Kota Makassar Tahun 2018. Jenis penelitian yang digunakan adalah observasional dengan desain cross sectional study. Populasi adalah seluruh balita yang berada di wilayah kerja Puskesmas Kaluku Bodoa. Sampel adalah balita yang memakai botol susu yang dipilih menggunakan teknik proportional random sampling, sebanyak 72 anak balita. Hasil penelitian menunjukkan bahwa tidak dapat melihat hubungan Escherichia coli pada botol dikarenakan seluruh sampe terdapat Escherichia coli dan tidak memenuhi  syarat,  sedangkan pada proses  pencucian (p=0.007), penyimpanan botol (p=0.041), menyiapkan botol (p=0.100), penyediaan air bersih (p=0.904), kebiasaan cuci tangan pakai sabun (p=0.229). Kesimpulan dari penelitian bahwa tidak dapat melihat perbandingan Escherichia coli pada botol susu dikarenakan seluruh sample terdapat bakteri E.coli. Terdapat hubungan yang signifikan antara pencucian dan  menyiapkan botol susu dengan kejadian diare pada balita di wilayah kerja Puskesmas Kaluku Bodoa Kota Makassar Tahun 2018. Penelitian ini menyarankan agar para ibu atau wali anak lebih memperhatikan cara pencucian botol susu dan  penyiapan botol susu. Diarrhea cases continue to increase in Makassar City as many as 23,334 cases in 2016. Toddlers are a group that is vulnerable to diarrhea. This study aims to determine the contamination of Escherichia coli bacteria in milk bottles with the incidence of diarrhea in infants in the working area of ​​Kaluku Bodoa Public Health Center Makassar City in 2018. The type of research used was observational with a cross sectional study design. The population is all children under five in the working area of ​​Kaluku Bodoa Health Center. Samples are toddlers who use milk bottles selected using proportional random sampling technique, as many as 72 children under five. The results showed that there was no relationship between Escherichia coli on the bottle because all Escherichia coli was present and did not meet the requirements, whereas in the washing process (p = 0.007), storage of bottles (p = 0.041), preparing bottles (p = 0.100), provision clean water (p = 0.904), handwashing habits with soap (p = 0.229). The conclusion from the study that can not see the comparison of Escherichia coli in milk bottles because all samples contained E.coli bacteria. There is a significant relationship between washing and preparing milk bottles with the incidence of diarrhea in infants in the working area of ​​the Kaluku Bodoa Public Health Center Makassar City in 2018. This study suggests that mothers or guardians of children pay more attention to how to wash bottles and prepare milk bottles.

scholarly journals Spectrum of antibiotic resistance in UTI caused by Escherichia coli among HIV-infected patients in Uganda: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
George Abongomera ◽  
Maurice Koller ◽  
Joseph Musaazi ◽  
Mohammed Lamorde ◽  
Marisa Kaelin ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibiotic Resistance ◽  
Bacterial Growth ◽  
Cross Sectional Study ◽  
World Health ◽  
Hiv Care ◽  
People Living With Hiv ◽  
Sectional Study ◽  
Cross Sectional ◽  
Tract Infections

Abstract Background Antimicrobial drug resistance is one of the top ten threats to global health according to the World Health Organization. Urinary tract infections (UTIs) are among the most common bacterial infections and main reason for antibiotic prescription. The incidence of UTIs appears to be high among people living with HIV. We sought to determine the most common UTI pathogens among HIV infected patients and evaluate their susceptibility towards antibiotics. Methods We performed a cross-sectional study among HIV-infected patients aged ≥ 18 years presenting at an HIV care specialized clinic with symptoms suggestive of a urethritis. Urine cultures were subjected to antibiotic susceptibility testing according to Clinical Laboratory Standards Institute. The data was analyzed using STATA, we performed Pearson’s Chi-square and Fisher’s exact tests to compare differences between proportions. Results Out of the 200 patients, 123 (62%) were female. The median age was 41.9 years (IQR 34.7–49.3). Only 32 (16%) urine cultures showed bacterial growth. Escherichia coli was the most commonly isolated uropathogen (72%), followed by Klebsiella pneumoniae (9%). E. coli was completely resistant to cotrimoxazole and ampicillin; resistance to ciprofloxacin and ceftriaxone was 44% and 35% respectively; 9% to gentamicin; no resistance detected to nitrofurantoin and imipenem. Conclusions Our findings are congruent with the Uganda national clinical guidelines which recommends nitrofurantoin as the first line antibiotic for uncomplicated UTI. Significant ciprofloxacin and ceftriaxone resistance was detected. In the era of emerging antibiotic resistance, understanding the local susceptibilities among sub-populations such as HIV infected patients is crucial. Further investigation is needed to address reasons for the low bacterial growth rate observed in the urine cultures.

scholarly journals Antibiotics stewardship in Ghana: a cross-sectional study of public knowledge, attitudes, and practices among communities.

2020 ◽  
Author(s):  
Tamara Jimah ◽  
Ama P. Fenny ◽  
Oladele Ogunseitan
Keyword(s):  
Antibiotic Resistance ◽  
Inappropriate Medication ◽  
Antibiotic Use ◽  
Antibiotic Consumption ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Attitudes And Practices ◽  
Individual Knowledge ◽  
Knowledge Attitudes And Practices

Abstract Background Antibiotic resistance is a major contributing factor to global morbidity and mortality and is associated with inappropriate medication use. However, the level of antibiotic consumption and knowledge about antibiotic resistance in Ghana is inadequately quantified. Our study identifies strategies for improved stewardship of antibiotics to prevent the proliferation of resistant pathogens by assessing the level of antibiotic knowledge, attitudes, and consumption behaviors by region, gender, age, and education in rural and urban Ghana. Methods A cross-sectional study was conducted in 12 communities in the urban Greater Accra and rural Upper West regions of Ghana. A questionnaire survey was administered to 400 individuals aged 18 years and older in selected locations during September-October 2018 to collect data on individual knowledge, attitudes, and practices concerning antibiotics and antibiotic resistance. Multivariate analysis was used to investigate the association between demographic characteristics and knowledge, attitudes, and related behaviors. Results Over 30% (125/400) had not received a doctor’s prescription during their last illness. Seventy percent (278/400) had taken at least one antibiotic in the year prior to the survey. The top five frequently used antibiotics were Amoxicillin, Amoxicillin-clavulanic acid, Ampicillin, Ciprofloxacin, and Metronidazole. Women and older adults had higher knowledge compared to their respective counterparts (p<0.01). Furthermore, prudent antibiotic use was significantly more prevalent in women than men (p<0.05). Although no regional differences were found in overall knowledge, compared to urban residents, individuals residing in rural settings exhibited higher knowledge about the ineffectiveness of antibiotics for viruses like the cold and HIV/AIDS (p<0.001). Two hundred and fifty-two (63%) respondents were unaware of antibiotic resistance. There was generally a low level of self-efficacy among participants regarding their role in preserving the effectiveness of antibiotics. Conclusion Antibiotic knowledge, attitudes, and use varied significantly across demographics, suggesting a context-specific approach to developing effective community interventions.

scholarly journals Are Antibiotics Prescribed to Inpatients According to Recommended Standard Guidelines in Juba Teaching Hospital, South Sudan? A Retrospective Cross-sectional Study

2021 ◽  
Author(s):  
Michael Ekubu Otim ◽  
Desmond Kabuya Demaya ◽  
Amina M Al-Marzouqi ◽  
Jean P. Mukasa
Keyword(s):  
Antibiotic Resistance ◽  
Teaching Hospital ◽  
South Sudan ◽  
Antibiotic Use ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hospitalised Patients ◽  
Antibiotics Use ◽  
High Level

Abstract Background: The emergence and spread of antibiotic resistance occurred at an alarming rate globally, and has limited the use of antibiotics for preventing and treating infectious diseases. Failure to follow guidelines and protocols for antibiotic use for rational therapeutics and infection control has led to overuse and misuse of antibiotics. However, there is paucity of data on the current pattern of antibiotics prescribing for hospitalised patients in South Sudan, which is among the youngest countries in the world. Therefore, this study aimed to explore the prescription and use of antibiotics at Juba Teaching Hospital (JTH) in South Sudan.Methods:A retrospective cross-sectional study was conducted among JTH inpatients between January and December 2016. A sample of 316 files from the medical and surgical wards were extracted using probability sampling proportional to ward size. Extracted files were reviewed to determine the pattern of antibiotics administration. Data on indications for antibiotic use were also collected. All data were entered twice and analysed using STATA version 13.0.Results: In all reviewed files, patients received treatment with antibiotics. Antibiotic use was highest in the medical ward (75.4%). Conditions in which antibiotic use was most prevalent were infectious and parasitic diseases (23.7%) and diseases of the digestive system (19.9%). The top three antibiotics prescribed were ceftriaxone (21.2%), metronidazole (20.0%) and amoxicillin (11.5%). The majority of patients (40.2%) were treated with two antibiotics. Conclusions: This study revealed a high level of inappropriate antibiotics use at JJTH. Furthermore, there is non-adherence to national/international guidelines in administration of these antibiotics among doctors. It is necessary to introduce antibiotic stewardship activity, along with continuous national surveillance and enforcement to reduce irrational antibiotics use and the associated risk for antibiotic resistance.

scholarly journals Is health literacy associated with antibiotic use, knowledge and awareness of antimicrobial resistance among non-medical university students in Egypt? A cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. e046453
Author(s):  
Aya Mostafa ◽  
Abdurrahman Abdelzaher ◽  
Salma Rashed ◽  
Salma I AlKhawaga ◽  
Shadwa K Afifi ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Health Literacy ◽  
Antimicrobial Resistance ◽  
University Students ◽  
Antibiotic Use ◽  
Cross Sectional Study ◽  
Health Concern ◽  
Sectional Study ◽  
Cross Sectional ◽  
Medical University

ObjectivesAntibiotic resistance is a global public health concern, especially in developing countries, where antibiotic misuse is widespread. However, studies investigating relevant factors, particularly in youth, are limited. This study examined the levels of health literacy (HL) and their association with antibiotic use, knowledge of antibiotics and awareness of antibiotic resistance among university students in Egypt.DesignA cross-sectional study was conducted using self-administered questionnaires during 2018. The Health Literacy Survey (HLS-EU-Q16) and the WHO Antibiotic resistance: Multi-Country Public Awareness Survey were used. Bivariate and multivariable analyses were used to compare responses on use and knowledge of antibiotics, and awareness of antibiotic resistance between the three levels of students’ HL.SettingUniversity, Cairo, Egypt.Participants508 non-medical university students.OutcomesStudents’ HL scores were categorised into sufficient, problematic and inadequate. Students’ knowledge of antibiotics was categorised into good and poor. Students’ awareness of antibiotic resistance was categorised into high, average and poor.Results35.1% of students had sufficient HL. 79.7% of students had poor knowledge of antibiotics. 39.9% of students reported having used antibiotics in the past month without a prescription. 92.2% had limited awareness of antibiotic resistance and 30.6% of students heard about the term ‘antimicrobial resistance’. Background characteristics did not significantly differ by HL levels or knowledge scores, except for students’ year of study. Sufficient HL was independently associated with students’ high awareness of antibiotic resistance (adjusted OR=2.8; 95% CI: 1.3 to 5.9).ConclusionsHL was insufficient in this sample of non-medical Egyptian university students. Across all levels of HL, knowledge of antibiotics and awareness of antibiotic resistance were limited, reflecting deficiency in relevant education programmes. Findings suggest that sufficient HL supports high awareness of antibiotic resistance. Incorporating HL and rational antibiotic use awareness raising programmes in university curricula is an urgent necessity to curb antibiotic resistance.

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