scholarly journals rTMS and Suicidality in Adulthood; An Exploratory Open-Labeled Neuromodulative Approach to Battle Suicide

2021 ◽  
Author(s):  
Farshad Sharifi ◽  
Mohammad Yoosef Mahjouri ◽  
Fahimeh Palizban ◽  
Seyed Masoud Arzaghi
Keyword(s):  
Suicidal Ideation ◽  
Health Systems ◽  
Treatment Approach ◽  
Solid Core ◽  
Low Resolution ◽  
Electromagnetic Tomography ◽  
Adult Men ◽  
Non Invasive ◽  
Suicidal Attempts ◽  
The Impact

Abstract Background: Suicidal attempts are one of the most critical issues with a huge burden on family and health systems all around the world. To decrease the hazardous outcomes of this issue, mental health systems are trying to apply the most effective and safe interventions. In this regard, repetitive Transcranial Magnetic Stimulation (rTMS ) as a non-invasive approach could be a proper treatment approach. We investigated the impact of rTMS method on the treatment of the patients with suicidal ideation. For this purpose, the application of rTMS when integrating with Low-Resolution Electromagnetic Tomography (LORETA) data has been assessed.Methods: As an open-labeled study we enrolled 7 adult men who were recently rescued from suicidal attempts and referred to our psychiatric clinic for three consecutive months (2018). The severity of suicidal ideation was measured by the Beck Scale of Suicidal Ideation (SSI) and brain activity via Low-Resolution Electromagnetic Tomography (LORETA), administered at baseline and the end of the treatment course. Repetitive TMS was delivered to the left and right dorsolateral prefrontal cortices (DLPFC) with a figure-eight solid core coil at 110% motor threshold, 10 Hertz (Hz) and 4 second (s) train duration, (3000 pulses) (total 12 sessions; 36,000 stimuli). Six sessions daily and six sessions within two weeks were scheduled.Results: According to the results of psychiatric re-interview, LORETA, and SSI scores of all patients revealed an impressive and statistically significant decrease in suicidal ideation. No side effects were seen during the treatment course.Conclusions: Scheduled three consecutive weeks rTMS course was significantly effective in remitting acute suicidal ideation in adult men regardless of psychiatric diagnosis. Larger double-blinded studies must be conducted to validate the clinical usage of this safe and non-invasive treatment approach in the area of psychiatry.

Impact of COVID-19 on Nuclear Medicine in Germany, Austria and Switzerland: An International Survey in April 2020

2020 ◽  
Vol 59 (04) ◽  
pp. 294-299 ◽  
Author(s):  
Lutz S. Freudenberg ◽  
Ulf Dittmer ◽  
Ken Herrmann
Keyword(s):  
Nuclear Medicine ◽  
Health Systems ◽  
Personal Protective Equipment ◽  
Large Scale ◽  
Diagnostic Procedures ◽  
Protective Equipment ◽  
Current Crisis ◽  
Web Based ◽  
Public Versus Private ◽  
The Impact

Abstract Introduction Preparations of health systems to accommodate large number of severely ill COVID-19 patients in March/April 2020 has a significant impact on nuclear medicine departments. Materials and Methods A web-based questionnaire was designed to differentiate the impact of the pandemic on inpatient and outpatient nuclear medicine operations and on public versus private health systems, respectively. Questions were addressing the following issues: impact on nuclear medicine diagnostics and therapy, use of recommendations, personal protective equipment, and organizational adaptations. The survey was available for 6 days and closed on April 20, 2020. Results 113 complete responses were recorded. Nearly all participants (97 %) report a decline of nuclear medicine diagnostic procedures. The mean reduction in the last three weeks for PET/CT, scintigraphies of bone, myocardium, lung thyroid, sentinel lymph-node are –14.4 %, –47.2 %, –47.5 %, –40.7 %, –58.4 %, and –25.2 % respectively. Furthermore, 76 % of the participants report a reduction in therapies especially for benign thyroid disease (-41.8 %) and radiosynoviorthesis (–53.8 %) while tumor therapies remained mainly stable. 48 % of the participants report a shortage of personal protective equipment. Conclusions Nuclear medicine services are notably reduced 3 weeks after the SARS-CoV-2 pandemic reached Germany, Austria and Switzerland on a large scale. We must be aware that the current crisis will also have a significant economic impact on the healthcare system. As the survey cannot adapt to daily dynamic changes in priorities, it serves as a first snapshot requiring follow-up studies and comparisons with other countries and regions.

Preliminary EEG and low resolution electromagnetic tomography correlates of migraine therapy

2009 ◽  
Vol 40 (01) ◽  
Author(s):  
D Keeser ◽  
L Tiemann ◽  
M Valet ◽  
E Schulz ◽  
M Ploner ◽  
...  
Keyword(s):  
Low Resolution ◽  
Migraine Therapy ◽  
Electromagnetic Tomography

scholarly journals The impact of economic sanctions on health and health systems in low- and middle-income countries

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
M Suhrcke ◽  
M Pinna Pintor ◽  
C Hamelmann
Keyword(s):  
Health Outcomes ◽  
Health System ◽  
Health Systems ◽  
Grey Literature ◽  
Economic Sanctions ◽  
Political Crisis ◽  
Middle Income ◽  
Financial Flows ◽  
Adverse Health ◽  
The Impact

Abstract Background Economic sanctions, understood as measures taken by one state or a group of states to coerce another into a desired conduct (eg by restricting trade and financial flows) do not primarily seek to adversely affect the health or health system of the target country's population. Yet, there may be indirect or unintended health and health system consequences that ought to be borne in mind when assessing the full set of effects of sanctions. We take stock of the evidence to date in terms of whether - and if so, how - economic sanctions impact health and health systems in LMICs. Methods We undertook a structured literature review (using MEDLINE and Google Scholar), covering the peer-reviewed and grey literature published from 1970-2019, with a specific focus on quantitative assessments. Results Most studies (23/27) that met our inclusion criteria focus on the relationship between sanctions and health outcomes, ranging from infant or child mortality as the most frequent case over viral hepatitis to diabetes and HIV, among others. Fewer studies (9/27) examined health system related indicators, either as a sole focus or jointly with health outcomes. A minority of studies explicitly addressed some of the methodological challenges, incl. control for relevant confounders and the endogeneity of sanctions. Taking the results at face value, the evidence is almost unanimous in highlighting the adverse health and health system effects of economic sanctions. Conclusions Quantitatively assessing the impact of economic sanctions on health or health systems is a challenging task, not least as it is persistently difficult to disentangle the effect of sanctions from many other, potentially major factors at work that matter for health (as, for instance, war). In addition, in times of severe economic and political crisis (which often coincide with sanctions), the collection of accurate and comprehensive data that could allow appropriate measurement is typically not a priority. Key messages The existing evidence is almost unanimous in highlighting the adverse health and health system effects of economic sanctions. There is preciously little good quality evidence on the health (system) impact of economic sanctions.

scholarly journals Detecting suicidal risk using MMPI-2 based on machine learning algorithm

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sunhae Kim ◽  
Hye-Kyung Lee ◽  
Kounseok Lee
Keyword(s):  
Machine Learning ◽  
Suicidal Ideation ◽  
Random Forest ◽  
Minnesota Multiphasic Personality Inventory ◽  
Learning Algorithm ◽  
Suicidal Risk ◽  
K Nearest Neighbors ◽  
Large Group ◽  
Suicidal Attempts ◽  
Scale Scores

AbstractMinnesota Multiphasic Personality Inventory-2 (MMPI-2) is a widely used tool for early detection of psychological maladjustment and assessing the level of adaptation for a large group in clinical settings, schools, and corporations. This study aims to evaluate the utility of MMPI-2 in assessing suicidal risk using the results of MMPI-2 and suicidal risk evaluation. A total of 7,824 datasets collected from college students were analyzed. The MMPI-2-Resturcutred Clinical Scales (MMPI-2-RF) and the response results for each question of the Mini International Neuropsychiatric Interview (MINI) suicidality module were used. For statistical analysis, random forest and K-Nearest Neighbors (KNN) techniques were used with suicidal ideation and suicide attempt as dependent variables and 50 MMPI-2 scale scores as predictors. On applying the random forest method to suicidal ideation and suicidal attempts, the accuracy was 92.9% and 95%, respectively, and the Area Under the Curves (AUCs) were 0.844 and 0.851, respectively. When the KNN method was applied, the accuracy was 91.6% and 94.7%, respectively, and the AUCs were 0.722 and 0.639, respectively. The study confirmed that machine learning using MMPI-2 for a large group provides reliable accuracy in classifying and predicting the subject's suicidal ideation and past suicidal attempts.

scholarly journals Flexible Potentiometric Sensor System for Non-Invasive Determination of Antioxidant Activity of Human Skin: Application for Evaluating the Effectiveness of Phytocosmetic Products

Chemosensors ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 76
Author(s):  
Aleksey V. Tarasov ◽  
Ekaterina I. Khamzina ◽  
Maria A. Bukharinova ◽  
Natalia Yu. Stozhko
Keyword(s):  
Antioxidant Activity ◽  
Human Skin ◽  
Skin Diseases ◽  
Silver Chloride ◽  
Potentiometric Sensor ◽  
Sensor System ◽  
Non Invasive ◽  
Pet Film ◽  
The Impact

In contemporary bioanalysis, monitoring the antioxidant activity (AOA) of the human skin is used to assess stresses, nutrition, cosmetics, and certain skin diseases. Non-invasive methods for skin AOA monitoring have certain advantages over invasive methods, namely cost-effectiveness, lower labor intensity, reduced risk of infection, and obtaining results in the real-time mode. This study presents a new flexible potentiometric sensor system (FPSS) for non-invasive determination of the human skin AOA, which is based on flexible film electrodes (FFEs) and membrane containing a mediator ([Fe(CN)6]3–/4–). Low-cost available materials and scalable technologies were used for FFEs manufacturing. The indicator FFE was fabricated based on polyethylene terephthalate (PET) film and carbon veil (CV) by single-sided hot lamination. The reference FFE was fabricated based on PET film and silver paint by using screen printing, which was followed by the electrodeposition of precipitate containing a mixture of silver chloride and silver ferricyanide (SCSF). The three-electrode configuration of the FPSS, including two indicator FFEs (CV/PET) and one reference FFE (SCSF/Ag/PET), has been successfully used for measuring the skin AOA and evaluating the impact of phytocosmetic products. FPSS provides reproducible (RSD ≤ 7%) and accurate (recovery of antioxidants is almost 100%) results, which allows forecasting its broad applicability in human skin AOA monitoring as well as for evaluating the effectiveness of topically and orally applied antioxidants.

scholarly journals A longitudinal study over 40 years to study the metabolic syndrome as a risk factor for cardiovascular diseases

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lars Lind ◽  
Johan Sundström ◽  
Johan Ärnlöv ◽  
Ulf Risérus ◽  
Erik Lampa
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Longitudinal Study ◽  
Clinical Intervention ◽  
The Elderly ◽  
Adult Men ◽  
The Metabolic Syndrome ◽  
The Impact ◽  
Over 40 Years

AbstractThe impact of most, but not all, cardiovascular risk factors decline by age. We investigated how the metabolic syndrome (MetS) was related to cardiovascular disease (CVD) during 40 years follow-up in the Uppsala Longitudinal Study of Adult Men (ULSAM, 2,123 men all aged 50 at baseline with reinvestigations at age 60, 70, 77 and 82). The strength of MetS as a risk factor of incident combined end-point of three outcomes (CVD) declined with ageing, as well as for myocardial infarction, ischemic stroke and heart failure when analysed separately. For CVD, the risk ratio declined from 2.77 (95% CI 1.90–4.05) at age 50 to 1.30 (95% CI 1.05–1.60) at age 82. In conclusion, the strength of MetS as a risk factor of incident CVD declined with age. Since MetS was significantly related to incident CVD also at old age, our findings suggest that the occurrence of MetS in the elderly should not be regarded as innocent. However, since our data were derived in an observational study, any impact of MetS in the elderly needs to be verified in a randomized clinical intervention trial.

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