scholarly journals Impaired executive functions predict repetitive behaviors in toddlers under 36 months old with autism spectrum disorder symptoms

2021 ◽  
Author(s):  
Saeid Sadeghi ◽  
Hamid Reza Pouretemad ◽  
Reza Shervin Badv
Keyword(s):  
Autism Spectrum Disorder ◽  
Executive Functioning ◽  
Executive Functions ◽  
Rating Scale ◽  
Repetitive Behavior ◽  
Autism Spectrum ◽  
Repetitive Behaviors ◽  
Spectrum Disorder ◽  
Future Research ◽  
Cross Sectional

Abstract Background: Executive Functions (EFs) deficit in Autism spectrum disorder (ASD) has been mainly investigated, while less is known about the EFs in toddlers. The study aimed was to investigate the relationship between EFs deficits and repetitive and restricted behaviors (RRBs) in toddlers with ASD symptoms. Finally, we examined whether EFs deficits were predictive of RRBs.Method: Cross-sectional data were collected from mothers of forty-five toddlers under 36 months old. The modified checklist for autism in toddlers (M-CHAT). The Gilliam autism rating scale (GARS-2), the behavior rating inventory of executive functioning-preschool version (BRIEF-P), and repetitive behavior scale- revised (RBS-R) administered to mothers.Findings: We found significant associations between parent-reported executive functions problems and (1) stereotyped behaviors, (2) self-injurious behaviors, (3) ritualistic behaviors, (4) sameness behaviors, (5) restricted behaviors, (6) compulsive behaviors, and (7) repetitive behaviors total score. There was a lack of association between M-CHAT and social interactions deficits of GARS-2 and the repetitive behaviors total score. Increases in the degree of EFs deficits predicted increments in repetitive behaviors.Discussion: These results support a link between executive disfunction and RRBs. Future research on RRBs in ASD may benefit from focusing on specific executive functioning abilities rather than general categories.

scholarly journals Possible tics diagnosed as stereotypies in patients with severe autism spectrum disorder: a video-based evaluation

2020 ◽  
Author(s):  
Cristiano Termine ◽  
Enzo Grossi ◽  
Valentina Anelli ◽  
Ledina Derhemi ◽  
Andrea E. Cavanna
Keyword(s):  
Autism Spectrum Disorder ◽  
Rating Scale ◽  
Young Patients ◽  
Autism Spectrum ◽  
Repetitive Behaviors ◽  
Spectrum Disorder ◽  
High Rate ◽  
Video Recordings ◽  
Significant Difference ◽  
Severe Autism

Abstract Background The association of stereotypies and tics is not rare in children with severe autism spectrum disorder (ASD). The differential diagnosis between stereotypies and tics in this patient population can be difficult; however, it could be clinically relevant because of treatment implications. Methods A total of 108 video recordings of repetitive behaviors in young patients with stereotypies in the context of ASD were reviewed by a movement disorders expert and a trainee, in order to assess the prevalence of possible co-morbid tics. The Modified Rush Videotape Rating Scale (MRVS) was used to rate tic frequency and severity. Results Out of 27 patients with stereotypies (24 males; mean age 14 years), 18 (67%) reported possible tics. The most frequently observed tics were eye blinking, shoulder shrugging, neck bending, staring, and throat clearing. The mean MRVS score was 5, indicating mild tic severity. The only significant difference between patients with tics and patients without tics was the total number of stereotypies, which was higher in the subgroup of patients without tics (p = 0.01). Conclusions Expert review of video-recordings of repetitive behaviors in young patients with ASD and stereotypies suggests the possibility of a relatively high rate of co-morbid tics. These findings need to be integrated with a comprehensive clinical assessment focusing on the diagnostic re-evaluation of heterogeneous motor manifestations.

scholarly journals 2288 Neural correlates of face processing in autism spectrum disorder: A quantitative meta-analysis of current literature and future directions

2018 ◽  
Vol 2 (S1) ◽  
pp. 21-22
Author(s):  
Carla J. Ammons ◽  
Mary-Elizabeth Winslett ◽  
Rajesh K. Kana
Keyword(s):  
Autism Spectrum Disorder ◽  
Face Processing ◽  
Repetitive Behavior ◽  
Autism Spectrum ◽  
Small Sample ◽  
Spectrum Disorder ◽  
Future Research ◽  
Healthy Controls ◽  
Specific Level

OBJECTIVES/SPECIFIC AIMS: Autism spectrum disorder (ASD) affects 1 in 68 people and includes restricted, repetitive behavior, and social communication deficits. Aspects of face processing (i.e., identity, emotion perception) are impaired in some with ASD. Neuroimaging studies have shown aberrant patterns of brain activation and connectivity of face processing regions. However, small sample sizes and inconsistent results have hindered clinical utility of these findings. The study aims to establish consistent patterns of brain responses to faces in ASD and provide directions for future research. METHODS/STUDY POPULATION: Neuroimaging studies were identified through a multi-database search according to PRISMA guidelines. In total, 23 studies were retained for a sample size of 383 healthy controls and 345 ASD. Peak coordinates were extracted for activation likelihood estimation (ALE) in GingerALE v2.3.6. Follow-up ALE analyses investigated directed Versus undirected gaze, static Versus dynamic, emotional Versus neutral, and familiar Versus unfamiliar faces. RESULTS/ANTICIPATED RESULTS: Faces produced bilateral activation of the fusiform gyrus (FG) in healthy controls (−42 −52 −20; 22 −74 −12, p<0.05, FDR) and left FG activation in ASD (−42 −54 −16, p<0.05, FDR). Activation in both groups was lateral to the mid-fusiform sulcus. Follow-up results pending. DISCUSSION/SIGNIFICANCE OF IMPACT: Reduced right FG activation to faces may inform biomarker or response to intervention studies. Mid-fusiform sulcus proved a reliable predictor of functional divides should be investigated on a subject-specific level.

scholarly journals Risk Factors for Unhealthy Weight Gain and Obesity among Children with Autism Spectrum Disorder

2019 ◽  
Vol 20 (13) ◽  
pp. 3285 ◽  
Author(s):  
Khushmol K. Dhaliwal ◽  
Camila E. Orsso ◽  
Caroline Richard ◽  
Andrea M. Haqq ◽  
Lonnie Zwaigenbaum
Keyword(s):  
Risk Factors ◽  
Autism Spectrum Disorder ◽  
Weight Gain ◽  
Autism Spectrum ◽  
Lifestyle Factors ◽  
Repetitive Behaviors ◽  
Spectrum Disorder ◽  
Future Research ◽  
Children With Asd ◽  
Unhealthy Weight

Autism Spectrum Disorder (ASD) is a developmental disorder characterized by social and communication deficits and repetitive behaviors. Children with ASD are also at a higher risk for developing overweight or obesity than children with typical development (TD). Childhood obesity has been associated with adverse health outcomes, including insulin resistance, diabetes, heart disease, and certain cancers. Importantly some key factors that play a mediating role in these higher rates of obesity include lifestyle factors and biological influences, as well as secondary comorbidities and medications. This review summarizes current knowledge about behavioral and lifestyle factors that could contribute to unhealthy weight gain in children with ASD, as well as the current state of knowledge of emerging risk factors such as the possible influence of sleep problems, the gut microbiome, endocrine influences and maternal metabolic disorders. We also discuss some of the clinical implications of these risk factors and areas for future research.

scholarly journals Sensory and repetitive behaviors among children with autism spectrum disorder at home

Autism ◽  
2016 ◽  
Vol 21 (2) ◽  
pp. 142-154 ◽  
Author(s):  
Anne V Kirby ◽  
Brian A Boyd ◽  
Kathryn L Williams ◽  
Richard A Faldowski ◽  
Grace T Baranek
Keyword(s):  
Autism Spectrum Disorder ◽  
Video Recording ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Free Play ◽  
Repetitive Behaviors ◽  
Spectrum Disorder ◽  
Future Research ◽  
Sensory Modalities ◽  
Behavior Types

Atypical sensory and repetitive behaviors are defining features of autism spectrum disorder and are thought to be influenced by environmental factors; however, there is a lack of naturalistic research exploring contexts surrounding these behaviors. This study involved video recording observations of 32 children with autism spectrum disorder (2–12 years of age) engaging in sensory and repetitive behaviors during home activities. Behavioral coding was used to determine what activity contexts, sensory modalities, and stimulus characteristics were associated with specific behavior types: hyperresponsive, hyporesponsive, sensory seeking, and repetitive/stereotypic. Results indicated that hyperresponsive behaviors were most associated with activities of daily living and family-initiated stimuli, whereas sensory seeking behaviors were associated with free play activities and child-initiated stimuli. Behaviors associated with multiple sensory modalities simultaneously were common, emphasizing the multi-sensory nature of children’s behaviors in natural contexts. Implications for future research more explicitly considering context are discussed.

AUTISM SPECTRUM DISORDER AND ASSOCIATED FACTORS AMONG CHILDREN AGED 24-72 MONTHS IN QUANG NGAI PROVINCE

2018 ◽  
Vol 8 (6) ◽  
pp. 218-225
Author(s):  
Duc Nguyen Tan ◽  
Khue Luong Ngoc ◽  
Vu Nguyen Thanh Quang ◽  
Thang Vo Van
Keyword(s):  
Autism Spectrum Disorder ◽  
Rural Areas ◽  
Urban Areas ◽  
Rating Scale ◽  
Total Sample ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Cross Sectional ◽  
Children With Asd ◽  
Red Flag

Introduction: Autism Spectrum Disorder (ASD) is a disability developed in the young age and lasts during the lifetime. Early diagnosis and timely interventions will help improve the situation and reduce consequences caused to persons with ASD, their families and society. Objectives: (1) To describe the prevalence of ASD of the children aged 24 – 72 months Quang Ngai Province; (2) To analyse some factors related to ASD of the children aged 24 – 72 months in Quang Ngai Province. Methodology: Cross sectional research on a total sample size of 74,308 children aged 24 – 72 months in Quang Ngai Province in a period of September to December 2016; doing interview the parents or care givers on the children’s family socio-economic characteristics; all the children were screened to examine ASD signs and standards using red flag signs, Modified-Checklist for Autism in Toddlers (M-CHAT) and Childhood Autism Rating Scale (CARS). Children were finally examined and clinically diagnosed using criteria Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-5). Results: 280 children aged 24 – 72 months, account for 3.8‰, were detected as ASD. Among the children with ASD, 63.57% were diagnosed severe, 36.34% diagnosed medium and slight. The boys with ASD is 3.1 times higher than girls (p<0.01). The children with ASD in urban areas is almost two times higher than those in rural areas (p<0.01). No any statistically significant association between factors of ethnicity, religion, ages of pregnant mothers or mother’s smoking habits with the children with ASD. Conclusions: Children aged 24 – 72 months with ASD in Quang Ngai Province accounted for 3.8‰, rather similar to the ASD prevalence in other similar studies over the world. It is a need to more deeply study on some factors related to ASD among children aged 24-72 months in Quang Ngai province. Key words: Autism Spectrum Disorder, ASD, Red flag signs, M-CHAT, CARS

Lack of mental flexibility as endophenotype in autism spectrum disorder and obsessive comulsive disorder families

2011 ◽  
Vol 26 (S2) ◽  
pp. 970-970
Author(s):  
V. Goussé ◽  
A. Hagi ◽  
J.-L. Stilgenbauer ◽  
R. Delorme
Keyword(s):  
Autism Spectrum Disorder ◽  
Executive Functions ◽  
Principal Component ◽  
Autism Spectrum ◽  
Repetitive Behaviors ◽  
Spectrum Disorder ◽  
Central Coherence ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
First Degree Relatives

IntroductionResults from clinical and molecular genetic studies suggest that autism spectrum disorder (ASD) and obsessive compulsive disorder (OCD) could have a shared pattern of heritability. Among a large number of clinical variables evaluated, obsessive compulsive/repetitive behaviors have been found to be highly correlated among autism probands and their relatives. Empirical evidence from neuropsychological studies suggest that an appropriate model for repetitive behaviours is a deficit of executive functions specifically flexibility. Given the lack of flexibility observed in ASD and OCD probands, we hypothesised that it could represent a shared endophenotype in both families.MethodsSeven cognitive tests belonging to executive functions, central coherence and theory of mind were proposed to 58 unaffected first-degree relatives of probands with ASD and 61 unaffected first-degree relatives of OCD patients and compared with 34 healthy controls. A principal component analysis (PCA) was performed.ResultsASD relatives - specifically mothers - performed significantly worse on all the tests than OCD relatives and controls. Moreover, inside the OCD group, female individuals performed significantly worse than males. Finally, the PCA indicate that the cognitive profiles of the ASD relatives and the OCD relatives were similar but distinct from controls.ConclusionLack of cognitive flexibility is observed in ASD and OCD families and might constitute a shared intermediate cognitive phenotype. Our study constitutes an effort to clarify the relationship between ASD and OCD having implications for our nosological understanding of both disorders.

scholarly journals Metaphor Comprehension in Individuals with Autism Spectrum Disorder: Core Language Skills Matter

2021 ◽  
Author(s):  
Tamara Kalandadze ◽  
Johan Braeken ◽  
Cecilia Brynskov ◽  
Kari-Anne Bottegaard Næss
Keyword(s):  
Autism Spectrum Disorder ◽  
Cross Sectional Study ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Future Research ◽  
Cross Sectional ◽  
Metaphor Comprehension ◽  
Core Language ◽  
The Relationship ◽  
Variable Performance

AbstractPoor metaphor comprehension was considered a hallmark of autism spectrum disorder (ASD), but recent research has questioned the extent and the sources of these difficulties. In this cross-sectional study, we compared metaphor comprehension in individuals with ASD (N = 29) and individuals with typical development (TD; N = 31), and investigated the relationship between core language and metaphor comprehension. Individuals with ASD showed more difficulty but also a more variable performance in both metaphor and literal items of the task used than individuals with TD did. This indicates that core language ability accounts for metaphor comprehension and should be considered in future research and interventions aiming to improve metaphor comprehension in individuals with ASD.

scholarly journals Screening for Autism Spectrum Disorder in Children up to Age 2.5 years in a Tertiary Care Hospital

2020 ◽  
Vol 1 (1) ◽  
pp. 5
Author(s):  
Anum Farooq ◽  
Shoaib Ahmed
Keyword(s):  
Autism Spectrum Disorder ◽  
Rating Scale ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Military Hospital ◽  
Care Hospital ◽  
Cross Sectional ◽  
Dsm 5

Objective: To investigate the frequency of Autistic Spectrum Disorder (ASD) by screening 16 to 30 months old children, reporting to a tertiary care hospital. Study Design: Cross sectional study.Place and Duration of Study: The study was conducted in the Paediatrics Outpatient Department of Military Hospital, Rawalpindi from November 2017 to August 2018.Materials and Methods: A total of 163 children between the age of 16-30 months were screened using Urdu translated version of Modified Checklist for Autism in Toddlers, revised with Follow-Up (M-CHAT-R/FTM). Those who screened positive on MCHAT-R were assessed using Childhood Autism Rating Scale-2 (CARS 2) and Diagnostic and Statistical Manual-5 (DSM-5) as diagnostic tools.Results: Among the 163 children screened with MCHAT, 33 were found positive for autism. The positive individuals were further assessed on CARS-2 and DSM-5; five children were diagnosed with ASD at moderate to severe level.  This study has shown that 3% of children visiting the hospital for various reasons suffer from ASD.Conclusion: This study concluded that 3% of the children coming to the hospital for any purpose were found to have ASD. There is a need to make Level 1 screening an essential part of regular check-ups of children in Paediatrics outpatient clinics. How to cite this: Farooq A, Ahmed S. Screening for Autism Spectrum Disorder in Children up to Age 2.5 years in a Tertiary Care Hospital. Life and Science. 2020; 1(1): 12-16.  doi: http://doi.org/10.37185/L&S.1.1.74

The State of Virtual and Augmented Reality Therapy for Autism Spectrum Disorder (ASD)

2019 ◽  
pp. 118-140 ◽  
Author(s):  
Sinan Turnacioglu ◽  
Joseph P McCleery ◽  
Julia Parish-Morris ◽  
Vibha Sazawal ◽  
Rita Solorzano
Keyword(s):  
Autism Spectrum Disorder ◽  
Augmented Reality ◽  
Behavioral Interventions ◽  
Autism Spectrum ◽  
Repetitive Behaviors ◽  
Spectrum Disorder ◽  
Reality Therapy ◽  
Future Research ◽  
Future Research Directions ◽  
Number Of Individuals

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition affecting a growing number of individuals across the lifespan. It is characterized by observable impairments in social communication, as well as repetitive behaviors and restricted patterns of interests. Early, intensive behavioral interventions improve long-term outcomes in ASD, but are often expensive and hard to administer consistently. This chapter describes a new approach to autism intervention, using highly motivating virtual reality (VR) and augmented reality (AR) technologies that could soon support traditional autism therapies across ages and ability levels. The chapter begins by reviewing the ASD phenotype, followed by a review of the current landscape of research on VR and AR in ASD. A discussion of ASD-specific benefits and risks is followed by a presentation of new, harnessed immersive VR technology from Floreo, Inc. Finally, we propose a series of future research directions.

scholarly journals Genetic contributions to autism spectrum disorder

2021 ◽  
pp. 1-14
Author(s):  
A. Havdahl ◽  
M. Niarchou ◽  
A. Starnawska ◽  
M. Uddin ◽  
C. van der Merwe ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Rare Variants ◽  
De Novo ◽  
Point Mutations ◽  
Autism Spectrum ◽  
Repetitive Behaviors ◽  
Spectrum Disorder ◽  
Individual Risk ◽  
Future Research ◽  
Risk Genes

Abstract Autism spectrum disorder (autism) is a heterogeneous group of neurodevelopmental conditions characterized by early childhood-onset impairments in communication and social interaction alongside restricted and repetitive behaviors and interests. This review summarizes recent developments in human genetics research in autism, complemented by epigenetic and transcriptomic findings. The clinical heterogeneity of autism is mirrored by a complex genetic architecture involving several types of common and rare variants, ranging from point mutations to large copy number variants, and either inherited or spontaneous (de novo). More than 100 risk genes have been implicated by rare, often de novo, potentially damaging mutations in highly constrained genes. These account for substantial individual risk but a small proportion of the population risk. In contrast, most of the genetic risk is attributable to common inherited variants acting en masse, each individually with small effects. Studies have identified a handful of robustly associated common variants. Different risk genes converge on the same mechanisms, such as gene regulation and synaptic connectivity. These mechanisms are also implicated by genes that are epigenetically and transcriptionally dysregulated in autism. Major challenges to understanding the biological mechanisms include substantial phenotypic heterogeneity, large locus heterogeneity, variable penetrance, and widespread pleiotropy. Considerable increases in sample sizes are needed to better understand the hundreds or thousands of common and rare genetic variants involved. Future research should integrate common and rare variant research, multi-omics data including genomics, epigenomics, and transcriptomics, and refined phenotype assessment with multidimensional and longitudinal measures.

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