scholarly journals Epigenetic alterations of the promoter region of the POMC gene in adolescent depressive disorder patients with non-suicidal self-injury behaviors

2020 ◽  
Author(s):  
Doudou Zheng ◽  
Xiaojiao Bi ◽  
Tianliang Zhang ◽  
Chao Han ◽  
Tantan Ma ◽  
...  
Keyword(s):  
Depressive Disorder ◽  
Methylation Level ◽  
Promoter Region ◽  
Depression Scale ◽  
Epigenetic Mechanism ◽  
Psychotic Symptoms ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
Female Patients ◽  
Self Injury

Abstract Background The incidence of non-suicidal self-injury (NSSI) behavior among adolescents increases year by year. Patients with a history of both depression and NSSI behaviors tend to have greater risk of suicide. At present, the mechanism of adolescent depressive disorder patients with NSSI behaviors is not clear, epigenetic mechanism may be involved. Proopiomelanocortin (POMC) gene may be associated with depressive disorder. The purpose of this study was to investigate deoxyribonucleic acid (DNA) methylation of POMC gene promoter region of adolescent depressive disorder patients with NSSI behaviors. Methods Bisulfite Sequencing PCR (BSP) was used to test the methylation level of POMC promoter of 15 adolescent depressive disorder patients with NSSI behaviors and 15 healthy controls (HC). The online software Methylation Share Rate (MSR) Calcalate was used to draw the lollipop model of the methylation state. Self-made questionnaires were used to collect clinical data of the case group and control group. Hamilton depression scale-24 (HAMD-24), Hamilton anxiety scale (HAMA), Symptom Checklist-90 (SCL-90) were used to evaluate the characteristics and severity of depressive, anxiety and psychotic symptoms. Adolescent self-injury questionnaire was used to assess NSSI behaviors and its severity. Results BSP analysis found that the POMC methylation level of cytosine-guanine dinucleotide 1 (CpG1) site was higher in adolescent depressive disorder patients with NSSI behaviors than that of HC (P < 0.05). Overall significance in POMC methylation at CpG1 sites between adolescent depressive disorder patients with NSSI behaviors and HC was gender-independent, methylation level at CpG1 sites was higher in both male and female patients than that in HC. The CpG1 methylation had correlation with the family history (P < 0.05). We also found that POMC methylation level at CpG17 sites in female patients was significantly higher than that of the female HC (P < 0.05). Conclusions There was abnormal methylation in the POMC promoter region of adolescent depressive disorder patients with NSSI behaviors, the methylation of CpG1 sites may act as epigenetic markers for those adolescents.

Influence of Depressive Disorder on Epilepsy Patients Life Quality

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
E. Suljic ◽  
A. Kucukalic ◽  
N. Loncarevic ◽  
A. Bravo-Mehmedbasic
Keyword(s):  
Depressive Disorder ◽  
Depressive Disorders ◽  
Life Quality ◽  
Depression Scale ◽  
Hamilton Depression Scale ◽  
Female Patients ◽  
Duration Of Illness ◽  
Clinical Center ◽  
Male Patients ◽  
Patients With Epilepsy

Introduction:Interictal depression as a co-morbid disorder can be seen among more than 40% of patients with epilepsy. Sex, epilepsy duration, type of seizures as well as applied antiepileptic drugs can cause development of depression which influence patient's life quality.Goal:To test relation between depressive disorders and patients sex, duration of illness, type of epileptic fits, antiepileptic therapy and life quality.Material and methods:Prospectively, randomly selected, we tested 300 patients with epilepsy, with or without depressive affective disorder at the Outpatient Department for Epilepsies at the Clinical Center Sarajevo. All patients answered Beck and Hamilton depression scale.Results:Baseline is consisded of male patients which made 54 % with the average age of 37.7 years, as well as female patients at average age 32.83 years. Depressive disorder according to the results at the Beck scale was present in 34%, and according to the Hamilton scale in 38.9%. Duration of illnesses longer than 20 years had 56% women with the expressed depressive disorder, compared to the 42% men's with depression (p< 0.01). Partial complex seizures were more often among women (p< 0.05). Carbamazepin as monotherapy was applied for more than a half of the baseline, and combined with carbamazepin significantly more frequently among men's (p< 0.0001), while female patients had significantly more often Lamotrigil.Conclusion:Depressive disorder is significantly more frequent among women with partial complex seizures, earlier epilepsy onset, and significantly more often on Phenobarbital therapy. Presence of depression with epilepsy significantly reduced patient's life quality.

scholarly journals Psychodramatic psychotherapy combined with pharmacotherapy in major depressive disorder: an open and naturalistic study

2006 ◽  
Vol 28 (1) ◽  
pp. 40-43
Author(s):  
Elisabeth Maria Sene Costa ◽  
Rosilda Antonio ◽  
Márcia Britto de Macedo Soares ◽  
Ricardo Alberto Moreno
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Social Adjustment ◽  
Depression Scale ◽  
Self Report ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
Major Depressive ◽  
The Social ◽  
Social Adjustment Scale

OBJETIVE: Recent literature has highlighted the role of psychotherapy in the treatment of major depressive disorder. Combined therapies comprising both psychotherapy and pharmacotherapy have presented the best results. Although several kinds of psychotherapies have been studied in the treatment of depressive disorders, there remains a lack of data on psychodramatic psychotherapy in the treatment of major depressive disorder. The objective of this study was to evaluate the impact of psychodramatic psychotherapy (in a sample of major depressive disorder patients. METHOD: This is an open, naturalistic, controlled, non-randomized study. Twenty major depressive disorder patients (according to the DSM-IV criteria), under pharmacological treatment for depression, with Hamilton Depression Scale total scores between 7 and 20 (mild to moderate depression), were divided into two groups. Patients in the psychotherapeutic group took part in 4 individual and 24 structured psychodramatic group sessions, whilst subjects in the control group did not participate in this psychodramatic psychotherapy. Both groups were evaluated with the Social Adjustment Scale - Self Report and the Hamilton Depression Scale. RESULTS: Psychotherapeutic group patients showed a significant improvement according to the Social Adjustment Scale - Self Report and the Hamilton Depression Scale scores at endpoint, compared to those of the control group. CONCLUSIONS: Results suggest that individual and group psychodramatic psychotherapy, associated to pharmacological treatment, provides good clinical benefits in the treatment of major depressive disorder.

scholarly journals Evaluation of the online-based self-help programme “Selfapy” in patients with unipolar depression: study protocol for a randomized, blinded parallel group dismantling study

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Rico Krämer ◽  
Stephan Köhler
Keyword(s):  
Depressive Symptoms ◽  
Depression Scale ◽  
Drop Out ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
Online Interventions ◽  
Phone Calls ◽  
Self Help ◽  
Low Threshold ◽  
The Impact

Abstract Background Patients with mild to moderate depressive symptoms can have limited access to regular treatment; to ensure appropriate care, low-threshold treatment is needed. Effective online interventions could increase the supply of low-threshold treatment. Further research is needed to evaluate the effectiveness of online interventions. This study aims to evaluate the online-based self-help programme “Selfapy” on a sample of depressive subjects and compares the impact of the programme’s unaccompanied version with its therapeutic accompanied version. Methods A sample of 400 subjects that have a mild to severe depressive episode (Becks Depression Inventory - II and Hamilton Depression Scale) will be used. Subjects are randomly assigned to immediate access to an unaccompanied course (no support from psychologist via weekly phone calls), immediate access to an accompanied course (support from a psychologist via weekly phone calls) or a waiting list control group (access to the intervention after 24 weeks). The intervention will last for a period of 12 weeks. Depressive symptoms as a primary parameter, as well as various secondary parameters, such as life satisfaction, therapeutic relationships, social activation, self-esteem, attitudes towards Internet interventions and drop-out rates, are recorded at four different points in time: at baseline (T1), 6 weeks after the start of the intervention (T2), 12 weeks after the start of the intervention (T3) and 3 months after completion of the treatment follow-up (T4). Conclusion This randomized and controlled, blinded study will make use of a “dismantled” approach to adequately compare the accompanied and unaccompanied versions of the intervention. Positive and meaningful results are expected that could influence the acceptance and implementation of online interventions. Trial registration German Clinical Trials Register DRKS00017191. Registered on 14 June 2019

scholarly journals FEATURES OF DEPRESSIVE DISORDER IN WOMAN DURING PREGNANCY

2020 ◽  
Vol 1 (1) ◽  
pp. 38-48
Keyword(s):  
Mental Illness ◽  
Depressive Disorder ◽  
Pregnant Women ◽  
Negative Impact ◽  
Depression Scale ◽  
Maternity Hospital ◽  
High Risk Group ◽  
Social Adaptation ◽  
Hamilton Depression Scale ◽  
Physical And Mental Health

Purpose of the article is to show features of depressive disorder during pregnancy and how it can be different according to various personal indicators. Pregnancy and depression often go hand in hand. This condition affects about every tenth pregnant woman. According to recent research, sudden surges and changes in the hormonal background that accompany the entire pregnancy can really affect brain biochemistry, which in turn can lead to real clinical depression. The procedure of research registered at the women's consultation and obstetric ward and pathology department of pregnancy in Maternity hospital No. 3 (Kyiv). It lasted for 5 months. The group of pregnant women consisted of 100 people aged 18 to 42 years. Among them were 35 women in 1 trimester of pregnancy, 40 women in 2 trimester of pregnancy, 25 women in 3 trimester of pregnancy. To identify the presence and severity of depression among pregnant women, we used the following methods: Hamilton Depression Scale, Behterev Depression Questionnaire (female version). Anxiety and depression in women during pregnancy require early detection and correction due to their significant negative impact on pregnancy, childbirth, postpartum and further psychophysical development and social adaptation of children. Different indicators of age and trimester affect the level of expression of the depressive disorder. If woman had problems with conception or she was treated for infertility, the probability of her depression in her pregnancy increases by 10 times. Depression may be more likely to eclipse pregnancy and women who have suffered mental illness, anxiety, or depression before conception. This disorder may also occur in problematic relationships, as well as in situations where relatives have had a depression or mental illness, a woman has already had a miscarriage or her current pregnancy is a high-risk group. Depression during pregnancy has significant implications for pregnancy outcomes and maternal and child health. There is a need to identify which family, physical and mental health factors are associated with depression during pregnancy.

scholarly journals Abnormalities in Electroencephalographic Microstates Among Adolescents With First Episode Major Depressive Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Yuqiong He ◽  
Qianting Yu ◽  
Tingyu Yang ◽  
Yaru Zhang ◽  
Kun Zhang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Depression Scale ◽  
First Episode ◽  
Hamilton Depression Scale ◽  
Healthy Controls ◽  
Major Depressive ◽  
Hamd Score ◽  
Eeg Changes ◽  
Microstate Analysis

Background: Recent studies have reported changes in the electroencephalograms (EEG) of patients with major depressive disorder (MDD). However, little research has explored EEG differences between adolescents with MDD and healthy controls, particularly EEG microstates differences. The aim of the current study was to characterize EEG microstate activity in adolescents with MDD and healthy controls (HCs).Methods: A total of 35 adolescents with MDD and 35 HCs were recruited in this study. The depressive symptoms were assessed by Hamilton Depression Scale (HAMD) and Children's Depression Inventory (CDI), and the anxiety symptoms were assessed by Chinese version of DSM-5 Level 2-Anxiety-Child scale. A 64-channel EEG was recorded for 5 min (eye closed, resting-state) and analyzed using microstate analysis. Microstate properties were compared between groups and correlated with patients' depression scores.Results: We found increased occurrence and contribution of microstate B in MDD patients compared to HCs, and decreased occurrence and contribution of microstate D in MDD patients compared to HCs. While no significant correlation between depression severity (HAMD score) and the microstate metrics (occurrence and contribution of microstate B and D) differing between MDD adolescents and HCs was found.Conclusions: Adolescents with MDD showed microstate B and microstate D changes. The obtained results may deepen our understanding of dynamic EEG changes among adolescents with MDD and provide some evidence of changes in brain development in adolescents with MDD.

scholarly journals Aggression and Non-Suicidal Self-Injury among Depressed Youths: The Mediating Effect of Resilience

2021 ◽  
Author(s):  
Ling ZHANG ◽  
Meiai CHEN ◽  
Benxian YAO ◽  
Ying ZHANG
Keyword(s):  
Psychological Health ◽  
Migrant Workers ◽  
Depression Scale ◽  
Mediating Effect ◽  
Control Group ◽  
Mediating Role ◽  
Self Injury ◽  
Depression Group ◽  
Resilience Scale ◽  
The Relationship

Background: The global spread of COVID-19 not only exerted an enormous impact on the public in different countries but also aggravated depression among youths. The aggressive tendencies of depressed individuals can harm their body and life and threaten those of others. The aggressive and non-suicidal self-injurious behaviors of depressed youths may seriously affect their physical and psychological health if not identified and mediated promptly. Method: A total of 875 young respondents (including college students, community youths, migrant workers, and so on) from three provinces in China were surveyed in 2020 using a depression scale, non-suicidal selfinjury scale, aggression scale, and resilience scale. Results: Depression, non-suicidal self-injury, and aggression are significantly higher among the members of the depression group compared with the members of the healthy control group (P<0.001), and the resilience of the members of the former group is remarkably lower than that of the members of the latter group (P<0.001). Aggression among the depressed youths exhibits a significant positive correlation with non-suicidal self-injury (r= 0.43, P<0.01), whereas aggression (r= –0.18, P<0.05) and non-suicidal self-injury (r= –0.20, P<0.05) demonstrates significant negative correlations with resilience. The resilience of the youths in the depression group plays a partial mediating role in the relationship between aggression and non-suicidal self-injury. Conclusion: The more aggressive the behaviors of the depressed youths, the more serious their non-suicidal self-injurious symptoms. Furthermore, resilience plays a partial mediating role in the relationship between aggression and non-suicidal self-injury.

scholarly journals Efficacy and Safety of Chuanxiong Qingnao Granule in Patients with Migraine: A Randomized, Double-Blind, Placebo-Controlled Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Yi-Fan Li ◽  
Hui-Min Hu ◽  
Bo-Ning Wang ◽  
Yi Zhang ◽  
Xing Liu ◽  
...  
Keyword(s):  
Treatment Group ◽  
Migraine Attack ◽  
Controlled Trial ◽  
Depression Scale ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
Efficacy And Safety ◽  
Attack Frequency ◽  
Double Blind ◽  
Double Blind Placebo

Objective. To evaluate the efficacy and safety of Chuanxiong Qingnao Granule (CQG) to treat migraine. Method. This study was a randomized, double-blind, placebo-controlled trial. All migraineurs were recruited and randomly assigned into a treatment group treated with CQG and a control group treated with a placebo. The whole research process included a 4-week baseline, 12-week intervention, and 12-week follow-up. The primary outcome was responder rate, defined as the percentage of migraineurs with 50% or more reduction in the frequency of migraine attack during treatment and posttreatment period compared with the baseline. The secondary outcomes were the number of migraine days, migraine attack frequency, visual analogue scale (VAS), Fatigue Severity Scale (FSS), Hamilton Depression Scale (HAMD), and Migraine Disability Assessment (MIDAS). Results. A total of 346 migraineurs completed the research and were included in the intention-treatment analyses. The response rates differed significantly between the treatment group and the control group (71.5% vs. 12.1% at week 12 and 83.1% vs. 3.4% at week 24). Attack frequency, days of headache attack, VAS, FSS, HAMD, and MIDAS decreased at week 12 in both groups with more reduction in the treatment group ( P < 0.001 ). No severe adverse events were observed in this trial. Conclusion. Chuanxiong Qingnao Granule can significantly improve headache symptoms in patients with migraine while improving disability, fatigue, and depression with a good safety profile.

scholarly journals Treatment of mixed anxiety and depressive disorder: results from a observational study of the efficacy and tolerability of agomelatine

2021 ◽  
Vol 13 (6) ◽  
pp. 48-54
Author(s):  
D. S. Petelin ◽  
I. V. Niinoya ◽  
O. V. Sorokina ◽  
D. V. Troshina ◽  
O. N. Voskresenskaya ◽  
...  
Keyword(s):  
Depressive Disorder ◽  
Short Form ◽  
Depression Scale ◽  
Life Questionnaire ◽  
Hamilton Depression Scale ◽  
Depression And Anxiety ◽  
Workplace Performance ◽  
Symptoms Of Depression ◽  
Hamilton Anxiety Scale

Objective: to study the efficacy, safety and tolerability of agomelatine in mixed anxiety and depressive disorder.Patients and methods. Agomelatine was administered to 30 patients diagnosed with mixed anxiety and depressive disorder for 3 months. The patients' condition was assessed using a battery of psychometric methods – the Hamilton Depression Scale, the Hamilton Anxiety Scale, and a short form of the SF-12v2 quality of life questionnaire.Results and discussion. It was shown that agomelatine effectively reduces both symptoms of depression and anxiety, begins to have a therapeutic effect a week after the start of administration, however, the drug shows the best clinical effect when administered for a period of three months or more. The predictors of complete remission on agomelatine therapy in this sample were: the presence of sleep disorders (early and medium, but not late insomnia), a greater severity of somatized anxiety, the presence of complaints of decreased workplace performance and activity.Conclusion. Our study has shown that agomelatine is an effective, safe and well-tolerated drug in the treatment of mixed anxiety and depressive disorder.

scholarly journals Psychotherapeutic care in the system of comprehensive rehabilitation of persons with limb amputation

2021 ◽  
Author(s):  
L. I. Mostovaya ◽  
E. P. Krivoschekov ◽  
E. B. Elshin ◽  
V. E. Romanov ◽  
M. Y. Khoroshilov
Keyword(s):  
Depression Scale ◽  
Vascular Diseases ◽  
Main Group ◽  
Psychological Help ◽  
Limb Amputation ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
The Difference ◽  
To Receive ◽  
Psychotherapeutic Care

Purpose. Study of the influence of psychotherapeutic assistance on the rehabilitation of persons who have undergone limb amputation.Materials and methods. A study of the psychological characteristics of 48 patients who underwent amputation of the lower extremity was carried out on the basis of the departments of vascular surgery and traumatology of the Samara Seredavin Regional Clinical Hospital. The control group included 25 people (16 men, 9 women), aged 45 to 70 years. Amputations of the extremities were performed by him in connection with the developed gangrene due to obliterating vascular diseases. The main group consisted of 23 people (14 men, 9 women) aged 35 to 60 years with a stable and prosperous social status, who received an acute sudden injury that ended in amputation of one or both lower extremities. The examination was carried out on the 3-5th day of the postoperative period, depending on the patient's condition. For the study, the following psychodiagnostic methods and techniques were used: 1) clinical conversation; 2) coping test by R. Lazarus, S. Folkman; 3) methodology for diagnosing the type of attitude to the disease; 4) Hamilton Depression Scale; 5) S. Rosenzweig's test of drawing frustration.Results. The difference between the group of patients and the control group was statistically confirmed in terms of “seeking social support” (higher in the control group), “confrontation” and “flight – avoidance” (higher in the group of patients) (p < 0.05). In the control group, depression is absent in 85% of the subjects, in 15% of patients there is a mild depressive state (p < 0.05). According to S. Rosenzweig's method, the predominance of extrapunitive reactions was revealed in both groups (E = 59.6 in the main group of patients and 44.1 in the control group) due to reactions of the ego-protective type (ED = 56.2 in the main group of patients and 46.3 – in the control group).Conclusion. Patients who underwent surgery for limb amputation and who took a conscious and active part in individual and group psychotherapy by the time of discharge from the hospital showed a decrease in anxiety and depressive manifestations, a decrease in the manifestations of outward aggression, the construction of optimistic prospects) than in patients who categorically refuse to receive psychological help and support. The provision of psychotherapeutic assistance to persons after amputation of limbs should begin in the first days after the operation. 

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