Association Between ABCA1 (R219K) Polymorphism and Lipid Profiles: A Meta-Analysis

Abstract Background Conflicting evidence was found about the relationship between lipid profiles and R219K in adenosine triphosphate-binding cassette exporter A1 (ABCA1) gene. A meta-analysis was conducted to assess the effect of R219K on lipid level. Methods Multi-database literature search was performed in accordance with PRISMA guidelines. The effect of each study was expressed by standard mean difference (SMD) and 95% confidence interval and pooled by meta-analysis in a random-effects model. Sub-group and meta-regression analyses were also conducted to explore potential heterogeneity sources. Results Overall pooled effect showed that individuals with RR genotype had significantly lower HDLC level (SMD = -0.17 mmol/L, 95% CI: -0.22 ~ -0.12, z = -6.39, P < 0.001) than those with K allele. However, this effect mainly presented in Asians (SMD = -0.24 mmol/L, 95% CI: -0.32 ~ -0.17, z = 6.60, P < 0.001) rather than Caucasian populations, and the difference was significant (Q = 5.20, df = 1, P = 0.02). The relationship between R219K polymorphism and LDLC, TC, and TG levels was not determined. Conclusions R219K polymorphism in the ABCA1 gene was associated with HDLC level in Asian populations in the present meta-analysis. This correlation was not substantially affected by the age, gender or health condition of individuals.

Download Full-text

Relationship between total plasma homocysteine and the risk of aneurysms – a meta-analysis

VASA ◽

10.1024/0301-1526/a000891 ◽

2020 ◽

pp. 1-6

Author(s):

Hanji Zhang ◽

Dexin Yin ◽

Yue Zhao ◽

Yezhou Li ◽

Dejiang Yao ◽

...

Keyword(s):

Large Scale ◽

Meta Analysis ◽

Single Species ◽

Total Plasma ◽

Control Groups ◽

Randomized Controlled ◽

Randomized Controlled Studies ◽

The Difference ◽

The Relationship ◽

Healthy Participants

Summary: Our meta-analysis focused on the relationship between homocysteine (Hcy) level and the incidence of aneurysms and looked at the relationship between smoking, hypertension and aneurysms. A systematic literature search of Pubmed, Web of Science, and Embase databases (up to March 31, 2020) resulted in the identification of 19 studies, including 2,629 aneurysm patients and 6,497 healthy participants. Combined analysis of the included studies showed that number of smoking, hypertension and hyperhomocysteinemia (HHcy) in aneurysm patients was higher than that in the control groups, and the total plasma Hcy level in aneurysm patients was also higher. These findings suggest that smoking, hypertension and HHcy may be risk factors for the development and progression of aneurysms. Although the heterogeneity of meta-analysis was significant, it was found that the heterogeneity might come from the difference between race and disease species through subgroup analysis. Large-scale randomized controlled studies of single species and single disease species are needed in the future to supplement the accuracy of the results.

Download Full-text

The relationship between migraine and infant colic: A systematic review and meta-analysis

Cephalalgia ◽

10.1177/0333102414534326 ◽

2014 ◽

Vol 35 (1) ◽

pp. 63-72 ◽

Cited By ~ 18

Author(s):

Amy A Gelfand ◽

Peter J Goadsby ◽

I Elaine Allen

Keyword(s):

Systematic Review ◽

Random Effects ◽

Odds Ratio ◽

Fixed Effects ◽

Meta Analysis ◽

Random Effects Model ◽

Fixed Effects Model ◽

Primary Analysis ◽

Infant Colic ◽

The Relationship

Context Infant colic is a common and distressing disorder of early infancy. Its etiology is unknown, making treatment challenging. Several articles have suggested a link to migraine. Objective The objective of this article was to perform a systematic review and, if appropriate, a meta-analysis of the studies on the relationship between infant colic and migraine. Data sources Studies were identified by searching PubMed and ScienceDirect and by hand-searching references and conference proceedings. Study selection For the primary analysis, studies specifically designed to measure the association between colic and migraine were included. For the secondary analysis, studies that collected data on colic and migraine but were designed for another primary research question were also included. Data extraction Data were abstracted from the original studies, through communication with study authors, or both. Two authors independently abstracted data. Main outcomes and measures The main outcome measure was the association between infant colic and migraine using both a fixed-effects model and a more conservative random-effects model. Results Three studies were included in the primary analysis; the odds ratio for the association between migraine and infant colic was 6.5 (4.6–8.9, p < 0.001) for the fixed-effects model and 5.6 (3.3–9.5, p = 0.004) for the random-effects model. In a sensitivity analysis wherein the study with the largest effect size was removed, the odds ratio was 3.6 (95% CI 1.7–7.6, p = 0.001) for both the fixed-effects model and random-effects model. Conclusions In this meta-analysis, infant colic was associated with increased odds of migraine. If infant colic is a migrainous disorder, this would have important implications for treatment. The main limitation of this meta-analysis was the relatively small number of studies included.

Download Full-text

Serum Sclerostin Levels in Patients with Ankylosing Spondylitis and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

BioMed Research International ◽

10.1155/2017/9295313 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7 ◽

Cited By ~ 7

Author(s):

Jianfeng Shi ◽

Haijian Ying ◽

Juping Du ◽

Bo Shen

Keyword(s):

Rheumatoid Arthritis ◽

Systematic Review ◽

Ankylosing Spondylitis ◽

Meta Analysis ◽

Cochrane Library ◽

Healthy Controls ◽

Data Analyses ◽

Standard Mean Difference ◽

The Difference ◽

Sclerostin Level

Objective. Current studies of serum sclerostin levels in AS and RA patients are inconsistent. This meta-analysis was performed to identify the association of serum sclerostin level with AS and RA patients. Methods. Embase, PubMed, MEDLINE, and Cochrane Library databases (up to 25 January 2017) were used to collect all relevant published articles. Studies were pooled and standard mean difference (SMD) with 95% confidence interval (CI) was calculated. All data analyses were performed using RevMan 5.3. Results. Totally eight studies of AS including 420 AS patients and 317 healthy controls (HC) and three studies of RA including 145 RA patients and 127 HC were finally included in this meta-analysis. The results revealed that the serum sclerostin levels in both AS patients (SMD=-0.14; 95% CI=[-0.39,0.11]; P=0.28) and RA patients (SMD=-0.10; 95% CI=[-0.34,0.15]; P=0.43) were not significantly different from those in HC. Conclusion. The difference of serum sclerostin levels in AS and RA patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of AS and RA.

Download Full-text

Association between fish intake and glioma risk: a systematic review and meta-analysis

Journal of International Medical Research ◽

10.1177/0300060520939695 ◽

2020 ◽

Vol 48 (8) ◽

pp. 030006052093969

Author(s):

Honcho Lei ◽

Chiho To ◽

Unpeng Lei

Keyword(s):

Effect Size ◽

Observational Studies ◽

Web Of Science ◽

Meta Analysis ◽

Fish Intake ◽

Random Effects Model ◽

Eligibility Criteria ◽

Fresh Fish ◽

Glioma Risk ◽

The Relationship

Objectives We investigated the association between the consumption of fresh and processed fish and glioma risk using a meta-analysis approach. Methods We selected and analyzed observational studies that discussed the relationships between fresh and processed fish intake on glioma risk from PubMed, Web of Science, Embase, and the SinoMed and Wanfang databases from inception to 31 March 2020. Studies were selected according to pre-established eligibility criteria and data were extracted separately by two researchers. A meta-analysis was conducted based on a random-effects model to provide pooled odds ratios (OR) and 95% confidence intervals (CIs). Results Eight studies considered the relationship between fish intake (seven fresh and seven processed fish) and glioma risk and were included in this meta-analysis. The OR effect size for fresh fish intake and glioma risk was 0.72 (95%CI 0.53–0.97) and the overall OR effect size for processed fish intake and glioma risk was 1.88 (95%CI 1.06–3.34). Conclusion Dietary intake of fresh fish may reduce the risk of glioma, but consumption of processed fish may increase the risk of glioma. This study had some limitations, and further studies are therefore required to clarify the associations between fish intake and glioma risk.

Download Full-text

Comparison of the efficacy and safety between dezocine injection and morphine injection for persistence of pain in Chinese cancer patients: a meta-analysis

Bioscience Reports ◽

10.1042/bsr20170243 ◽

2017 ◽

Vol 37 (3) ◽

Cited By ~ 4

Author(s):

Lei Wang ◽

Xudong Liu ◽

Jianfeng Wang ◽

Yingjiao Sun ◽

Guozhuan Zhang ◽

...

Keyword(s):

Meta Analysis ◽

Statistical Significance ◽

Morphine Injection ◽

Efficacy And Safety ◽

Patients With Cancer ◽

Study Heterogeneity ◽

The Difference ◽

Effective Pain Relief ◽

Chinese Cancer Patients ◽

The Relationship

The association between the efficacy and safety of dezocine injection and morphine injection for persistence of pain in patients with cancer had yielded controversial results. Therefore, we conduct a meta-analysis of existing observational published studies to assess the relationship between them among Chinese. We conducted a comprehensive research from the databases of PubMed, Web of Science, and Wan Fang Med Online for the related studies up to October 2016. Summary odds ratio (OR) with 95% confidence interval (95% CI) were calculated with the random effects model. Nine published studies comprising 333 dezocine injection patients and 321 morphine injection patients were included in this meta-analysis. Our results suggested that there was no statistical significance between dezocine injection and morphine injection at the case number of effective pain relief (EPR) [OR = 0.97, 95% CI (0.77–1.22), I2 = 0.0, P for heterogeneity = 1.000]. However, the rate of adverse drug reaction (ADR) caused by dezocine injection was 56% less than that caused by morphine injection, the difference was statistically significant [OR = 0.44, 95% CI (0.30–0.65), I2 = 0.0, P for heterogeneity = 0.980]. No between-study heterogeneity and publication bias were found. In conclusions, this meta-analysis indicates that there is no significant association on the efficacy of persistence of pain in patients with cancer between dezocine injection and morphine injection among Chinese. However, dezocine injection was with less ADR compared with morphine injection.

Download Full-text

Relationship Between Dietary Omega-3 and Omega-6 Polyunsaturated Fatty Acids Level and Sarcopenia. A Meta-Analysis of Observational Studies

Frontiers in Nutrition ◽

10.3389/fnut.2021.738083 ◽

2022 ◽

Vol 8 ◽

Author(s):

Yi Zhang ◽

Hongbin Guo ◽

Jieyu Liang ◽

Wenfeng Xiao ◽

Yusheng Li

Keyword(s):

Fatty Acids ◽

Polyunsaturated Fatty Acids ◽

Observational Studies ◽

Meta Analysis ◽

Current Evidence ◽

Omega 3 ◽

Control Subjects ◽

Standard Mean Difference ◽

Omega 6 ◽

The Relationship

Objective: This study investigates the relationship between dietary omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) levels and sarcopenia.Methods: A comprehensive literature search in the databases of PubMed, Web of Science, and Embase (up to July 2021) were conducted to identify the observational studies on the relationship between dietary omega-3 and omega-6 PUFAs level and sarcopenia. The pooled odds ratio (OR) of sarcopenia for the highest vs. lowest dietary omega-3 and omega-6 PUFAs level and the standard mean difference (SMD) of dietary omega-3 and omega-6 PUFAs levels for sarcopenia vs. control subjects were calculated.Results: A total of six studies were identified in this meta-analysis. The overall multi-variable adjusted OR showed that dietary omega-3 PUFAs level was inversely associated with sarcopenia (OR = 0.41, 95% CI: 0.26–0.65; P = 0.0001). Moreover, the overall combined SMD showed that the dietary omega-3 PUFAs level in sarcopenia was lower than that in control subjects (SMD = −0.19, 95% CI: −0.32 to −0.07; P = 0.002). With regard to dietary omega-6 PUFAs level, the overall multi-variable adjusted OR suggested no significant relationship between dietary omega-6 PUFAs level and sarcopenia (OR = 0.64, 95% CI: 0.33–1.24; P = 0.19). However, the overall combined SMD showed that the dietary omega-6 PUFAs level in sarcopenia was slightly lower than that in control subjects (SMD = −0.15, 95% CI: −0.27 to −0.02; P = 0.02).Conclusion: Our results suggested that the dietary omega-3 PUFAs level was inversely associated with sarcopenia. However, current evidence is still insufficient to demonstrate the definite relationship between dietary omega-6 PUFAs levels and sarcopenia. More well-designed prospective cohort studies with the dietary omega-3/omega-6 PUFAs ratio are still needed.

Download Full-text

Associations of m.5178C>A variant with serum lipids levels: A systematic review and meta-analysis

Bioscience Reports ◽

10.1042/bsr20212246 ◽

2021 ◽

Author(s):

Fuqiang Liu ◽

Jiyun He ◽

Shengping Wang ◽

Feng Yu ◽

Zhi Luo

Keyword(s):

Meta Analysis ◽

Low Density Lipoprotein ◽

Population Attributable Risk ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Chinese Populations ◽

Asian Populations ◽

Standard Mean Difference ◽

Artery Disease ◽

Cad Risk

Background: Emerging evidence shows that m.5178C>A variant is associated with a lower risk of coronary artery disease (CAD). However, the specific mechanisms remain elusive. Since dyslipidemia is one of the most critical risk factors for CAD and accounts for at least 50% of the population-attributable risk, it is tempting to speculate that the reduced CAD risk caused by the m.5178C>A variant may stem from an improved lipid profile. In order to verify this hypothesis, we conducted this study to clarify the associations of m.5178C>A variant with lipid levels.  Methods: By searching ten databases for studies published before June 30, 2021. Thirteen East Asian populations (7,587 individuals) were included for the analysis.</p>  Results: The present study showed that m.5178C>A variant was associated with higher high-density lipoprotein cholesterol (HDL-C) [standard mean difference (SMD) = 0.12, 95% CI = 0.06—0.17, P< 0.001] and total cholesterol (TC) (SMD = 0.08, 95% CI = 0.02—0.14, P= 0.01) levels. In subgroup analysis, the association of m.5178C>A variant with higher HDL-C levels were observed in Japanese (SMD = 0.09, 95% CI = 0.01—0.17, P= 0.03) and Chinese populations (SMD = 0.13, 95% CI = 0.07—0.20, P< 0.001). However, the association of m.5178C>A variant with lower low-density lipoprotein cholesterol (LDL-C) levels were only observed in Japanese populations (SMD = -0.11, 95% CI = -0.22—-0.00, P= 0.04).</p>  Conclusions: The m.5178C>A variant was associated with higher HDL-C and lower LDL-C levels in Japanese populations, which may contribute to decreased CAD risk and longevity of Japanese.

Download Full-text

The Value of Epicardial Adipose Tissue for the Patients Treated with Percutaneous Coronary Intervention: A Systemic Review and Meta-analysis

10.21203/rs.3.rs-80640/v1 ◽

2020 ◽

Author(s):

Tan Xu ◽

Ming Xu

Keyword(s):

Percutaneous Coronary Intervention ◽

Adipose Tissue ◽

Infarct Size ◽

Epicardial Adipose Tissue ◽

Meta Analysis ◽

Coronary Intervention ◽

Systemic Review ◽

Standard Mean Difference ◽

Percutaneous Coronary ◽

The Relationship

Abstract BackgroundAccumulating evidences suggest that the prognostic value of epicardial adipose tissue (EAT) on no-reflow, in-stent restenosis (ISR), infarct size, and main adverse cardiovascular events (MACE) for the patients treated with percutaneous coronary intervention (PCI). The relationship between EAT and outcomes of patients underwent PCI is still partly elusive. MethodsTo elucidate the relationship in detail, we searched PubMed, web of science, and the Cochrane Library for studies evaluating the association of EAT and patients treated with PCI. Thirteen studies enrolling 3683 patients were eventually include in our systemic review and meta-analysis. ResultsThe EAT measured by thickness or volume was significantly higher in the ISR group compared to those in the non-ISR group (The standard mean difference -0.34, 95% CI, -0.49, -0.18, p <0.0001; I2 =36%). The incidence of no-reflow was significantly higher in thicker EAT group compared to thin EAT group (pooled relative ratio 1.52, 95%CI 1.29-1,80, p <0.0001; I2 =0%). Thicker EAT was significantly associated with MACEs (pooled relative ratio 1.50, 95% 1.18-1.90, p =0.008). A lower EAT volume is associated with larger infarct size in ST elevated myocardial infarction patients treated with primary PCI (standard mean difference was -5.45, 95% CI -8.10, -2.80; p <0.0001; I2 =0%). In summary, our systemic review and meta-analysis suggest that high EAT is related with a significant increased risk of non-reflow, MACE and decreased infarct size in patients with coronary artery disease treated with PCI. This paradox phenomenon demonstrates that the quality of EAT may play more important role than the solely thickness or volume of EAT.

Download Full-text

Meta Analysis of Study Habits and Academic Achievement

Shanlax International Journal of Arts, Science and Humanities ◽

10.34293/sijash.v8i4.3722 ◽

2021 ◽

Vol 8 (4) ◽

pp. 139-145

Author(s):

M Elango ◽

G Manimozhi

Keyword(s):

College Students ◽

Academic Achievement ◽

Random Effects ◽

Fixed Effects ◽

Meta Analysis ◽

Study Habits ◽

Random Effects Model ◽

Inclusion Criteria ◽

Analytical Review ◽

The Relationship

A Meta analytical review investigated the study habits and academic achievement of school and college students. In this study the sample consists of twenty seven reviews based on study habits and academic achievement/ performance. The sample of the review based on inclusion criteria such as study habits and academic achievement. The review was collected by following details such as title of the study, Name of the author, Sample of the study, correlation Value and findings of the study. The Meta analysis is on the relationship between study habits and academic achievement. The main aim of the study is to find the fixed effects, random effects model values, Heterogeneity and forest plots. A Meta analysis of research paper was formed the conclusion.

Download Full-text

Transmission routes of influenza A(H1N1)pdm09: analyses of inflight outbreaks

Epidemiology and Infection ◽

10.1017/s0950268818001772 ◽

2018 ◽

Vol 146 (13) ◽

pp. 1731-1739 ◽

Cited By ~ 3

Author(s):

H. Lei ◽

J. W. Tang ◽

Y. Li

Keyword(s):

Influenza A ◽

Index Case ◽

Meta Analysis ◽

Convincing Evidence ◽

Flight Duration ◽

Influenza A H1n1 ◽

Outbreak Investigations ◽

The Difference ◽

The Relationship ◽

Index Cases

AbstractKnowledge about the infection transmission routes is significant for developing effective intervention strategies. We searched the PubMed databases and identified 10 studies with 14 possible inflight influenza A(H1N1)pdm09 outbreaks. Considering the different mechanisms of the large-droplet and airborne routes, a meta-analysis of the outbreak data was carried out to study the difference in attack rates for passengers within and beyond two rows of the index case(s). We also explored the relationship between the attack rates and the flight duration and/or total infectivity of the index case(s). The risk ratios for passengers seated within and beyond the two rows of the index cases were 1.7 (95% confidence interval (CI) 0.98–2.84) for syndromic secondary cases and 4.3 (95% CI 1.25–14.54) for laboratory-confirmed secondary cases. Furthermore, with an increase of the product of the flight duration and the total infectivity of the index cases, the overall attack rate increased linearly. The study indicates that influenza A(H1N1)pdm09 may mainly be transmitted via the airborne route during air travel. A standardised approach for the reporting of such inflight outbreak investigations would help to provide more convincing evidence for such inflight transmission events.

Download Full-text