scholarly journals Screening of cognitive impairment in childhood acute lymphoblastic leukemia survivors with P300 event-related potentials: comparison of different treatment protocols.

2020 ◽  
Author(s):  
Slawomir Kroczka ◽  
Konrad Stepien ◽  
Szymon Skoczen
Keyword(s):  
Cognitive Impairment ◽  
Acute Lymphoblastic Leukemia ◽  
Reaction Time ◽  
Lymphoblastic Leukemia ◽  
Event Related Potentials ◽  
Control Group ◽  
Treatment Protocols ◽  
P300 Potentials ◽  
Related Potentials ◽  
The Mean

Abstract BackgroundModern treatment protocols in childhood acute lymphoblastic leukemia (ALL) resulted in high cure rate and improved long-term survival. However, due to their high intensity, they are also associated with many side effects, including central nervous system toxicity. The aim of our study was to evaluate the use of P300 event-related potentials in screening of cognitive impairment in childhood ALL survivors.MethodsA group of 136 patients, 66 males (48.5%), aged 4.9 to 27.9 years who have completed ALL therapy, were screened for cognitive impairment with endogenous P300 potentials. ALL therapy was conducted according to modified New York (NY) (30 patients) and subsequent revisions of modified Berlin-Frankfurt-Münster (BFM): previous BFM protocols (pBFM) (32 patients) and BFM95 (74 patients). The control group consisted of 58 patients, 34 males (58.6%), aged 6 to 17 years after a syncope episode (n = 29) as well as healthy subjects (n = 29).ResultsThe total group of ALL survivors had significantly prolonged the mean latency of P300 (331.31 vs 298.14 ms, P < 0.001) and reaction time (439.51 vs 380.11 ms, P = 0.002) compared to the control group. Abnormalities in endogenous evoked potentials were observed in 10 (33.33%) NY, 5 (15.63%) pBFM and 21 (28.38%) BFM95 patients. The mean latency time was significantly longer compared to the control group (298.14 ms) in all analyzed protocols and the highest values were observed in pBFM patients (NY: 329.13 ms, P = 0.001; pBFM: 332.97 ms, P < 0.001; BFM95: 331.47 ms, P < 0.001). The reaction time was similarly prolonged compared to the control group. The largest and also significant prolongation was recorded in the NY group (461.8 vs 380.1 ms, P = 0.039).Analyzing the effect of radiotherapy on P300 potentials, a significantly higher frequency of prolonged reaction time in non-irradiated BFM95 patients was found (21.62 vs 15.85%, P=0.007). Radiotherapy methods used in NY and pBFM protocols have also significantly reduced the P300 wave amplitude (mean values: 10.395 vs 12.739 ms, P=0.027).ConclusionsEndogenous P300 event-related potentials may be useful in screening assessment of late cognitive impairment in ALL survivors. The type of treatment protocol significantly modulates the individual parameters of the registered P300 potentials.

scholarly journals Screening of subclinical P300 event-related potentials changes in childhood acute lymphoblastic leukemia survivors: comparison of different treatment protocols.

2020 ◽  
Author(s):  
Slawomir Kroczka ◽  
Konrad Stepien ◽  
Szymon Skoczen
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Reaction Time ◽  
Lymphoblastic Leukemia ◽  
Event Related Potentials ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Control Group ◽  
Treatment Protocols ◽  
P300 Potentials ◽  
Related Potentials ◽  
The Mean

Abstract Background: Modern treatment protocols in childhood acute lymphoblastic leukemia (ALL) resulted in high cure rate and improved long-term survival. However, due to their high intensity, they are also associated with many side effects, including central nervous system toxicity. The aim of our study was to evaluate the use of screening of subclinical P300 event-related potentials changes in childhood ALL survivors. Methods: A group of 136 patients, 66 males (48.5%), aged 4.9 to 27.9 years who have completed ALL therapy, were screened for subclinical P300 potentials changes. ALL therapy was conducted according to modified New York (NY) (30 patients) and subsequent revisions of modified Berlin-Frankfurt-Münster (BFM): previous BFM protocols (pBFM) (32 patients) and BFM95 (74 patients). The control group consisted of 58 patients, 34 males (58.6%), aged 6 to 17 years after a syncope episode (n=29) as well as healthy subjects (n=29). Results: The total group of ALL survivors had significantly prolonged the mean latency of P300 (331.31±28.71 vs 298.14±38.76 ms, P<0.001) and reaction time (439.51±119.86 vs 380.11±79.94 ms, P=0.002) compared to the control group. Abnormalities in endogenous evoked potentials were observed in 10 (33.33%) NY, 5 (15.63%) pBFM and 21 (28.38%) BFM95 patients. The mean latency time was significantly longer compared to the control group in all analyzed protocols and the highest values were observed in pBFM patients (NY: 329.13±28.07 ms, P=0.001; pBFM: 332.97±23.97 ms, P<0.001; BFM95: 331.47±31.05 ms, P<0.001). The reaction time was similarly prolonged compared to the control group. The largest and also significant prolongation was recorded in the NY group (461.8±140.3 vs 380.1±78.04 ms, P=0.039). Analyzing the effect of radiotherapy on P300 potentials, a significantly higher frequency of prolonged reaction time in non-irradiated BFM95 patients was found (21.62 vs 15.85%, P=0.007). Radiotherapy methods used in NY and pBFM protocols have also significantly reduced the P300 wave amplitude (mean values: 10.395±5.727 vs 12.739±6.508 ms, P=0.027). Conclusions: Endogenous P300 event-related potentials may be useful in screening assessment of late subclinical cognitive changes in ALL survivors. The type of treatment protocol significantly modulates the individual parameters of the registered P300 potentials.

scholarly journals The Influence of Subclinical Neck Pain on Neurophysiological and Behavioral Measures of Multisensory Integration

2019 ◽  
Vol 9 (12) ◽  
pp. 362
Author(s):  
Antonia M. Karellas ◽  
Paul Yielder ◽  
James J. Burkitt ◽  
Heather S. McCracken ◽  
Bernadette A. Murphy
Keyword(s):  
Reaction Time ◽  
Neck Pain ◽  
Multisensory Integration ◽  
Performance Measures ◽  
Brain Activity ◽  
Event Related Potentials ◽  
Control Group ◽  
Neural Processing ◽  
Significant Group ◽  
Related Potentials

Multisensory integration (MSI) is necessary for the efficient execution of many everyday tasks. Alterations in sensorimotor integration (SMI) have been observed in individuals with subclinical neck pain (SCNP). Altered audiovisual MSI has previously been demonstrated in this population using performance measures, such as reaction time. However, neurophysiological techniques have not been combined with performance measures in the SCNP population to determine differences in neural processing that may contribute to these behavioral characteristics. Electroencephalography (EEG) event-related potentials (ERPs) have been successfully used in recent MSI studies to show differences in neural processing between different clinical populations. This study combined behavioral and ERP measures to characterize MSI differences between healthy and SCNP groups. EEG was recorded as 24 participants performed 8 blocks of a simple reaction time (RT) MSI task, with each block consisting of 34 auditory (A), visual (V), and audiovisual (AV) trials. Participants responded to the stimuli by pressing a response key. Both groups responded fastest to the AV condition. The healthy group demonstrated significantly faster RTs for the AV and V conditions. There were significant group differences in neural activity from 100–140 ms post-stimulus onset, with the control group demonstrating greater MSI. Differences in brain activity and RT between individuals with SCNP and a control group indicate neurophysiological alterations in how individuals with SCNP process audiovisual stimuli. This suggests that SCNP alters MSI. This study presents novel EEG findings that demonstrate MSI differences in a group of individuals with SCNP.

Investigation of Epidemiologic Factors in Children with Acute Lymphoblastic Leukemia

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 3948-3948
Author(s):  
Oznur Yilmaz ◽  
Cetin Timur ◽  
Asim Yoruk ◽  
Muferet Erguven ◽  
Elif Aktekin ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Ventilatory Support ◽  
Control Group ◽  
Healthy Children ◽  
High Concentration ◽  
Pediatric Hematology ◽  
Epidemiologic Factors ◽  
Significant Difference ◽  
The Mean

Abstract In this study, we aimed to investigate epidemiologic factors in children with Acute Lymphoblastic leukemia (ALL). The parents of 105 children diagnosed and treated as ALL between the years 1997 –2007 in our Clinic of Pediatric Hematology-Oncology were questioned and results were compared with control group that consisted of 102 healthy children with similar age and gender. The mean age of the patients was 8.57 ± 3.95 years. The mean age at diagnosis was 5.87 ± 3.73 years. There was no significant difference between the groups in terms of type of delivery, birth weight, asphyxia at birth, resuscitation with high-concentration oxygen and ventilatory support (p&gt;0.05). There was also no significant difference between the groups in terms of duration of breast feeding. The rate of exposure to infections prior to diagnosis was higher in control group (p:0.003). Besides that, the rate of going to nursery was also significantly higher in control group (p:0.014). There was no difference between the groups in terms of X-ray exposure (p&gt;0.05). In conclusion over-protection from infectious agents in and delay in meeting with some specific agents seems to increase ALL risk. Infections in early infantile period can be protective against leukemia. There has to be more extended studies on this subject.

scholarly journals Event-related potentials (P300) and neuropsychological assessment in boys exhibiting Duchenne muscular dystrophy

2007 ◽  
Vol 65 (1) ◽  
pp. 59-62 ◽  
Author(s):  
Marcus Vinicius Della Coletta ◽  
Rosana Herminia Scola ◽  
Gislaine Richter Minhoto Wiemes ◽  
Cláudia Nasser Fonseca ◽  
Maria Joana Mäder ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Neuropsychological Test ◽  
Event Related Potentials ◽  
Poor Performance ◽  
Control Group ◽  
Test Results ◽  
Neuropsychological Dysfunction ◽  
P300 Potentials ◽  
Related Potentials

OBJECTIVE: To examine auditory cognitive evoked potentials (P300 potentials) and neuropsychological dysfunction in patients with Duchenne muscular dystrophy (DMD). METHOD: P300 potentials and neuropsychological test results were obtained from 16 healthy control boys and 20 DMD patients. Full Intelligence Quotients (IQ) were estimated for patients and control group. Mean age was 9.5 years in the DMD patient group, and 10 years in the control group (p>0.05). RESULTS: The mean IQ values were 64.35 in the DMD patients and 82.68 in the control group (p=0.01). Mean P300 values were 347.6 in the DMD group and 337.4 in the control group (p=0.14). There was no significant correlation between parameters in each group. CONCLUSION: DMD patients showed a poor performance as evaluated by P300 potential compared to the control group, although the difference was not statistically significant. Systematic alterations in neuropsychological test results were found, the differences paralleling those detected in IQ.

scholarly journals Auditory P300 Event-Related Potentials in Children with Sydenham?s Chorea

2014 ◽  
Vol 72 (8) ◽  
pp. 603-608 ◽  
Author(s):  
Hasan Hüseyin Ozdemir ◽  
Kaan Demiroren ◽  
Caner F. Demir ◽  
Mine Hapsen Serin
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Processing ◽  
Event Related Potentials ◽  
Control Group ◽  
Healthy Children ◽  
Auditory P300 ◽  
Significant Prolongation ◽  
Significant Difference ◽  
Related Potentials ◽  
Auditory Erps

P300 event-related potentials (ERPs), objective measures related to cognitive processing, have not been studied in Sydenham’s chorea (SC) patients. Purpose: To assess cognitive impairment with P300 ERPs. Method: Seventeen patients with SC and 20 unaffected healthy children were included. Stanford–Binet test was used for psychometric assessment, and odd-ball paradigm was used for auditory ERPs. Results: There was no significant difference in P300 latencies between the SC-pretreatment group, SC-posttreatment group and control group (p>0.05). Mean interpeak latencies in SC-pretreatment group and SC-posttreatment group showed significant prolongation compared with the control group (p<0.05). Mean interpeak latencies in SC-posttreatment group were significantly decreased compared with SC-pretreatment group (p<0.05). Compared to controls, patients did not show significant difference in Stanford-Binet intelligence examination. Conclusion: This report suggests that interpeak latencies and amplitudes of P300 ERPs could be useful for detecting and monitoring cognitive impairment in SC patients.

The Effects of 43 Hours of Sleep Deprivation on Executive Control Functions: Event-Related Potentials in a Visual Go/No Go Task

2010 ◽  
Vol 38 (1) ◽  
pp. 29-42 ◽  
Author(s):  
Jian-Lin Qi ◽  
Yong-Cong Shao ◽  
Danmin Miao ◽  
Ming Fan ◽  
Guo-Hua Bi ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Executive Control ◽  
Event Related Potentials ◽  
Control Group ◽  
Control Functions ◽  
Correct Reaction ◽  
Related Potentials ◽  
The Mean ◽  
Eeg Recordings ◽  
Electroencephalogram Eeg

The aim of this study was to investigate how 43 hours of total sleep deprivation (TSD) influences executive control functions. Forty participants were assigned to either a TSD or a control group (no sleep deprivation; NSD group) and both groups were tested at 2:00am on day 3 (after 43 hours of sleep deprivation for the TSD group). Electroencephalogram (EEG) recordings were taken using 32 electrodes while a Go/No go task was administered. The amplitude of the N2 was significantly larger on the No-go trials as compared to the Go trials. In the No-go trials, the amplitudes of the No go-N2 and the No go-P3 were smaller in the TSD group than in the control group in terms of prolonged latencies. The mean correct reaction time, number of misses, and the false-alarm rate were also significantly longer and increased in the NSD group. Results indicated that executive control functions were noticeable impaired after 43 hours of sleep deprivation.

Serum Osteopontin Growth hormone , and Other Biochemical Parameters in Children with Acute Lymphoblastic Leukemia

2011 ◽  
Vol 7 (1) ◽  
pp. 1169-1174 ◽  
Author(s):  
Atheer A. Mehde ◽  
Wesen A. Mehdi ◽  
Karima F. Ali
Keyword(s):  
Growth Hormone ◽  
Acute Lymphoblastic Leukemia ◽  
Biochemical Parameters ◽  
Lymphoblastic Leukemia ◽  
White Blood Cells ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
Control Group ◽  
Surface Receptors ◽  
The Mean

Acute lymphoblastic leukemia (ALL) is a custom of leukemia, or cancer of the white blood cells categorized by excess lymphoblasts and Chemotherapy is the initial treatment of choice. Most ALL patients will receive a combination of different treatments.Osteopontin (OPN) is a glycoprotein that cooperates with a variety of cell surface receptors, as well as several integrins and CD44. OPN is secreted by numerous human malignancies. We aimed to evaluate serum levels of osteopontin and growth hormone(GH) in patients with Acute lymphoblastic leukemia in childhood. We studied serum levels of OPN ,GH and other biochemical levels of 60 patients that diagnosis as  acute lymphoblastic leukemia.      The mean levels of OPN were significantly higher in patients (10.00± 1.15 ng/ml) than in control (7.62± 0.60 ng/ml). The mean levels of GH levels were significantly lower in patients (2.98± 0.51ng/dl) than in control  (6.02± 1.00 ng/dl. The mean levels of the iron and total protein  in ALL patients  were (95.78± 10.11 µg/dl), (6.08 ± 1.16 g/dl)respectively. The present study  showed a significant  negative correlation between GH with  osteopontin (OPN) ,while there a positive significant  correlate  between GH with  hemoglobin  in patients group compared to control group. The present study Conclude that elevated levels of osteopontin and decreased GH levels at the diagnosis may predict an unfavorable result in  ALL childhood .

STIMULUS-LOCKED LATERALIZED READINESS POTENTIAL AND PERFORMANCE: USEFUL MARKERS FOR DIFFERENTIATING BETWEEN AMNESTIC SUBTYPES OF MILD COGNITIVE IMPAIRMENT

2016 ◽  
pp. 1-8
Author(s):  
S. Cid-Fernández ◽  
M. Lindín ◽  
F. Díaz
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Sensitivity And Specificity ◽  
Response Selection ◽  
Event Related Potentials ◽  
Control Group ◽  
Neurocognitive Deficits ◽  
Compensatory Mechanisms ◽  
Cross Sectional ◽  
Related Potentials

BACKGROUND: The findings of previous studies, in which event-related potentials (ERPs) related to stimulus evaluation were measured, do not fully explain the behavioral decline observed in amnestic mild cognitive impairment (aMCI; prodromal stage of Alzheimer’s Disease). OBJECTIVES: Motor ERPs were evaluated in this study with the aim of discovering complementary explanations and identifying aMCI biomarkers. DESIGN: Cross-sectional study. SETTING: Santiago de Compostela, Galicia, Spain. PARTICIPANTS: Nineteen healthy control (52-81 years old), 21 single-domain aMCI (sdaMCI; 51-87 years old) and 12 multi-domain aMCI (mdaMCI, 62-85 years old) adults. MEASUREMENTS: Reaction times (RTs), percentage of hits, and stimulus-locked and response-locked lateralized readiness potentials (sLRP and rLRP, indexes of response selection and preparation) were evaluated. RESULTS: mdaMCI participants showed longer RTs than control adults and less hits than control and sdaMCI participants. In addition, the mdaMCI group showed lower sLRP amplitudes than the control participants, and the sdaMCI group showed longer sLRP peak latencies. CONCLUSIONS: Control and sdaMCI groups did not differ in relation to RTs or hits, although sLRP peak latencies (sensitivity and specificity >.73) were longer in the sdaMCI group, which may be a sign of compensatory mechanisms or early indication of a decline in motor control. RTs were longer and sLRP amplitudes were smaller in the mdaMCI than in the Control group, and mdaMCI scored fewer hits than control and sdaMCI participants, indicating behavioral and neurocognitive deficits. The combination of hits and RTs discriminated mdaMCI from control adults (sensitivity and specificity >.82); and the combination of sLRP peak latency and hits discriminated mdaMCI from sdaMCI adults (sensitivity=1.00, specificity=.88).

scholarly journals Quantitative Determination of Serum Level of TLR4, TLR7 and TLR9 in Pediatric Acute Lymphoblastic Leukemia (ALL) Patients in Basrah, Iraq

2021 ◽  
Vol 14 (4) ◽  
pp. 2255-2260
Author(s):  
Rasha Adnan Mustafa ◽  
Hanadi Abdulqader Jasim ◽  
Sadeq Khalaf Ali Al-Salait
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Serum Level ◽  
Lymphoblastic Leukemia ◽  
Mean Value ◽  
Control Group ◽  
P Value ◽  
Serum Samples ◽  
Immune Evasion Mechanism ◽  
The Mean ◽  
The Difference

Acute Lymphoblastic Leukemia (ALL) is one of most frequent malignancy detected in children, accounting for three quarters of all leukemia occurrences in children. Toll-Like Receptors (TLRs) have been shown to be expressed or up regulated in tumors (solid) and tumor cell lines, but their expression level or role in the etiology and progression of acute lymphoblastic leukemia in children is not studied widely. This study intended to explore the association of serum level of TLR4, TLR7, and TLR9 in children with acute lymphoblastic leukemia. A case control study was conducted on patients (pediatric) with ALL who have been admitted to Basrah Children Specialty Hospital, Basrah, Iraq. Three ml of serum samples were collected for the measurement of TLRs concentration by using Sandwich Enzyme-Linked Immuno Sorbent Assay (ELISA). The mean level of TLR4, TLR7 and TLR9 in patients were higher than the control group. However, the difference was statistically significant for TLR4 and TLR7 (P-value less than 0.005) but not for TLR9. The mean value of TLRs are higher in the newly diagnosed group than the relapse. The higher serum concentration of TLR4, TLR7 and TLR9 in patients, whether new or in relapse, compared to control group might be part of the immune-evasion mechanism developed by the malignant cells that plays a serious role in leukomogenicity and disease advancement.

scholarly journals The Evaluation of Cognitive Impairment in Alcohol-Dependent Patients Through RBANS Combined With ERPs

2021 ◽  
Vol 11 ◽  
Author(s):  
Hui Cao ◽  
Chao Hou ◽  
Saiping Huang ◽  
Xiafeng Zhou ◽  
Jun Yang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Alcohol Dependence ◽  
Normal Control ◽  
Event Related Potentials ◽  
Normal Control Group ◽  
Control Group ◽  
P300 Latency ◽  
Neuropsychological Status ◽  
Related Potentials ◽  
Attention Function

Background: Recently, the cognitive impairment of patients with alcohol dependence has attracted more and more attention. The combination of Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and event-related potentials (ERPs) for evaluating the degree of cognitive impairment in patients with alcohol dependence has not undergone enough in-depth investigation.Method: Sixty patients with alcohol dependence were selected as alcohol-dependence group, whereas 40 healthy volunteers served as a normal control group. The original scores of the RBANS sub-items, the incubation period, and volatility of ERPs between the two groups were compared, and the correlation among the above indicators in the alcohol-dependence group was further analyzed.Results: The RBANS test showed that the original scores of speech function, attention function, delayed memory, and immediate attention in the alcohol-dependence group were significantly lower than those in the normal control group. Compared with the normal control group, the latencies of P200 and P300 in the alcohol-dependence group were significantly prolonged, and the amplitude of P200 and P300 was significantly reduced. Correlation analysis between RBANS and ERPs in alcohol-dependence group showed that immediate attention score was positively correlated with P300 and P200 amplitude, visual breadth score was positively correlated with P200 latency, and attention function score was negatively correlated with P300 latency.Conclusion: As RBANS scale was highly correlated with the results of ERPs, the combined use of these two scales may serve as an objective basis for early diagnosis of cognitive impairment in patients with alcohol dependence.

Sign in / Sign up

Export Citation Format

Share Document