scholarly journals Quantitative Determination of Serum Level of TLR4, TLR7 and TLR9 in Pediatric Acute Lymphoblastic Leukemia (ALL) Patients in Basrah, Iraq

2021 ◽  
Vol 14 (4) ◽  
pp. 2255-2260
Author(s):  
Rasha Adnan Mustafa ◽  
Hanadi Abdulqader Jasim ◽  
Sadeq Khalaf Ali Al-Salait
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Serum Level ◽  
Lymphoblastic Leukemia ◽  
Mean Value ◽  
Control Group ◽  
P Value ◽  
Serum Samples ◽  
Immune Evasion Mechanism ◽  
The Mean ◽  
The Difference

Acute Lymphoblastic Leukemia (ALL) is one of most frequent malignancy detected in children, accounting for three quarters of all leukemia occurrences in children. Toll-Like Receptors (TLRs) have been shown to be expressed or up regulated in tumors (solid) and tumor cell lines, but their expression level or role in the etiology and progression of acute lymphoblastic leukemia in children is not studied widely. This study intended to explore the association of serum level of TLR4, TLR7, and TLR9 in children with acute lymphoblastic leukemia. A case control study was conducted on patients (pediatric) with ALL who have been admitted to Basrah Children Specialty Hospital, Basrah, Iraq. Three ml of serum samples were collected for the measurement of TLRs concentration by using Sandwich Enzyme-Linked Immuno Sorbent Assay (ELISA). The mean level of TLR4, TLR7 and TLR9 in patients were higher than the control group. However, the difference was statistically significant for TLR4 and TLR7 (P-value less than 0.005) but not for TLR9. The mean value of TLRs are higher in the newly diagnosed group than the relapse. The higher serum concentration of TLR4, TLR7 and TLR9 in patients, whether new or in relapse, compared to control group might be part of the immune-evasion mechanism developed by the malignant cells that plays a serious role in leukomogenicity and disease advancement.

scholarly journals Assessment of the Tissue Response to Modification of the Surface of Dental Implants with Carboxyethylphosphonic Acid and Basic Fibroblastic Growth Factor Immobilization (Fgf-2): An Experimental Study on Minipigs

Biology ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 358
Author(s):  
Javier Aragoneses ◽  
Ana Suárez ◽  
Nansi López-Valverde ◽  
Francisco Martínez-Martínez ◽  
Juan Manuel Aragoneses
Keyword(s):  
Surface Treatment ◽  
Test Group ◽  
Mean Value ◽  
Control Group ◽  
P Value ◽  
Implant Surface ◽  
Bone Contact ◽  
Bone Implant ◽  
Significant Difference ◽  
The Mean

The aim of this study was to evaluate the effect of implant surface treatment with carboxyethylphosphonic acid and fibroblast growth factor 2 on the bone–implant interface during the osseointegration period in vivo using an animal model. The present research was carried out in six minipigs, in whose left tibia implants were inserted as follows: eight implants with a standard surface treatment, for the control group, and eight implants with a surface treatment of carboxyethylphosphonic acid and immobilization of FGF-2, for the test group. At 4 weeks after the insertion of the implants, the animals were sacrificed for the histomorphometric analysis of the samples. The means of the results for the implant–bone contact variable (BIC) were 46.39 ± 17.49% for the test group and 34.00 ± 9.92% for the control group; the difference was not statistically significant. For the corrected implant–bone contact variable (BICc), the mean value of the test group was 60.48 ± 18.11%, and that for the control group, 43.08 ± 10.77%; the difference was statistically significant (p-value = 0.035). The new bone formation (BV/TV) showed average results of 27.28 ± 3.88% for the test group and 26.63 ± 7.90% for the control group, meaning that the differences were not statistically significant (p-value = 0.839). Regarding the bone density at the interthread level (BAI/TA), the mean value of the test group was 32.27 ± 6.70%, and that of the control group was 32.91 ± 7.76%, with a p-value of 0.863, while for the peri-implant density (BAP/TA), the mean value of the test group was 44.96 ± 7.55%, and that for the control group was 44.80 ± 8.68%, without a significant difference between the groups. The current research only found a significant difference for the bone–implant contact at the cortical level; therefore, it could be considered that FGF-2 acts on the mineralization of bone tissue. The application of carboxyethylphosphonic acid on the surface of implants can be considered a promising alternative as a biomimetic coating for the immobilization of FGF-2. Despite no differences in the new bone formation around the implants or in the interthread or peri-implant bone density being detected, the biofunctionalization of the implant surface with FGF-2 accelerates the mineralization of the bone–implant interface at the cortical level, thereby reducing the osseointegration period.

scholarly journals True and Pseudo Cholinesterase levels in short and long-term of pesticides exposures

2020 ◽  
pp. 9-12
Author(s):  
Mohammed Abdul Rahman ◽  
Raghunatha Rao D ◽  
Vasantha L
Keyword(s):  
Whole Blood ◽  
Acute Poisoning ◽  
Mean Value ◽  
Serum Cholinesterase ◽  
Control Group ◽  
Study Group ◽  
Chronic Poisoning ◽  
The Mean ◽  
The Difference ◽  
And Control

The present study is aimed to study and analyze the true and pseudo Cholinesterase levels in the subjects exposed to pesticides during short term by intentional or accidental intake and long term exposure due to their occupation were studied at Department of Biochemistry, SVS medical college and hospital mahbubnagar district. Whole blood cholinesterase levels and Pseudo cholinesterase levels were estimated. 150 people were taken as controls who had no medical illness and a total number of 300 cases of pesticide poisoning were selected, aged between 20 to 55 years, which consist of 150 acute poisoning and 150 chronic poisoning subjects in Mahbubnagar district, were taken as case study, the detailed case history and the type of organophosphorus pesticide taken were recorded. Mean and standard deviation (S.D) of all variables were calculated and compared with those of controls. Statistical significance was assessed and P-value <0.05 were considered significant.           During acute poisoning the mean value of Whole blood cholinesterase/True cholinesterase (U / L) in acute poisoning cases on first day was 1.267± 0.612 on 3th day was 1.651±0.647, on 7th day was 2.221±0.684 and at the end of 6 months was 3.970±0.404.The difference between the study group and control group (4.0 ± 0.39) was found to be statistically significant in1st, 3rd, 7th day but not significant at the end of 6 months. The mean value of serum cholinesterase/pseudo cholinesterase (U/L) in acute poisoning cases on first day was 2213.05 ± 1749.81, on 3th day was 2862.3 ± 2025.6, on 7th day was 4008.4 ± 2355.9 and at the end of 6 months was 7708.34 ± 880.72.The difference between the study group and control group (7991.97 ± 1276.5) was found to be statistically significant in1st, 3rd, 7th day but not significant at the end of 6 months. During chronic poisoning (exposure) the mean value of Whole blood cholinesterase (U/L) in controls is 4.0 ± 0.39 as compared to 3.019 ± 0.848 in cases of chronic poisoning. The difference between the study group and control group was found to be statistically significant. The mean value of serum cholinesterase/pseudo cholinesterase (U/L) in controls was 7991.97 ± 1276.5 as compared to 6214 ± 1189 in cases of chronic poisoning. The difference between the study group and control group was found to be statistically significant.

Investigation of Epidemiologic Factors in Children with Acute Lymphoblastic Leukemia

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 3948-3948
Author(s):  
Oznur Yilmaz ◽  
Cetin Timur ◽  
Asim Yoruk ◽  
Muferet Erguven ◽  
Elif Aktekin ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Ventilatory Support ◽  
Control Group ◽  
Healthy Children ◽  
High Concentration ◽  
Pediatric Hematology ◽  
Epidemiologic Factors ◽  
Significant Difference ◽  
The Mean

Abstract In this study, we aimed to investigate epidemiologic factors in children with Acute Lymphoblastic leukemia (ALL). The parents of 105 children diagnosed and treated as ALL between the years 1997 –2007 in our Clinic of Pediatric Hematology-Oncology were questioned and results were compared with control group that consisted of 102 healthy children with similar age and gender. The mean age of the patients was 8.57 ± 3.95 years. The mean age at diagnosis was 5.87 ± 3.73 years. There was no significant difference between the groups in terms of type of delivery, birth weight, asphyxia at birth, resuscitation with high-concentration oxygen and ventilatory support (p&gt;0.05). There was also no significant difference between the groups in terms of duration of breast feeding. The rate of exposure to infections prior to diagnosis was higher in control group (p:0.003). Besides that, the rate of going to nursery was also significantly higher in control group (p:0.014). There was no difference between the groups in terms of X-ray exposure (p&gt;0.05). In conclusion over-protection from infectious agents in and delay in meeting with some specific agents seems to increase ALL risk. Infections in early infantile period can be protective against leukemia. There has to be more extended studies on this subject.

scholarly journals PERBANDINGAN STATUS KEBERSIHAN GIGI DAN MULUTPADA ANAK BERKEBUTUHAN KHUSUS SLB-B DAN SLB-C KOTA TOMOHON

e-GIGI ◽  
2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Vivie Indahwati ◽  
Max F. J. Mantik ◽  
Paulina N. Gunawan
Keyword(s):  
Oral Hygiene ◽  
Mean Value ◽  
T Test ◽  
P Value ◽  
Special Needs Children ◽  
Normal Children ◽  
Children With Disability ◽  
The Mean ◽  
The Difference ◽  
Better Than

Abstract: Special need children is children with disability mental, physical, and emotion which different with the normal children, thus their more needed parents help in keeping hygene especially oral hygene. Every disability they have influenced the behaviour of special need children in keeping their oral hygiene. This study aimed to obtain the difference of oral hygiene between special needs children in SLB-B and SLB-C in Tomohon.This was a descriptive analytical study. Samples were obtained by total sampling method. This study was conducted at SLB-B GMIM Damai Tomohon and SLB-C Katolik Santa Anna Tomohon. There were 101 children in this study. The results of independent t test showed that there were significant differences between the mean value of OHI-S status at SLB-B (1.86) and the mean value OHI-S status at SLB-B ( 2.50) with a P value of <0,05. Conclusion: Oral hygiene of SLB-B children was significantly better than of SLB-C children.Keywords: oral hygiene, special need childrenAbstrak: Anak berkebutuhan khusus merupakan anak yang memiliki keterbatasan mental, fisik dan emosi yang berbeda dengan anak normal, sehingga mereka memerlukan bantuan dalam menjaga kebersihan diri khusunya kebersihan gigi dan mulut. Perbedaan keterbatasan yang mereka miliki, memengaruhi perilaku anak berkebutuhan khusus dalam menjaga kebersihan gigi dan mulut. Penelitian ini bertujuan untuk melihat bagaimana perbedaan status kebersihan gigi dan mulut pada anak berkebutuhan khusus di SLB-B dan SLB-C kota Tomohon, Jenis penelitian yang digunakan adalah deskriptif analitik. Pengambilan sampel penelitian ini secara total sampling. Pengambilan data dilaksanakan di SLB-B GMIM Damai Tomohon dan SLB-C Katolik Santa Anna Tomohon. Jumlah anak dalam penelitian sebanyak 101 anak. Hasil penelitian diolah dengan uji statistik t tidak berpasangan (independent t test).Dari uji statistik diperoleh bahwa terdapat perbedaan rerata yang bermakna, antara status OHI-S SLB-B dengan nilai rata-rata 1,86 dibandingkan status OHI-S SLB-C dengan nilai rata-rata 2,50 dan nilai p<0,05. Simpulan: Rerata status kebersihan gigi dan mulut SLB-B lebih baik secara bermakna dibandingkan dengan SLB-C.Kata kunci: kebersihan gigi dan mulut, anak berkebutuhan khusus

scholarly journals The Impact of Strengthening Exercise on Dynamic Balance in Patients with Knee Osteoarthritis

2021 ◽  
Vol 15 (10) ◽  
pp. 3429-3431
Author(s):  
Shenbaga Subramanian Sundaram ◽  
Makesh Babu Subramanian ◽  
Riziq Allah Mustafa Gaowgeh ◽  
Mikhled Falah Maayah ◽  
Ziyad Neamatallah ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Dynamic Balance ◽  
Mean Value ◽  
Control Group ◽  
P Value ◽  
Strengthening Exercise ◽  
Significant Difference ◽  
The Mean ◽  
The Impact ◽  
Experimental Group

Background: Knee osteoarthritis is characterised clinically by usage-related pain and/or functional limitation. OA that is associated with physical dysfunction and decline in health-related quality of life caused the main disability worldwide and is expected to increase due to aging and obesity rates and further load on the population and health system. The strengthening exercises that normally used is knee flexion and extensions, isometric quadriceps exercise, isometric hamstring exercise, and sit to stand to improve the balance. Objectives: is to find out the impact of Strengthening exercise on Balance in patients with knee Osteoarthritis Study Design: Quasi experimental study Methods: Fifty-six (n=56) of knee OA patients were involved in this study by judgemental sampling design. Researcher will first demonstrate and explain the Y-balance tools testing procedure based on Plisky and colleagues study. Participants are given to practice six trials before the formal testing, stated that SEBT have a significant learning effect and found that the reaching distances reached the longest distance after six trials and then will be constant. Results: Independent t-test shows significant difference in only anterior direction. In the experimental group the mean value is 69.83 with a SD of 11.62 while in the control group the mean value is 63.51 with a SD of 11.36; p-value of .045 and t-value of 2.056. In postero-lateral directions result shows there is no significant difference, experimental group the mean value is 91.10 with a SD of 9.74 while in control group mean value is 90.88 with SD value of 12.68; p-value of .947 and t-value of .067. Result of postero-medial shows no significant difference too, in experimental group the mean value of 95.16 with SD of 10.92 while in control group the mean value is 93.40 with SD of 8.20; p=value of .501 and t-value of .678. Conclusion: This study has proven strengthening exercise using YBT improved only anterior direction of YBT but no significant difference in postero-lateral and postero-medial direction. Key Words: Knee Osteoarthritis, Strengthening exercise, Dynamic Balance, Star excursion test

scholarly journals Effect of Nursing Training on Improving Knowledge, Skills, and Attitudes of Clinical Nurses

2019 ◽  
Vol 2 (1) ◽  
pp. 31-38
Author(s):  
I Ketut Sudiarta ◽  
Emiliana Tarigan ◽  
Sudibyo Supardi
Keyword(s):  
Quantitative Research ◽  
Intervention Group ◽  
Mean Value ◽  
Posttest Score ◽  
Control Group ◽  
P Value ◽  
Clinical Nurses ◽  
The Mean ◽  
Increasing Knowledge ◽  
Nursing Training

Background: Clinical nurses are competent with good knowledge, skills and attitudes. These efforts are carried out through integrated training adaptation of the concept of From Novice to Expert Patricia Benner. The study aims to determine the effect of nursing training on increasing knowledge, skills and attitudes. Method: This quantitative research quasy experiment, using a non randomized control group pretest and posttest design. The study sample was 100 people, divided into two groups, namely the same intervention and control group. The research instrument was a valid and reliable questionnaire (Chronbach's alpha 0.989). Research for 12 weeks, March-June 2018 with nursing training interventions in the intervention group respondents. Results: The results of the study were the majority of respondents were female, aged 20-35, career level of clinical nurse level I. Diploma education and work period of 1-5 years. Bivariate results with the mean value of posttest score knowledge 97.20, increased by 21.6%, statistically meaningful knowledge of p value=0.000. The mean value of the posttest skill was score 92.96, increased by 23.92%, the skill statistically was significant p value=0.000 and the mean value of posttest attitude was 50.06, increased by 6.44%, statistically meaningful p value=0.000, there was an effect of nursing training on improving the knowledge, skills and attitudes of clinical nurses. The results of multivariate analysis of nursing training were statistically significant towards increasing knowledge of clinical nurses (p value=0.000), having the possibility of knowledge increasing 10 times, increasing skills statistically significant (p value=0.000), having the possibility of increasing skills 1.4 times and increasing statistically meaningful attitudes (p value=0.000), having an increased likelihood of attitudes 0.8 times compared to not getting training, no confounding variables were found. Conclusion: Based on this research, the increase in knowledge, skills and attitudes is influenced by nursing training from the aspects of material, methods, facilities, instructors and post-training evaluation methods. Thus to achieve optimal quality of knowledge, skills and attitude, it is advisable to conduct mentoring, supervision, mentoring and guidance in an integrated manner

Evaluation of the Stability of the Subjects with Anterior Cruciate Injuries Reconstruction

2020 ◽  
Author(s):  
Hossein Akbari Aghdam ◽  
Mahsa Kavyani ◽  
Maryam Bosak ◽  
Mohammad Taghi Karimi ◽  
Mehdi Motififard
Keyword(s):  
Acl Reconstruction ◽  
Postural Stability ◽  
Center Of Pressure ◽  
Mean Value ◽  
P Value ◽  
Before And After ◽  
The Mean ◽  
The Difference ◽  
Anterior Cruciate ◽  
The Stability

AbstractAnterior cruciate ligament (ACL) is the most frequently injured ligament in the knee and is often injured during sport-related activities. ACL injuries influence the abilities of the subjects during standing and walking. Although early surgical intervention is preferred treatment for the majority of knee surgeons, the effect of this approach on postural stability of patients is not fully understood. Therefore, the aim of this study was to determine the difference between stability of ACL-reconstructed subjects before and after surgery. A group of 15 consecutive ACL injured patients participated in this study. Postural stability of the patients was evaluated 1 week before and 6 months after surgery (ACL reconstruction with hamstring autograft). A Kistler force plate was used to evaluate center of pressure (COP) sway during quiet standing. The mean values of the COP parameters were obtained in pre and postsurgery conditions. Paired sample t-test was used to evaluate the difference between the stability parameters of the two conditions. The significant point was set at 0.05. The mean value of path length of COP velocity in mediolateral (ML) direction was 1,485.57 ± 479.42 mm and 2,641.33 ± 996.26 mm before and after surgery, respectively (p-value = 0.01). Although the mean value of COP velocity in anteroposterior and ML directions increased after surgery, the difference was only significant for velocity in ML direction (p-value = 0.049). The results of this study showed that the standing stability of those with ACL reconstruction decreased significantly after ACL reconstruction, which may be due to the effects of the surgery on sensory mechanism of ACL and inability of patients to return to their previous deep sense perception and knee proprioception.

Pseudonormokalemia in Patients with Thrombocytosis.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3964-3964
Author(s):  
Amir S. Steinberg ◽  
Raimonda Goldman ◽  
Randy L. Levine ◽  
Georgia Panagopoulos ◽  
Marvin C. Cooper
Keyword(s):  
Platelet Count ◽  
Serum Potassium ◽  
Interim Analysis ◽  
Plasma Potassium ◽  
Normal Serum ◽  
Control Group ◽  
P Value ◽  
Significant Difference ◽  
The Mean ◽  
The Difference

Abstract Introduction: Pseudohyperkalemia represents an artificial elevation in serum potassium concentration. It is well described that patients with thrombocytosis may have elevated serum but normal plasma potassium. The difference between serum and plasma potassium is felt to be due to potassium release from platelets during clotting. We propose to prove that a similar mechanism will lead to a "pseudonormokalemia," where serum potassium appears to be in the normal range (3.5–5.0 MEq/L) despite below-normal levels in the plasma(&lt;3.5 MEq/L). Method: This is an interim analysis of a prospective, IRB-approved planned comparison of 146 patients. We compared 36 thrombocytosis patients (platelets&gt;500,000/uL) to 36 control patients (platelets&lt;500,000/uL). Patients were identified from a list of lab results generated by a computer search and serum and plasma potassium and CBC were then drawn concomitantly. The two groups were compared using either the t-test or the Mann-Whitney U test depending on the distribution of the variables. A p &lt;.05 was considered a priori to indicate statistical significance. Results: There was no statistically significant difference in sex distribution or age between the two groups. The average platelet count was 643,190/uL in the thrombocytosis group (SD 134,426 uL) and 280,220/uL (SD 106,217 uL) in the control group with a p value &lt;0.001. While the serum potassium was noted to be significantly different between the two groups, the plasma potassium was not (see table). This was reflected in the difference between the serum and plasma potassium in the two groups. The thrombocytosis group was noted to have a difference between serum and plasma potassium of .52 MEq/L (SD .32 MEq/L) while the control group had a difference of .18 MEq/L (SD .23 MEq/L). The thrombocytosis group had 14 cases in which the difference between serum and plasma potassium was over 0.5 MEq/L whereas the control group had none. Conclusion: In this study, patients with thrombocytosis had higher mean serum potassium levels than the control group but similar mean plasma potassium levels. The mean difference between serum and plasma potassium (Delta) exceeded 0.5 MEq/L in the thrombocytosis arm and there was a statistically significant difference in the Delta values between the two groups. The mean platelet volume (MPV) of the thrombocytosis group was smaller than that of the control group. This indicates that the elevation in serum potassium in the thrombocytosis group cannot be attributed to the actual size of the platelets but rather to the number of platelets involved. Patients with thrombocytosis and normal serum potassium may actually be hypokalemic as this study demonstrates. As we continue to evaluate patients, we believe this difference will become more demonstratable. On interim analysis, our study suggests that in patients with thrombocytosis and normal serum potassium, plasma potassium should be considered along with routine labs. Group Comparison Values (N=36) Thrombocytosis Group-Platelets&gt;500,000/uL Control Group-Platelets&lt;500,000/uL p value Age 60.33 yrs 57.53 yrs p =.50 Serum K+ 4.43 MEq/L 4.15 MEq/L &lt;.001 Plasma K+ 3.91 MEq/L 3.97 MEq/L p =.54 Mean Delta between Serum and Plasma K+ .52 MEq/L (SD .32) .18 MEq/L (SD .23) &lt;0.001 Platelet Count 643.19 X103/uL 280.22X103/uL &lt;0.001 MPV 7.27 fl 8.24 fl &lt;0.001 WBC 12.05 mm3 9.98 mm3 p =.16

scholarly journals ANALYSIS OF BONE IMPLANT TO CONTACT VALUE USING SCANNING ELECTRON MICROSCOPE IN POST IMMEDIATE IMPLANTS WITH ADDITION OF GEL-EXTRACTED ROSELLA FLOWER

2019 ◽  
pp. 234-236
Author(s):  
MOHAMMAD DHARMAUTAMA ◽  
BAHRUDDIN THALIB ◽  
YULI SUSANIAWATY ◽  
IRFAN DAMMAR ◽  
ANDI ADYTHA MIR
Keyword(s):  
Bone Growth ◽  
Mean Value ◽  
Control Group ◽  
Bone Implant ◽  
Flower Extract ◽  
Inflammatory Phase ◽  
Immediate Implants ◽  
Bone To Implant Contact ◽  
The Mean ◽  
The Difference

Objective: The objective of the study was to analyze the difference of bone to implant contact (BIC) value post-immediate implants with or withoutinjecting rosella flower extracts gel in mongrel.Methods: A total of 18 implants were inserted in 9 mongrel’s dog. The implant was divided into two groups. The first one (test implant) was implantedimmediately after injection of gel-extracted rosella flower 10%, while another group (control implant) was implanted immediately after the toothextraction. The histomorphometry analysis was done after 14, 28, and 56 days to find out the BIC value.Result: The mean value of BIC rosella group was 63.44% and the mean value of the control group was 52.11%, with p=0.041.Conclusion: Rosella flower extract is able to shorten the inflammatory phase after implantation, accelerate and expand bone growth by spurringcollagen deposition as well as inhibiting osteoclast activity.

scholarly journals Assessment of left atrial function in feline hypertrophic cardiomyopathy by using two- dimensional speckle tracking echocardiography

2020 ◽  
Author(s):  
Arisara Kiatsilapanan ◽  
Sirilak Surachetpong
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Left Atrial ◽  
Speckle Tracking ◽  
Longitudinal Strain ◽  
Speckle Tracking Echocardiography ◽  
Mean Value ◽  
Control Group ◽  
P Value ◽  
Two Dimensional ◽  
The Difference

Abstract Background : Left atrial (LA) function plays an important role in diastolic dysfunction in cats with hypertrophic cardiomyopathy (HCM). Two-dimensional speckle tracking echocardiography (2D-STE) is a novel technique for assessing LA function. This study aimedto evaluate changes in the LA function inHCM cats compared to normal cats, using 2D-STE. Results: Seventeen client-owned cats affected with HCM and twenty healthy control cats. Conventional echocardiographic and 2D-STE variables were measured and compared between groups (the normal and HCM groups). The difference between two groups was compared by using the independent Student’s t-test. A p -value less than 0.05 was considered significant. Variability from the 2D-STE variables tests displayed good reproducibility (coefficient of variation ≤15%). The mean value of peak atrial longitudinal strain (PALS) in the HCM group (13.16 ± 8.64) was lower in the control group (28.54 ±10.31) ( p < 0.001). PALS was lowest at the LA roof region. The atrial longitudinal strain of septal and lateral regions was significantly lower in the HCM group than the normal group. PALS correlated with the percentage of the LA fractional shortening (LA-FS) (r=0.538, p =0.001), the percentage of the LA ejection fraction (LA-EF) (r =0.797, p <0.001), and the LA fractional area change (FAC) (r =0.746, p <0.001). Conclusions: PALS can be used to evaluate changes in theLA function in HCM cats. It is a reproducible method for assessing the LA function in cats affected with HCM. Keywords cats; heart; left atrium; strain

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