scholarly journals The Reliability of Ponderal Index in Predicting Short-Term Complications of Small for Gestational Age Term Infants.

2021 ◽  
Author(s):  
Secil Ercin ◽  
Yeşim Coşkun ◽  
Tuğba Gürsoy
Keyword(s):  
Gestational Age ◽  
Hospitalization Rate ◽  
Ponderal Index ◽  
Short Term ◽  
Term Infants ◽  
Severe Morbidity ◽  
Group 3 ◽  
Group 2 ◽  
Fair Assessment ◽  
Group 1

Abstract The birth weight (BW) for gestational age (GA) ensure a fair assessment of the nutritional status of small for gestational (SGA) infants. Ponderal index (PI) is used to identify wasting. This study aims to evaluate the association between PI values and short-term complications of term SGA infants and evaluate the reliability of PI. A total of 489 term SGA infants were included in this retrospective study. According to the PI values, the neonates were divided into three groups. Group 1 consisted of infants with low PI (PI < 10th percentile) (n=45), group 2 consisted of infants with appropriate PI (PI 10th-90th percentile) (n=405) and the ones with high PI (PI> 90th percentile) (n=39) constituted group 3. Demographic and clinical data of the mothers and neonates including clinical and laboratory assessments were collected and compared statistically. No difference was observed between the groups other than the incidence of hypoglycemia, jaundice requiring treatment and hospitalization rate, which were all significantly higher in low PI group than the group 2 and 3 (p=0.01, p=0.006 and p=0.04, respectively). None of the babies had severe morbidity or died.Conclusion: Although short-term complications were higher in term SGA infants with low PI, all term SGA infants should be defined as high-risk neonates and deserve special neonatal care and surveillance to prevent short-term complications.

scholarly journals Neonatal Problems and Infancy Growth of Term SGA Infants: Does “SGA” Definition Need to Be Re-evaluated?

2021 ◽  
Vol 9 ◽  
Author(s):  
Saygin Abali ◽  
Serdar Beken ◽  
Eda Albayrak ◽  
Aysegul Inamlik ◽  
Burcu Bulum ◽  
...  
Keyword(s):  
Gestational Age ◽  
Severe Hypoglycemia ◽  
Point Of View ◽  
Control Group ◽  
Term Infants ◽  
Group 3 ◽  
Group 2 ◽  
Definition Of ◽  
Neonatal Problems ◽  
Group 1

Introduction: The exact definition of small-for-gestational-age (SGA) infant is still controversial among clinicians. In this study, we aimed to understand which definition is better in terms of establishing both early postnatal problems and growth. In this way, we compared early neonatal problems and infancy growth of term infants with birth weight (BW) &lt; -2 SDS and with BW between 10th percentile (−1.28 SDS) and −2 SDS.Methods: A single center retrospective cohort study was conducted. Preterm infants, multiple gestations and newborns with any congenital anomalies were excluded from the study. Study group was defined as Group 1 (n = 37), infants BW &lt; −2.00 SDS; Group 2 (n = 129), between −1.28 and −2.00 SDS; and Group 3 (n = 137), randomly selected newborns with optimal-for-gestational-age (BW between −0.67 and +0.67 SDS) as a control group.Results: The incidence of severe hypoglycemia was highest in Group 1 (%10.8) and Group 2 and 3 had similar rates of severe hypoglycemia (0.8 and 0.7%, respectively). The incidence of polycythemia was 5.4% in Group 1 and was significantly higher than Group 3 (0.0%) while it was 2.3% in Group 2. Short stature (length &lt; −2 SDS) ratio at the age of 1 and 2 years were similar in each group. Overweight/obesity ratio at the age of 1 were 9.5, 20.8 and 16.7% in each group, respectively (p = 0.509).Conclusion: This study was planned as a pilot study to determine potential differences in the problems of hypoglycemia, polycythemia, and growth according to the differences in definition. Short term disturbances such as hypoglycemia and polycythemia are found to be higher in infants with a BW SDS below −2. From this point of view, of course, it will not be possible to change the routine applications immediately, however this study will be an initiative for discussions by making long-term studies.

Strength of the Breuer-Hering inflation reflex in term and preterm infants

1995 ◽  
Vol 79 (6) ◽  
pp. 1986-1990 ◽  
Author(s):  
J. P. De Winter ◽  
I. T. Merth ◽  
A. Berkenbosch ◽  
R. Brand ◽  
P. H. Quanjer
Keyword(s):  
Preterm Infants ◽  
Respiratory System ◽  
Gestational Age ◽  
Blood Gases ◽  
First Year ◽  
Static Compliance ◽  
Term Infants ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The effect of the presence of the respiratory distress syndrome (RDS) or related factors (static compliance of the respiratory system and transcutaneous blood gases) and gestational age on the strength of the Breuer-Hering inflation reflex (BHIR) was studied in three groups of infants. Twenty-six ventilated preterm infants with and without RDS were studied 6 h after birth (group 1). In 24 preterm infants, we followed the development of reflex strength during the first year of life (group 2). Twenty-one healthy nonintubated term infants were studied within the first week of life (group 3). The BHIR was initiated by end-inspiratory occlusions, and the strength was characterized by the ratio of expiratory time after and without preceding airway occlusion. The static compliance of the respiratory system in ventilated infants was assessed by the multiple-occlusion technique. In group 1, reflex strength declined with increasing gestational age; in the presence of RDS or low respiratory compliance, the decline was less. Transcutaneous blood gases did not affect reflex strength. At term age, reflex strength was similar in spontaneously breathing preterm (group 2) and term infants (group 3). The BHIR decreased in strength during the first year after preterm birth. We conclude that 1) the strength of the BHIR decreases with increasing gestational and postnatal ages and 2) RDS, due to changes in respiratory system mechanics, causes an increase in reflex strength.

scholarly journals Vermal Length and Transcerebellar Diameter in Gestational Age Estimation: A Guide to Forensic Expert

2019 ◽  
Vol 08 (03) ◽  
pp. 101-105
Author(s):  
Nadia Ahmad ◽  
S. L. Jethani ◽  
Deepa Singh ◽  
Ruchira Nautiyal
Keyword(s):  
Gestational Age ◽  
Age Determination ◽  
Linear Increase ◽  
Group 4 ◽  
Age Regression ◽  
Group 3 ◽  
Group 2 ◽  
Gestational Age Estimation ◽  
Formalin Fixed ◽  
Group 1

Abstract Background Transcerebellar diameter is one of the reliable, constant predicting parameters to assess the gestational age and fetal growth. Other than this, measurements of vermis, mostly the vermal length (height), have also been mentioned by authors to assess gestational age. Establishing a correlation between parameters and advancing gestation would be helpful in estimating the gestational age of fetus. Aims and Objectives To establish a correlation of vermal length and transcerebellar diameter with gestational age. Materials and Methods An observational and descriptive study conducted on 60 formalin-fixed human cerebellums. Fetuses with gross congenital/neurological abnormality were excluded. Fetuses were grouped into four groups—group 1 (13–17 weeks), group 2 (18–22 weeks), group 3 (23–27 weeks), and group 4 (28–32 weeks of gestation). Vermal length and transcerebellar diameter were measured with help of Vernier calipers. The data obtained were analyzed using statistical software SPSS version 20.0 and one-way analysis of variance. Observation A linear increase in vermal length parameters and transcerebellar diameter were seen with increasing gestational age. Regression analysis was done and regression equation was derived for each parameter. Conclusion Such correlations would help in fetal age determination in the field of forensic studies.

The effects of intrafetal ACTH administration on the outcome of pregnancy in the mare

1998 ◽  
Vol 10 (4) ◽  
pp. 359 ◽  
Author(s):  
J. C. Ousey ◽  
P. D. Rossdale ◽  
F. E. Dudan ◽  
A. L. Fowden
Keyword(s):  
Gestational Age ◽  
Plasma Cortisol ◽  
Maternal Plasma ◽  
Sterile Water ◽  
Adaptive Responses ◽  
Gestational Length ◽  
Adrenocortical Activity ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Enhanced adrenocortical activity in the fetus is related to the onset of parturition in many species. The aim of this study was to determine the effect of injection of fetal ACTH on gestational length and fetal viability in the horse. Pony mares (n=23) were studied from 300 days gestation. Seven control mares (Group 1) received three consecutive intrafetal injections of sterile water, while fetuses of a further 16 mares received Depot ACTH1–24. These mares were either allowed to foal spontaneously (Group 2, n=4) or delivery was induced within 3 days of the last fetal injection (Group 3, n=7); 5 mares aborted within 48 h of intrafetal ACTH injection. Maternal plasma progestagen concentrations increased significantly (P<0.05) in Groups 2 and 3 mares following intrafetal ACTH injection, compared with Group 1 mares. All Group 1 mares delivered live foals at a median gestational age of 327 days (interquartile range, 323–334), except one that aborted 16 days after the last fetal injection. Gestational length was significantly (P<0.05) shortened in Group 2 mares (median 314 [312–314]) days compared with controls. Group 1 and Group 2 foals showed normal postnatal adaptive responses and endocrine (plasma cortisol/progestagens) patterns. Group 3 mares delivered live foals at 306 (306–308) days gestation except one that aborted. Their foals were less mature compared with Groups 1 and 2 foals. Eight ACTH-injected fetuses were meconium-stained at delivery, including four that were aborted. Eight mares had thickened placentae, including three that aborted. The data show that both precocious maturation of the equine fetus and a significant reduction in gestational length compared with controls may be achieved in pony mares by intrafetal ACTH injections. This is probably mediated via adrenal regulation of fetal maturation and production of maternal progestagens.

scholarly journals Outcome of Infants with Hypoxic-Ischemic Encephalopathy Treated by Whole Body Cooling and Magnesium Sulfate

2021 ◽  
Vol 11 (01) ◽  
pp. e280-e286
Author(s):  
Safwat M. Abdel-Aziz ◽  
Mohamed Sabry M. Abdel Rahman ◽  
Asmaa H. Shoreit ◽  
Moustafa Ez El Din ◽  
Enas A. Hamed ◽  
...  
Keyword(s):  
Magnesium Sulfate ◽  
Therapy Group ◽  
Whole Body ◽  
P Value ◽  
Short Term ◽  
Group 3 ◽  
Group 2 ◽  
Body Cooling ◽  
Whole Body Cooling ◽  
Group 1

AbstractTherapeutic hypothermia (TH) either by selective head cooling or whole-body cooling decreases brain damage and provide neuroprotection and reduced mortality rate in cases of moderate-to-severe hypoxia-ischemia encephalopathy (HIE) of newborns, especially if started at first 6 hours after birth. Also, management with adjuvant therapies like magnesium sulfate (MS) provides more neuroprotection. The interventional randomized controlled research aimed to assess short-term actions of TH as sole therapy and in combination with MS as a neuroprotective agent for the treatment of HIE newborn infants. A total of 36 full-terms and near-term infants delivered at Assiut University Children's Hospital and fulfilled HIE criteria were enrolled. They were divided equally into three groups; Group 1 (n = 12) received whole body cooling during first 6 hours of life as a sole therapy; Group 2 (n = 12) received whole body cooling in addition to MS as adjuvant therapy; Group 3 (n = 12) received supportive intensive care measures as a control. TH plus MS group (group 2) had a significantly good short-term outcomes as short period of respiratory support and mechanical ventilation (p-value =0.001), less in incidence of convulsion (p-value = 0.001) and early in feeding initiation (p-value = 0.009), compared with other groups managed by TH (group 1) or by supportive treatment (group 3). In conclusion, whole body cooling in addition to MS as adjunctive therapy for the treatment of HIE neonates is safe therapy that improves short-term outcome both clinically and radiologically.

scholarly journals Mean arterial pressure within 24 hours of admission predicts short-term prognosis in patients with intermediate-risk and high-risk pulmonary embolism

2020 ◽  
Author(s):  
Jialong Chen ◽  
Jing Lin ◽  
Dansen Wu ◽  
XiaoLan Guo ◽  
XiuHua Li ◽  
...  
Keyword(s):  
High Risk ◽  
Cox Regression ◽  
Hospital Death ◽  
Intermediate Risk ◽  
Short Term ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Group 1

Abstract Objective: Pulmonary embolism is a terrible cardiovascular condition with considerable morbidity and mortality. Previous studies have investigated systolic blood pressure (systolic BP) and diastolic blood pressure (diastolic BP) as being related to 30-day and in-hospital mortality. We aimed to determine whether the average mean arterial pressure (aMAP) in the first 24 hours of hospital admission is useful in predicting short-term outcomes of intermediate-risk and high-risk PE patients. Method: We conducted a single-center retrospective study. From May 2012 to April 2019, 122 intermediate-risk and high-risk PE patients were included. The primary outcome was in-hospital mortality. The secondary outcome was adverse events. ROC curves and cut-off values for aMAP predicting in-hospital death were computed. According to cut-off values, we categorized five groups defined as follows: group 1: aMAP<70 mmHg; group 2: 70 mmHg≤aMAP<80 mmHg; group 3: 80 mmHg≤aMAP<90 mmHg; group 4: 90 mmHg≤aMAP<100 mmHg; and group 5: aMAP≥100 mmHg. Cox regression models were calculated to investigate associations between aMAP and in-hospital death. Results: In the study group of 122 patients, 15 patients (12.30%) died in the hospital due to PE. ROC analysis for MAP predicting in-hospital death revealed an AUC of 0.729 with a cut-off value of 79.4 mmHg. Cox regression models showed a significant association between in-hospital death and aMAP group 1 (ref), aMAP group 2 (OR 1.680, 95% CI 0.020-140.335), aMAP group 3 (OR 0.003, 95% CI 0.0001-0.343), aMAP group 4 (OR 0.006, 95% CI 0.0001-1.671), and aMAP group 5 (OR 0.003, 95% CI 0.0001-9.744). In particular, those with an aMAP of 80-90 mmHg suffer from minimum adverse events. Conclusion: The prognostic role of MAP during the first 24 hours of hospital admission should be emphasized in patients with PE. The optimal range of MAP for intermediate-risk and high-risk PE patients may be 80 to 90 mmHg.

Major factors affecting intraocular pressure spike after intravitreal ranibizumab injection: Vitreous reflux and its amount

2019 ◽  
Vol 29 (4) ◽  
pp. 361-367 ◽  
Author(s):  
Enes Uyar ◽  
Fatih Ulas ◽  
Saygin Sahin ◽  
Serdal Celebi
Keyword(s):  
Intraocular Pressure ◽  
Intravitreal Injection ◽  
Short Term ◽  
Intravitreal Ranibizumab ◽  
Chi Square ◽  
Factors Affecting ◽  
Group 3 ◽  
Group 2 ◽  
Major Factors ◽  
Group 1

Purpose:The aim of this study was to assess the effect of vitreous reflux and its amount on short-term intraocular pressure after intravitreal injection of ranibizumab.Methods:The study included 316 eyes of 276 patients. Intraocular pressures were measured before intravitreal injection (preIOP), immediately after intravitreal injection (postIOP0), and 30 min after intravitreal injection (postIOP30). The amount of vitreous reflux was evaluated by measuring conjunctival bleb diameter, and patients were grouped as; group 1: no vitreous reflux, group 2: less vitreous reflux, and group 3: more vitreous reflux. The data were analyzed using variance analysis, chi-square test, and regression analysis.Results:PostIOP0 values were highest in group 1, followed by group 2 and group 3 (all p values < 0.001). PostIOP30 values were similar in group 1 and group 2 (p = 0.261), but were lower in group 3 than other two groups (p < 0.001, p = 0.001, respectively). Vitreous reflux was identified as the only factor affecting postinjection intraocular pressure changes (p < 0.001), and a negative correlation was found between the total number of intravitreal injection and vitreous reflux (p = 0.032).Conclusion:The major factor affecting short-term postinjection intraocular pressure elevation was vitreous reflux, and intraocular pressure levels increased as the amount of vitreous reflux decreased. Vitreous reflux and its amount decreased as the total number of intravitreal injection increased.

scholarly journals Changes in calcium channel proteins according to magnesium sulfate administration in placentas from pregnancies with pre-eclampsia or fetal growth restriction

2018 ◽  
Vol 67 (2) ◽  
pp. 319-326
Author(s):  
Hyun-Hwa Cha ◽  
Jae-Ryoung Hwang ◽  
Ji Hee Sung ◽  
Suk-Joo Choi ◽  
Soo-young Oh ◽  
...  
Keyword(s):  
Magnesium Sulfate ◽  
Fetal Growth ◽  
Gestational Age ◽  
Fetal Growth Restriction ◽  
Growth Restriction ◽  
Bewo Cells ◽  
Gestational Age At Delivery ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

We aimed to evaluate the changes in plasma membrane Ca2+-ATPase (PMCA) and sarcoendoplasmic reticulum CA2+-ATPase (SERCA-2) according to the antepartal magnesium sulfate (MgSO4) administration in the placentas from pregnancies with pre-eclampsia (PE) or fetal growth restriction (FGR). Pregnant women were classified as follows: (group 1) pregnancies without PE or FGR (n=16), (group 2) pregnancies with PE or FGR but without MgSO4 administration (n=14), and (group 3) pregnancies with PE or FGR and with MgSO4 administration (n=28). We observed the localization of PMCA and SERCA-2 in placentas and compared its expression among 3 groups. And we observed its expression in BeWo cells following treatment with MgSO4 and CoCl2. PMCA staining was more observed in the basal membrane, whereas SERCA-2 staining was observed predominantly under the microvillous membrane. SERCA-2 expression was significantly increased in group 3 compared with that in group 1. Considering the gestational age at delivery, PMCA expression was increased in group 2 and group 3 compared with that in group 1 after 36 weeks of gestation. SERCA-2 was increased in group 3, but not in group 2 compared with that in group 1 after 36 weeks of gestation. In BeWo cells, MgSO4 treatment increased PMCA and SERCA-2 expression. PMCA expression was influenced by gestational age at delivery, and SERCA-2 expression was increased in the presence of PE and antepartal MgSO4 administration. This indicates that antepartal MgSO4 administration has a greater influence on SERCA-2 than PMCA.

Thyroid Hormone and Thyrotropin Responses to Parturition in Premature Infants With and Without the Respiratory Distress Syndrome

PEDIATRICS ◽  
1979 ◽  
Vol 63 (3) ◽  
pp. 380-385
Author(s):  
Alan H. Klein ◽  
Barbara Foley ◽  
Frederic M. Kenny ◽  
Delbert A. Fisher
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Premature Infants ◽  
Distress Syndrome ◽  
Mean Value ◽  
Term Infants ◽  
Serum T4 ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Serum thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3), thyrotropin (TSH), and thyroxine-binding globulin (TBG) concentrations were measured in well full-term infants (group 1), well premature infants (group 2), and premature infants with the respiratory distress syndrome (group 3). Samples were collected at birth and at 2, 12, and 24 hours after delivery. Significant increases in mean serum TSH concentrations occurred in all three groups two hours after delivery, but the two-hour levels measured in groups 2 and 3 were less than those in group 1 infants. Serum T4 concentrations increased significantly after delivery in groups 1 and 2 but not in group 3 newborns; mean TBG concentrations did not vary significantly in any of the groups. Serum T4, concentrations increased significantly at two hours in all three groups but were significantly depressed at 12 and 24 hours in group 3 infants. Mean serum rT3, concentrations decreased after birth in group 2 and 3 in contrast to group 1 newborns; the mean value increased significantly between 2 and 24 hours in group 3 infants. The pattern of decreasing senrum T3 and increasing rT3 concentrations in group 3 infants between 2 and 24 hours resembles the pattern of change in triiodothyronines in ill adult patients, which suggests that these variations are due primarily to illness and not to prematurity.

THE EFFECTS OF CIGARETTE SMOKING ON RABBIT TIBIAL VASCULAR ENDOTHELIUM

2001 ◽  
Vol 05 (04) ◽  
pp. 235-242 ◽  
Author(s):  
YUAN-KUN TU ◽  
STEVE WEN-NENG UENG
Keyword(s):  
Cigarette Smoking ◽  
Vascular Endothelium ◽  
Phase 1 ◽  
Phase 2 ◽  
Short Term ◽  
Phase 3 ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Cigarette smoking is hazardous for various tissues in human. The cigarette smoke inhalation has been proved to delay bone healing. However, no previous study demonstrates the smoking effect on bony microcirculation. In this study, we investigated the effect of cigarette smoking on tibial vascular endothelium and blood flow by using the bone chamber model. Eighteen adult New Zealand rabbits were divided into 3 groups. Group 1: Control, Group 2: 1 week smoking, and Group 3: 6 weeks smoking. All these rabbits were then anesthetized, and their nutrient arteries of tibia were identified and cannulated. We put the tibia into bone chamber after cannulation, perfused with Krebs-Ringer solution (phase 1), and then compared the effect of vasospasm by norepinephrine dose-response curve (NEDRC). Acetylcholine (phase 2) and L-NMMA (phase 3) were also perfused and the NEDRC recorded. Acetylcholine can stimulate the release of nitric oxide and lower the NEDRC. L-NMMA inhibits NO synthesis in vascular endothelium, and hence results in vasoconstriction under various stimuli. Data collection and statistic processing were performed by ANOVA analysis. The NEDRC data in Group 1 (control) was set to be 100%. In phase 1 study, our results showed that 1 week cigarette smoking significantly increased NEDRC in Group 2 (142.5%, p<0.01). However, 6 weeks smoking strikingly boosted the response of NEDRC in Group 3 (226.5%, p<0.01). In phase 2 study, Group 2 tibia showed the NEDRC under acetylcholine perfusion to be without any difference in comparison with Group 1 (p>0.05). Nevertheless, Group 3 tibia showed significant vasospasm even under acetylcholine perfusion. In phase 3 study, L-NMMA perfused data revealed that; Group 3 tibia had the highest NEDRC, i.e. the most severe vasospasm. Based on our study, both short-term and long-term cigarette smoking are hazardous to the bony vascular endothelium. The nitric oxide production significantly attenuated in Group 2 and 3 tibia. However, the adverse effect of smoking seems reversible in short-term (Group 2). Long-term smoking (Group 3) causes irreversible damage to vascular endothelium and muscarinic receptor.

Sign in / Sign up

Export Citation Format

Share Document