scholarly journals Mitochondria-targeted antioxidant supplementation improves 8 km time trial performance in middle-aged trained male cyclists

2020 ◽  
Author(s):  
Sophie Broome ◽  
Andrea Braakhuis ◽  
Cameron Mitchell ◽  
Troy Merry
Keyword(s):  
Perceived Exertion ◽  
Average Power ◽  
Time Trial ◽  
Cycling Performance ◽  
Middle Aged ◽  
Clinical Trial Registry ◽  
Double Blind ◽  
Nutritional Strategy ◽  
Exercise Induced ◽  
Respiratory Gases

Abstract BackgroundExercise increases skeletal muscle ROS production, which may contribute to the onset of muscular fatigue and impair athletic performance. Mitochondria-targeted antioxidants such as MitoQ are becoming popular amongst active individuals as they are designed to accumulate within mitochondria and may provide targeted protection against exercise-induced oxidative stress. However, the effect of MitoQ supplementation on cycling performance is currently unknown. Here we investigate whether MitoQ supplementation can improve cycling performance measured as time to complete an 8 km time trial.MethodIn a randomised, double-blind, placebo-controlled crossover study, 19 middle-aged (age: 44 ± 4 years) recreationally trained (VO2peak: 58.5 ± 6.2 ml·kg·min− 1, distance cycled per week during six months prior to study enrollment: 158.3 ± 58.4 km) male cyclists completed 45 min cycling at 70% VO2peak followed by an 8 km time trial after 28 days of supplementation with MitoQ (20 mg/day) and a placebo. Free F2-isoprostanes were measured in plasma samples collected at rest, after 45 min cycling at 70% VO2peak and after completion of the time trial. Respiratory gases and measures of rate of perceived exertion (RPE) were also collected.ResultsMean completion time for the time trial was 1.3% faster with MitoQ (12.91 ± 0.94 min) compared to placebo (13.09 ± 0.95 min, P = 0.04 95% CI [0.05, 2.64], d = 0.2). There was no difference in RPE during the time trial between conditions (P = 0.82) despite average power output during the time trial being higher following MitoQ supplementation (280 ± 53 W) compared to placebo (270 ± 51 W, P = 0.04). Plasma F2-isoprostanes were lower on completion of the time trial following MitoQ supplementation (35.89 ± 13.6 pg/ml) compared to placebo (44.7 ± 16.9 pg/ml P = 0.03).ConclusionThese data suggest that MitoQ supplementation may be an effective nutritional strategy to attenuate exercise-induced increases in oxidative damage to lipids and improve cycling performance.Trial registrationThis study was registered with the Australia New Zealand Clinical Trial Registry (ACTRN12619000451101) on 19th March 2019.

scholarly journals Mitochondria-targeted antioxidant supplementation improves 8 km time trial performance in middle-aged trained male cyclists

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
S. C. Broome ◽  
A. J. Braakhuis ◽  
C. J. Mitchell ◽  
T. L. Merry
Keyword(s):  
Perceived Exertion ◽  
Average Power ◽  
Time Trial ◽  
Cycling Performance ◽  
Rating Of Perceived Exertion ◽  
Middle Aged ◽  
Double Blind ◽  
Nutritional Strategy ◽  
Exercise Induced ◽  
Respiratory Gases

Abstract Background Exercise increases skeletal muscle reactive oxygen species (ROS) production, which may contribute to the onset of muscular fatigue and impair athletic performance. Mitochondria-targeted antioxidants such as MitoQ, which contains a ubiquinone moiety and is targeted to mitochondria through the addition of a lipophilic triphenylphosphonium cation, are becoming popular amongst active individuals as they are designed to accumulate within mitochondria and may provide targeted protection against exercise-induced oxidative stress. However, the effect of MitoQ supplementation on cycling performance is currently unknown. Here, we investigate whether MitoQ supplementation can improve cycling performance measured as time to complete an 8 km time trial. Method In a randomized, double-blind, placebo-controlled crossover study, 19 middle-aged (age: 44 ± 4 years) recreationally trained (VO2peak: 58.5 ± 6.2 ml·kg− 1·min− 1, distance cycled per week during 6 months prior to study enrollment: 158.3 ± 58.4 km) male cyclists completed 45 min cycling at 70% VO2peak followed by an 8 km time trial after 28 days of supplementation with MitoQ (20 mg·day− 1) and a placebo. Free F2-isoprostanes were measured in plasma samples collected at rest, after 45 min cycling at 70% VO2peak and after completion of the time trial. Respiratory gases and measures of rating of perceived exertion (RPE) were also collected. Results Mean completion time for the time trial was 1.3% faster with MitoQ (12.91 ± 0.94 min) compared to placebo (13.09 ± 0.95 min, p = 0.04, 95% CI [0.05, 2.64], d = 0.2). There was no difference in RPE during the time trial between conditions (p = 0.82) despite there being a 4.4% increase in average power output during the time trial following MitoQ supplementation compared to placebo (placebo; 270 ± 51 W, MitoQ; 280 ± 53 W, p = 0.04, 95% CI [0.49, 8.22], d = 0.2). Plasma F2-isoprostanes were lower on completion of the time trial following MitoQ supplementation (35.89 ± 13.6 pg·ml− 1) compared to placebo (44.7 ± 16.9 pg·ml− 1p = 0.03). Conclusion These data suggest that MitoQ supplementation may be an effective nutritional strategy to attenuate exercise-induced increases in oxidative damage to lipids and improve cycling performance.

THE INFLUENCE OF AN AMARANTH-BASED BEVERAGE ON CYCLING PERFORMANCE: A PILOT STUDY

Biotecnia ◽  
2018 ◽  
Vol 20 (2) ◽  
pp. 31-36
Author(s):  
Ever Espino-González ◽  
María J. Muñoz-Daw ◽  
Juan M. Rivera-Sosa ◽  
María L. De la Torre-Díaz ◽  
Gabriel E. Cano-Olivas ◽  
...  
Keyword(s):  
Perceived Exertion ◽  
Average Power ◽  
Time Trial ◽  
Cycling Performance ◽  
Hydration Status ◽  
Caloric Content ◽  
Ratings Of Perceived Exertion ◽  
Exercise Tests ◽  
Sports Beverage ◽  
Trial Performance

The present study aimed to evaluate the effectiveness of an amaranth-based beverage (CHO-P) on cycling performance and hydration status, despite containing a total caloric content higher than that of a commercial sports beverage (CHO-P: 52.48 kcal per 100 mL vs CHO: 24 kcal per 100 mL). In a randomized, crossover design, six cyclists performed two exercise tests separated by seven days. Each test comprised two time-trials (32.20 km and 5 km) separated by 10 min of rest. Participants consumed either an amaranth-based beverage (CHO-P; 10% and 1.5% concentrations) or a commercial sports beverage (CHO; 6%). Changes in hematocrit and body mass, ratings of perceived exertion, and average power were assessed throughout both tests. 32.2-km time-trial performance was enhanced with CHO-P compared to CHO (54.3 ± 4.1 min vs 55.6 ± 4.8 min; p<0.05). However, no other variablemeasured in this study was significantly different between beverage types. Further laboratory based research should be performed to further explore the ergogenic potential of amaranth supplementation during endurance exercise.

The Effect of Siberian Ginseng (Eleutherococcus Senticosus) on Substrate Utilization and Performance during Prolonged Cycling

2000 ◽  
Vol 10 (4) ◽  
pp. 444-451 ◽  
Author(s):  
L. Christopher Eschbach ◽  
Michael J. Webster ◽  
Joseph C. Boyd ◽  
Patrick D. McArthur ◽  
Tammy K. Evetovich
Keyword(s):  
Steady State ◽  
Perceived Exertion ◽  
Time Trial ◽  
Cycling Performance ◽  
Substrate Utilization ◽  
Rating Of Perceived Exertion ◽  
Time Interval ◽  
Double Blind ◽  
Eleutherococcus Senticosus ◽  
Siberian Ginseng

It has been suggested that Eleutherococcus senticosus (ES). also known as Siberian ginseng or ciwuija. increases fat utilization in humans. The purpose of this study was to examine the physiological responses to supplementation with ES in endurance cyclists. Using arandomized. double-blind crossover design. 9 highly-trained men (28 ± 2 years. V̇O2max 57.3±2.0 ml · kg−1 · min−1) cycled for 120 min at 60% V̇O2max followed by a simulated 10-km lime trial. Diet was controlled, and ES (1,200 mg · day−1) or a placebo (P) were administered for 7 days prior to each of the two trials. Oxygen consumption, respiratory exchange ratio, and heart rate were recorded every 30 min, and rating of perceived exertion. plasma [lactate], and plasma [glucose j were recorded every 20 min during the 120 min of steady state cycling. There were no significant differences (p > .05) between the ES and P groups at any steady-state time interval or during the cycling time trial (ES = 18.10 ± 0.42, P = 17.83 ± 0.47 min). In contrast with previous reports, the results of this study suggest that ES supplementation does not alter steady-state substrate utilization or 10-km cycling performance time.

Impact of sodium citrate ingestion during recovery after dehydrating exercise on rehydration and subsequent 40-km cycling time-trial performance in the heat

2018 ◽  
Vol 43 (6) ◽  
pp. 571-579 ◽  
Author(s):  
Silva Suvi ◽  
Martin Mooses ◽  
Saima Timpmann ◽  
Luule Medijainen ◽  
Daria Narõškina ◽  
...  
Keyword(s):  
Water Intake ◽  
Perceived Exertion ◽  
Sodium Citrate ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Time Trial ◽  
Cycling Performance ◽  
Double Blind ◽  
Warm Environment ◽  
The Impact

The purpose of this study was to assess the impact of sodium citrate (CIT) ingestion (600 mg·kg−1) during recovery from dehydrating cycling exercise (DE) on subsequent 40-km cycling performance in a warm environment (32 °C). Twenty male nonheat-acclimated endurance athletes exercised in the heat until 4% body mass (BM) loss occurred. After 16 h recovery with consumption of water ad libitum and prescribed diet (evening meal 20 kcal·kg−1, breakfast 12 kcal·kg−1) supplemented in a double-blind, randomized, crossover manner with CIT or placebo (PLC), they performed 40-km time-trial (TT) on a cycle ergometer in a warm environment. During recovery greater increases in BM and plasma volume (PV) concomitant with greater water intake and retention occurred in the CIT trial compared with the PLC trial (p < 0.0001). During TT there was greater water intake and smaller BM loss in the CIT trial than in the PLC trial (p < 0.05) with no between-trial differences (p > 0.05) in sweat loss, PV decrement, ratings of perceived exertion, or TT time (CIT 68.10 ± 3.28 min, PLC 68.11 ± 2.87 min). At the end of TT blood lactate concentration was higher (7.58 ± 2.44 mmol·L−1 vs 5.58 ± 1.32 mmol·L−1; p = 0.0002) and rectal temperature lower (39.54 ± 0.50 °C vs 39.65 ± 0.52 °C; p = 0.033) in the CIT trial than in the PLC trial. Compared with pre-DE time point, PV had decreased to a lower level in the PLC trial than in the CIT trial (p = 0.0001). In conclusion, CIT enhances rehydration after exercise-induced dehydration but has no impact on subsequent 40-km cycling TT performance in a warm uncompensable environment.

Menthol Mouth Rinsing and Cycling Performance in Females Under Heat Stress

2020 ◽  
pp. 1-7
Author(s):  
Erica H. Gavel ◽  
Heather M. Logan-Sprenger ◽  
Joshua Good ◽  
Ira Jacobs ◽  
Scott G. Thomas
Keyword(s):  
Heart Rate ◽  
Confidence Interval ◽  
Core Temperature ◽  
Perceived Exertion ◽  
Thermal Sensation ◽  
Average Power ◽  
Time Trial ◽  
Cycling Performance ◽  
Thermal Perception ◽  
Ratings Of Perceived Exertion

Purpose: The effects of menthol (MEN) mouth rinse (MR) on performance, physiological, and perceptual variables in female cyclists during a 30-km independent time trial (ITT) were tested. Methods: The participants (n = 9) cycled for 30 km in hot conditions (30°C [0.6°C], 70% [1%] relative humidity, 12 [1] km/h wind speed) on 2 test occasions: with a placebo MR and with MEN MR. Handgrip and a 5-second sprint were measured before, following the first MR, and after the ITT. Ratings of perceived exertion Borg 6 to 20, thermal sensation, and thermal pleasantness were recorded every 5 km. Core temperature and heart rate were recorded throughout. Results: The ITT performance significantly improved with MEN MR by 2.3% (2.7%) relative to the placebo (62.6 [5.7] vs 64.0 [4.9] min P = .034; d = 0.85; 95% confidence interval, 0.14 to 2.8 min). The average power output was significantly higher in the MEN trial (P = .031; d = 0.87; 95% confidence interval, 0.9 to 15.0 W). No significant interaction of time and MR for handgrip (P = .581, η2 = .04) or sprint was observed (P = .365, η2 = .103). Core temperature, heart rate, ratings of perceived exertion, and thermal sensation did not significantly differ between trials at set distances (P > .05). Pleasantness significantly differed between the placebo and MEN only at 5 km, with no differences at other TT distances. Conclusion: These results suggest that a nonthermal cooling agent can improve 30-km ITT performance in female cyclists, although the improved performance with MEN MR is not due to altered thermal perception.

Predicting Cycling Performance in Trained to Elite Male and Female Cyclists

2014 ◽  
Vol 9 (4) ◽  
pp. 610-614 ◽  
Author(s):  
Robert P. Lamberts
Keyword(s):  
Power Output ◽  
High Performance ◽  
Perceived Exertion ◽  
Maximal Oxygen Consumption ◽  
Average Power ◽  
Time Trial ◽  
Cycling Performance ◽  
Gas Analysis ◽  
Peak Power Output ◽  
Male And Female

In high-performance cycling, it is important to maintain a healthy balance between training load and recovery. Recently a new submaximal cycle test, known as the Lamberts and Lambert Submaximal Cycle Test (LSCT), has been shown to be able to accurately predict cycling performance in 15 well-trained cyclists. The aim of this study was to determine the predictive value of the LSCT in 102 trained to elite cyclists (82 men and 20 women). All cyclists performed an LSCT test followed by a peak-power-output (PPO) test, which included respiratory-gas analysis for the determination of maximal oxygen consumption (VO2max). They then performed the LSCT test followed by a 40-km time trial (TT) 72 h later. Average power output during the 3 stages of the LSCT increased from 31%, 60%, and 79% of PPO, while the ratings of perceived exertion increased from 8 to 13 to 16. Very good relationships were found between actual and LSCT-predicted PPO (r = .98, 95%CI: .97–.98, P < .0001), VO2max (r = .96, 95%CI: .97–.99, P < .0001) and 40-km-TT time (r = .98, 95%CI: .94–.97, P < .0001). No gender differences were found when predicting cycling performance from the LSCT (P = .95). The findings of this study show that the LSCT is able to accurately predict cycling performance in trained to elite male and female cyclists and potentially can be used to prescribe and fine-tune training prescription in cycling.

Effects of Caffeine, Sodium Bicarbonate, and Their Combined Ingestion on High-Intensity Cycling Performance

2012 ◽  
Vol 22 (3) ◽  
pp. 175-183 ◽  
Author(s):  
Andrew E. Kilding ◽  
Claire Overton ◽  
Jonathan Gleave
Keyword(s):  
Sodium Bicarbonate ◽  
High Intensity ◽  
Perceived Exertion ◽  
Time Trial ◽  
Cycling Performance ◽  
Cycle Ergometer ◽  
Performance Measurements ◽  
Mean Power ◽  
Double Blind ◽  
Cycling Time Trial

Purpose:To determine the effects of ingesting caffeine (CAFF) and sodium bicarbonate (SB), taken individually and simultaneously, on 3-km cycling time-trial (TT) performance.Method:Ten well-trained cyclists, age 24.2 ± 5.4 yr, participated in this acute-treatment, double-blind, crossover study that involved four 3-km cycling TTs performed on separate days. Before each TT, participants ingested either 3 mg/kg body mass (BM) of CAFF, 0.3 g · kg−1 · BM−1 of SB, a combination of the two (CAFF+SB), or a placebo (PLAC). They completed each 3-km TT on a laboratory-based cycle ergometer, during which physiological, perceptual, and performance measurements were determined. For statistical analysis, the minimal worthwhile difference was considered ~1% based on previous research.Results:Pretrial pH and HCO3 were higher in SB and CAFF+SB than in the CAFF and PLAC trials. Differences across treatments for perceived exertion and gastric discomfort were mostly unclear. Compared with PLAC, mean power output during the 3-km TT was higher in CAFF, SB, and CAFF+SB trials (2.4%, 2.6%, 2.7% respectively), resulting in faster performance times (–0.9, –1.2, –1.2% respectively). Effect sizes for all trials were small (0.21–0.24).Conclusions:When ingested individually, both CAFF and SB enhance high-intensity cycling TT performance in trained cyclists. However, the ergogenic effect of these 2 popular supplements was not additive, bringing into question the efficacy of coingesting the 2 supplements before short-duration high-intensity exercise. In this study there were no negative effects of combining CAFF and SB, 2 relatively inexpensive and safe supplements.

The Effect of Beta-Alanine Supplementation on Isokinetic Force and Cycling Performance in Highly Trained Cyclists

2013 ◽  
Vol 23 (6) ◽  
pp. 562-570 ◽  
Author(s):  
Samuel T. Howe ◽  
Phillip M. Bellinger ◽  
Matthew W. Driller ◽  
Cecilia M. Shing ◽  
James W. Fell
Keyword(s):  
Short Duration ◽  
Average Power ◽  
Force Production ◽  
Time Trial ◽  
Cycling Performance ◽  
Controlled Study ◽  
Fatigue Index ◽  
Double Blind ◽  
Beta Alanine ◽  
Blood Ph

Beta-alanine may benefit short-duration, high-intensity exercise performance. The aim of this randomized double-blind placebo-controlled study was to examine the effects of beta-alanine supplementation on aspects of muscular performance in highly trained cyclists. Sixteen highly trained cyclists (mean ± SD; age = 24 ± 7 yr; mass = 70 ± 7kg; VO2max = 67 ± 4ml·kg−1·min–1) supplemented with either beta-alanine (n = 8, 65 mg·kg−1BM) or a placebo (n = 8; dextrose monohydrate) over 4 weeks. Pre- and postsupplementation cyclists performed a 4-minute maximal cycling test to measure average power and 30 reciprocal maximal isokinetic knee contractions at a fixed angular velocity of 180°·sec−1 to measure average power/repetition, total work done (TWD), and fatigue index (%). Blood pH, lactate (La−) and bicarbonate (HCO3-) concentrations were measured preand postisokinetic testing at baseline and following the supplementation period. Beta-alanine supplementation was 44% likely to increase average power output during the 4-minute cycling time trial when compared with the placebo, although this was not statistically significant (p = .25). Isokinetic average power/repetition was significantly increased post beta-alanine supplementation compared with placebo (beta-alanine: 6.8 ± 9.9W, placebo: –4.3 ± 9.5 W, p = .04, 85% likely benefit), while fatigue index was significantly reduced (p = .03, 95% likely benefit). TWD was 89% likely to be improved following beta-alanine supplementation; however, this was not statistically significant (p = .09). There were no significant differences in blood pH, lactate, and HCO3− between groups (p > .05). Four weeks of beta-alanine supplementation resulted in worthwhile changes in time-trial performance and short-duration muscular force production in highly trained cyclists.

scholarly journals Does caffeine supplementation alter energy contribution during a work-based ~30 min cycling time-trial?

2020 ◽  
Vol 34 (3) ◽  
pp. 471-481
Author(s):  
Gabriel Barreto ◽  
Rafael Pires da Silva ◽  
Guilherme Yamaguchi ◽  
Luana Farias de Oliveira ◽  
Vitor de Salles Painelli ◽  
...  
Keyword(s):  
Perceived Exertion ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Time Trial ◽  
Energy System ◽  
Energy Contribution ◽  
Mean Power ◽  
Double Blind ◽  
Cycling Time Trial ◽  
Cycling Time

Caffeine has been shown to increase anaerobic energy contribution during short-duration cycling time-trials (TT) though no information exists on whether caffeine alters energy contribution during more prolonged, aerobic type TTs. The aim of this study was to determine the effects of caffeine supplementation on longer and predominantly aerobic exercise. Fifteen recreationally-trained male cyclists (age 38±8 y, height 1.76±0.07 m, body mass 72.9±7.7 kg) performed a ~30 min cycling TT following either 6 mg·kg-1BM caffeine (CAF) or placebo (PLA) supplementation, and one control (CON) session without supplementation, in a double- -blind, randomised, counterbalance and cross-over design. Mean power output (MPO) was recorded as the outcome measure. Respiratory values were measured throughout exercise for the determination of energy system contribution. Data were analysed using mixed-models. CAF improved mean MPO compared to CON (P=0.01), and a trend towards an improvement compared to PLA (P=0.07); there was no difference in MPO at any timepoint throughout the exercise between conditions. There was a main effect of Condition (P=0.04) and Time (P<0.0001) on blood lactate concentration, which tended to be higher in CAF vs. both PLA and CON (Condition effect, both P=0.07). Ratings of perceived exertion increased over time (P<0.0001), with no effect of Condition or interaction (both P>0.05). Glycolytic energy contribution was increased in CAF compared to CON and PLA (both P<0.05), but not aerobic or ATP-CP (both P>0.05). CAF improved aerobic TT performance compared to CON, which could be explained by increased glycolytic energy contribution.

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