Left Atrial diameter Index as a prognostic factor for STEMI: a case-control study

Abstract Background：The left atrium has a considerable role in cardiac function because of its unique anatomy and physiological function. We evaluated the role of the size of the left atrium in the prognosis of STEMI by quantifying the left atrium by introducing a left atrial diameter index(LAdI).Methods: This is a retrospective study conducted in a University Affiliated Hospital. Echocardiography is used to evaluate the size of left atrial diameter. It is indexed by body surface(BSA) area to evaluate the significance of LAdI on the prognosis of STEMI.This study was approved by the medical ethics committee of The First Hospital of Jilin University. All subjects in this trial gave written informed consent.Results: A total of 473 patients with a first STEMI within two years met the inclusion criteria to be included in this study. LA（OR=6.945；95%CI 1.398~34.499；P=0.018）and EF （OR=0.931；95%CI 0.904~0.960; P=0.000 ）were independent risk factors for MACEs.Conclusion:Patients with a first STEMI with a greater LAdI have a greater risk of MACEs than patients with a normal left atrium despite well-established PCI therapies.

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MMP-9 in Myocardial Fibrosis and Structural Remodeling in Rheumatic Heart Disease Patients with Atrial Fibrillation: A Single-center Prospective Case-control Study

10.21203/rs.3.rs-140322/v1 ◽

2021 ◽

Author(s):

Shuguo Yuan ◽

Wan Li ◽

Liangqiu Tang ◽

Chengquan Liao ◽

Shaochun Ma ◽

...

Keyword(s):

Atrial Fibrillation ◽

Heart Disease ◽

Left Atrial ◽

Case Control Study ◽

Case Control ◽

Single Center ◽

Structural Remodeling ◽

Left Atrial Diameter ◽

Control Study ◽

Prospective Case Control Study

Abstract Background: Atrial fibrillation (AF) is a common arrhythmia that induces disability or death; however, the underlying pathogenesis is yet unclear. This study aimed to investigate the expression of matrix metalloproteinase-9 (MMP-9) in rheumatic valvular heart disease (RVHD) and its value in predicting AF.Methods: In this single-center, prospective case-control study, 30 patients who received valve replacement for the treatment of RVHD in the Cardiac and Major Vascular Department, Yue Bei People’s Hospital between August 2012 and January 2015 were included in this study. The patients were categorized equally into two groups according to the electrocardiogram characteristics: sinus rhythm (SR) group and chronic atrial fibrillation (AF) group. In patients hospitalized for RVHD, the fasting serum was collected on the following day in the morning, and the tissues of right auricle were collected during the operation. Hematoxylin and eosin staining and Masson staining were performed to assess the pathological structures of myocardial tissues and changes in collagen fibers. Enzyme-linked immunosorbent assay was used to measure the level of MMP-9 in serum, and the distribution of the protein in myocardial tissues was assessed by immunohistochemistry. Echocardiography was performed before the surgery to measure the left atrial diameter and ejection fraction.Results: The MMP-9 expression was significantly higher in the AF group than the SR group (4.2281 ± 0.9165 ng/mg vs. 2.7613 ± 1.2166 ng/mg, p < 0.05). The MMP-9 levels were positively associated with left atrial diameter (LAD) (p < 0.01) and collagen volume fraction (CVF) (p < 0.05).Conclusions: MMP-9 expression is elevated in AF patients and could be one of the major factors involved in the remodeling of atrial structures in AF. MMP-9 influences the metabolism of collagen and promotes the fibrosis of the myocardium, participates in cardiac structural remodeling, and plays a role in the onset and maintenance of AF.

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Diagnostic utility of a Ferritin-to-Procalcitonin Ratio to differentiate patients with COVID-19 from those with Bacterial Pneumonia: A multicenter study

Open Forum Infectious Diseases ◽

10.1093/ofid/ofab124 ◽

2021 ◽

Author(s):

Amal A Gharamti ◽

Fei Mei ◽

Katherine C Jankousky ◽

Jin Huang ◽

Peter Hyson ◽

...

Keyword(s):

Bacterial Pneumonia ◽

Operating Characteristic ◽

Case Control Study ◽

Receiver Operating Characteristic Analysis ◽

Similar Proportion ◽

Characteristic Analysis ◽

Multivariable Analyses ◽

Prevalence Of Diabetes Mellitus ◽

Control Study

Abstract Background There is an urgent need for accurate, rapid, inexpensive biomarkers that can differentiate COVID-19 from bacterial pneumonia. We assess the role of the ferritin-to-procalcitonin (F/P) ratio to classify pneumonia cases into those due to COVID-19 or due to bacterial pathogens. Methods This multicenter case-control study compared patients with either COVID-19 and bacterial pneumonia, admitted between March 1 and May 31, 2020. Patients with COVID-19 and bacterial pneumonia co-infection were excluded. The F/P in patients with COVID-19 or with bacterial pneumonia were compared. Receiver operating characteristic analysis determined the sensitivity and specificity of various cut-off F/P values for COVID-19 versus bacterial pneumonia. Results A total of 242 COVID-19 pneumonia cases and 34 bacterial pneumonia controls were included. Patients with COVID-19 pneumonia had a lower mean age (57.11 vs 64.4 years, p=0.02) and a higher BMI (30.74 vs 27.15 kg/m 2, p=0.02) compared to patients with bacterial pneumonia. Cases and controls had a similar proportion of women (47% vs 53%, p=0.5) and COVID-19 patients had a higher prevalence of diabetes mellitus (32.6% vs 12%, p=0.01). The median F/P was significantly higher in patients with COVID-19 (4037.5) compared to the F/P in bacterial pneumonia (802, p<0.001). An F/P ≥ 877 used to diagnose COVID-19 resulted in a sensitivity of 85% and a specificity of 56%, with a positive predictive value of 93.2%, and a likelihood ratio of 1.92. In multivariable analyses, an F/P ≥ 877 was associated with greater odds of identifying a COVID-19 case (OR: 11.27, CI: 4-31.2, p<0.001). Conclusion An F/P ≥ 877 increases the likelihood of COVID-19 pneumonia compared to bacterial pneumonia.

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Gly972Arg Variant of Insulin Receptor Substrate 1 Gene and Colorectal Cancer Risk in Overweight/Obese Subjects

The International Journal of Biological Markers ◽

10.5301/jbm.5000159 ◽

2016 ◽

Vol 31 (1) ◽

pp. 68-72 ◽

Cited By ~ 3

Author(s):

Touraj Mahmoudi ◽

Keivan Majidzadeh-A ◽

Khatoon Karimi ◽

Hamid Farahani ◽

Reza Dabiri ◽

...

Keyword(s):

Colorectal Cancer ◽

Insulin Receptor ◽

Case Control Study ◽

Insulin Receptor Substrate ◽

Protective Effects ◽

Insulin Receptor Substrate 1 ◽

Pcr Rflp ◽

Obese Subjects ◽

Control Study

Background Given the major role of obesity and insulin resistance (IR) in colorectal cancer (CRC), we investigated whether genetic variants in ghrelin ( GHRL), resistin ( RETN) and insulin receptor substrate 1 ( IRS1) were associated with CRC risk. Methods This study was conducted as a case-control study, and 750 subjects, including 438 controls and 312 patients with CRC, were enrolled and genotyped using the PCR-RFLP method. Results No significant differences were observed for GHRL (rs696217), RETN (rs3745367) and IRS1 (rs1801278, Gly972Arg or G972R) gene variants between the cases and controls. However, the IRS1 G972R R allele compared with the G allele and the G972R RR+GR genotype compared with the GG genotype appeared to be markers of decreased CRC susceptibility in the overweight/obese subjects (p = 0.024; odds ratio [OR] = 0.42, 95% confidence interval [95% CI], 0.20-0.91; and p = 0.048; OR = 0.42, 95% CI, 0.17-0.99, respectively). Furthermore, the R allele and RR+GR genotype were also associated with decreased risks for obesity in the patients with CRC (p = 0.007; OR = 0.35, 95% CI, 0.15-0.77; and p = 0.015; OR = 0.35, 95% CI, 0.15-0.72, respectively). Conclusions In accordance with previous studies, our findings suggest that the IRS1 G972R R allele and RR+GR genotype have protective effects for CRC in overweight/obese patients and for obesity in patients with CRC. Nevertheless, further studies are required to confirm these findings.

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The possible role of endocrine disrupting chemicals in the aetiology of cryptorchidism and hypospadias: a population-based case?control study in rural Sicily

International Journal of Andrology ◽

10.1111/j.1365-2605.2006.00703.x ◽

2007 ◽

Vol 30 (1) ◽

pp. 3-13 ◽

Cited By ~ 54

Author(s):

P. Carbone ◽

F. Giordano ◽

F. Nori ◽

A. Mantovani ◽

D. Taruscio ◽

...

Keyword(s):

Case Control Study ◽

Endocrine Disrupting Chemicals ◽

Population Based ◽

Case Control ◽

Endocrine Disrupting ◽

Control Study

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A multi-centre prospective case-control study of campylobacter infection in persons aged 5 years and older in Australia

Epidemiology and Infection ◽

10.1017/s0950268806007576 ◽

2006 ◽

Vol 135 (6) ◽

pp. 978-988 ◽

Cited By ~ 61

Author(s):

R. J. STAFFORD ◽

P. SCHLUTER ◽

M. KIRK ◽

A. WILSON ◽

L. UNICOMB ◽

...

Keyword(s):

Case Control Study ◽

Case Control ◽

Cross Contamination ◽

Multivariable Logistic Regression Model ◽

Final Model ◽

Independent Risk Factors ◽

Community Controls ◽

Population Attributable Risks ◽

Campylobacter Infection ◽

Control Study

SUMMARYThere are an estimated 277 000 cases of campylobacteriosis in Australia each year, most of which are thought to be sporadically acquired. To explore causes for these infections, we conducted a multi-centre case-control study of patients and community controls across five Australian States during 2001–2002. A total of 881 campylobacter cases and 833 controls aged ⩾5 years were recruited into the study. Crude logistic analyses were conducted within various food and non-food exposure groups. A final most parsimonious multivariable logistic regression model was developed and adjusted odds ratios (aOR), 95% confidence intervals (95% CI) were derived together with adjusted population attributable risks (PAR). Consumption of undercooked chicken (aOR 4·7, 95% CI 2·6–8·4) and offal (aOR 2·0, 95% CI 1·0–4·0), ownership of domestic chickens aged <6 months (aOR 12·4, 95% CI 2·6–59·3) and domestic dogs aged <6 months (aOR 2·1, 95% CI 1·1–4·2) were found to be independent risk factors for illness in the final model. The PAR proportions indicate that eating chicken meat, either cooked or undercooked may account for approximately 30% of campylobacter cases that occur each year in Australia. These results justify the continued need for education of consumers and foodhandlers about the risks associated with the handling of raw chicken and the potential for cross-contamination.

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P2-233: The role of hippocampal atrophy for the differentiation between MCI subtypes: Results of a case-control study

Alzheimer s & Dementia ◽

10.1016/j.jalz.2012.05.940 ◽

2012 ◽

Vol 8 (4S_Part_9) ◽

pp. P341-P341

Author(s):

Martha Dlugaj ◽

Christoph Mönninghoff ◽

Hans-Jürgen Huppertz ◽

Isabel Wanke ◽

Daniel Jokisch ◽

...

Keyword(s):

Case Control Study ◽

Case Control ◽

Hippocampal Atrophy ◽

Control Study

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Risk factors associated with anthrax in cattle on smallholdings

Epidemiology and Infection ◽

10.1017/s0950268811002408 ◽

2011 ◽

Vol 140 (10) ◽

pp. 1888-1895 ◽

Cited By ~ 10

Author(s):

P. K. BISWAS ◽

M. Z. ISLAM ◽

S. K. SHIL ◽

R. K. CHAKRABORTY ◽

S. S. U. AHMED ◽

...

Keyword(s):

Risk Factors ◽

Eichhornia Crassipes ◽

Case Control Study ◽

Conditional Logistic Regression ◽

Study Data ◽

Matched Pair ◽

Matched Pair Analysis ◽

Independent Risk Factors ◽

Pair Analysis ◽

Control Study

SUMMARYUnprecedented high rates of anthrax outbreaks have been observed recently in cattle and humans in Bangladesh, with 607 human cases in 2010. By enrolling 15 case and 15 control cattle smallholdings in the spatial zone in July–September 2010, we conducted a case-control study, data of which were analysed by matched-pair analysis and multivariable conditional logistic regression. Feeding animals with uprooted and unwashed grass [odds ratio (OR) 41·2, 95% confidence interval (CI) 3·7–458·8, P=0·003], and feeding water hyacinth (Eichhornia crassipes) (OR 22·2, 95% CI 1·2–418·7, P=0·039) were independent risk factors for anthrax in cattle.

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Association between CTSS gene polymorphism and the risk of acute atherosclerotic cerebral infarction in Chinese population: a case–control study

Bioscience Reports ◽

10.1042/bsr20180586 ◽

2018 ◽

Vol 38 (6) ◽

Cited By ~ 2

Author(s):

Lian Luo ◽

Mingli Zhu ◽

Jiajun Zhou

Keyword(s):

Cerebral Infarction ◽

Case Control Study ◽

Case Control ◽

Cathepsin S ◽

Control Group ◽

Study Group ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Independent Risk Factors ◽

Control Study

Objective: To investigate the association between the gene polymorphisms of rs774320676, rs768437857, rs928508030, and rs2275235 loci of Cathepsin S (CTSS) and risk of acute atherosclerotic cerebral infarction. Methods: A total of 315 patients with acute atherosclerotic cerebral infarction (study group) and 220 healthy subjects (control group) were enrolled in the present study. The genetic polymorphism of rs774320676, rs768437857, rs928508030, and rs2275235 loci of CTSS of subjects was analyzed by PCR-Sanger sequencing. Results: The proportion of carriers with mutant T allele at rs774320676 locus and mutant G allele at rs928508030 locus of CTSS in study group was significantly higher than the proportion in control group (P=0.000, adjusted odds ratio (OR) = 1.332, 95% confidence interval (CI) = 1.200–1.460; P<0.001, adjusted OR = 1.185, 95% CI = 1.055–1.314; P=0.002). The T allele at rs774320676 locus and the G allele at rs928508030 locus of CTSS were independent risk factors for acute atherosclerotic cerebral infarction (OR = 2.534, 95% CI = 1.020–4.652, P=0.006; OR = 2.016, 95% CI = 1.031–4.385, P=0.031). Conclusion: The single nucleotide polymorphisms (SNPs) of rs774320676 and rs928508030 of CTSS gene were related with risk for acute atherosclerotic cerebral infarction. The T allele at rs774320676 locus and G allele at rs928508030 locus of CTSS were genetic susceptibility genes of acute atherosclerotic cerebral infarction.

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