scholarly journals Tumor-Targeted Drug Delivery as a Successful Approach for Reducing Doxorubicin–Induced Cardiotoxicity

2021 ◽  
Author(s):  
Nasibeh Mohammad Ali Pourradi ◽  
Yadollah Azarmi ◽  
Hossien Babaei ◽  
Behzad Baradaran ◽  
Behrooz Shokouhi-Gogani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Nlrp3 Inflammasome ◽  
Targeted Drug Delivery ◽  
Left Ventricular ◽  
Heart Weight ◽  
Inflammasome Activation ◽  
Body Distribution ◽  
Nlrp3 Inflammasome Activation ◽  
Targeted Drug

Abstract Doxorubicin (DOX) is an effective chemotherapy drug used to treat many malignancies, including breast cancer. However, its clinical application is severely limited by cardiotoxicity. This study investigated if using thermo/pHsensitive magnetic nanoparticles decorated with folate (folate-poly-MNPs) as tumor-targeted drug delivery systems (DDSs) could reduce the cardiotoxicity and inflammatory properties of DOX in a rat model of breast cancer. In this study, forty rats were intravenously administered the control, DOX, DOX-poly-MNPs, and DOXfolate-poly-MNPs every 48 hours for 12 days. The cardiac health monitoring following breast cancer therapy confirmed that the novel smart DDS improved ECG pattern, left ventricular function, blood pressure parameters, and heart weight index. Moreover, it could decrease myocardial cell death by decreasing the protein levels of BAX, c-PARP1, and c-caspase-3, with concomitant downregulation of the BAX/Bcl-2 ratio, compared to the commercial DOX. In addition, the DOXfolate-poly-MNPs treatment significantly reduced NLRP3 inflammasome activation in cardiomyocytes, which was mediated by caspase-1 inhibition, and suppressed upregulation of IL-1β and IL18 protein expression to prevent myocardial damage. In this regard, the developed folatepolyMNPs could be represented as a new potential drug delivery system for breast cancer chemotherapy due to the combination of passive and active targeting aimed at preventing nonspecific body distribution, inhibiting NLRP3 inflammasome activation, and consequently reducing DOX cardiotoxicity as its main adverse effect.

Identification of protein targets and the mechanism of the cytotoxic action of Ipomoea turpethum extract loaded nanoparticles against breast cancer cells

2019 ◽  
Vol 7 (39) ◽  
pp. 6048-6063 ◽  
Author(s):  
Mohd Mughees ◽  
Mohd Samim ◽  
Yadhu Sharma ◽  
Saima Wajid
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Breast Cancer Cells ◽  
Cytotoxic Action ◽  
Protein Targets ◽  
Targeted Drug

The shortcomings of the currently available anti-breast cancer agents compel the development of the safer targeted drug delivery for the treatment of breast cancer.

ROS-Switchable Polymeric Nanoplatform with Stimuli-Responsive Release for Active Targeted Drug Delivery to Breast Cancer

2017 ◽  
Vol 9 (14) ◽  
pp. 12227-12240 ◽  
Author(s):  
Yu Zhang ◽  
Qin Guo ◽  
Sai An ◽  
Yifei Lu ◽  
Jianfeng Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Stimuli Responsive ◽  
Targeted Drug

scholarly journals Targeted Drug Delivery Systems Mediated by a Novel Peptide in Breast Cancer Therapy and Imaging

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66128 ◽  
Author(s):  
Ruei-Min Lu ◽  
Min-Shan Chen ◽  
De-Kuan Chang ◽  
Chien-Yu Chiu ◽  
Wei-Chuan Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Breast Cancer Therapy ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

Synthesis of a novel, sequentially active-targeted drug delivery nanoplatform for breast cancer therapy

Biomaterials ◽  
2015 ◽  
Vol 59 ◽  
pp. 88-101 ◽  
Author(s):  
Arpan Satsangi ◽  
Sudipa S. Roy ◽  
Rajiv K. Satsangi ◽  
Anthony W. Tolcher ◽  
Ratna K. Vadlamudi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Targeted Drug Delivery ◽  
Breast Cancer Therapy ◽  
Targeted Drug

scholarly journals Protection of Sacubitril/Valsartan against Pathological Cardiac Remodeling by Inhibiting the NLRP3 Inflammasome after Relief of Pressure Overload in Mice

2020 ◽  
Vol 34 (5) ◽  
pp. 629-640
Author(s):  
Xueling Li ◽  
Qin Zhu ◽  
Qingcheng Wang ◽  
Qinggang Zhang ◽  
Yaru Zheng ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Cardiac Remodeling ◽  
Cardiac Fibrosis ◽  
Pressure Overload ◽  
Myocardial Cell ◽  
Heart Weight ◽  
Inflammasome Activation ◽  
Clinical Prognosis ◽  
Nlrp3 Inflammasome Activation ◽  
Neprilysin Inhibitor

Abstract Background/aims The persistent existence of pathological cardiac remodeling, resulting from aortic stenosis, is related to poor clinical prognosis after successful transcatheter aortic valve replacement (TAVR). Sacubitril/valsartan (Sac/Val), comprising an angiotensin receptor blocker and a neprilysin inhibitor, has been demonstrated to have a beneficial effect against pathological cardiac remodeling, including cardiac fibrosis and inflammation in heart failure. The aim of this study was to determine whether Sac/Val exerts a cardioprotective effect after pressure unloading in mice. Methods and results Male C57BL/6 J mice were subjected to debanding (DB) surgery after 8 weeks (wk) of aortic banding (AB). Cardiac function was assessed by echocardiography, which indicated a protective effect of Sac/Val after DB. After treatment with Sac/Val post DB, decreased heart weight and myocardial cell size were observed in mouse hearts. In addition, histological analysis, immunofluorescence, and western blot results showed that Sac/Val attenuated cardiac fibrosis and inflammation after DB. Finally, our data indicated that Sac/Val treatment could significantly suppress NF-κB signaling and NLRP3 inflammasome activation in mice after relief of pressure overload. Conclusion Sac/Val exerted its beneficial effects to prevent maladaptive cardiac fibrosis and dysfunction in mice following pressure unloading, which was at least partly due to the inhibition of NLRP3 inflammasome activation.

A Review on Targeting Nanoparticles for Breast Cancer

2019 ◽  
Vol 20 (13) ◽  
pp. 1087-1107 ◽  
Author(s):  
Hasanain Gomhor J. Alqaraghuli ◽  
Soheila Kashanian ◽  
Ronak Rafipour
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Targeted Drug Delivery ◽  
Breast Cancer Cells ◽  
Pharmaceutical Research ◽  
Chemotherapeutic Agents ◽  
Great Promise ◽  
Targeted Drug

Chemotherapeutic agents have been used extensively in breast cancer remedy. However, most anticancer drugs cannot differentiate between cancer cells and normal cells, leading to toxic side effects. Also, the resulted drug resistance during chemotherapy reduces treatment efficacy. The development of targeted drug delivery offers great promise in breast cancer treatment both in clinical applications and in pharmaceutical research. Conjugation of nanocarriers with targeting ligands is an effective therapeutic strategy to treat cancer diseases. In this review, we focus on active targeting methods for breast cancer cells through the use of chemical ligands such as antibodies, peptides, aptamers, vitamins, hormones, and carbohydrates. Also, this review covers all information related to these targeting ligands, such as their subtypes, advantages, disadvantages, chemical modification methods with nanoparticles and recent published studies (from 2015 to present). We have discussed 28 different targeting methods utilized for targeted drug delivery to breast cancer cells with different nanocarriers delivering anticancer drugs to the tumors. These different targeting methods give researchers in the field of drug delivery all the information and techniques they need to develop modern drug delivery systems.

Herbal Based Polymeric Nanoparticles as a Therapeutic Remedy for Breast Cancer

2020 ◽  
Vol 20 ◽  
Author(s):  
Mohd Mughees ◽  
Saima Wajid
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Herbal Extract ◽  
Future Research ◽  
Delivery Methods ◽  
Cancer Breast ◽  
Conventional Drug ◽  
Targeted Drug

Background: The currently available anti breast cancer agents as well as conventional drug delivery methods have some limitations. Objective: In view of these limitations, researchers used phytochemicals/herbal extracts as anti-breast cancer agents together with the polymeric nanoparticles to provide an effective way of targeted drug delivery with lesser /no side effects. Methods: The literature for this review was searched during the year 2014 to 2018 by using the keywords, ‘ ‘breast cancer’, ‘breast cancer and its current treatments’, ‘plants against the breast cancer’, ‘polymeric nanoparticles’, ‘herbal based polymeric nanoparticles’. The databases i.e. PubMed, Science Direct and Google Scholar were used for collecting the information. Results: In the present review, we try to summarize the potential of herbal based nanoformulation as specific and high efficacy therapeutic strategy in order to pave a way for the future research involving screening and use of herbal nanoparticles for the treatment of breast cancer. Conclusion: The encapsulation of the herbal extract in the polymeric nanoparticles is the prominent, effective and emerging way of targeted drug delivery for cancer. It may serve as safer way of targeted drug delivery and may be the answer of the complications related to the currently available anti-breast cancer agents as well as limitations of conventional method of drug delivery.

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