Cannabinoid Receptors: A Novel Target for Treating Prostate Cancer

2006 ◽  
Author(s):  
Hasan Mukhtar ◽  
Farrukh Afaq ◽  
Sami Sarfaraz
Keyword(s):  
Prostate Cancer ◽  
Cannabinoid Receptors ◽  
Novel Target

Cannabinoid Receptors: A Novel Target for Therapy of Prostate Cancer

2007 ◽  
Author(s):  
Hasan Mukhtar ◽  
Farrukh Afaq ◽  
Sami Sarfaraz
Keyword(s):  
Prostate Cancer ◽  
Cannabinoid Receptors ◽  
Novel Target

Emerging Biomarkers and Contributing Factors of Prostate Cancer.

2020 ◽  
Vol 16 ◽  
Author(s):  
Mini Dahiya ◽  
Monu Yadav ◽  
Kalpana Nagpal ◽  
Nidhi Sharma ◽  
Kajal Joshi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Tumor Suppressor Genes ◽  
Therapeutic Strategy ◽  
Cannabinoid Receptors ◽  
Contributing Factors ◽  
Cause Of Deaths ◽  
Pharmaceutical Industries ◽  
Brca1 Brca2 ◽  
Molecular Pathophysiology

: Prostate Cancer (PC) is one the most prominent cause of deaths in males worldwide especially in western countries. The exhaustive research into prostate cancer to date has demonstrated ELAC2, RNASEL, MSR1, NBS1, CHEK2, MYC, BCL-2, c-Kit, tumor suppressor genes, BRCA1, BRCA2, PACE4, GSTP1, PTEN,CDKN1B, NKX3.1, KLF6, FOXA1, Retinoblastoma, p53, androgen receptor, kallikreins, ETS, CYP17, SRD5A2, E-cadherin, KAI1/CD82, hepsin, AMACR, PIM1, MTA-1, EZH2, EPHB2, growth factors & its receptors, cannabinoid receptors, annexins, oxidative stress and inflammation are entailed changes underlying the initiation, development, and progression of PC. Furthermore, oncology would shift from a reactive to proactive discipline so exploring these targets open new area of research. Therefore, the present review is focused on molecular pathophysiology biomarkers for the progression of PC that would encourage the researchers and pharmaceutical industries to investigate potential therapeutic strategy to overcome demerits of currently available clinically therapies.

scholarly journals LINC01006 facilitates cell proliferation, migration and invasion in prostate cancer through targeting miR-34a-5p to up-regulate DAAM1

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Enhui Ma ◽  
Qianqian Wang ◽  
Jinhua Li ◽  
Xinqi Zhang ◽  
Zhenjia Guo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Gland ◽  
Inhibitory Effect ◽  
Luciferase Reporter ◽  
Migration And Invasion ◽  
Protein Coding ◽  
Novel Target

Abstract Background Prostate cancer (PCa) is a kind of malignancy occurring in the prostate gland. Substantial researches have proved the major role of long noncoding RNAs (lncRNAs) in PCa. However, the role of long intergenic non-protein coding RNA 1006 (LINC01006) in PCa has not been investigated yet. Methods RT-qPCR was used to examine the expression levels of LINC01006 and its downstream targets. The function of LINC01006 in PCa was tested by in vitro and in vivo assays. With application of RNA pull down, RNA immunoprecipitation (RIP) and luciferase reporter assays, the interaction among LINC01006, miR-34a-5p and disheveled associated activator of morphogenesis 1 (DAAM1) were verified. Results LINC01006 expression presented high in PCa cell lines. LINC01006 silencing suppressed cell proliferative, migratory, invasive capacities while accelerated apoptotic rate. Besides, LINC01006 knockdown also suppressed tumor growth and metastasis in vivo. Furthermore, miR-34a-5p, a tumor suppressor in PCa, was sponged by LINC01006. Moreover, DAAM1 was targeted by miR-34a-5p and promoted PCa progression. More intriguingly, rescue assays suggested that the inhibitory effect of LINC01006 knockdown on PCa development was offset by DAAM1 overexpression. Conclusions LINC01006 promoted PCa progression by sponging miR-34a-5p to up-regulate DAAM1, providing a novel target for PCa therapy.

scholarly journals Treatment with Cannabinoids as a Promising Approach for Impairing Fibroblast Activation and Prostate Cancer Progression

2020 ◽  
Vol 21 (3) ◽  
pp. 787 ◽  
Author(s):  
Pietrovito ◽  
Iozzo ◽  
Bacci ◽  
Giannoni ◽  
Chiarugi
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Stromal Cells ◽  
Cannabinoid Receptors ◽  
Smooth Muscle Actin ◽  
Prostate Tumor ◽  
Autocrine Loop ◽  
Stromal Component ◽  
Win 55

Endo-, phyto- and synthetic cannabinoids have been proposed as promising anti-cancer agents able to impair cancer cells’ behavior without affecting their non-transformed counterparts. However, cancer outcome depends not only on cancer cells’ activity, but also on the stromal cells, which coevolve with cancer cells to sustain tumor progression. Here, we show for the first time that cannabinoid treatment impairs the activation and the reactivity of cancer-associated fibroblasts (CAFs), the most represented stromal component of prostate tumor microenvironment. Using prostate cancer-derived CAFs, we demonstrated that WIN 55-212.2 mesylate, a synthetic full agonist of cannabinoid receptors (CBs) 1 and 2, downregulates α-smooth muscle actin and matrix metalloprotease-2 expression, and it inhibits CAF migration, essential features to ensure the activated and reactive CAF phenotype. Furthermore, by impairing stromal reactivity, WIN 55-212.2 mesylate also negatively affects CAF-mediated cancer cells’ invasiveness. Using selective antagonists of CBs, we proved that CAFs response to WIN 55-212.2 mesylate is mainly mediated by CB2. Finally, we suggest that endocannabinoids self-sustain both prostate tumor cells migration and CAFs phenotype by an autocrine loop. Overall, our data strongly support the use of cannabinoids as anti-tumor agents in prostate cancer, since they are able to simultaneously strike both cancer and stromal cells.

scholarly journals MCT4 is a novel target for prostate cancer

2016 ◽  
Vol 13 (3) ◽  
pp. 123-123
Author(s):  
Rebecca Kelsey
Keyword(s):  
Prostate Cancer ◽  
Novel Target

scholarly journals 1002. L1 Cell Adhesion Molecule, a Novel Target of Prostate Cancer Gene Therapy

2006 ◽  
Vol 13 ◽  
pp. S386
Author(s):  
Kristen Bisanz ◽  
Jie Yu ◽  
Ira Rajbhandari ◽  
Bill Spohn ◽  
Mien-Chie Hung ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gene Therapy ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Novel Target ◽  
L1 Cell Adhesion Molecule

scholarly journals CXCR4 Is a Novel Target of Cancer Chemopreventative Isothiocyanates in Prostate Cancer Cells

2015 ◽  
Vol 8 (5) ◽  
pp. 365-374 ◽  
Author(s):  
Kozue Sakao ◽  
Avani R. Vyas ◽  
Sreenivasa R. Chinni ◽  
Ali I. Amjad ◽  
Rahul Parikh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Novel Target
Sign in / Sign up

Export Citation Format

Share Document