scholarly journals The effectiveness of the combination of Lactobacillus rhamnosus GG and prebiotics in the treatment of atopic dermatitis in children

2021 ◽  
pp. 52-56
Author(s):  
T. G. Malanicheva ◽  
N. V. Ziatdinova ◽  
I. N. Serdinskaya
Keyword(s):  
Blood Pressure ◽  
Atopic Dermatitis ◽  
Clinical Efficacy ◽  
Comparison Group ◽  
Lactobacillus Rhamnosus ◽  
Main Group ◽  
Lactobacillus Rhamnosus Gg ◽  
Old Patients ◽  
Clinical Methods ◽  
Complex Therapy

Introduction. Traditional antiallergic therapy for atopic dermatitis, including allergen elimination, therapeutic cosmetic skin care, external anti-inflammatory therapy and antihistamines, does not always lead to the desired result. On this basis, the search for new methods of treatment is urgent and promisingAim. To study the clinical efficacy of a combination of Lactobacillus rhamnosus GG and prebiotics in children in the first years of life with atopic dermatitis (AD).Materials and methods. The observed children were divided into 2 parts: 30 children aged from 1 month to 3 years old, patients with AD constituted the main group, it differed in that these patients were synbiotic (combination of Lactobacillus rhamnosus GG and prebiotics) – 1 sachet per day for 14 days. This drug was prescribed as part of complex therapy. The remaining 25 children with AD made up a comparison group, which was characterized by the fact that children received only antiallergic therapy without symbiotic. Clinical methods of blood pressure examination, laboratory instrumental and specific allergological methods were carried out.Results and discussion. Against the background of the therapy in children with blood pressure in the main group, общий overall treatment effect was higher and amounted to 86.6 + 4.0%, and in the comparison group – 76.0 + 3.9%, p < 0.05. This was manifested in a decrease in the duration of the exacerbation period by 1.4 times, the prevalence of a high individual therapeutic effect by 1.5 times, a decrease in the SCORAD index by 4 times against the background of an increase in the number of bifidobacteria and lactobacilli in the intestine. The revealed clinical efficacy was noted against the background of an increase in the number of bifidobacteria and lactobacilli in the intestine.Conclusions. The obtained results allow us to recommend a combination of Lactobacillus rhamnosus GG and prebiotics in children in the first years of life as part of complex therapy to increase the effectiveness of treatment.

scholarly journals THE PREVALENCE OF PERIODONTAL TISSUE DISEASES IN YOUNG INDIVIDUALS ON THE BACKGROUND OF CROWDED TEETH

2018 ◽  
pp. 28-31
Author(s):  
A.V. Mandych
Keyword(s):  
Comparison Group ◽  
Periodontal Diseases ◽  
Adult Population ◽  
Study Groups ◽  
Main Group ◽  
Periodontal Tissue ◽  
Facial Skeleton ◽  
Old Patients ◽  
Periodontal Tissues ◽  
Upper Jaw

The abnormalities of maxillodental system take one of the leading places among diseases of the maxillofacial area. Thus, they are diagnosed more than in 50% cases among the younger population and in 30% cases among the adult population.   Most often, there are prerequisites for the incorrect position of individual teeth: anomalies are formed at the genetic level because of heredity of pathologies of size, amount, shape of teeth and size of the jaw bones of the facial skeleton. If the position of the teeth is incorrect, the periodontium retains the occlusal load of the functional injury. Therefore, the aim of our research was to study the prevalence of periodontal tissue diseases in young individuals on the background of crowded teeth. The material and research methods. The study was conducted on the base of Dental Center of Danylo Galytsky Lviv National Medical University during 2015−2017 years. 1146 people at the age from 18 to 44 years were examined. Every participant of research underwent general dental examination, as well as a special examination aimed at clarification of orthodontic treatment. The diagnosis of periodontal tissue diseases was made according to the classification of N. F. Danilevskyi and was determined using paraclinical indicators. The obtained results were worked out statistically using functions of MS Excel and Statistica 6. Results of the research and their discussion. The total number of the examined with orthodontic pathology was found on average in 77.24% of patients (885 people). At the same time, abnormalities of dental jaw system were not detected in about 261 (22.76%) of the examined. As a result of the conducted studies we found that among the examined without dental jaw abnormalities 38.89±.,32% of patients had intact periodontium, that was 1.6 times more for data in individuals with crowding − 23.73±2.00, p<0.01. At the same time, in patients of the main group the prevalence of periodontal tissue diseases was 1.2 times higher than in the examined of the comparative group (76.27±2.00% against 61.11±3.32%, respectively, p<0.01). It should be noted, that with the increase of the age of patients the prevalence of periodontal tissue diseases increased in both study groups, but in patients with crowded teeth this tendency was more pronounced. So, in the younger age group in patients with crowding the prevalence of periodontal diseases was 1.5 times higher in relation to the data of their peers from the comparison group (71.37±3.00% vs. 46.99±5.48%, p<0.01). In 27−35-year-old patients the prevalence of periodontal tissue diseases amounted to 72.38±4.03% of the examined of the main group and 65.62±5.94% of the examined of the comparison group, but the obtained data were not statistically significant, p>0.05. At the same time, in the patients of the main group aged 36−44 years the prevalence of periodontal tissue diseases was maximal and exceeded the value of their peers in the comparison group by 1.2 times (92.08±2.69% vs. 73.91±5.29%, respectively, p<0.01). The analysis of the obtained data allowed to assert that on average crowding of teeth on the upper jaw was found in 237 patients (52.55%) and on the lower jaw in 214 patients (47.45%). Thus, the maximum frequency of crowded teeth on the upper jaw was observed in the examined in the age range of 27−35 years, 60.16±4.41% of patients, with the minimum prevalence of this pathology in the youngest group (18−26 years), 49.34±4, 72%. The analysis of diagnostic structure of periodontal tissue diseases showed that inflammatory diseases of periodontal tissues (gingivitis, localized periodontitis) were found in patients with crowded teeth, on average 1.2 times more often than in patients without orthodontic pathology (42.42±1.88% vs. 36.33±3.54%, respectively, p<0.05). Conclusions. Thus, as a result of the conducted studies, higher prevalence of periodontal tissue diseases was proved in patients with crowding of teeth, which made progress in increasing the age of the examined than in patients without orthodontic pathology.

scholarly journals Metabolic support of patients with myocardial infarction and liver dysfunction

2019 ◽  
Vol 26 (1) ◽  
pp. 40-48
Author(s):  
M. I. Shved ◽  
O. A. Prokopovych
Keyword(s):  
Myocardial Infarction ◽  
Liver Dysfunction ◽  
Comparison Group ◽  
Clinical Laboratory ◽  
Main Group ◽  
Hemodynamic Parameters ◽  
Liver Disorders ◽  
Conduction Disorders ◽  
Complex Therapy ◽  
Antioxidant Protection System

The aim – to improve the existing therapeutic programs for patients with myocardial infarction (MI) by differentiated approach to therapy depending on the presence or absence of liver dysfunction. Materials and methods. 149 patients with acute MI were included to the study – 114 (76.5 %) men and 35 (23.5 %) women of average age 59.9±1.0 years. A comparative clinical-laboratory and instrumental examination was performed in these groups: 107 patients with MI with functional liver disorders (main group) and 42 patients with MI without functional liver disorders (comparison group). For the study of intracardiac hemodynamics, echocardiography was performed in B-mode. 52 patients of main group and 22 patients of comparison group received standard treatment for MI (ACE-inhibitors, β-blockers, clopidogrel and acetylsalicylic acid, anticoagulant therapy, statins). The other 55 patients of main group and 20 patients of comparison group received modified treatment with the addition of the antioxidant bioflavonoid – quercetin to the standard scheme. Results and discussion. In the initial condition of patients of main group there are more pronounced violations of central and peripheral hemodynamics which cause the disorders of protein synthesis, detoxification, energetic dysfunction of liver and lipid metabolism. At the same time there is an excessive activation of lipid peroxidation, suppressed activity of enzymes of the antioxidant protection system, deepening of pathological processes in the heart and in the liver. Inclusion of bioflavonoid quercetin to the complex therapy of patients with myocardial infarction provided the improvement of hemodynamic parameters – increased EF by 22.89 % and elimination of diastolic dysfunction, which were accompanied by normalization of clinical and laboratory parameters of liver function disorders – normalization of levels of bilirubin and ALT, GGT, ALP on 14-th day and reduction of LDL-level by 25.61 % after 3 weeks was marked. Conclusions. Introduction of bioflavonoid quercetin to the complex therapy of patients with MI provided improvement of hemodynamic parameters and restoration of oxidation-reduction equilibrium, reduction of clinical and laboratory manifestations of liver dysfunction and contributed to a significant decrease in the frequency of MI complications development. Restoration of parameters of cardiac hemodynamics, metabolic processes and liver functions provides a significant reduction in the rate of development of acute heart failure by 63.9 %, early post-infarction angina by 22.2 %, rhythm and conduction disorders by 43.6 %.

scholarly journals Optimization of healing in patients with odontogenic phlegmon of the maxillofacial region

2020 ◽  
Vol 24 (6) ◽  
pp. 387-390
Author(s):  
O. V. Shvets ◽  
Tatiana V. Gaivoronskaya ◽  
E. E. Esaulenko ◽  
N. I. Bykova
Keyword(s):  
Comparative Effectiveness ◽  
Comparison Group ◽  
Clinical Manifestations ◽  
Main Group ◽  
Maxillofacial Region ◽  
Traditional Treatment ◽  
Parameter Group ◽  
Antioxidant Agents ◽  
Complex Therapy ◽  
Group 2

Aim. This study aims to increase the efficiency of the wound process in patients with odontogenic phlegmons of the maxillofacial region by using energotropic and antioxidant agents. Material and methods. The clinical study included 42 patients with odontogenic phlegmons of the maxillofacial region. The patients were divided into two groups: comparison group (patients received traditional treatment) and main group (patients received treatment with Cytoflavin in the treatment regimen). Results. In the main group, the appearance of the first granulations occurred 2.1 times faster (on average on the 3rd day) in comparison with the granulation tissue in patients of the comparison group. Signs of edge epithelialization of wounds appeared almost 3 days earlier (on average on the 6th day) in the main group than in the comparison group; on the 7th day, secondary sutures were already applied, which was 1.6 times faster than the same parameter group 2, clearly suggesting the acceleration of reparative processes. Conclusion. The dynamics of clinical manifestations indicates the comparative effectiveness of using Cytoflavin as part of complex therapy. This finding is confirmed by the accelerated terms of wound healing, the appearance of granulations, epithelialization of the wound edges, and the imposition of secondary sutures.

scholarly journals New approaches to prophylaxis of endometrium hyperplasia relaps in premenopausal women

2021 ◽  
pp. 63-72
Author(s):  
V.O. Beniuk ◽  
V.H. Ginzburg ◽  
D.O. Govsieiev ◽  
V.F. Oleshko ◽  
T.V. Kovaliuk ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Folic Acid ◽  
Body Mass ◽  
Endometrial Hyperplasia ◽  
Comparison Group ◽  
Endometrial Thickness ◽  
Transvaginal Ultrasound ◽  
Premenopausal Women ◽  
Main Group ◽  
Positive Treatment

Research aim: to evaluate the effectiveness of therapy aimed at preventing endometrial hyperplasia recurrence in premenopausal women.Materials and methods. Clinical and paraclinical examinations of 76 premenopausal women were carried out. Transvaginal ultrasound was performed, levels of estradiol, progesterone, homocysteine, folic acid, serum HOMA index evaluated, body mass index and blood pressure assessed. Women were divided into two groups after histological results obtained: the main group included 40 women who received oral progestins (dydrogesterone 10 mg) twice a day in combination with Depapilin® 395 mg twice a day; the comparison group included 36 women who received only oral progestins (dydrogesterone 10 mg) twice a day. Comparison of the therapy effectiveness was performed 6 and 9 months after the start of treatment.Results. Endometrial thickness stabilized within 9 months in women of the main group, and was within the physiological norm (before treatment – 22 ± 3.1 mm, 6 months after the start of treatment – 8,3 ± 0.46 mm, after 9 months – 9,7 ± 0.31 mm, p <0.05). The positive treatment effect consisted in a significant decrease in the frequency of endometrial hyperplasia recurrence, which was 17 (17.5%) cases in the main group and 16 (44.4%) cases in the comparison group (p <0.05). Women of the main group also showed stable normalization of the level of estrogen and progesterone, a steady decrease in the level of homocysteine and a synergistic increase in the level of folic acid, normalization of blood pressure and reduction of body mass index.Conclusions. Depapilin® inclusion in the basic therapy of endometrial hyperplasia in premenopausal aged women is pathogenetically justified due to the complex effect of the drug components on the extragonadal estrogens synthesis and the antiproliferative effect on the endometrium.

Randomized, placebo-controlled trial of Lactobacillus rhamnosus GG as treatment of atopic dermatitis in infancy

Allergy ◽  
2007 ◽  
Vol 62 (11) ◽  
pp. 1270-1276 ◽  
Author(s):  
C. Grüber ◽  
M. Wendt ◽  
C. Sulser ◽  
S. Lau ◽  
M. Kulig ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Controlled Trial ◽  
Lactobacillus Rhamnosus ◽  
Lactobacillus Rhamnosus Gg

scholarly journals Possibilities of immunocorrection in COVID-19 therapy of patients on an outpatient basis

2021 ◽  
Vol 5 (7) ◽  
pp. 468-472
Author(s):  
L.R. Mukhamadieva ◽  
◽  
G.A. Mavzyutova ◽  
G.Kh. Mirsayeva ◽  
G.M. Khasanova ◽  
...  
Keyword(s):  
Standard Therapy ◽  
Comparison Group ◽  
Main Group ◽  
Outpatient Basis ◽  
Moderate Degree ◽  
Reactive Protein ◽  
Complex Therapy ◽  
Pathogenetic Therapy ◽  
Coronavirus Infection ◽  
Russian Medical

Aim: to evaluate the clinical efficacy of azoximer bromide inclusion in the complex therapy of patients with a confirmed diagnosis of COVID-19 (moderate degree) who were receiving treatment on an outpatient basis. Patients and Methods: data from medical records of 100 patients who were treated in outpatient clinics for COVID-19 in Ufa (June–November 2020) were retrospectively evaluated. There were 2 groups of 50 patients: the main group receiving azoximer bromide and the comparison group receiving only standard therapy. The criteria for evaluating the therapy efficacy were the dynamics of the disease clinical picture, laboratory parameters characterizing inflammation. Results: in the main group, the relief of complaints and a significant condition improvement according to physical examination were recorded significantly earlier — after 9.68±5.23 days versus 13.00±4.95 days in the comparison group (p=0.0012). The period of body temperature normalization in patients receiving immunomodulatory therapy was 7.20±1.41 days, which is significantly less than in patients receiving standard therapy — 16.20±2.74 days (p=0.0001). When contacting the outpatient clinic, all patients had an increase in the level of C-reactive protein: in the main group — up to 13.91±17.28 mg/L, in the comparison group — up to 12.22±8.32 mg/L (p=0.71). The result of therapy was a decrease in this indicator to 6.28±5.06 mg/L and 4.44±3.73 mg/L, respectively (p=0.0314). On the 17th day after the treatment initiation, all patients had antibodies (IgM and IgG) to SARS-CoV-2. Conclusions: azoximer bromide inclusion in the complex therapy of patients with COVID-19 allows for faster normalization of the patients’ condition, is not accompanied by adverse events and can be considered as a pathogenetic therapy variant of patients with COVID-19 with a predominantly severe course in the setting of concomitant diseases. KEYWORDS: coronavirus infection, SARS-CoV-2, COVID-19, pneumonia, immunocorrection, pathogenetic therapy, azoximer bromide. FOR CITATION: Mukhamadieva L.R., Mavzyutova G.A., Mirsayeva G.Kh. et al. Possibilities of immunocorrection in COVID-19 therapy of patients on an outpatient basis. Russian Medical Inquiry. 2021;5(7):468–472 (in Russ.). DOI: 10.32364/2587-6821-2021-5-7-468-472.

Ingestion of heat-treated Lactobacillus rhamnosus GG prevents development of atopic dermatitis in NC/Nga mice

2007 ◽  
Vol 37 (2) ◽  
pp. 296-303 ◽  
Author(s):  
J. Sawada ◽  
H. Morita ◽  
A. Tanaka ◽  
S. Salminen ◽  
F. He ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Lactobacillus Rhamnosus ◽  
Lactobacillus Rhamnosus Gg ◽  
Heat Treated

scholarly journals Comparison between the efficacy plant and synthetic origin dental products in the treatment of chronic catarrhal gingivitis.

2020 ◽  
Vol 101 (1) ◽  
pp. 25-30
Author(s):  
Y S Lyamin ◽  
Yu S Fedorova ◽  
P V Kulpin ◽  
N I Suslov ◽  
D V Kucheryavyi
Keyword(s):  
Quality Of Life ◽  
Comparison Group ◽  
Main Group ◽  
Subjective Quality ◽  
Control Group ◽  
Chlorhexidine Digluconate ◽  
Subjective Quality Of Life ◽  
Complex Therapy ◽  
Complex Drug

Aim. Comparative clinical study of hygienic dental product of plant origin based -mangostin [1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one], a xanthone from mangosteen fruit, having antimicrobial and anti-inflammatory activity in the treatment of chronic generalized catarrhal gingivitis. Methods. The study included 319 patients aged 22 to 45 years. All patients were divided into two groups: the control group 20 people (males 40%, females 60%), average age 34.88.00 years; the comparison group 20 people (males 45%, females 55%), average age 35.07.10 year; the main group 20 people (males 40%, females 60%), average age 34.97.86 years. There were no statistically significant differences between all groups (p 0.05). The nosological form of the disease in the studied patients is chronic generalized catarrhal gingivitis (K05.1). Treatment in all groups was carried out using the standard regimen of complex therapy of chronic generalized catarrhal gingivitis. Therapy of the main group patients was supplemented by the use of the hygienic gel containing 1% -mangostin [1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one], whereas treatment of the comparison group patients was supplemented by the complex preparation containing 1% metronidazole and 0.25% chlorhexidine digluconate. The dental examination included a questionnaire with the registration of subjective data (patient complaints) and objective data on the state of the tissues of the mouth (index score) before and after therapy, as well as the dynamics of the indicators fixing during the entire treatment. Results. The performing a comparative study of the treatment effectiveness of chronic generalized catarrhal gingivitis, using a dental hygienic gel containing 1% -mangostin [1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one] as a part of complex therapy in comparison with the standard complex treatment regimen supplemented by dental product containing 1% metronidazole and 0.25% chlorhexidine digluconate, showed a marked improvement in subjective quality of life of patients. Pain during individual oral hygiene and food intake (decrease to 0%, p1 0.05, p2 0.05), a feeling of bursting in the gum (decrease to 0%, p1 0.05, p2 0.05), bad breath (decrease to 0%, p1 0.05, p2 0.05) and bleeding gums (decrease to 0%, p1 0.05, p2 0.05) were completely eliminated. Compared to the control group, OHI-S index of the main group decreased by 79% (from 1.9 to 0.4, p1 0.001, p2 0.001), PI index decreased by 80.6% (from 3.1 to 0.6, p1 0.001, p2 0.001) and SBI index decreased by 100% (from 3 to 0, p1 0.001, p2 0.001). During the course of treatment of patients with chronic generalized catarrhal gingivitis, a decrease in the average values of the PMA index was observed. In the group of patients using hygienic gel as a supplement to treatment, the decrease in this index was 85% (from 651.53 to 100.82%; p1 0.001, p2 0.05), and when using a complex drug containing 1% metronidazole and 0.25% chlorhexidine digluconate, the value of the PMA index decreased by 51% (from 611.17 to 301.4%; p1 0.001), in the control group, the index value decreased by 28% (from 671.67 to 481.26%; p1 0.001). Conclusion. In assessing of the subjective quality of life and index indicators of the periodontal status in the treatment of chronic generalized catarrhal gingivitis, the best results were observed in the group using a dental hygiene gel based on -mangostin [1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one], a xanthone from mangosteen fruit, compared with the control group and the group using a complex drug (1% metronidazole and 0.25% chlorhexidine digluconate).

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