scholarly journals Effect of The Sweet Potato Against Mice on Blood Glucose of Diabetes Mellitus

2018 ◽  
Vol 2 (1) ◽  
pp. 1
Author(s):  
Ai Kustiani ◽  
Wilda Raziq
Keyword(s):  
Blood Glucose ◽  
Treatment Group ◽  
Sweet Potato ◽  
Control Group ◽  
Diabetic Mellitus ◽  
Glucose Levels ◽  
Positive Effects ◽  
Blood Glucose Levels ◽  
Significant Difference ◽  
Average Blood Glucose

<p class="Default"><em>The </em><em>aim</em><em> of this study was to analyze </em><em>the effects</em><em> of the sweet potato to the levels of blood glucose on diabetic mellitus mice. This study had been carried out with a sample of 25 mice which were divided into 5 groups. The levels of blood glucose on mice before treating with rice flour and sweet potato flour on the negative control group (KN) was 76.2 ± SD, on the positive control group (KP) was 159.4 ± SD, on the 1<sup>st</sup> treatment group (P1) was 159.4 ± SD, on the 2<sup>nd</sup> treatment group (P2) was 166.6 ± SD and 3<sup>rd</sup> treatment group (P3) was 161.2 ± SD. The average blood glucose levels on the 2<sup>nd</sup> treatment group (P2) before treatment was 166.6 ± SD and after treatment was 109.0 ± SD. The result showed a significant difference based on the statistical data (p &lt; 0.05) between 4 test groups of mice. There was a big difference on the average blood glucose levels before and after treatment o P2 and P3. It is concluded that the treatment of sweet potatoes gives a positive effects on the blood glucose levels of diabetic mellitus mice. </em></p>

scholarly journals Decreased Blood Glucose and Histopathology Improvement in Hyperbaric Hyperoxic Conditions Alloxan-induced rats(Laboratory Experimental Study)

2019 ◽  
Vol 12 (4) ◽  
pp. 54-62
Author(s):  
Retno Budiarti
Keyword(s):  
Blood Glucose ◽  
Treatment Group ◽  
Hyperbaric Oxygen ◽  
Control Group ◽  
Glucose Levels ◽  
Oxygen Exposure ◽  
White Rats ◽  
Blood Glucose Levels ◽  
Significant Difference ◽  
Hyperbaric Oxygen Exposure

Background: Diabetes mellitus is still a problem in Indonesia, related to the number of organs involved. This disease has relatively high morbidity and mortality rates. Adjuvant therapy is needed considering the long-term therapy that must be consumed by patients. Objective: To explain the effect of hyperbaric oxygen in reducing blood glucose levels, and repairing histopathological damage to the pancreas and liver. Method : this study was an experimental laboratory study using whistar strain rats (Rattus Norvegicus) which were given a normal diet then induced alloxan to create a hyperglycemia condition. After that, 12 rats from the treatment group were given 3 x 30’ hyperbaric oxygen exposure for 6 days. Blood glucose levels, histopathological changes in the pancreas and liver was measured between the treatment group and the control group were not given hyperbaric oxygen exposure. Results: There was a significant difference (α< 0,05) in decreasing blood glucose and repairing histopathological damage in pancreatic and liver tissue between treated group and control group. Conclusion: hyperbaric oxygen treatment as much as 3 x 30'for days at 2.4 ATA O2 100% reduce blood glucose levels and repair histopathological damage to pancreatic tissue and liver of alloxan- induced white rats.

scholarly journals Pengaruh pemberian susu almond terhadap glukosa darah puasa pada tikus diabetes

2019 ◽  
Vol 7 (2) ◽  
pp. 86-91
Author(s):  
Ryta Ristantia Ningsih ◽  
Enny Probosari ◽  
Binar Panunggal
Keyword(s):  
Blood Glucose ◽  
Treatment Group ◽  
Metabolic Diseases ◽  
Fasting Blood Glucose ◽  
Glucose Measurement ◽  
Control Group ◽  
Control Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference

Background: Type 2 Diabetes Mellitus is a group of metabolic diseases with characteristic hyperglycemia that occurs due to abnormalities in insulin secretion and insulin action. Diet plus high fiber can help control glucose levels. Almond contains fiber, vitamin E, and magnesium that contributes to the fasting blood glucose levels. This study aimed to analyze the effect of almond milk to the fasting blood glucose diabetic rats.Method: This study used an experimental design with pre-post test control group design. The sample were Rattus norvegicus Wistar which were divided into 4 groups: K (-), K (+), A1 and A2. Almond milk was given in the group treatmeant for 14 days with a dose of 4.32 ml and 8.64 ml. Fasting blood glucose measurement taken before and after treatment used Oxidase Glucose - Peroxidase Aminoantypirin (GOD PAP). Analysis of data used paired t-test, ANOVA and Post Hoc.Results: The fasting blood glucose levels decreased significantly (p = 0.01) in the treatment group which were intervened with almond milk. A decrease in fasting blood glucose levels in a dose treatment group 1 for 116.96 ± 4.45 (p = 0:01), whereas in the group treated at a dose of 2 for 155.53 ± 3.15 (p = 0.01). There were a significant difference in decreased of the fasting blood glucose levels between the two treatment groups (p = 0.01).Conclusion:  Giving a dose almond milk 4.32 ml and 8.64 ml for 14 days can lower the fasting blood glucose levels significantly.

PENGARUH PEMBERIAN FRAKSI ETILASETAT KULIT UBI JALAR UNGU TERHADAP KADAR MALONDIALDEHID (MDA) SERUM MENCIT PUTIH JANTAN HIPERGLIKEMIA

2018 ◽  
Vol 8 (2) ◽  
pp. 144
Author(s):  
Ria Afrianti
Keyword(s):  
Blood Glucose ◽  
Statistical Analysis ◽  
Sweet Potato ◽  
Ethyl Acetate Fraction ◽  
Serum Levels ◽  
Negative Control ◽  
Control Group ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Purple Sweet Potato

This study aims to determine the effect giving of ethylacetate fraction of leather  purple sweet potato (Ipomoea batatas (L.) Lam, on levels of malondialdehyde (MDA) serum in mice hyperglicemia were induced with streptozocin dose of 50 mg/kgBW. Mice were divided into 5 groups, each group consisting of 3 tails, group I is a negative control, group II is a positive control, group III,IV and V is given ethylacetate fraction a dose of 100 mg/kgBW, 300 mg/kgBW, and 600 mg/kgBW. Ethyl Acetate Fraction leather purple sweet potato given orally for 15 days after the animal is declared hyperglicemia and measurement of blood glucose levels on 5, 10, and 15 day after giving test preparation in animal experiments. On the 16 day throughout the mice were taken serum levels measured malondialdehid. The statistical analysis results showed that giving of ethyl acetate fraction of leather purple sweet potato at a dose of 100 mg/kgBW, 300 mg/kgBW, and 600 mg/kgBW can lower blood glucose levels in mice hyperglycemia significantly (p<0.05). Malondialdehid levels on average in each group is 1.35 nmol/ml, 3.00 nmol/ml, 2.72 nmol/ml, 2.20 nmol/ml and 2.61 nmol/ml, the results of statistical analysis showed a decrease in melondialdehid serum levels were significantly (p<0.05), where a dose of 300 mg/kgBW is an effective dose for lowering blood glucose levels followed by decreased levels of malondialdehid which give effect approaching negative control.

The Effect of Yacon Leaf Powder (Smallanthus Sonchifolius) on White Rats (Rattus norvegicus) Blood Glucose Levels with High Sugar Diet

2021 ◽  
Vol 8 (2) ◽  
pp. 217-220
Author(s):  
Thatit Nurmawati ◽  
Sandi Alfa Wiga Arsa ◽  
Nawang Wulandari ◽  
Agus Saparudin
Keyword(s):  
Blood Glucose ◽  
Treatment Group ◽  
Carbohydrate Diet ◽  
Glucose Levels ◽  
Smallanthus Sonchifolius ◽  
High Carbohydrate ◽  
White Rats ◽  
Blood Glucose Levels ◽  
Treatment Dose ◽  
Significant Difference

Maintaining a lifestyle can reduce the incidence of DM (diabetes mellitus). DM occurs due to insulin disorders so that blood glucose levels increase, which can lead to various complications. The management of blood glucose levels by activating the insulin function can be done by using natural ingredients such as the Yakon (Smallanthus sonchifolius) plant. Yakon leaves contain phenol which can reduce blood glucose. The design of this study was experimental with a pre-posttest approach with control-group design, using male and healthy white rats (Rattus norvegicus). Rats were divided into 3 groups, treatment dose 1, treatment dose 2 and control. The rats were given a high carbohydrate diet during 9 weeks to make the rats hyperglycemic. In the treatment group, dose 1 was 150 mg/kg BW, dose 2 was 300 mg kg BW, and was given for 3 days. The results showed that the rats in the treatment group dose 1 had decreased in the average blood sugar level of 114.10 mg / dl (p 0.002) and dose 2 was 105.27 mg / dl (p 0.005). This showed that there was an effect of treatments on blood sugar levels. The comparison results showed that there was a significant difference between the dose 1, the dose 2 group and the control (Sig. (2-tailed) = 0.001 (α) = 0.05). There was no significant difference in the treatment group dose 1 and treatment dose 2 (Sig. (2-tailed) = 0.693, (α) = 0.05). Yakon leaves can be used alternative to lower to control blood glucose levels in rats receiving a high-carbohydrate diet

scholarly journals UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL BUAH CABAI MERAH ( Capsicum annuum L. ) TERHADAP MENCIT PUTIH JANTAN

2019 ◽  
Vol 9 (1) ◽  
pp. 86 ◽  
Author(s):  
Zulkarni Zulkarni
Keyword(s):  
Blood Glucose ◽  
Capsicum Annuum ◽  
Fasting Blood Glucose ◽  
Ethanol Extract ◽  
Negative Control ◽  
Control Group ◽  
Glucose Levels ◽  
Capsicum Annuum L ◽  
Blood Glucose Levels ◽  
Significant Difference

This Research was conducted to determine the effect of ethanol extract from red chilli (Capsicum annuum L)in lowering blood glucose levels of hyperglycemic male white mices. This study used 30 malewhitemices and divided into 6 groups: negative control group, the positive control group, the treatmentgroup withdosage of 200 mg / kgweight, 400 mg / kgwieght, 600 mg / kg weight and a comparison group with glibenclamide with dosage of 5 mg / kgweightadministered orally for 21 days. The level of fasting blood glucose was checked 6 days after dexamethasone induced, and after the ethanol extract of red chilies on day 7th, 14th, and 21st. The data was analyzed statistically with one –way and two-way Anova by usingSPSS16 program and proceed with the test Duncan to look the significant difference between treatments. The results showed that the ethanol extract from red chilies with a dosage of 200mg / kgweight, 400mg / kgweight, 600 mg / kgweight showed the effect in lowering blood sugar levels in male white mices hyperglycemia significantly (p <0.05). The duration ethanol extract of red chili affected blood glucose levels. The most effective duration in lowering blood glucose levels is the administration of a preparation within 21 days.

scholarly journals Red dragon fruit (Hylocereus spp.) peel marmalade effectively improve blood glucose and lipid profile of hypercholesterolemic wistar rats

2020 ◽  
Vol 9 (1) ◽  
pp. 61-67
Author(s):  
Natalia Desy Putriningtyas ◽  
Intan Permatasari ◽  
Dita Oktaviani ◽  
Anastasia Servia Raha ◽  
Siti Wahyuningsih
Keyword(s):  
Blood Glucose ◽  
Functional Food ◽  
Wistar Rats ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Fruit Peel ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Dragon Fruit ◽  
Significant Difference

Background: Polyphenols, antioxidants, dietary fiber, and vitamin contained in the red dragon fruit peel. Red dragon fruit peel can be processed into marmalade. Red dragon fruit peel marmalade has the potential to be a functional food. Functional food is food that has a physiological function based on scientific studies.Objectives: The objective of this study is to analyze the effect of red dragon fruit peel marmalade on fasting blood glucose levels, HDL, LDL, and triglycerides levels of hypercholesterolemic Wistar rats.Methods: This study used a pre-&post-test control group design. Hypercholesterolemic male Wistar rats were randomly assigned into five groups. Hypercholesterolemia was induced by 1% cholesterol powder and 0.5% cholic acid for two weeks. All groups received standard chow. Samples were grouped into five groups: K-; K+; K1 (0.94 g/kg b.wt/day); K2 (1.41 g/kg b.wt/day); K3 (1.88 g/kg b.wt/day). The intervention was carried out for 28 days. GDP level was measured using the GOD-PAP. HDL, LDL, and triglyceride were analyzed with spectrophotometry. GDP, HDL, LDL, and triglyceride levels were measured twice before fasting. A paired t-test and one-way ANOVA were used to analyze the data.Results: The result showed that K-; K1; K2; K3 had a significant difference between groups before and after the intervention (p<0.05). Red dragon fruit peel Marmalade was able to reduce the levels of GDP, LDL, triglycerides, and increase HDL (p <0.05).Conclusion: Red dragon fruit peel marmalade reduced fasting blood glucose levels, LDL, triglyceride levels, and increased HDL levels of hypercholesterolemic Wistar rats.

scholarly journals Association Between Exercise and Blood Glucose Levels In Diabetic Patients

2017 ◽  
Vol 4 (2) ◽  
pp. 188
Author(s):  
Eryna Laili Putri
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Design Data ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Average Blood Glucose ◽  
Intensity Of Exercise

Diabetes Mellitus (DM) is a chronic disease with high prevalence, associated with various debilitating complications and can decreases the quality of life in people with it. It is important for people with DM to doing exercise to control the stability of their blood glucose levels. The purpose of this study was to finding out the association between frequency, duration, and intensity of exercise with average blood glucose levels in people with DM. This was an observational study that used case control design. Data obtained from interview with 20 samples from case group and 20 samples from control group, that had been chosen with systematic random sampling technique. Dependent variable of this study was the average blood glucose levels and independents variables were frequency, duration, intensity, and the kind of exercise. This study used Chi Square test 3 × 2 contingency tables to finding out the association and risk of dependent variable with independent variables,. The results showed that exercise factors that associated to average blood glucose levels were duration of exercise (p = 0.022) and intensity of exercise (p = 0.021). The frequency of exercise does not associated to average blood glucose levels (p = 0.340). Diabetic patients who did not do any exercise have the risk of having uncontrolled blood glucose levels. The conclusion was duration and intensity of exercise related significantly to blood glucose levels. By doing exercise three times a week for 30 minutes or more can decreases the risk of uncontrolled blood glucose levels in people with DM.Keywords: Diabetes mellitus, exercise, average blood glucose levels

scholarly journals Uji Efektivitas Beras Herbal Forte terhadap Penurunan Kadar Glukosa Darah Pasien Diabetes Melitus Tipe 2 (Study of the Herbal Rice Forte Effectiveness on Decreasing Blood Glucose of Diabetes Mellitus Type 2 Patient)

2018 ◽  
Vol 6 (1) ◽  
pp. 85
Author(s):  
Gema Akbar Wakhidana ◽  
Ancah Caesarina Novi Marchianti ◽  
Ali Santosa
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Treatment Group ◽  
Metabolic Diseases ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Type 2 Dm

Diabetes mellitus is metabolic diseases characterized by hyperglycemia caused by disturbances in insulin secretion or insulin activity. Herbal Forte Rice is rice synthetic material composed of main purple sweet potato and corn flour. It contains antioksidan, fiber, resistant starch and having moderate glycemic index. This study aimed to determine the effectivity of Herbal Forte Rice on decreasing blood glucose levels of patients type 2 DM. It used a cross-over design, the role of research subjects was both as control and treatment groups. Total sample of this research consisted of 60 samples. The treatment group was given Herbal Forte Rice for 7 days in 2 consecutive meals, while the control group did not receive any intervention. The results showed the average level of Fasting Blood Glucose (FBG) beginning and end of the treatment group 179.76 mg/dL and 138.7 mg/dL; FBG beginning and end of the control 180.87 mg/dL and 187.63 mg/dL; 2 hours post prandial Blood Glucose (2hppBG) levels of beginning and end of the treatment group 284.37 mg/dL and 183.8 mg/dL; 2hppBG levels beginning and end of the control 280.57 mg/dL and 284.13 mg/dL. This study concludes that Herbal Forte Rice effective on decreasing blood glucose levels of patients type 2 DM.   Keywords: diabetes mellitus, Rice Herbal Forte, GDP and GD2PP  

scholarly journals ANTIDIABETIC ACTIVITY TEST USING AMLA FRUIT (PHYLLANTHUS EMBLICA L) EXTRACT IN ALLOXAN-INDUCED BALB/C MICE

2019 ◽  
Vol 3 (2) ◽  
pp. 53
Author(s):  
Putu Lakustini Cahyaningrum ◽  
Sang Ayu Made Yuliari ◽  
Ida Bagus Putra Suta
Keyword(s):  
Blood Glucose ◽  
Treatment Group ◽  
Positive Control ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Phyllanthus Emblica ◽  
Fruit Extract ◽  
Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels

Background: The content of secondary metabolites in amla (phyllanthus emblica L.) such as flavonoids and phenols have the potential as an antioxidant. One of the benefits of antioxidants is to prevent degenerative diseases, such as diabetes mellitus. Purpose: This research to determine activity of amla fruit extract in reducing blood glucose levels at balb/c mice induced with alloxan. Methods. This research method uses a pre and posttest-controlled group design with 35 balb/c mice divided into five treatments groups. In the positive control group and the treatment group alloxan was injected for 14 days. Results: Amla (Phyllanthus emblica L.) fruit extract at a dose of 40 mg / 20 g BW was equivalent to positive control of glibenclamide dose 3 mg / 20 g BW compared to the treatment group at a dose of 10 mg / 20 g BW and 20 mg /20 g BW. Conclusion: From this research, it was obtained that the best dose of Amla fruit (phylanthus emblica L) extract applied to blood glucose was 40 mg/20mg BW with a decrease percentage of 56,93% with an effective dose value (ED50) 50% of 34.00 mg / 20 g BW.

scholarly journals NANOEMULSION OF OKRA FRUIT EXTRACT AS ANTIDIABETIC TREATMENT

2020 ◽  
pp. 138-142
Author(s):  
RATNA DJAMIL ◽  
SARAH ZAIDAN ◽  
DENI RAHMAT ◽  
DIAH KARTIKA PRATAMI ◽  
FELIX HAKIM
Keyword(s):  
Blood Glucose ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Glucose Levels ◽  
Antidiabetic Treatment ◽  
Blood Glucose Levels ◽  
Average Blood Glucose

Objective: Okra (Abelmoschus esculentus (L.) Moench) has potential antidiabetic activity. This study created a nanoemulsion of okra extract (NOE) and examined its activity on alloxan-induced diabetes mellitus in mice. Methods: Okra was macerated with 70% ethanol and dried in a rotary evaporator into the crude extract. The extract was encapsulated in a solution of glyceryl caprylate, propylene glycol, and glycerine to form a nanoemulsion. To determine the antihyperglycaemic effect of okra extract, 35 male mice (Mus musculus L.) were divided into seven groups: a non-diabetic normal control group and six diabetic mice groups (untreated negative control, glibenclamide-treated positive control, and four treatments with okra ethanol extract (OEE) at 200 and 400 mg/kg BW and NOE at 200 and 400 mg/kg BW). Results: The group treated with NOE at 400 mg/kg BW (NOE400) had the lowest average blood glucose level of 93.4 mg/dL among hyperglycaemic mice. The decrease in blood glucose levels in NOE400 (52.05%) was significantly different from those in the positive control (42.63%) and OEE treatments (39.32%). The nanoemulsion used in this study fulfills quality requirements, with a mean particle size of 134.7 nm, a polydispersity index of 0.512, and a zeta value of −26.72 mV. Conclusion: NOE reduced blood glucose levels in alloxan-induced hyperglycaemic mice better than OEE. Nanoemulsion can improve the antidiabetic activity of okra extract by increasing penetration of active compounds into interstitial space so that their delivery and bioavailability are higher.

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