scholarly journals UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL BUAH CABAI MERAH ( Capsicum annuum L. ) TERHADAP MENCIT PUTIH JANTAN

2019 ◽  
Vol 9 (1) ◽  
pp. 86 ◽  
Author(s):  
Zulkarni Zulkarni
Keyword(s):  
Blood Glucose ◽  
Capsicum Annuum ◽  
Fasting Blood Glucose ◽  
Ethanol Extract ◽  
Negative Control ◽  
Control Group ◽  
Glucose Levels ◽  
Capsicum Annuum L ◽  
Blood Glucose Levels ◽  
Significant Difference

This Research was conducted to determine the effect of ethanol extract from red chilli (Capsicum annuum L)in lowering blood glucose levels of hyperglycemic male white mices. This study used 30 malewhitemices and divided into 6 groups: negative control group, the positive control group, the treatmentgroup withdosage of 200 mg / kgweight, 400 mg / kgwieght, 600 mg / kg weight and a comparison group with glibenclamide with dosage of 5 mg / kgweightadministered orally for 21 days. The level of fasting blood glucose was checked 6 days after dexamethasone induced, and after the ethanol extract of red chilies on day 7th, 14th, and 21st. The data was analyzed statistically with one –way and two-way Anova by usingSPSS16 program and proceed with the test Duncan to look the significant difference between treatments. The results showed that the ethanol extract from red chilies with a dosage of 200mg / kgweight, 400mg / kgweight, 600 mg / kgweight showed the effect in lowering blood sugar levels in male white mices hyperglycemia significantly (p <0.05). The duration ethanol extract of red chili affected blood glucose levels. The most effective duration in lowering blood glucose levels is the administration of a preparation within 21 days.

Efek Ekstrak Etanol Kulit Petai (Parkia speciosa Hassk) Terhadap Penurunan Kadar Glukosa Darah Mencit Jantan

2018 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Verawaty Verawaty ◽  
Dhea Claudia Novel
Keyword(s):  
Blood Glucose ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Male Mice ◽  
Glucose Levels ◽  
The Third ◽  
Blood Glucose Levels

<p>Penelitian ini bertujuan untuk melihat pengaruh pemberian ekstrak etanol kulit petai (Parkia speciosa Hassk) terhadap penurunan kadar glukosa darah mencit jantan yang diinduksi aloksan. Hewan percobaan dibagi atas 5 kelompok diantaranya kelompok kontrol negatif, kelompok kontrol positif,dosis I (280 mg/kgBB mencit), dosis II (560 mg/kg BB mencit), dosis III (840 mg/kg BB mencit). Penelitian dilakukan selama 21 hari. Persentase penurunan kadar glukosa darah mencit jantan setelah diberikan ekstrak etanol kulit petai pada hari ke-21 adalah dosis I (77,52 %) lebih besar dibandingkan dengan dosis II (69,5 %) dan dosis III (73,37 %). Data yang diperoleh dianalisis dengan uji Two Way Anova dengan program SPSS 17. Hasil penelitian ini menunjukkan bahwa pemberian ekstrak etanol kulit petai untuk tiga variasi dosis menyatakan perbedaan yang bermakna secara statistik terhadap penurunan kadar glukosa darah mencit jantan.</p><p><em>Petai (Parkia speciosa Hassk) has a compound β-sitosterol and stigmasterol that have efficacy to decreased blood glucose levels. This study aimed to determine the effect of ethanol extract of petai peel for decrease blood glucose levels of male mice induced by alloxan. Experimental animals were divided into 5 groups including negative control group, positive control group, the first dose (280 mg/kg in mice), the second dose (560 mg/kg in mice), the third dose (840 mg/kg in mice). The study was conducted for 21 days. After 21 days, the result found that the percentage of blood glucose levels after the male mice given the ethanol extract of petai peel was, the first dose (77.52%) biger than the second dose (69.5%) and the third dose (73.37%). The data obtained were analyzed by Two Way ANOVA using SPSS 17. The results showed that have signicantly difference between three dose variation of ethanol extract of petai peel in blood glucose levels.</em></p>

scholarly journals UJI ANTIDIABETIK EKSTRAK ETANOL BUNGA PEPAYA (Carica papaya L.) TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI ALOKSAN

PHARMACON ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 160
Author(s):  
Adinda Fransisca Pongoh ◽  
Edwin De Queljoe ◽  
Henki Rotinsulu
Keyword(s):  
Blood Glucose ◽  
Rattus Norvegicus ◽  
Carica Papaya ◽  
Fasting Blood Glucose ◽  
Ethanol Extract ◽  
Control Group ◽  
Homogeneity Test ◽  
Glucose Levels ◽  
White Rats ◽  
Blood Glucose Levels

ABSTRACT This study aims to determine the antidiabetic activity of papaya flower ethanol extract (Carica papaya L.) against male white rats (Rattus norvegicus) induced by alloxan. This research is experimental. Fifteen rats were divided into 5 treatment groups, each group consisted of 3 rats. The first group was the negative control group given Aquades, the second group was positive control given Glibenklamid, the three groups were 200 mg dose variation groups, four groups were 400 mg dose variations, and the five groups were 800 mg dose variations. Previously, rats were examined fasting blood glucose levels, then mice were induced by an alloxan dose of 120 mg / kgBW intraperitoneally. On the 3rd day blood glucose levels were examined and then treated according to groups for 7 days, measurement of blood glucose levels after the treatment was carried out once every 3 days namely day 3, day 7, and day 10. Data obtained were then analyzed statistically using SPSS , including normality test (Shapiro-Wilk), homogeneity test (Levene), ANOVA test (One way). The results of this study indicate that Papaya Flower (Carica papaya L.) Ethanol Extract can provide the best blood glucose level reduction effect at a dose of 800 mg. Keywords : Antidiabetic, Papaya Flower Extract (Carica papaya L.), Diabettes Mellitus, Male White Rat (Rattus norvegicus), Aloxan.  ABSTRAK Penelitian ini bertujuan untuk mengetahui efektivitas Antidiabetik Ekstrak Etanol Bunga Pepaya (Carica papaya L.) Terhadap Tikus Putih Jantan (Rattus norvegicus) Yang Diinduksi Aloksan. Penelitian ini bersifat eksperimental. Sebanyak 15 ekor tikus dibagi ke dalam 5 kelompok perlakuan masing- masing kelompok terdiri dari 3 ekor tikus. Kelompok pertama kelompok Kontrol negatif yang diberikan Aquades, Kelompok kedua Kontrol Positif yang diberikan Glibenklamid, kelompok tiga kelompok variasi dosis 200 mg, kelompok empat kelompok variasi dosis 400 mg, dan kelompok lima kelompok variasi dosis 800 mg. Sebelumnya tikus dilakukan pemeriksaan kadar glukosa darah puasa, selanjutnya tikus diinduksi Aloksan dosis 120 mg/kgBB secara intraperitoneal. Pada hari ke 3 diperiksa kadar Glukosa darah kemudian diberikan perlakuan sesuai kelompok selama 7 hari, pengukuran kadar glukosa darah setelah perlakuan dilakukan 3 hari sekali yaitu hari ke 3, hari ke 7, dan hari ke 10. Data yang diperoleh kemudian dianalisis secara statistik menggunakan SPSS, meliputi uji normalitas (Shapiro-Wilk), uji homogenitas (Levene), uji ANOVA (One way). Hasil penelitian ini menunjukkan bahwa Ekstrak Etanol Bunga Pepaya (Carica papaya L.)  dapat memberikan efek penurunan kadar glukosa darah yang paling baik yaitu pada dosis 800 mg. Kata kunci : Antidiabetik, Ekstrak Bunga pepaya (Carica papaya L.), Diabettes Mellitus, TikusPutih Jantan (Rattus norvegicus), Aloksan.

The Effect of Ethanol Extract of Guava Leaf on Hypercholesterolemia-Diabetes of White Rats Male Induced by High Fat Feed and Streptozotocin

2021 ◽  
Vol 7 (2) ◽  
pp. 177-187
Author(s):  
Joni Tandi ◽  
Franciska Diana Pratiwi ◽  
Surisna Surisna ◽  
Niluh Puspita Dewi ◽  
Magfirah Magfirah
Keyword(s):  
Blood Glucose ◽  
Effective Dose ◽  
Ethanol Extract ◽  
Negative Control ◽  
Control Group ◽  
Glucose Levels ◽  
White Rats ◽  
Blood Glucose Levels ◽  
Group I ◽  
Guava Leaf

This study aims to determine the effect of guava leaf extract (Psidiium guajava L) on hypercholesterolemia-diabetes and the effective dose for reducing cholesterol and blood glucose levels. This study is a laboratory experimental study using 30 rats divided into 6 test animals. the treatment group, each group consisted of 5 rats. Group I was normal control, group II negative control was given Na-CMC suspension, group III positive control was given simvastatin group IV dose 150 mg / kg BW, group V dose 250 mg / kg BW and group VI dose 350 mg / kg BW. The results showed that the ethanol extract of guava leaves had an effect on reducing blood glucose levels of male white rats with an effective dose of 250mg / kg BW with an average reduction of 119 mg/dL and effectively reduce cholesterol levels at a dose of 150 mg /kg BW with an average reduction of 28,33 mg/dL.

scholarly journals Red dragon fruit (Hylocereus spp.) peel marmalade effectively improve blood glucose and lipid profile of hypercholesterolemic wistar rats

2020 ◽  
Vol 9 (1) ◽  
pp. 61-67
Author(s):  
Natalia Desy Putriningtyas ◽  
Intan Permatasari ◽  
Dita Oktaviani ◽  
Anastasia Servia Raha ◽  
Siti Wahyuningsih
Keyword(s):  
Blood Glucose ◽  
Functional Food ◽  
Wistar Rats ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Fruit Peel ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Dragon Fruit ◽  
Significant Difference

Background: Polyphenols, antioxidants, dietary fiber, and vitamin contained in the red dragon fruit peel. Red dragon fruit peel can be processed into marmalade. Red dragon fruit peel marmalade has the potential to be a functional food. Functional food is food that has a physiological function based on scientific studies.Objectives: The objective of this study is to analyze the effect of red dragon fruit peel marmalade on fasting blood glucose levels, HDL, LDL, and triglycerides levels of hypercholesterolemic Wistar rats.Methods: This study used a pre-&post-test control group design. Hypercholesterolemic male Wistar rats were randomly assigned into five groups. Hypercholesterolemia was induced by 1% cholesterol powder and 0.5% cholic acid for two weeks. All groups received standard chow. Samples were grouped into five groups: K-; K+; K1 (0.94 g/kg b.wt/day); K2 (1.41 g/kg b.wt/day); K3 (1.88 g/kg b.wt/day). The intervention was carried out for 28 days. GDP level was measured using the GOD-PAP. HDL, LDL, and triglyceride were analyzed with spectrophotometry. GDP, HDL, LDL, and triglyceride levels were measured twice before fasting. A paired t-test and one-way ANOVA were used to analyze the data.Results: The result showed that K-; K1; K2; K3 had a significant difference between groups before and after the intervention (p<0.05). Red dragon fruit peel Marmalade was able to reduce the levels of GDP, LDL, triglycerides, and increase HDL (p <0.05).Conclusion: Red dragon fruit peel marmalade reduced fasting blood glucose levels, LDL, triglyceride levels, and increased HDL levels of hypercholesterolemic Wistar rats.

scholarly journals NANOEMULSION OF OKRA FRUIT EXTRACT AS ANTIDIABETIC TREATMENT

2020 ◽  
pp. 138-142
Author(s):  
RATNA DJAMIL ◽  
SARAH ZAIDAN ◽  
DENI RAHMAT ◽  
DIAH KARTIKA PRATAMI ◽  
FELIX HAKIM
Keyword(s):  
Blood Glucose ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Glucose Levels ◽  
Antidiabetic Treatment ◽  
Blood Glucose Levels ◽  
Average Blood Glucose

Objective: Okra (Abelmoschus esculentus (L.) Moench) has potential antidiabetic activity. This study created a nanoemulsion of okra extract (NOE) and examined its activity on alloxan-induced diabetes mellitus in mice. Methods: Okra was macerated with 70% ethanol and dried in a rotary evaporator into the crude extract. The extract was encapsulated in a solution of glyceryl caprylate, propylene glycol, and glycerine to form a nanoemulsion. To determine the antihyperglycaemic effect of okra extract, 35 male mice (Mus musculus L.) were divided into seven groups: a non-diabetic normal control group and six diabetic mice groups (untreated negative control, glibenclamide-treated positive control, and four treatments with okra ethanol extract (OEE) at 200 and 400 mg/kg BW and NOE at 200 and 400 mg/kg BW). Results: The group treated with NOE at 400 mg/kg BW (NOE400) had the lowest average blood glucose level of 93.4 mg/dL among hyperglycaemic mice. The decrease in blood glucose levels in NOE400 (52.05%) was significantly different from those in the positive control (42.63%) and OEE treatments (39.32%). The nanoemulsion used in this study fulfills quality requirements, with a mean particle size of 134.7 nm, a polydispersity index of 0.512, and a zeta value of −26.72 mV. Conclusion: NOE reduced blood glucose levels in alloxan-induced hyperglycaemic mice better than OEE. Nanoemulsion can improve the antidiabetic activity of okra extract by increasing penetration of active compounds into interstitial space so that their delivery and bioavailability are higher.

Daya Antihiperglikemia Yoghurt Pada Mencit Putih Jantan

2019 ◽  
Vol 4 (2) ◽  
pp. 72
Author(s):  
Irene Puspa Dewi ◽  
Roza Septriani ◽  
Verawaty Verawaty ◽  
Dwi Mulyani
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Positive Control ◽  
Negative Control ◽  
Positive Control Group ◽  
Control Group ◽  
Percentage Increase ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference

<p><em>Research has been conducted on the antihyperglycemic of yogurt in male white mice. Yogurt contains probiotics that have a positive effect on both type 1 and types 2 diabetes mellitus. Yogurt is given for 3 weeks at a dose of 200 grams / Kg BW / day and 400 grams / Kg BW / day to mice that have been alloxan-induced. As a comparison, a positive control group was created, the alloxan-induced mice group, but not given yogurt and a negative control group, the mice group without any treatment. After 3 weeks of treatment with yogurt, it was found that there was a significant difference between the average blood glucose levels in the mice of the 200 grams/ Kg BW group and the 400 grams / Kg BW dose with the positive control group. From the data on the percentage increase in blood glucose levels of mice, it is known that by giving yogurt for 3 weeks, reducing the high percentage of increase in blood glucose levels in mice. From these data, it can be concluded that the administration of yogurt with a dose of 200 grams / Kg / day and 400 grams / Kg / day can help reduce blood glucose levels in alloxan-induced mice.</em></p><p> </p><p><em>Telah dilakukan penelitian mengenai daya antihiperglikemia yogurt pada mencit putih jantan. Yogurt mengandung probiotik  yang memberikan pengaruh positif terhadap diabetes mellitus baik tipe 1 maupun tipe 2. Yogurt diberikan selama 3 minggu dengan dosis 200/Kg BB/hari dan 400 gram/Kg BB/hari kepada mencit yang telah diinduksi aloksan. Sebagai pembanding dibuat kelompok kontrol positif yaitu kelompok mencit yang diinduksi aloksan, namun tidak diberi yogurt dan kelompok kontrol negatif, yaitu kelompok mencit tanpa perlakuan apapun. Setelah 3 minggu perlakuan dengan yogurt, didapatkan hasil bahwa terdapat perbedaan bermakna antara rata-rata kadar glukosa darah mencit kelompok dosis 200 gram/Kg BB dan dosis 400 gram/Kg BB dengan kelompok kontrol postif. Dari data persentase kenaikan kadar glukosa darah mencit, diketahui bahwa dengan pemberian yogurt selama 3 minggu, mengurangi tingginya persentase kenaikan kadar glukosa darah mencit.dari data-data tersebut, dapat disimpulkan bahwa pemberian yogurt dengan dosis 200 gram/Kg BB/hari dan 400 gram/Kg BB/hari dapat membantu menurunkan kadar glukosa darah mencit yang diinduksi aloksan.</em></p>

scholarly journals Prophylactic Effect of Ethanol Extract of Azadirachta indica Leaf in Streptozotocin-induced Diabetic Rats

2020 ◽  
pp. 15-27
Author(s):  
O. C. Ezeigwe ◽  
C. J. Ononamadu ◽  
M. E. Onuegbu ◽  
O. R. Ikpeogu ◽  
I. C. Agugom ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Ethanol Extract ◽  
Diabetic Rats ◽  
Control Group ◽  
Prophylactic Effect ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Pre Treatment

Background: Medicinal plants are now becoming indispensable in the treatment and management of many ailments. The unaffordability, unavailability and adverse effects of conventional therapy in the treatment and management of many diseases have geared keen interest in the use of herbal medicine. This work was carried out to investigate the prophylactic effect of the ethanol extract of Azadirachta indica leaf in streptozotocin-induced diabetic rats.   Methods: A total of one hundred (100) rats were randomized into four (4) groups (n=25) and used for the study. Each group of 25 rats was sub-divided into five (5) groups (n=5). The sub-groups comprise: Group A-normal control that was not treated, group B-100 mg/kg body weight of metformin and groups C to E - graded doses (100 mg/kg, 200 mg/kg and 400 mg/kg body weight) of the ethanol leaf extracts of A. indica leaves. The standard drug and the extracts were consecutively administered to groups B-E for 7, 14, 21 and 28 days before the induction of diabetes. Diabetes was induced intraperitoneally using 50 mg/kg bodyweight of streptozotocin. Results: The groups that were administered 100, 200 and 400 mg/kg bw of ethanol extract of A. indica showed a significant (p<0.05) increase in their weight after 21 and 28 days of pre-treatment compared with the control group that was not treated. The graded doses of the extract also have a remarkable effect in the fasting blood glucose levels which was made visible by the significant (p<0.05) reduction recorded in the fasting blood glucose levels compared with the control group that was not pre-treated and the group pre-treated with metformin. Conclusion: The results obtained in this research suggest that ethanol extract of A. indica has the potential to protect against diabetes by delaying its onset. However, the longer the period of pre-treatment, the better the condition of the animals pre-treated as well as the protection as can be seen from the results of the weight and fasting blood glucose levels.

scholarly journals Pengaruh pemberian susu almond terhadap glukosa darah puasa pada tikus diabetes

2019 ◽  
Vol 7 (2) ◽  
pp. 86-91
Author(s):  
Ryta Ristantia Ningsih ◽  
Enny Probosari ◽  
Binar Panunggal
Keyword(s):  
Blood Glucose ◽  
Treatment Group ◽  
Metabolic Diseases ◽  
Fasting Blood Glucose ◽  
Glucose Measurement ◽  
Control Group ◽  
Control Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference

Background: Type 2 Diabetes Mellitus is a group of metabolic diseases with characteristic hyperglycemia that occurs due to abnormalities in insulin secretion and insulin action. Diet plus high fiber can help control glucose levels. Almond contains fiber, vitamin E, and magnesium that contributes to the fasting blood glucose levels. This study aimed to analyze the effect of almond milk to the fasting blood glucose diabetic rats.Method: This study used an experimental design with pre-post test control group design. The sample were Rattus norvegicus Wistar which were divided into 4 groups: K (-), K (+), A1 and A2. Almond milk was given in the group treatmeant for 14 days with a dose of 4.32 ml and 8.64 ml. Fasting blood glucose measurement taken before and after treatment used Oxidase Glucose - Peroxidase Aminoantypirin (GOD PAP). Analysis of data used paired t-test, ANOVA and Post Hoc.Results: The fasting blood glucose levels decreased significantly (p = 0.01) in the treatment group which were intervened with almond milk. A decrease in fasting blood glucose levels in a dose treatment group 1 for 116.96 ± 4.45 (p = 0:01), whereas in the group treated at a dose of 2 for 155.53 ± 3.15 (p = 0.01). There were a significant difference in decreased of the fasting blood glucose levels between the two treatment groups (p = 0.01).Conclusion:  Giving a dose almond milk 4.32 ml and 8.64 ml for 14 days can lower the fasting blood glucose levels significantly.

scholarly journals The Effectiveness of Vitamin D Addition to Decreasing Blood Glucose Levels of Hyperglycemic Mice Model with Glimepirid Therapy

2020 ◽  
Vol 6 (2) ◽  
pp. 71
Author(s):  
Tsintani Nur Aristiana ◽  
Cholis Abrori ◽  
Muhammad Ali Shodikin
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Negative Control ◽  
Control Group ◽  
Mice Model ◽  
Control Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels

Abstract Low 25-hydrocyvitamin D (25(OH)D3) levels are usually found in patients with type 1 and type 2 diabetes mellitus. This study aims to compare the effectiveness of fasting blood glucose levels in hyperglycemic mice model with glimepirid single therapy, hyperglycemic mice model with vitamin D, and mice model of hyperglycemic with glimepirid therapy plus vitamin D. This study used the true experimental research design with the randomized posttest only control group design. There were 25 male mice (Mus musculus) strain Balb/C with 20-30 g body weight and 2-3 months old which were grouped into 5 groups. The negative control group (K1) was injected with placebo and the positive control group (K2) was injected with STZ 150 mg/kgBW i.p. Groups P1, P2, and P3 were given STZ injection of 150 mg/kgBW i.p and given glimepirid 0.26 mg/kgBW; vitamin D 6,5 ml/kgBW; glimepirid 0,26 mg/kgBW with vitamin D supplementation 6,5 ml/kgBW. The results of the Tukey post hoc tests obtained differences in the mean of delta KGD between groups P1 and K2 = 122,55; in group P2 with K2 = 81,60; and in group P3 with K2 = 74,40. From these data, it can be concluded that in the group given glimepirid plus vitamin D there was no additional effectiveness in decreasing fasting blood glucose levels of hyperglycemic mice model compared to the group given only glimepirid therapy and the group given vitamin D alone. Keywords: diabetes mellitus, vitamin D, glimepiride, streptozotocin.

scholarly journals Effect of Celery Extract on Fructose Induced Insulin Resistance Rattus norvegicus

2021 ◽  
Vol 56 (4) ◽  
pp. 269
Author(s):  
Devitya Angielevi Sukarno ◽  
Arifa Mustika ◽  
Purwo Sri Rejeki
Keyword(s):  
Insulin Resistance ◽  
Blood Glucose ◽  
Treatment Group ◽  
Rattus Norvegicus ◽  
Therapy Group ◽  
Fasting Blood Glucose ◽  
Negative Control ◽  
Control Group ◽  
Glucose Levels ◽  
Blood Glucose Levels

Diabetes mellitus (DM) is one of the global health problems and in the top 4th ranks as the main cause of death in developing countries (IDF, 2015). The pathogenesis of type II DM involves abnormalities in insulin secretion and activity that leads to insulin resistance. This research aims to study the efficacy of celery (Apiumgraveolens) as a prevention of insulin resistance. In this study, the samples were 45 Wistar rats (Rattus norvegicus), male sex, aged 4-6 weeks, weight 150-175 grams,and had normal fasting blood glucose levels by tested before treatment. The experimental animals were divided into 5 groups, K1 was negative control group (insulin resistance by given 20% fructose 1,86 g/kg BW PO qDay);K2 was positive control group (those given 20% fructose 1,86 g/kg BW PO qDayand standard insulin resistance therapy metformin 500 mg/kg BW PO qDay); the K3 treatment group was given 20% fructose 1,86 g/kg BW PO qDay and celery extract 200 mg/kg BW PO qDay; the K4 treatment group was given fructose 20% 1,86 mg/kg BW PO qDay and celery extract 400 mg/kg BW PO qDay; and the K5 treatment group was given fructose 20% 1,86 mg/kg BW PO qDay and celery extract 600 mg/kg BW PO qDay. The treatment had been given every day for 60 days.Fasting blood glucose levels were measured using a Glucometer. Fasting blood insulin levels were measured using ELISA, HOMA-IR was calculated using a standardized formula, and GLUT4 protein expression was measured using immunohistochemistry. It the end of the intervention, there was a significant decreased in fasting blood glucose (FBG) in K4 group compared with K1 (p <0.05), insulin resistance in K1 was characterized by a higher HOMA-IR value compared to the therapy group, especially K4 and K5 (p <0.05). There was an increase in GLUT-4 expression on K4 and K5 compared with K1 (p <0.05). It can be concluded that celery extract has antihyperglycemia effect and furthermore it can prevent insulin resistance condition.

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