The role of oxidative stress-related biomarkers in ascending aortic dilatation: Malondialdehyde and paraoxonase-1 activity

SummaryBackground:The objective here is to examine the role of overall oxidative stress in the etiopathogenesis of gluten-sensitive enteropathy disease and its relationship with gluten free diet and autoantibodies.Methods:Eighty gluten-sensitive enteropathy patients and 80 control group participants were included in the study. As oxidative stress parameters, we researched total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase-1 and arylesterase parameters in the serum samples of gluten-sensitive enteropathy patients.Results:In comparison to the control group, gluten-sensitive enteropathy patients had lower TAS, paraoxonase-1 and arylesterase levels and gluten-sensitive enteropathy patients had considerable TOS and OSI levels. In contrast, patients who agreed to the gluten free eating routine had a higher OSI proportion and patients who did not conform to the gluten free eating regimen had a lower paraoxonase-1 level. An affirming reciprocation was de tected amidst TOS and OSI proportion and gluten-sensitive enteropathy autoantibodies and C-reactive protein levels and a negative correlation was found between arylesterase level and gluten-sensitive enteropathy autoantibodies.Conclusions:We observed oxidative stress levels to be higher in gluten-sensitive enteropathy patients contrasted with the control group. Oxidative stress level showed differences in gluten-sensitive enteropathy patients depending on gluten diet content and autoantibody positivity. In point of fact, C-reactive protein and gluten-sensitive enteropathy autoantibodies are identified with oxidative anxiety parameters resulting in the possibility that oxidative stress might be successful in the gluten-sensitive enteropathy pathogenesis.

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ROLE OF BILIRUBIN AS A POTENTIALANTIOXIDANT IN SMOKERS

10.36106/ijsr/9801381 ◽

2021 ◽

pp. 43-45

Author(s):

Varshini. S ◽

A. Preethi ◽

G. Udayakumari

Keyword(s):

Oxidative Stress ◽

Antioxidant Properties ◽

Antioxidant Property ◽

Mean Value ◽

Paraoxonase 1 ◽

P Value ◽

College Hospital ◽

Chronic Respiratory Diseases ◽

The Mean

Introduction: Globally, smoking causes about 71% of lung cancer, 42% of chronic respiratory diseases and about 10% of cardiovascular disease. Smokers are exposed to potential oxidative damage. This leads to depletion of the body's defense against oxidative stress, like decrease in the levels of Paraoxanase -1. This study aimed to assess the antioxidant property of Bilirubin in comparison to Paraoxonase-1 in smokers. Materials & methods: This case control study was carried out at Govt. Kilpauk Medical College Hospital after obtaining ethical committee approval and informed consent. This study involves 2 groups with 90 chronic smokers and 90 apparently healthy individuals who are not smokers. Serum Bilirubin and Paraoxanase -1 levels were estimated and compared between these two groups. Correlation between Bilirubin and Paraoxanase-1 was analyzed. Statistical analysis was done using SPSS package version 20. Results: The mean value for Bilirubin is 0.566 +/- 0.03 mg/dL in smokers and 0.620 +/- 0.05 mg/dL in non-smokers. There is signicant difference in bilirubin levels between smokers and non smokers (p value - 0.049). The mean value for Paraoxonase-1 is 3.291+/- 0.75 ng/dL in smokers and 4.513+/- 0.96 ng/dL in non-smokers. There is signicant difference in Paraoxanase -1 levels between smokers and non smokers (p value - 0.025). The scatter plot between Paraoxanase -1 and Bilirubin shows no signicant correlation. Conclusion: The Paraoxanase -1 and Bilirubin values in smokers are considerably reduced in comparison to that of non-smokers. This shows that Paraoxanase -1 and Bilirubin exhibits potential antioxidant properties. Bilirubin estimation is inexpensive and can be easily measured rather than measuring other known antioxidants such as PON-1. Role of Bilirubin as a marker to detect the oxidative stress levels in smokers is established in this study

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Beta-Thalassemia Minor and the risk of Atherosclerosis: the role of the erythrocytic oxidative stress and paraoxonase 1 levels as aggravating factors

Revista Brasileira de Análises Clínicas ◽

10.21877/2448-3877.201600404 ◽

2017 ◽

Vol 49 (1) ◽

Author(s):

FERNANDO MINERVO PIMENTEL REIS ◽

Fabiano Timbó Barbosa ◽

Fernando Wagner da Silva Ramos

Keyword(s):

Oxidative Stress ◽

Paraoxonase 1 ◽

Beta Thalassemia ◽

Thalassemia Minor

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Effect of Co Enzyme Q10 Alone or in Combination with Vitamin C on Lipopolysaccharide-Induced Brain Injury in Rats

Biomedical & Pharmacology Journal ◽

10.13005/bpj/1483 ◽

2018 ◽

Vol 11 (3) ◽

pp. 1215-1226

Author(s):

Nabila A. El-Laithy ◽

Elsayed M.E. Mahdy ◽

Eman R. Youness ◽

Nermeen Shafee ◽

Mohamed S.S. Mowafy ◽

...

Keyword(s):

Oxidative Stress ◽

Vitamin C ◽

Brain Tissue ◽

Paraoxonase 1 ◽

Intraperitoneal Dose ◽

High Doses ◽

C 50 ◽

Histopathological Results ◽

The Impact

Our was to determine the impact of CoenzymeQ10 (Co Q10) and vitamin C alone or in combination on oxidative stress in brain tissue of rats during endotoxemia induced by single intraperitoneal dose of Lipopolysaccharide (LPS), 500µg/kg. Both CoQ10&vitamin C were given orally to rats with doses (200&100 mg/kg) respectively for 7successive days prior induction of endotoxemia .LPS injected, with Co Q10 with doses (100 &200 mg/kg) &vit. C (50&100 mg/kg).In addition CoQ10 and vitamin C together in doses (100&50 mg/kg) & (200&100 mg/kg) respectively were added to LPS-treated rats. Then euthanized 4 hours later. Histopathological assessment of brain tissue was done. Results: LPS injection induced oxidative stress in brain tissue, resulting in marked increase in malondiadehyde (MDA), nitrite (NO) and Amyloid beta (Aβ), while decreasing reduced glutathione (GSH), paraoxonase-1 (PON1) and brain derived neurotrophic factor (BDNF).CoQ10 and vit.C administration with doses(200&100 mg/ kg) before endotoxemia result in reduction of brain MDA, NO and Aβ, while increasing levels of GSH, PON1 and BDNF compared to controls. The addition of both Co Q10 &vit.C to LPS- treated rats lead to decrease of brain NO, MDA and Aβ, also increase of GSH, PON1 and BDNF. This effect was more obviouswith high doses, this due to the ameliorating effect of both CoQ10 and vit.C on oxidative stress of brain tissue during endotoxemia.This consisted with the histopathological results. Conclusion: this work focuses on the possible role of CoQ10 &vit.C as antioxidants in protecting brain tissue.

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A review of paraoxonase 1 properties and diagnostic applications

Polish Journal of Veterinary Sciences ◽

10.1515/pjvs-2016-0028 ◽

2016 ◽

Vol 19 (1) ◽

pp. 225-232 ◽

Cited By ~ 16

Author(s):

M. Kulka

Keyword(s):

Oxidative Stress ◽

Laboratory Animal ◽

Density Lipoprotein ◽

Protective Role ◽

Paraoxonase 1 ◽

Oxidative Stress Marker ◽

State Changes ◽

Diagnostic Applications ◽

Oxidative State

Abstract Paraoxonase 1 (PON1) is an arylesterase associated with serum high density lipoprotein particles. Its name is derived from hydrolyzing one of several organophosphate compounds, namely paraoxon. Recent studies have shown that PON1 plays a protective role in diseases associated with oxidative stress such as atherosclerosis and diabetes mellitus. Studies have demonstrated reduction-oxidative state changes involving PON1 in humans and laboratory animal models. Although there is less information about the role of this enzyme in veterinary medicine, new data suggest that PON1 might be a new oxidative stress marker in animal patients, similarly to humans.

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