The impact of Vaccination worldwide on SARS-CoV-2 infection: A Review on Vaccine Mechanisms, Results of Clinical Trials, Vaccinal Coverage and Interactions with Novel Variants

2021 ◽  
Vol 28 ◽  
Author(s):  
Douglas Henrique Pereira Damasceno ◽  
Arthur Aguiar Amaral ◽  
Cecília Andrade Silva ◽  
Ana Cristina Simões e Silva
Keyword(s):  
Immune Response ◽  
Clinical Trials ◽  
Placebo Group ◽  
Mechanisms Of Action ◽  
Novel Variants ◽  
The Impact ◽  
Positive Results ◽  
Epidemiological Information ◽  
Long Term Studies

Background: The COVID-19 pandemic demanded a global effort towards quickly developing safe and effective vaccines against SARS-CoV-2. Objective: This review aimed to discuss the main vaccines available, their mechanisms of action, results of clinical trials and epidemiological behavior. The implications of viral variants were also debated. Methods: A non-systematic literature review was performed between February and March 2021 by searching the Pubmed, Scopus, and SciELO databases, using different combinations of the following terms: "vaccines", "clinical trials" , "SARS-CoV-2", "Coronavirus", "COVID-19", "mechanisms of action". Data regarding clinical trials of SARS-CoV-2 vaccines and epidemiological information were also searched. Results: The mechanisms of action included vector-virus, mRNA and inactivated virus vaccines. The vaccines showed positive results in phases 2/3 clinical trials. The efficacy of the mRNA 1273 and of mRNA BNT 162b2 vaccines were 94.1% and 95%, respectively. The effectiveness of the ChAdOx1 nCoV-19 vaccine varied according to the scheme, with an overall value of 70.4%. The Gam-COVID-Vac vaccine had an efficacy of 91.6%. Regarding the Ad26.COV2.S vaccine, 99% or more of seroconversion was observed in all subgroups 29 days after vaccination. The CoronaVac vaccine induced an immune response in 92% of the volunteers receiving 3ug and in 98% with 6ug, in comparison to 3% in the placebo group. Conclusion: Global efforts have resulted in vaccines available in record time, with good safety and immunogenicity profile. However, only long-term studies can provide more information on duration of immunity and the need for additional doses.

scholarly journals Intestinal Microbiota and Allergy. Probiotics and Prebiotics in Prevention and Treatment of Allergic Diseases

2019 ◽  
Vol 16 (1) ◽  
pp. 7-18 ◽  
Author(s):  
Svetlana G. Makarova ◽  
Leyla S. Namazova-Baranova ◽  
Oksana A. Ereshko ◽  
Dmitry S. Yasakov ◽  
Pavel E. Sadchikov
Keyword(s):  
Immune Response ◽  
Clinical Trials ◽  
Intestinal Microbiota ◽  
Practical Interest ◽  
Allergic Diseases ◽  
Evidence Based ◽  
Prevention And Treatment ◽  
The Impact ◽  
Positive Results ◽  
Intestinal Microbiocenosis

Intestinal microbiota is the factor that identifies considerably the human health. The impact of the microbial factor on a child begins long before his birth. Children have certain features in forming of immune response and intestinal microbiocenosis even before birth. Decline in diversity of intestinal microbiota is common in children with allergic disease even during first months of life, before allergic pathology development. Capabilities for microbiota development adjustment are sufficiently restricted. However it is clinically proven that early (within the first hours of life) breastfeeding attachment, breastfeeding itself within at least first 6 months of life, the use of prebiotics in milk formulas as well as the use of probiotics can give positive results on allergy management. In this review we present results of recent metaanalyses and consensus papers of international medical communities about use of probiotics and prebiotics in prevention and treatment of allergic diseases. Despite great scientific and practical interest to this topic, authors of metaanalyses bring our attention to the lack of evidence-based clinical trials.

scholarly journals Stability of temperatures from TIMED/SABER v1.07 (2002–2009) and Aura/MLS v2.2 (2004–2009) compared with OH(6-2) temperatures observed at Davis Station, Antarctica

2010 ◽  
Vol 10 (9) ◽  
pp. 21547-21565 ◽  
Author(s):  
W. J. R. French ◽  
F. J. Mulligan
Keyword(s):  
Cold Bias ◽  
Spatial And Temporal Scales ◽  
Ground Station ◽  
Volume Emission ◽  
The Difference ◽  
Miss Distance ◽  
Hydroxyl Layer ◽  
The Impact ◽  
Long Term Studies

Abstract. Temperature profiles from two satellite instruments – TIMED/SABER and Aura/MLS – have been used to calculate hydroxyl-layer equivalent temperatures for comparison with values measured from OH(6-2) emission lines observed by a ground-based spectrometer located at Davis Station, Antarctica (68° S, 78° E). The profile selection criteria – <500 km from the ground station and solar zenith angles >97° – yielded a total of 2359 SABER profiles over 8 years (2002–2009) and 7407 MLS profiles over 5.5 years (2004–2009). The availability of simultaneous OH volume emission rate (VER) profiles from the SABER (OH-B channel) enabled an assessment of the impact of several different weighting functions in the calculation of OH-equivalent temperatures. The maximum difference between all derived hydroxyl layer equivalent temperatures was less than 3 K. Restricting the miss-distance and miss-time criteria showed little effect on the bias, suggesting that the OH layer is relatively uniform over the spatial and temporal scales considered. However, a significant trend was found in the bias between SABER and Davis OH of ~0.7 K/year over the 8-year period with SABER becoming warmer compared with the Davis OH temperatures. In contrast, Aura MLS exhibited a cold bias of 9.9 ± 0.4 K compared with Davis OH, but importantly, the bias remained constant over the 2004–2009 year period examined. The difference in bias behaviour of the two satellites has significant implications for multi-annual and long-term studies using their data.

scholarly journals CONGENITAL ANOMALIES IN CHILDREN OF UKRAINE: 25-YEAR MONITORING OF MORBIDITY AND PREVALENCE

2020 ◽  
Vol 73 (10) ◽  
pp. 2193-2197
Author(s):  
Oleksandr P. Volosovets ◽  
Tetyana O. Kryuchko ◽  
Viktor L. Veselskyi ◽  
Sergii P. Kryvopustov ◽  
Tetiana M. Volosovets ◽  
...  
Keyword(s):  
Congenital Anomalies ◽  
Congenital Defects ◽  
Negative Effects ◽  
Epidemiological Analysis ◽  
Child Population ◽  
Total Incidence ◽  
Industrial Regions ◽  
The Impact ◽  
Long Term Studies

The aim: Of the work was to study 25-year trends in the incidence of congenital anomalies in the child population of Ukraine in order to determine the impact of ecotoxic environmental factors on their development, in particular radiation. Materials and methods: Methods of statistical assessment, epidemiological analysis of materials at the Center for Medical Statistics of the MOH of Ukraine were used. Results: The rate of congenital anomalies growth for the recent 25 years has exceeded the growth rate of the total incidence in the child population of Ukraine by 1.6 times, occupying the leading place in Europe by the level of environment pollution. Over the last 25 years, the growth of the Ukrainian children’s congenital anomalies incidence level by 59.5% is observed, mostly in children from large industrial regions of Ukraine, due to the significant ecotoxic effect of pollutants on the child’s body. Children living permanently in the areas contaminated by the Chernobyl accident had significantly higher rates of congenital anomalies in 1986 than in the early 1990s, but over the recent 25 years the incidence in this contingent has decreased. Conclusions: The results of such long-term studies performed by a group of leading Ukrainian scientists from different regions of Ukraine indicate that in children experiencing negative effects of ecotoxic factors, including radiation, an increase in the detection and prevalence of congenital defects is observed, which requires complex international and intersectoral measures to prevent and reduce child mortality.

Large-scale randomized evidence: Trials and meta-analyses of trials

2020 ◽  
pp. 51-66
Author(s):  
Colin Baigent ◽  
Richard Peto ◽  
Richard Gray ◽  
Natalie Staplin ◽  
Sarah Parish ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Large Scale ◽  
Meta Analysis ◽  
False Negative ◽  
Premature Deaths ◽  
Common Causes ◽  
The Common ◽  
Meta Analyses ◽  
Positive Results

Clinical trials generally need to be able to detect or to refute realistically moderate (but still worthwhile) differences between treatments in long-term disease outcome. Large-scale randomized evidence should be able to detect such effects, but medium-sized trials or medium-sized meta-analyses can, and often do, yield false-negative or exaggeratedly positive results. Hundreds of thousands of premature deaths each year could be avoided by seeking appropriately large-scale randomized evidence about various widely practicable treatments for the common causes of death, and by disseminating this evidence appropriately. This chapter takes a look at the use of large-scale randomized evidence—produced from trials and meta-analysis of trials—and how this data should be handled in order to produce accurate result.

scholarly journals Intestinal Explant Cultures from Gilthead Seabream (Sparus aurata, L.) Allowed the Determination of Mucosal Sensitivity to Bacterial Pathogens and the Impact of a Plant Protein Diet

2020 ◽  
Vol 21 (20) ◽  
pp. 7584
Author(s):  
David Sánchez Peñaranda ◽  
Christine Bäuerl ◽  
Ana Tomás-Vidal ◽  
Miguel Jover-Cerdá ◽  
Guillem Estruch ◽  
...  
Keyword(s):  
Immune Response ◽  
Phase Ii ◽  
Plant Protein ◽  
Gilthead Seabream ◽  
Growth Stages ◽  
Short Term ◽  
Short Term Exposure ◽  
Cox 2 ◽  
The Impact

The interaction between diet and intestinal health has been widely discussed, although in vivo approaches have reported limitations. The intestine explant culture system developed provides an advantage since it reduces the number of experimental fish and increases the time of incubation compared to similar methods, becoming a valuable tool in the study of the interactions between pathogenic bacteria, rearing conditions, or dietary components and fish gut immune response. The objective of this study was to determine the influence of the total substitution of fish meal by plants on the immune intestinal status of seabream using an ex vivo bacterial challenge. For this aim, two growth stages of fish were assayed (12 g): phase I (90 days), up to 68 g, and phase II (305 days), up to 250 g. Additionally, in phase II, the effects of long term and short term exposure (15 days) to a plant protein (PP) diet were determined. PP diet altered the mucosal immune homeostasis, the younger fish being more sensitive, and the intestine from fish fed short-term plant diets showed a higher immune response than with long-term feeding. Vibrio alginolyticus (V. alginolyticus) triggered the highest immune and inflammatory response, while COX-2 expression was significantly induced by Photobacterium damselae subsp. Piscicida (P. damselae subsp. Piscicida), showing a positive high correlation between the pro-inflammatory genes encoding interleukin 1β (IL1-β), interleukin 6 (IL-6) and cyclooxygenase 2(COX-2).

Laboratory Investigations on the Effects of Bacteria on Fine-Grained Soils

2017 ◽  
Vol 21 ◽  
pp. 352-357 ◽  
Author(s):  
S. Sowmya ◽  
P.S. Meenu ◽  
R. Asha Latha ◽  
Devendra Narain Singh
Keyword(s):  
Preliminary Investigation ◽  
Biological Processes ◽  
Fine Grained ◽  
Recent Developments ◽  
Prospective Application ◽  
Laboratory Investigations ◽  
The Impact ◽  
Geotechnical Problems ◽  
Long Term Studies

Over the years, the field of geotechnical engineering focused on physical, chemical and mechanical aspects of the geomaterials. However, recent developments in environmental geotechnics have highlighted the impact of biological processes on geo-materials and their performance. Also, the present day geotechnical problems favour biological interventions to develop eco-friendly and sustainable technology. In view of this, the present study is a preliminary investigation on the impact of microbial loading on fine-grained soils. In addition, a protocol has been developed to establish ‘bio-geo interface’ between bacteria and the geo-material. However, long term studies are demanded in this direction for in-depth understanding of the mechanism for development of prospective application.

scholarly journals Stability of temperatures from TIMED/SABER v1.07 (2002–2009) and Aura/MLS v2.2 (2004–2009) compared with OH(6-2) temperatures observed at Davis Station, Antarctica

2010 ◽  
Vol 10 (23) ◽  
pp. 11439-11446 ◽  
Author(s):  
W. J. R. French ◽  
F. J. Mulligan
Keyword(s):  
Cold Bias ◽  
Spatial And Temporal Scales ◽  
Ground Station ◽  
Volume Emission ◽  
The Difference ◽  
Miss Distance ◽  
Hydroxyl Layer ◽  
The Impact ◽  
Long Term Studies

Abstract. Temperature profiles from two satellite instruments – TIMED/SABER and Aura/MLS – have been used to calculate hydroxyl-layer equivalent temperatures for comparison with values measured from OH(6-2) emission lines observed by a ground-based spectrometer located at Davis Station, Antarctica (68° S, 78° E). The profile selection criteria – miss-distance <500 km from the ground station and solar zenith angles >97° – yielded a total of 2359 SABER profiles over 8 years (2002–2009) and 7407 MLS profiles over 5.5 years (2004–2009). The availability of simultaneous OH volume emission rate (VER) profiles from the SABER (OH-B channel) enabled an assessment of the impact of several different weighting functions in the calculation of OH-equivalent temperatures. The maximum difference between all derived hydroxyl layer equivalent temperatures was less than 3 K. Restricting the miss-distance and miss-time criteria showed little effect on the bias, suggesting that the OH layer is relatively uniform over the spatial and temporal scales considered. However, a significant trend was found in the bias between SABER and Davis OH of ~0.7 K/year over the 8-year period with SABER becoming warmer compared with the Davis OH temperatures. In contrast, Aura/MLS exhibited a cold bias of 9.9 ± 0.4 K compared with Davis OH, but importantly, the bias remained constant over the 2004–2009 year period examined. The difference in bias behaviour of the two satellites has significant implications for multi-annual and long-term studies using their data.

scholarly journals A Dual Infection/Competition Assay Shows a Correlation between Ex Vivo Human Immunodeficiency Virus Type 1 Fitness and Disease Progression

2000 ◽  
Vol 74 (19) ◽  
pp. 9222-9233 ◽  
Author(s):  
Miguel E. Quiñones-Mateu ◽  
Sarah C. Ball ◽  
Andre J. Marozsan ◽  
Vincent S. Torre ◽  
Jamie L. Albright ◽  
...  
Keyword(s):  
Immune Response ◽  
Human Immunodeficiency Virus ◽  
Disease Progression ◽  
Ex Vivo ◽  
Relative Fitness ◽  
Immunodeficiency Virus ◽  
The Impact ◽  
Hiv 1

ABSTRACT This study was designed to examine the impact of human immunodeficiency virus type 1 (HIV-1) fitness on disease progression through the use of a dual competition/heteroduplex tracking assay (HTA). Despite numerous studies on the impact of HIV-1 diversity and HIV-specific immune response on disease progression, we still do not have a firm understanding of the long-term pathogenesis of this virus. Strong and early CD8-positive cytotoxic T-cell and CD4-positive T-helper cell responses directed toward HIV-infected cells appear to curb HIV pathogenesis. However, the rate at which the virus infects the CD4+ T-cell population and possibly destroys the HIV-specific immune response may also alter the rate of disease progression. For HIV-1 fitness studies, we established conditions for dual HIV-1 infections of peripheral blood mononuclear cells (PBMC) and a sensitive HTA to measure relative virus production. A pairwise comparison was then performed to estimate the relative fitness of various non-syncytium-inducing/CCR5-tropic (NSI/R5) and syncytium-inducing/CXCR4-tropic (SI/X4) HIV-1 isolates. Four HIV-1 strains (two NSI/R5 and two SI/X4) with moderate ex vivo fitness were then selected as controls and competed against primary HIV-1 isolates from an HIV-infected Belgian cohort. HIV-1 isolates from long-term survivors (LTS) were outcompeted by control strains and were significantly less fit than HIV-1 isolates from patients with accelerated progression to AIDS (PRO). In addition, NSI/R5 HIV-1 isolates from PRO overgrew control SI/X4 strains, suggesting that not all SI/X4 HIV-1 isolates replicate more efficiently than all NSI/R5 isolates. Finally, there were strong, independent correlations between viral load and the total relative fitness values of HIV-1 isolates from PRO (r = 0.84, P = 0.033) and LTS (r = 0.86, P = 0.028). Separation of the PRO and LTS plots suggest that HIV-1 fitness together with viral load may be a strong predictor for the rate of disease progression.

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