Antimicrobial, Anticancer Drug Carrying Properties of Biopolymers-based Nanocomposites- A Mini Review

2019 ◽  
Vol 24 (32) ◽  
pp. 3859-3866 ◽  
Author(s):  
Kandasamy Saravanakumar ◽  
Davoodbasha M. Ali ◽  
Kandasamy Kathiresan ◽  
Myeong-Hyeon Wang
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Cancer Therapy ◽  
Drug Carrier ◽  
Disease Diagnosis ◽  
Healthcare Application ◽  
Biopolymer Composites ◽  
Source Extraction ◽  
Microbial Treatments

Biopolymers are ubiquitous in biomedical and healthcare application. Its nanocomposites have gained more attention as antimicrobials, a drug carrier, sensors, disease diagnosis, tissue engineering, wound healing, and cancer therapy. These biopolymer composites are efficient in holding, protecting and releasing bioactive drugs such as pharmaceutics, nutraceuticals, enzymes, and probiotics. Several studies revealed a polymer-based drug delivery system in cancer therapy and microbial treatments. However, this mini-review emphasized the source, extraction, and characterizations of the biopolymers and their use in the fabrication of various drug or metals based nanocomposites followed by its utilization as drug carrier or drug to treat the various diseases such as antimicrobial infections and cancer.

scholarly journals Synthesis of surface capped mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

MedChemComm ◽  
2017 ◽  
Vol 8 (9) ◽  
pp. 1797-1805 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Kang Dae Lee ◽  
Junghwan Oh
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Drug Delivery Applications

Herein, we propose a “host–guest” complexation-based mesoporous silica drug carrier, MSNs@Mela@TTM, for pH-responsive drug delivery applications in cancer therapy.

Multifunctional smart hydrogels: potential in tissue engineering and cancer therapy

2018 ◽  
Vol 6 (29) ◽  
pp. 4714-4730 ◽  
Author(s):  
Xian Li ◽  
Xiulan Su
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Cancer Therapy

Multifunctional smart hydrogels are used for tissue engineering, drug delivery and cancer therapy.

scholarly journals Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance

2015 ◽  
Vol 112 (10) ◽  
pp. 2978-2983 ◽  
Author(s):  
Tuo Wei ◽  
Chao Chen ◽  
Juan Liu ◽  
Cheng Liu ◽  
Paola Posocco ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Drug Carrier ◽  
Drug Loading ◽  
Cancer Drug ◽  
Self Assembling

Drug resistance and toxicity constitute challenging hurdles for cancer therapy. The application of nanotechnology for anticancer drug delivery is expected to address these issues and bring new hope for cancer treatment. In this context, we established an original nanomicellar drug delivery system based on an amphiphilic dendrimer (AmDM), which could generate supramolecular micelles to effectively encapsulate the anticancer drug doxorubicin (DOX) with high drug-loading capacity (>40%), thanks to the unique dendritic structure creating large void space for drug accommodation. The resulting AmDM/DOX nanomicelles were able to enhance drug potency and combat doxorubicin resistance in breast cancer models by significantly enhancing cellular uptake while considerably decreasing efflux of the drug. In addition, the AmDM/DOX nanoparticles abolished significantly the toxicity related to the free drug. Collectively, our studies demonstrate that the drug delivery system based on nanomicelles formed with the self-assembling amphiphilic dendrimer constitutes a promising and effective drug carrier in cancer therapy.

scholarly journals Antibacterial cellulose-based aerogels for wound healing application: A review

2020 ◽  
Vol 7 (10) ◽  
pp. 4032-4040
Author(s):  
Esam Bashir Yahya ◽  
Marwa Mohammed Alzalouk ◽  
Khalifa A. Alfallous ◽  
Abdullah F. Abogmaza
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Wound Dressing ◽  
Biomedical Applications ◽  
Inorganic Materials ◽  
Medical Applications ◽  
Tissue Engineering Scaffolds

Aerogels have been steadily developed since its first invention to become one of the most promising materials for various medical and non-medical applications. It has been prepared from organic and inorganic materials, in pure forms or composites. Cellulose-based aerogels are considered one of the promising materials in biomedical applications due to their availability, degradability, biocompatibility and non-cytotoxicity compared to conventional silica or metal-based aerogels. The unique properties of such materials permit their utilization in drug delivery, biosensing, tissue engineering scaffolds, and wound dressing. This review presents a summary of aerogel development as well as the properties and applications of aerogels. Herein, we further discuss the recent works pertaining to utilization of cellulose-based aerogels for antibacterial delivery.

An integrated targeting drug delivery system based on the hybridization of graphdiyne and MOFs for visualized cancer therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (24) ◽  
pp. 11709-11718 ◽  
Author(s):  
Zhongbo Xue ◽  
Mengyao Zhu ◽  
Yuze Dong ◽  
Tong Feng ◽  
Zhuozhi Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carrier ◽  
Tumor Therapy ◽  
Framework Structure

Graphdiyne and UIO-66-NH2 form a framework structure as a drug carrier and apply to tumor therapy.

Recent advances of self-assembling peptide-based hydrogels for biomedical applications

Soft Matter ◽  
2019 ◽  
Vol 15 (8) ◽  
pp. 1704-1715 ◽  
Author(s):  
Jieling Li ◽  
Ruirui Xing ◽  
Shuo Bai ◽  
Xuehai Yan
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Biomedical Applications ◽  
3D Bioprinting ◽  
Biological Applications ◽  
Antitumor Therapy ◽  
Self Assembling ◽  
Recent Advances

The review introduces several methods for fabrication of robust peptide-based hydrogels and their biological applications in the fields of drug delivery and antitumor therapy, antimicrobial and wound healing materials, and 3D bioprinting and tissue engineering.

Synthesis and Applications of Hydrogels in Cancer Therapy

2020 ◽  
Vol 20 (12) ◽  
pp. 1431-1446
Author(s):  
Anchal Singhal ◽  
Niharika Sinha ◽  
Pratibha Kumari ◽  
Manoushikha Purkayastha
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Cancer Therapy ◽  
Mechanical Strength ◽  
Biomedical Applications ◽  
Three Dimensional ◽  
Polymer Chains ◽  
Human Tissues ◽  
Methods Of Synthesis

: Hydrogels are water-insoluble, hydrophilic, cross-linked, three-dimensional networks of polymer chains having the ability to swell and absorb water but do not dissolve in it, that comprise the major difference between gels and hydrogels. The mechanical strength, physical integrity and solubility are offered by the crosslinks. The different applications of hydrogels can be derived based on the methods of their synthesis, response to different stimuli, and their different kinds. Hydrogels are highly biocompatible and have properties similar to human tissues that make it suitable to be used in various biomedical applications, including drug delivery and tissue engineering. The role of hydrogels in cancer therapy is highly emerging in recent years. In the present review, we highlighted different methods of synthesis of hydrogels and their classification based on different parameters. Distinctive applications of hydrogels in the treatment of cancer are also discussed.

scholarly journals Silica Materials for Medical Applications

2008 ◽  
Vol 2 (1) ◽  
pp. 1-9 ◽  
Author(s):  
María Vallet-Regí ◽  
Francisco Balas
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Chemical Composition ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Delivery Systems ◽  
Medical Applications ◽  
Synthesis Techniques ◽  
Silica Materials ◽  
Bone Repairing

The two main applications of silica-based materials in medicine and biotechnology,i.e.for bone-repairing devices and for drug delivery systems, are presented and discussed. The influence of the structure and chemical composition in the final characteristics and properties of every silica-based material is also shown as a function of the both applications presented. The adequate combination of the synthesis techniques, template systems and additives leads to the development of materials that merge the bioactive behavior with the drug carrier ability. These systems could be excellent candidates as materials for the development of devices for tissue engineering.

scholarly journals Multifunctional Hydrogel Nanocomposites for Biomedical Applications

2021 ◽  
Author(s):  
Emma Barrett-Catton ◽  
Murial L. Ross ◽  
Prashanth Asuri
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Wound Healing ◽  
Physical Properties ◽  
Biomedical Applications ◽  
Biochemical Properties ◽  
Broad Applicability ◽  
Hydrogel Nanocomposites

Hydrogels are used for various biomedical applications due to their biocompatibility, capacity to mimic the extracellular matrix, and ability to encapsulate and deliver cells and therapeutics. However, traditional hydrogels have a few shortcomings, especially regarding their physical properties, thereby limiting their broad applicability. Recently, researchers have investigated the incorporation of nanoparticles (NPs) into hydrogels to improve and add to the physical and biochemical properties of hydrogels. This brief review focuses on papers that describe the use of nanoparticles to improve more than one property of hydrogels. Such multifunctional hydrogel nanocomposites have enhanced potential for various applications, including tissue engineering, drug delivery, wound healing, bioprinting and biowearable devices.

scholarly journals Nanotechnology and Global Applications: Bench to Community

2020 ◽  
Vol 11 (2) ◽  
pp. 181
Author(s):  
Ashok Chakraborty ◽  
Smita Guha ◽  
Prabir Patra
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Molecular Imaging ◽  
Medical Equipment ◽  
Disease Diagnosis ◽  
Health Science ◽  
Health Issues ◽  
Science Technology

Advances in nanotechnology has become enormously promising in the field of health science, in developing many medical equipment. The possible effects of novel nanomedical technology significantly improve the diagnosis and therapeutic aspects of many diseases. Nanomaterials are being applied in operation, disease diagnosis as well as therapy, molecular imaging, implant technology, tissue engineering, as well as a device for efficient drug delivery, protein and gene release. In this review we discussed the utility of nanoscience in health issues, and the knowledge from there how can be disseminated to the educators and parents for expanding STEM (Science, Technology, Engineering and Math) programs.

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