The Relationship Between Prostate Cancer and Metformin Consumption: A Systematic Review and Meta-analysis Study

2019 ◽  
Vol 25 (9) ◽  
pp. 1021-1029 ◽  
Author(s):  
Bahareh Ghiasi ◽  
Diana Sarokhani ◽  
Farid Najafi ◽  
Morteza Motedayen ◽  
Ali Hasanpour Dehkordi
Keyword(s):  
Prostate Cancer ◽  
Lung Cancer ◽  
Significant Relationship ◽  
Odds Ratio ◽  
Web Of Science ◽  
Meta Analysis ◽  
Analysis Study ◽  
Prisma Statement ◽  
Meta Regression ◽  
The Relationship

Introduction: Prostate cancer is the most common malignant cancer in men worldwide and after lung cancer, it is the second leading cause of cancer mortality in men. The purpose of this study was to investigate the relationship between prostate cancer and metformin consumption in men. Methods: The current study is a systematic and meta-analysis review based on the PRISMA statement. To access the studies of domestic and foreign databases, Iran Medex, SID, Magiran, Iran Doc, Medlib, ProQuest, Science Direct, PubMed, Scopus, Web of Science and the Google Scholar search engine were searched during the 2009- 2018 period for related keywords. In order to evaluate the heterogeneity of the studies, Q test and I2 indicator were used. The data were analyzed using the STATA 15.1 software. Results: In 11 studies with a sample size of 877058, the odds ratio of metformin consumption for reducing prostate cancer was estimated at 0.89 (95%CI: 0.67-1.17). Meta-regression also showed there was no significant relationship between the odds ratio and the publication year of the study. However, there was a significant relationship between the odds ratio and the number of research samples. Conclusion: Using metformin in men reduces the risk of prostate cancer but it is not statistically significant.

scholarly journals Prostate cancer topography and tumour conspicuity on multiparametric magnetic resonance imaging: A systematic review and meta-analysis

2021 ◽  
Author(s):  
Pranav Satish ◽  
Alex Freeman ◽  
Daniel Kelly ◽  
Alex Kirkham ◽  
Clement Orczyk ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
Meta Analysis ◽  
Peripheral Zone ◽  
Transitional Zone ◽  
Dynamic Contrast Enhancement ◽  
Significant Difference ◽  
Prisma Statement ◽  
Tumour Location ◽  
The Relationship

Introduction The implications of tumour location on mpMRI conspicuity are not fully understood. Identifying topographical correlates that influence conspicuity may improve outcomes. Here, we present the first systematic review and meta-analysis describing the effect of tumour location on prostate cancer conspicuity on mpMRI. Methods Medline, PubMed, EMBASE and Cochrane databases were systematically searched and results were assessed as per the PRISMA statement. Differential tumour conspicuity on mpMRI was compared between cancers in the peripheral zone (PZ), transitional zone (TZ), base, apex, anterior and posterior. Meta-analysis was conducted to compare diagnostic odds ratios (DOR) of mpMRI detection for tumours in the PZ and TZ. PROSPERO registration: CRD42021228087. Results Thematic synthesis showed apical and basal tumours had reduced conspicuity compared to mid-gland tumours. Cancer in the TZ demonstrated increased conspicuity on T2-weighted imaging, whilst PZ cancers had higher conspicuity on diffusion-weighted and dynamic contrast enhancement imaging. mpMRI had better diagnostic accuracy for PZ lesions, albeit higher specificity for TZ lesions. Meta-analysis showed an increased DOR for PZ tumours (OR: 7.206 [95% CI: 4.991;10.403], compared to TZ (OR: 5.310 [95% CI: 3.082; 9.151]). However, the test for subgroup differences was not significant (p = 0.2743). Conclusions Cancer in the apex or base of the prostate may be less conspicuous than mid-gland tumours. Similarly, TZ cancer appears to have reduced conspicuity compared to PZ cancer, however, meta-analysis did not show a significant difference between DOR. Future larger studies with prospective datasets are required to clarify the relationship between tumour position and conspicuity.

scholarly journals Clinicopathologic Relevance of Claudin 18.2 Expression in Gastric Cancer: A Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Bogdan Silviu Ungureanu ◽  
Cristian-Virgil Lungulescu ◽  
Daniel Pirici ◽  
Adina Turcu-Stiolica ◽  
Dan Ionut Gheonea ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Targeted Therapy ◽  
Odds Ratio ◽  
Web Of Science ◽  
Meta Analysis ◽  
Pathological Features ◽  
Potential Efficacy ◽  
The Relationship ◽  
Review Manager

An increasing number of tumor markers have been discovered to have potential efficacy as diagnostic and prognostic tools in gastric cancer. We aimed to assess putative correlations between claudin 18.2 expression and pathological or prognosis features in patients with gastric cancer. MEDLINE, Web of Science, EBSCO, and ClinicalTrials.gov were used to search for relevant studies from their inception to 30 October 2020. Finally, a total of six articles were included in this meta-analysis. Review Manager 5 software was applied to examine the heterogeneity among the studies and to calculate the odds ratio with 95% CI by selecting corresponding models, in evaluating the strength of the relationship. Publication bias test was also conducted. No bias and no significant correlations were found between CLDN 18.2 and TNM stages, Lauren classification, HER2, grading, or overall survival. This meta-analysis expounded that the relationship with CLDN 18.2 and pathological features depends on the percentage of staining of tumor cells for which CLDN 18.2 is considered positive. Our pooled outcomes suggest that targeted therapy for CLDN 18.2 could be effective if certain criteria were established.

scholarly journals A Systematic Review and Meta-Analysis on the Association between Hypertension and Tinnitus

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Pan Yang ◽  
Wenjun Ma ◽  
Yiqing Zheng ◽  
Haidi Yang ◽  
Hualiang Lin
Keyword(s):  
Risk Factor ◽  
Odds Ratio ◽  
Prevention And Control ◽  
Web Of Science ◽  
Meta Analysis ◽  
Sufficient Information ◽  
Random Effects Model ◽  
Hypertension Prevention ◽  
Meta Regression ◽  
And Control

Hypertension has been suggested to be one possible risk factor of tinnitus, but the association between hypertension and tinnitus remains uncertain. The authors performed a meta-analysis of the existing studies on the association between hypertension and tinnitus. We performed literature search of studies using SinoMed, CNKI, WanFang, PubMed, Scopus, Web of Science, and Google Scholar. Studies reported the odds ratio and 95% confidence interval (CI) (or provided sufficient information for calculation) of the association between hypertension and tinnitus were included. A total of 19 eligible studies with 20 effect estimates were used in this study. They included 63,154 participants with age ranging from 14 to 92. The pooled OR, which was pooled using a random effects model, was 1.37 (95% CI: 1.16 to 1.62). There was no evidence of publication bias (p=0.11for Begg’s test,p=0.96for Egger’s test). By meta-regression, we found that study design may be one possible factor of heterogeneity. Sensitivity analysis found that the result was stable. This study suggests that hypertension might be one risk factor of tinnitus, and hypertension prevention and control might be helpful in preventing tinnitus.

scholarly journals The Relationship of ICH Score and 30-Day Mortality Rate in Hemorrhagic Stroke Patient: Systematic Review and Meta-Analysis

2021 ◽  
Vol 4 (2) ◽  
Author(s):  
Samuel Sitohang ◽  
Sabri
Keyword(s):  
Mortality Rate ◽  
Significant Relationship ◽  
Hemorrhagic Stroke ◽  
Meta Analysis ◽  
High Accuracy ◽  
Stroke Patients ◽  
Analysis Study ◽  
Ich Score ◽  
Gcs Score ◽  
The Relationship

Hemorrhagic stroke is a type of stroke that causes more deaths than ischemic stroke. The prognosis of hemorrhagic stroke patients can be determined with ICH Score. ICH score has a value range of 0-6. The variables of ICH Score are GCS score (0-2), bleeding volume (0-1), intraventricular bleeding (0-1), infratentorial origin (0-1), and age (0-1). Aim: This meta-analysis study aims to determine the relationship between ICH Score and 30-day mortality rate in hemorrhagic stroke patients. Methods: This meta-analysis study uses online literature sourced from Pubmed, Science Direct and Google Scholar. Result: Based on data analysis, there is a significant relationship between the ICH Score and the mortality rate in hemorrhagic stroke patients (OR 18.04, 95% CI: 10.65; 30.55). Analysis of the ICH Score accuracy found that the ICH Score had high accuracy to predict the mortality of hemorrhagic stroke patients (AUC 0.827, 95% CI: 0.796; 0.858). Conclusion: ICH Score has a significant relationship with the 30-day mortality rate in hemorrhagic stroke patients and has high accuracy for predicting mortality in hemorrhagic stroke patients.

scholarly journals Higher Dietary Inflammatory Index Scores Increase the Risk of Diabetes Mellitus: A Meta-Analysis and Systematic Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Qing-Qing Tan ◽  
Xin-Yi Du ◽  
Chen-Lin Gao ◽  
Yong Xu
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Web Of Science ◽  
Meta Analysis ◽  
Positive Association ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
The Relationship

The relationship between dietary inflammatory index (DII) scores and the risk of diabetes mellitus (DM) is unclear; therefore, a systematic review and meta-analysis of the current published literature was conducted. Relevant studies published online (PubMed, Embase, and Web of Science) until February 1, 2021 were identified for review. The initial search yielded 13 reports, and after perusing their titles, abstracts, and full texts, 5 studies were deemed appropriate for inclusion in the systematic review and meta-analysis. Individuals with higher DII scores (representing a more proinflammatory diet) had a higher risk of DM (pooled odds ratio 1.32, 95% confidence interval 1.01–1.72, I2 58.6%, p < 0.05). Although the current meta-analysis indicated a trend toward a positive association between DII and DM, further evidence—especially from larger prospective studies in different countries—is needed to clarify this association.

Meta-analysis and Scientific Mapping of Well-being and Job Performance

2020 ◽  
Vol 23 ◽  
Author(s):  
Oscar Iván Gutiérrez ◽  
Jean David Polo ◽  
Milton José Zambrano ◽  
Diana Carolina Molina
Keyword(s):  
Job Performance ◽  
Web Of Science ◽  
Meta Analysis ◽  
Well Being ◽  
Science Base ◽  
Prisma Statement ◽  
And Performance ◽  
Meta Analyses ◽  
The Relationship ◽  
Productive Worker

Abstract In this article, we present a meta-analysis and a scientific mapping about the relationship between different types of well-being and job performance. We followed The PRISMA statement for reporting systematic reviews and meta-analyses (Moher et al., 2009), and conduct the search in Web of Science, SCOPUS, Ebscohost, Proquest, and Jstor databases. We identified 43 studies from 1994 to early 2020 that represent 45 independent samples, 34,221 participants, and 77 correlations between four types of well-being and six of job performance. Meta-analysis results show that are different forms of relations between types and there is not only one form to explain the happy-productive worker hypothesis. The scientific mapping shows that there are seven clusters of topics about well-being and job performance in the Web of Science base articles: (I) Burnout and axiety, (II) Stress and depression, (III) Individual resources, (IV) Work context, (V) Work engagement and commitment, (VI) Justice, and (VII) Human resources practices. We organize the topics from each cluster in the different groups of variables of the contextual model of individual work, well-being and performance (van Veldhoven & Peccei, 2015) to explain their impact in well-being and job performance. We included the observations of our analysis and identified the future key directions for the field.

scholarly journals P478 Thiopurines’ metabolites levels and drug toxicity: a systematic review and meta-analysis

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S422-S422
Author(s):  
P C Sousa ◽  
M Estevinho ◽  
C C Dias ◽  
D Martins ◽  
E Cancela ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Web Of Science ◽  
Meta Analysis ◽  
Haematological Toxicity ◽  
Therapeutic Drug ◽  
General Toxicity ◽  
Inflammatory Bowel ◽  
The Mean ◽  
Clinical Conditions ◽  
The Relationship

Abstract Background Besides Inflammatory Bowel Disease, thiopurines are used in a broad range of clinical conditions. Even though therapeutic drug monitoring (TDM) is widely used with biologics, there are still many unanswered questions regarding TDM for thiopurines. This study aimed to establish a relationship between the levels of thiopurines’ metabolites and treatment toxicity. Methods Literature search was carried out in 3 databases (Pubmed, Web of Science and Scopus) following PRISMA guidelines. Studies evaluating the relationship between the levels of thiopurines’ metabolites and their toxicity (haematological and hepatoxicity, pancreatitis, intolerance and infection), regardless of the disease to which they were prescribed, were included. Results From the 16194 identified records 74 were eligible for further analysis. A meta-analysis of mean comparisons, correlations and odds ratio (OR) were performed. The levels of 6-thioguanine nucleotides (6-TGN) were significantly higher in patients with general toxicity and leukopenia when the Lennard method was used for quantification (Figure 1). Significant correlations were obtained between the 6-TGN levels and leucocytes (r = -0.21;p < 0.001), neutrophils (r = -0.34;p < 0.001) and alanine aminotransferase (ALT) levels (r = -0.24;p < 0.001). The pooled OR (95%IC) for general toxicity, haematological toxicity and leukopenia in patients with 6-TGN concentrations above the predefined thresholds was 2.78(1.54–5.00), 8.54(3.55–20.56) and 5.26(3.34–8.15), respectively. Regarding 6-methylmercaptopurine metabolites (6-MMP), there was a significant correlation of their levels with general toxicity and leukopenia when the Lennard method was used for quantification (Figure 2), and with hepatotoxicity. 6-MMP levels were significantly correlated with ALT (r = 0.35;p < 0.001). The pooled OR (95%IC) for haematological toxicity, leukopenia and hepatotoxicity in patients with 6-MMP above the predefined thresholds was 4.12(1.80–9.47), 4.09(1.98–8.45) and 4.31(3.21–5.78), respectively. The studies evaluating the relationship between the ratio 6-MMP/TGN and thiopurines’ toxicity did not find differences between the mean ratio in patients with haematological toxicity and leukopenia. The pooled OR for hepatotoxicity in patients with a ratio above the predefined threshold was 4.44(IC 95%2.92–6.75). Conclusion These results reinforce that TDM may be used to prevent the occurrence of toxicity during thiopurines’ treatment. However, the cut-off values for this association may depend on the method used to measure metabolites’ levels.

scholarly journals Associations of TLR4 and IL-8 genes polymorphisms with Age-related macular degeneration (AMD): a systematic review and meta-analysis

2020 ◽  
Author(s):  
Nasrin Roshanipour ◽  
Elham Shahriyari ◽  
Maryam Ghaffari Laleh ◽  
Leila Vahedi ◽  
Sousan Mirnajd Gerami ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Odds Ratio ◽  
Literature Search ◽  
Web Of Science ◽  
Meta Analysis ◽  
Case Control ◽  
Age Related Macular Degeneration ◽  
Case Control Studies ◽  
Analysis Study ◽  
Age Related

Abstract BackgroundThe results of different studies have indicated the possible associations of TLR4 and IL-8 genes polymorphisms with Age-Related Macular Degeneration (AMD). A meta-analysis study was designed to evaluate the possible associations of TLR4 and IL-8 genes polymorphisms with Age-Related Macular Degeneration (AMD). MethodA systematic literature search was carried out in PubMed, Embase, Web of Science, and Scopus databases to identify relevant publications. Pooled Odds Ratio (OR) with 95% Confidence Interval (CI) was used to evaluate the power of association.ResultsA total of 12 case-control studies with 4804 AMD patients and 4422 healthy controls were included in this meta-analysis. We found significant associations under the genotypic and allelic models of TLR4/rs4986790 (AA vs. AG+GG: OR=0.73 [0.55-0.97], P=0.03; and AA vs. AG: OR=0.71 [0.53-0.95], P=0.02) and IL-8/rs2227306 (TT vs. CC: OR=1.63 [1.04-2.56], P=0.03; CC vs. TT+TC: OR=0.62 [0.48-0.80], P<0.001; CC vs. TC: OR=0.65 [0.47-0.89], P=0.007; and C vs. T: OR=0.71 [0.64-0.78], P<0.001). However, the data from this meta-analysis declined the associations of TLR4/rs4986791 and IL-8/rs4073 polymorphisms.ConclusionThe current meta-analysis study suggested that IL-8/rs2227306 and TLR4/rs4986790 polymorphisms are associated with susceptibility to AMD.

scholarly journals Aqueous Humor Mediator and Cytokine Aberrations in Diabetic Retinopathy and Diabetic Macular Edema: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
Jingyang Wu ◽  
Yifan Zhong ◽  
Song Yue ◽  
Kaibo Yang ◽  
Guisen Zhang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Diabetic Retinopathy ◽  
Aqueous Humor ◽  
Significant Relationship ◽  
Web Of Science ◽  
Meta Analysis ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Standardized Mean Difference ◽  
The Relationship

Purpose. To evaluate the relationship between the aqueous humor levels of VEGF, TNF-α, IL-10, IL-6, IL-12, MCP-1, and IP-10 with DR/DME. Methods. PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang databases were searched up to October 2018. Systematic review and meta-analysis were conducted. Results. 18 studies comprising 362 cases with DR (100 with DME) and 620 controls without DR were included in this meta-analysis. There was a significant association between VEGF levels in the aqueous humor and DR (standardized mean difference (SMD) 1.94 (95% CI 1.05-2.83)) and DME (1.07 (0.71, 1.42)). Furthermore, a significant correlation was observed between levels of IL-6 and DR (3.53 (0.37, 6.69)), and similarly correlation with DME (1.26 (0.30, 2.21)). The relationship between MCP-1 and DR and DME was significant, in which the SMD was (0.49 (0.09, 0.89)) and (1.49 (0.78, 2.20)), respectively. However, IL-12, IP-10, and TNF-α had no correlation with DR and DME, whereas there was a significant relationship between IL-8 and DME (1.68 (0.97, 2.40)). Conclusion. Elevated levels of VEGF, IL-6, and MCP-1 in the aqueous humor were associated with the risk for the presence of DR, and levels of VEGF, IL-6, IL-8, and MCP-1 were associated with the risk of DME. Furthermore, these biomarkers may be used as potential predictors or therapeutic targets for DR/DME.

The Relationship Between Fear of COVID-19 and Depression, Anxiety, and Stress

2021 ◽  
Vol 26 (4) ◽  
pp. 323-333
Author(s):  
Eyüp Sabır Erbiçer ◽  
Ahmet Metin ◽  
Ali Çetinkaya ◽  
Sedat Şen
Keyword(s):  
Web Of Science ◽  
Mental Health Problems ◽  
Meta Analysis ◽  
Strong Relationship ◽  
Regression Analyses ◽  
Inclusion Criteria ◽  
Meta Regression ◽  
High Level ◽  
Sample Age ◽  
The Relationship

Abstract. The COVID-19 pandemic has had significant effects on public health. Previous studies showed that the fear of COVID-19 was positively correlated with depression, anxiety, and stress. This study aims to compile and meta-analyze the relationship between fear of COVID-19 and depression, anxiety, and stress among the general population. The studies published between March 2020 and June 2021 were scanned from various databases (Google Scholar, PubMed, Web of Science [ISI], and SCOPUS). As a result of the literature search, 746 studies were reached, 88 studies were found suitable, and 21 met the inclusion criteria. Comprehensive Meta-Analysis (CMA Version 3.0) and metafor package in R were used for analyses. A strong relationship was observed between the fear of COVID-19 and anxiety ( r = .55, p < .001); there were moderate relationships between the fear of COVID-19 and depression ( r = .34, p < .001) and stress ( r = .44, p < .001). All these relationships were significant. The results showed that the relationships between the fear of COVID-19 and depression, anxiety, and stress had a high level of heterogeneity. Meta-regression analyses revealed that the average of the sample age was a significant predictor of the relationship between fear of COVID-19 and anxiety. However, other covariates (female proportion and culture) were not statistically significant for the relationship between fear of COVID-19 and anxiety. None of these covariates was significant predictors of the relationship between fear of COVID-19 with depression and stress. Although the current meta-analysis has some limitations, the results revealed that the fear of COVID-19 is associated with mental health problems such as depression, anxiety, and stress.

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