Drug Target Group Prediction with Multiple Drug Networks

2020 ◽  
Vol 23 (4) ◽  
pp. 274-284 ◽  
Author(s):  
Jingang Che ◽  
Lei Chen ◽  
Zi-Han Guo ◽  
Shuaiqun Wang ◽  
Aorigele
Keyword(s):  
Drug Target ◽  
Low Cost ◽  
Machine Learning Algorithms ◽  
Classification Model ◽  
Support Vector ◽  
Multiple Drug ◽  
Property A ◽  
Multiple Networks ◽  
Proposed Model ◽  
The One

Background: Identification of drug-target interaction is essential in drug discovery. It is beneficial to predict unexpected therapeutic or adverse side effects of drugs. To date, several computational methods have been proposed to predict drug-target interactions because they are prompt and low-cost compared with traditional wet experiments. Methods: In this study, we investigated this problem in a different way. According to KEGG, drugs were classified into several groups based on their target proteins. A multi-label classification model was presented to assign drugs into correct target groups. To make full use of the known drug properties, five networks were constructed, each of which represented drug associations in one property. A powerful network embedding method, Mashup, was adopted to extract drug features from above-mentioned networks, based on which several machine learning algorithms, including RAndom k-labELsets (RAKEL) algorithm, Label Powerset (LP) algorithm and Support Vector Machine (SVM), were used to build the classification model. Results and Conclusion: Tenfold cross-validation yielded the accuracy of 0.839, exact match of 0.816 and hamming loss of 0.037, indicating good performance of the model. The contribution of each network was also analyzed. Furthermore, the network model with multiple networks was found to be superior to the one with a single network and classic model, indicating the superiority of the proposed model.

Machine Learning Models for Finger Bend Evaluation using Implemented Low cost Flex Sensor

2021 ◽  
Vol 9 (VI) ◽  
pp. 3605-3611
Author(s):  
Pratyush Kaware
Keyword(s):  
Machine Learning ◽  
Support Vector Machine ◽  
Low Cost ◽  
Learning Algorithms ◽  
Cost Effective ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Learning Models ◽  
Machine Learning Models

In this paper a cost-effective sensor has been implemented to read finger bend signals, by attaching the sensor to a finger, so as to classify them based on the degree of bent as well as the joint about which the finger was being bent. This was done by testing with various machine learning algorithms to get the most accurate and consistent classifier. Finally, we found that Support Vector Machine was the best algorithm suited to classify our data, using we were able predict live state of a finger, i.e., the degree of bent and the joints involved. The live voltage values from the sensor were transmitted using a NodeMCU micro-controller which were converted to digital and uploaded on a database for analysis.

scholarly journals Sales Growth Rate Forecasting Using Improved PSO and SVM

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Xibin Wang ◽  
Junhao Wen ◽  
Shafiq Alam ◽  
Xiang Gao ◽  
Zhuo Jiang ◽  
...  
Keyword(s):  
Growth Rate ◽  
Decisive Role ◽  
Convergence Speed ◽  
Classification Model ◽  
Support Vector ◽  
Local Optimum ◽  
Sales Growth ◽  
Local Optima ◽  
Proposed Model ◽  
Forecasting Performance

Accurate forecast of the sales growth rate plays a decisive role in determining the amount of advertising investment. In this study, we present a preclassification and later regression based method optimized by improved particle swarm optimization (IPSO) for sales growth rate forecasting. We use support vector machine (SVM) as a classification model. The nonlinear relationship in sales growth rate forecasting is efficiently represented by SVM, while IPSO is optimizing the training parameters of SVM. IPSO addresses issues of traditional PSO, such as relapsing into local optimum, slow convergence speed, and low convergence precision in the later evolution. We performed two experiments; firstly, three classic benchmark functions are used to verify the validity of the IPSO algorithm against PSO. Having shown IPSO outperform PSO in convergence speed, precision, and escaping local optima, in our second experiment, we apply IPSO to the proposed model. The sales growth rate forecasting cases are used to testify the forecasting performance of proposed model. According to the requirements and industry knowledge, the sample data was first classified to obtain types of the test samples. Next, the values of the test samples were forecast using the SVM regression algorithm. The experimental results demonstrate that the proposed model has good forecasting performance.

A Supervised Learning Model for AGV Perception in Unstructured Environment

2015 ◽  
pp. 334-353
Author(s):  
Rizwan Aqeel ◽  
Saif Ur Rehman ◽  
Saira Gillani ◽  
Sohail Asghar
Keyword(s):  
Clustering Algorithm ◽  
Research Problem ◽  
Classification Model ◽  
Support Vector ◽  
Ground Vehicle ◽  
Second Stage ◽  
Initial Stage ◽  
Cluster Area ◽  
Proposed Model ◽  
Unstructured Environment

This chapter focuses on an Autonomous Ground Vehicle (AGV), also known as intelligent vehicle, which is a vehicle that can navigate without human supervision. AGV navigation over an unstructured road is a challenging task and is known research problem. This chapter is to detect road area from an unstructured environment by applying a proposed classification model. The Proposed model is sub divided into three stages: (1) - preprocessing has been performed in the initial stage; (2) - road area clustering has been done in the second stage; (3) - Finally, road pixel classification has been achieved. Furthermore, combination of classification as well as clustering is used in achieving our goals. K-means clustering algorithm is used to discover biggest cluster from road scene, second big cluster area has been classified as road or non road by using the well-known technique support vector machine. The Proposed approach is validated from extensive experiments carried out on RGB dataset, which shows that the successful detection of road area and is robust against diverse road conditions such as unstructured nature, different weather and lightening variations.

Combination with Machine Learning Algorithms for the Classification in E-Bussiness

2011 ◽  
Vol 230-232 ◽  
pp. 625-628
Author(s):  
Lei Shi ◽  
Xin Ming Ma ◽  
Xiao Hong Hu
Keyword(s):  
Machine Learning ◽  
Support Vector Machines ◽  
Set Theory ◽  
Rough Set ◽  
Rough Set Theory ◽  
Machine Learning Algorithms ◽  
Classification Model ◽  
Support Vector ◽  
Mathematical Tool ◽  
Vector Machines

E-bussiness has grown rapidly in the last decade and massive amount of data on customer purchases, browsing pattern and preferences has been generated. Classification of electronic data plays a pivotal role to mine the valuable information and thus has become one of the most important applications of E-bussiness. Support Vector Machines are popular and powerful machine learning techniques, and they offer state-of-the-art performance. Rough set theory is a formal mathematical tool to deal with incomplete or imprecise information and one of its important applications is feature selection. In this paper, rough set theory and support vector machines are combined to construct a classification model to classify the data of E-bussiness effectively.

scholarly journals A Spectral Feature Based Convolutional Neural Network for Classification of Sea Surface Oil Spill

2019 ◽  
Vol 8 (4) ◽  
pp. 160 ◽  
Author(s):  
Bingxin Liu ◽  
Ying Li ◽  
Guannan Li ◽  
Anling Liu
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Convolutional Neural Network ◽  
Convolutional Neural Networks ◽  
Machine Learning Algorithms ◽  
Classification Model ◽  
Support Vector ◽  
Oil Film ◽  
One Dimensional

Spectral characteristics play an important role in the classification of oil film, but the presence of too many bands can lead to information redundancy and reduced classification accuracy. In this study, a classification model that combines spectral indices-based band selection (SIs) and one-dimensional convolutional neural networks was proposed to realize automatic oil films classification using hyperspectral remote sensing images. Additionally, for comparison, the minimum Redundancy Maximum Relevance (mRMR) was tested for reducing the number of bands. The support vector machine (SVM), random forest (RF), and Hu’s convolutional neural networks (CNN) were trained and tested. The results show that the accuracy of classifications through the one dimensional convolutional neural network (1D CNN) models surpassed the accuracy of other machine learning algorithms such as SVM and RF. The model of SIs+1D CNN could produce a relatively higher accuracy oil film distribution map within less time than other models.

scholarly journals On the Prediction of Biogas Production from Vegetables, Fruits, and Food Wastes by ANFIS- and LSSVM-Based Models

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Yong Yang ◽  
Shuaishuai Zheng ◽  
Zhilu Ai ◽  
Mohammad Mahdi Molla Jafari
Keyword(s):  
Mean Squared Error ◽  
Fuzzy Inference ◽  
Biogas Production ◽  
Input Parameter ◽  
Machine Learning Algorithms ◽  
Least Square ◽  
Support Vector ◽  
Robust Algorithms ◽  
Inference System ◽  
Proposed Model

This study is aimed at modeling biodigestion systems as a function of the most influencing parameters to generate two robust algorithms on the basis of the machine learning algorithms, including adaptive network-based fuzzy inference system (ANFIS) and least square support vector machine (LSSVM). The models are assessed utilizing multiple statistical analyses for the actual values and model outcomes. Results from the suggested models indicate their great capability of predicting biogas production from vegetable food, fruits, and wastes for a variety of ranges of input parameters. The values that are calculated for the mean relative error (MRE %) and mean squared error (MSE) were 29.318 and 0.0039 for ANFIS, and 2.951 and 0.0001 for LSSVM which shows that the latter model has a better ability to predict the target data. Finally, in order to have additional certainty, two analyses of outlier identification and sensitivity were performed on the input parameter data that proved the proposed model in this paper has higher reliability in assessing output values compared with the previous model.

scholarly journals Use of a Low-Cost, Chest-Mounted Accelerometer to Evaluate Transfer Skills of Wheelchair Users During Everyday Activities: Observational Study (Preprint)

2018 ◽  
Author(s):  
Giulia Barbareschi ◽  
Catherine Holloway ◽  
Nadia Bianchi-Berthouze ◽  
Sharon Sonenblum ◽  
Stephen Sprigle
Keyword(s):  
Predictive Accuracy ◽  
Multinomial Logistic Regression ◽  
Low Cost ◽  
Relevant Literature ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Accelerometer Data ◽  
Wheelchair Users ◽  
Limb Injuries ◽  
Evaluation And Monitoring

BACKGROUND Transfers are an important skill for many wheelchair users (WU). However, they have also been related to the risk of falling or developing upper limb injuries. Transfer abilities are usually evaluated in clinical settings or biomechanics laboratories, and these methods of assessment are poorly suited to evaluation in real and unconstrained world settings where transfers take place. OBJECTIVE The objective of this paper is to test the feasibility of a system based on a wearable low-cost sensor to monitor transfer skills in real-world settings. METHODS We collected data from 9 WU wearing triaxial accelerometer on their chest while performing transfers to and from car seats and home furniture. We then extracted significant features from accelerometer data based on biomechanical considerations and previous relevant literature and used machine learning algorithms to evaluate the performance of wheelchair transfers and detect their occurrence from a continuous time series of data. RESULTS Results show a good predictive accuracy of support vector machine classifiers when determining the use of head-hip relationship (75.9%) and smoothness of landing (79.6%) when the starting and ending of the transfer are known. Automatic transfer detection reaches performances that are similar to state of the art in this context (multinomial logistic regression accuracy 87.8%). However, we achieve these results using only a single sensor and collecting data in a more ecological manner. CONCLUSIONS The use of a single chest-placed accelerometer shows good predictive accuracy for algorithms applied independently to both transfer evaluation and monitoring. This points to the opportunity for designing ubiquitous-technology based personalized skill development interventions for WU. However, monitoring transfers still require the use of external inputs or extra sensors to identify the start and end of the transfer, which is needed to perform an accurate evaluation.

scholarly journals Screening of COVID-19 using Cough Audio Frequencies

2021 ◽  
Vol 10 (3) ◽  
pp. 1851-1861
Keyword(s):  
The Body ◽  
Machine Learning Algorithms ◽  
Classification Model ◽  
Breathing Patterns ◽  
Audio Signals ◽  
Distinctive Features ◽  
Proposed Model ◽  
Digital Methods ◽  
Effective Analysis ◽  
Sound Data

Clinicians routinely use biomedical and audio signals (e.g. sighs, breathing, pulse, digestion, sounds of vibration) as markers to diagnose diseases or to evaluate the progression of diseases. Until recently, these signals were normally obtained during scheduled visits by manual auscultation. With the advancement of technologies, digital methods are used to collect the body sounds for cardiovascular or respiratory testing (e.g. digital stethoscopes to predict the progression of diseases. A few early studies showed promising results for the detection of COVID-19 using voice and diagnostic signals. In the proposed model, an effective analysis is performed through the collection of large, multi-group, airborne acoustic sound data to perform the screening of COVID-19. The technique uses cough and breathing patterns to show the distinctive features of COVID-19 and it is reported that the cough patterns of COVID-19 are identifiable from asthma cough patterns. Using machine learning algorithms, an efficient classification model is developed for the screening of COVID-19.The area below the curve (AUC) of our proposed model exceeds 80%. The present study also explores the analysis of air patterns that can be recorded using the breathing styles of the infected persons to enhance the efficiency of the proposed screening techniques.

scholarly journals Machine learning in the diagnosis of Myocardial Infarction with Non-Obstructive Coronary Arteries

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
M J Espinosa Pascual ◽  
P Vaquero Martinez ◽  
V Vaquero Martinez ◽  
J Lopez Pais ◽  
B Izquierdo Coronel ◽  
...  
Keyword(s):  
Machine Learning ◽  
Myocardial Infarction ◽  
Support Vector Machine ◽  
Logistic Regression ◽  
Random Forest ◽  
Obstructive Coronary Artery Disease ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Classification Model ◽  
Support Vector

Abstract Introduction Out of all patients admitted with Myocardial Infarction, 10 to 15% have Myocardial Infarction with Non-Obstructive Coronaries Arteries (MINOCA). Classification algorithms based on deep learning substantially exceed traditional diagnostic algorithms. Therefore, numerous machine learning models have been proposed as useful tools for the detection of various pathologies, but to date no study has proposed a diagnostic algorithm for MINOCA. Purpose The aim of this study was to estimate the diagnostic accuracy of several automated learning algorithms (Support-Vector Machine [SVM], Random Forest [RF] and Logistic Regression [LR]) to discriminate between people suffering from MINOCA from those with Myocardial Infarction with Obstructive Coronary Artery Disease (MICAD) at the time of admission and before performing a coronary angiography, whether invasive or not. Methods A Diagnostic Test Evaluation study was carried out applying the proposed algorithms to a database constituted by 553 consecutive patients admitted to our Hospital with Myocardial Infarction. According to the definitions of 2016 ESC Position Paper on MINOCA, patients were classified into two groups: MICAD and MINOCA. Out of the total 553 patients, 214 were discarded due to the lack of complete data. The set of machine learning algorithms was trained on 244 patients (training sample: 75%) and tested on 80 patients (test sample: 25%). A total of 64 variables were available for each patient, including demographic, clinical and laboratorial features before the angiographic procedure. Finally, the diagnostic precision of each architecture was taken. Results The most accurate classification model was the Random Forest algorithm (Specificity [Sp] 0.88, Sensitivity [Se] 0.57, Negative Predictive Value [NPV] 0.93, Area Under the Curve [AUC] 0.85 [CI 0.83–0.88]) followed by the standard Logistic Regression (Sp 0.76, Se 0.57, NPV 0.92 AUC 0.74 and Support-Vector Machine (Sp 0.84, Se 0.38, NPV 0.90, AUC 0.78) (see graph). The variables that contributed the most in order to discriminate a MINOCA from a MICAD were the traditional cardiovascular risk factors, biomarkers of myocardial injury, hemoglobin and gender. Results were similar when the 19 patients with Takotsubo syndrome were excluded from the analysis. Conclusion A prediction system for diagnosing MINOCA before performing coronary angiographies was developed using machine learning algorithms. Results show higher accuracy of diagnosing MINOCA than conventional statistical methods. This study supports the potential of machine learning algorithms in clinical cardiology. However, further studies are required in order to validate our results. FUNDunding Acknowledgement Type of funding sources: None. ROC curves of different algorithms

scholarly journals Detection of Online Fake News Using Blending Ensemble Learning

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Arvin Hansrajh ◽  
Timothy T. Adeliyi ◽  
Jeanette Wing
Keyword(s):  
Machine Learning ◽  
Performance Metrics ◽  
Machine Learning Algorithms ◽  
Stochastic Gradient Descent ◽  
Support Vector ◽  
Fake News ◽  
Learning Models ◽  
Linear Discriminant ◽  
Proposed Model ◽  
Machine Learning Models

The exponential growth in fake news and its inherent threat to democracy, public trust, and justice has escalated the necessity for fake news detection and mitigation. Detecting fake news is a complex challenge as it is intentionally written to mislead and hoodwink. Humans are not good at identifying fake news. The detection of fake news by humans is reported to be at a rate of 54% and an additional 4% is reported in the literature as being speculative. The significance of fighting fake news is exemplified during the present pandemic. Consequently, social networks are ramping up the usage of detection tools and educating the public in recognising fake news. In the literature, it was observed that several machine learning algorithms have been applied to the detection of fake news with limited and mixed success. However, several advanced machine learning models are not being applied, although recent studies are demonstrating the efficacy of the ensemble machine learning approach; hence, the purpose of this study is to assist in the automated detection of fake news. An ensemble approach is adopted to help resolve the identified gap. This study proposed a blended machine learning ensemble model developed from logistic regression, support vector machine, linear discriminant analysis, stochastic gradient descent, and ridge regression, which is then used on a publicly available dataset to predict if a news report is true or not. The proposed model will be appraised with the popular classical machine learning models, while performance metrics such as AUC, ROC, recall, accuracy, precision, and f1-score will be used to measure the performance of the proposed model. Results presented showed that the proposed model outperformed other popular classical machine learning models.

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