scholarly journals A Review: Underutilized plant of Sabah and Its Potential Value

2021 ◽  
Vol 22 ◽  
Author(s):  
Nor Amirah Shamsudin ◽  
Lucky Poh Wah Goh ◽  
Mohd Khalizan Sabullah ◽  
Suraya Abdul Sani ◽  
Rahmath Abdulla ◽  
...  
Keyword(s):  
Additional Data ◽  
Biological Activities ◽  
Local Area ◽  
Pharmacological Properties ◽  
Health Product ◽  
Sustainable Resources ◽  
Potential Value ◽  
Medicinal Value ◽  
Anti Cancer ◽  
Pharmacological Studies

Abstract: Underutilized plants are referred to a plant species which their potential is not fully utilized yet and they are usually found abundantly in certain local area but globally rare. Sabah is known for a high biodiversity and contains many underutilized plants. To our knowledge, this is the first review is to provide an overview information of medicinal value and pharmacological properties of underutilized plant in Sabah. Extract and metabolites in different part of several underutilized plant contains multiple beneficial bioactive compounds and exploitation of these compounds was supported by additional data which plays various biological activities including anti-atherosclerotic, anti-cancer, antihypercholesterolemic and anti-ulcerogenic. A handful of pharmacological studies on the natural product these underutilized plants have conclusively outlined the mode of action in treatment of several diseases and in other health aspects. This paper limits its scope to reviewe and highlight the potential of using underutilized plants in Sabah only which could serve as reliable resource for health product development in pharmaceutical and nutraceutical through continuous discovering of more active and sustainable resources as well as ingredients for food and medicine.

scholarly journals Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties

2019 ◽  
Vol 20 (17) ◽  
pp. 4238 ◽  
Author(s):  
Yaqi Ren ◽  
Chunlan Wang ◽  
Jiakun Xu ◽  
Shuaiyu Wang
Keyword(s):  
Furan Ring ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coffee Beans ◽  
Anti Cancer ◽  
Underlying Mechanisms ◽  
Target Alternative ◽  
Anti Inflammation

Cafestol and kahweol are natural diterpenes extracted from coffee beans. In addition to the effect of raising serum lipid, in vitro and in vivo experimental results have revealed that the two diterpenes demonstrate multiple potential pharmacological actions such as anti-inflammation, hepatoprotective, anti-cancer, anti-diabetic, and anti-osteoclastogenesis activities. The most relevant mechanisms involved are down-regulating inflammation mediators, increasing glutathione (GSH), inducing apoptosis of tumor cells and anti-angiogenesis. Cafestol and kahweol show similar biological activities but not exactly the same, which might due to the presence of one conjugated double bond on the furan ring of the latter. This review aims to summarize the pharmacological properties and the underlying mechanisms of cafestol-type diterpenoids, which show their potential as functional food and multi-target alternative medicine.

A link between chemical structure and biological activity in triterpenoids

2021 ◽  
Vol 16 ◽  
Author(s):  
Zang Li ◽  
Hao Xu ◽  
Chao Huang ◽  
Cunqin Wang ◽  
Rongbin Wang ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Biological Activities ◽  
Chemical Structures ◽  
Pentacyclic Triterpenoid ◽  
Medicinal Value ◽  
Anti Cancer ◽  
Cell Death Signaling ◽  
Cancer Activity ◽  
Novel Therapeutic ◽  
Skeleton Structure

Background: Plants with triterpenoid compounds in nature have various biological activities and are reported in many scientific works of literature. Triterpenoids are compounds that draw the attention of scientists because of their wide source, wide variety, high medicinal value, and anti-tumor properties. However, a lack of approach to understand their chemical structures has limited the fundamental comprehension of these compounds in cancer cell therapy. Objective: To seek anti-cancer activity of the structures of triterpenoid compounds and their derivatives, we summarized a number of plants and their derivatives that are a source of potential novel therapeutic anti-cancer agents. Methods: This work focuses on relevant 1036 patents and references that detail the structure of organic compounds and derivatives for the treatment of tumors. Result: Compared to tetracyclic triterpenoid, pentacyclic triterpenoid has contributed more to improve the autophagic signaling pathways of cancer cells. Conclusion: The heterogenous skeleton structure of triterpenoids impaired the programmed cell death signaling pathway in various cancers

scholarly journals Synthesis, Modification and Biological Activity of Diosgenyl β-d-Glycosaminosides: An Overview

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5433
Author(s):  
Daria Grzywacz ◽  
Beata Liberek ◽  
Henryk Myszka
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
Protecting Groups ◽  
Pharmacological Properties ◽  
Amino Group ◽  
Reaction Conditions ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Wide Group ◽  
Derivatives Of

Saponins are a structurally diverse class of natural glycosides that possess a broad spectrum of biological activities. They are composed of hydrophilic carbohydrate moiety and hydrophobic triterpenoid or steroid aglycon. Naturally occurring diosgenyl glycosides are the most abundant steroid saponins, and many of them exhibit various pharmacological properties. Herein, we present an overview of semisynthetic saponins syntheses–diosgenyl β-d-glycosaminosides (d-gluco and d-galacto). These glycosides possess a 2-amino group, which creates great possibilities for further modifications. A wide group of glycosyl donors, different N-protecting groups and various reaction conditions used for their synthesis are presented. In addition, this paper demonstrates the possibilities of chemical modifications of diosgenyl β-d-glycosaminosides, associated with functionalisation of the amino group. These provide N-acyl, N-alkyl, N,N-dialkyl, N-cinnamoyl, 2-ureido and 2-thiosemicarbazonyl derivatives of diosgenyl β-d-glycosaminosides, for which the results of biological activity tests (antifungal, antibacterial, anti-cancer and hemolytic) are presented.

scholarly journals Phytoconstituents and Biological Activities of Garcinia Dulcis (Clusiaceae): A Review

2017 ◽  
Vol 12 (3) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Nanthaphong Khamthong ◽  
Nongporn Hutadilok-Towatana
Keyword(s):  
Current Knowledge ◽  
Biological Activities ◽  
Fruit Tree ◽  
Pharmacological Properties ◽  
Tropical Fruit ◽  
Anti Cancer ◽  
History Of ◽  
Phytochemical Constituents ◽  
History Of Use ◽  
Review Current

Garcinia dulcis (Roxb.) Kurz is a tropical fruit tree native to Southeast Asia where it has a long history of use as a traditional medicine for the treatment of ailments such as lymphatitis, parotitis, struma, scurvy, cough, and sore throat. Despite its medicinal values, this plant is not well known and rarely found nowadays. Research on the phytochemical constituents and biological activities of G. dulcis have demonstrated that various parts of the plant contain an abundance of bioactive compounds mainly xanthones and flavonoids, with significant pharmacological properties such as anti-atherosclerosis, anti-bacterial, anti-cancer, anti-hypertension, and anti-malarial. In the present review, current knowledge of the phytochemistry of G. dulcis and biological activities of its active constituents based on the available literature are summarized in order to explore application potentials and prospective research works on this plant.

scholarly journals The GenusSpilanthesEthnopharmacology, Phytochemistry, and Pharmacological Properties: A Review

2013 ◽  
Vol 2013 ◽  
pp. 1-22 ◽  
Author(s):  
Jayaraj Paulraj ◽  
Raghavan Govindarajan ◽  
Pushpangadan Palpu
Keyword(s):  
Traditional Medicine ◽  
Biological Activities ◽  
Mechanisms Of Action ◽  
Biologically Active ◽  
The Internet ◽  
Pharmacological Properties ◽  
Pharmacological Effects ◽  
Over The Counter ◽  
Traditional Medicines ◽  
Pharmacological Studies

Spilanthesspp. are popular, over-the-counter remedies; they are sold over the internet under various names and are widely used in traditional medicine in various cultures. This review will summarize the important reports on the ethnopharmacology, botany, phytochemistry, and pharmacological properties as described in the literature from recent years (1920 to 2013).Spilanthesspp. are used for more than 60 types of disorders. They are reported to contain a number of biologically active phytochemicals, although a large number of ethnopharmacological uses have been documented; only a few of these species have been investigated for their chemical and biological activities. The studies are carried out mainly onSpilanthesextracts and a few metabolites substantiate the uses of these plants in traditional medicine. Well-conducted pharmacological studies are still needed for several traditional indications, and the mechanisms of action by which the plant extracts and the active compounds exert their pharmacological effects remain to be studied. They are predominantly used as extracts in personal care products, traditional medicines, and the pharmaceutical and culinary areas. Suggestions are made regarding some of the possible mechanisms of action as to how the known compounds may exert their biological activity.

Lipase catalyzed betulinic acid derivatives and its cytotoxic activity

2010 ◽  
Vol 7 (1) ◽  
pp. 65
Author(s):  
Yamin Yasin ◽  
Faujan Ahmad
Keyword(s):  
Acetic Anhydride ◽  
Cytotoxic Activity ◽  
Betulinic Acid ◽  
Acid Ester ◽  
Benzoyl Chloride ◽  
Pharmacological Properties ◽  
Anti Cancer ◽  
Pharmacological Studies ◽  
Anti Hiv

Betulinic acid, a triterpenoid found in many plant species, has attracted attention due to its important pharmacological properties, such as anti-cancer and anti-HIV activities. In order to obtain derivatives potentially useful for detailed pharmacological studies, derivatives were synthesized through the reaction of betulinic acid with benzoyl chloride and acetic anhydride using a lipase catalyst. Enzyme-catalyzed reaction of betulinic acid with benzoyl chloride yielded 3B-benzoil-lup-20(29)-ene-28-oic acid ester (BCL), whereas the acetic anhydride reaction yielded 3B-acetoxy-lup-20(29)-ene-28-oic acid ester (BAA). The BAA underwent further reaction with l-decanol to produce 3B-acetoxy-lup-20(29)-ene-28 decanoate (BAAD). The prepared betulinic acid derivatives were tested for cytotoxic activity on three callcer cell lines in vitro: all tested compunds showed greater activity than betulinic acid.

scholarly journals Lindera aggregata (Sims) Kosterm: Review on phytochemistry and biological activities

2020 ◽  
Vol 19 (6) ◽  
pp. 527-541
Author(s):  
Wan Mohd Nuzul Hakimi Wan Salleh ◽  
Keyword(s):  
Web Of Science ◽  
Biological Activities ◽  
Biological Significance ◽  
Structural Diversity ◽  
Scientific Journals ◽  
Literature Analysis ◽  
Medicinal Value ◽  
Pharmacological Significance ◽  
Pharmacological Studies ◽  
Pharmacological Potential

The genus Lindera consists of approximately 100 species that are widely distributed in tropical and subtropical areas throughout the world. Most Lindera plants, particularly Lindera aggregata is a well-known traditional Chinese medicine that has important medicinal value and health benefits. Contemporary chemical and pharmacological studies have shown that L. aggregata are a source of structurally diverse molecules having pharmacological potential. In an effort to promote research on L. aggregata and develop therapeutic and pharmacological products, this review describes the structural diversity of its components and pharmacological and biological significance of L. aggregata. This review is based on a literature analysis of scientific journals from electronic sources, such as Science Direct, PubMed, Google Scholar, Scopus and Web of Science. Thus, with the growing interest in traditional medicine and botanical drugs worldwide, L. aggregata will increasingly capture chemists’ and pharmacologists’ attention because they produce diverse and structurally novel compounds having pharmacological significance.

Chemical Constituents and Bioactivities of Gorgonian Corals

2020 ◽  
Vol 24 (12) ◽  
pp. 1315-1330
Author(s):  
Hui Lei ◽  
Peng Jiang ◽  
Dan Zhang
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Structural Features ◽  
Mechanisms Of Action ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Lead Compounds ◽  
Medicinal Value ◽  
Gorgonian Corals ◽  
New Compounds

Gorgonian corals are considered as a rich source of secondary metabolites with unique structural features and biological activities. A large number of novel metabolites with potent pharmacological properties have been isolated from gorgonian corals. Some of these compounds have exhibited to possess new mechanisms of action, which hold great promises as potential lead compounds in future marine drug development. This review aims to provide an overview of chemical constituents and biological activities of gorgonian corals from 2015 to December, 2019. Some 145 metabolites, including 16 sesquiterpenoids, 62 diterpenoids, 62 steroids and 5 alkaloids were reported during this period and their pharmacological activities were investigated. Moreover, the peculiar structure and potential medicinal value of these new compounds are discussed in this review.

Lipase Catalyzed Betulinic Acid Derivatives and its Cytotoxic Activity

2010 ◽  
Vol 7 (1) ◽  
pp. 65
Author(s):  
Yamin Yasin ◽  
Faujan Ahmacl
Keyword(s):  
Acetic Anhydride ◽  
Cytotoxic Activity ◽  
Betulinic Acid ◽  
Acid Ester ◽  
Benzoyl Chloride ◽  
Pharmacological Properties ◽  
Anti Cancer ◽  
Pharmacological Studies ◽  
Anti Hiv

Betulinic acid. a triterpenoid found in many plant species, has attracted attention due to its important pharmacological properties, such as anti-cancer and anti-HIV activities. In order to obtain derivatives potentially useful for detailed pharmacological studies, derivatives were synthesized through the reaction of betulinic acid with benzoyl chloride and acetic anhydride using a lipase catalyst. Enzyme-catalyzed reaction of betulinic acid with benzoyl chloride yielded 3b-benzoil-lup-20(29)-ene-28-oic acid ester (BCL), whereas the acetic anhydride reaction yielded 3b-acetoxy-lup-20(29)-ene-28-oic acid ester (BAA). The BAA underwent further reaction with 1-decanol to produce 3b-acetoxy-lup-20(29)-ene-28 decanoate (BAAD). The prepared betulinic acid derivatives were tested for cytotoxic activity on three cancer cell lines in vitro: all tested compounds showed greater activity than betulinic acid.

Pharmacologically potentials of different substituted coumarin derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Benzene Ring ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coumarin Derivatives ◽  
Wide Range ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

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