Quercetin: A Potential Candidate For The Treatment Of Arthritis

Current Molecular Medicine ◽

10.2174/1566524021666210315125330 ◽

2021 ◽

Vol 21 ◽

Author(s):

Ahsas Goyal ◽

Neetu Agrawal

Keyword(s):

Rheumatoid Arthritis ◽

Medicinal Plants ◽

Therapeutic Potential ◽

Gouty Arthritis ◽

Potential Candidate ◽

Protective Effects ◽

Preclinical Models ◽

Healthy Life ◽

Health Promoting ◽

Dietary Component

: Diet plays a significant role in ensuring healthy life and the bioactive compounds present in food and medicinal plants may be developed as drugs that combat various illnesses. A bioactive flavanoid, quercetin which is a dietary component possesses numerous health-promoting effects. In preclinical models of rheumatoid arthritis, gouty arthritis and osteoarthritis, quercetin has shown significant joint protective effects. Taking into account the significance of this compound, the present review discusses its anti-arthritic properties, demonstrating its mechanism of action for the treatment of arthritis with its therapeutic potential.

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Uncaria tomentosa (Willd. ex Schult.): focus on nutraceutical aspects

Current Bioactive Compounds ◽

10.2174/1573407217666210903113347 ◽

2021 ◽

Vol 17 ◽

Author(s):

Amirhossein Nazhand ◽

Alessandra Durazzo ◽

Massimo Lucarini ◽

Amelia M. Silva ◽

Selma B. Souto ◽

...

Keyword(s):

Medicinal Plants ◽

Therapeutic Potential ◽

Production Costs ◽

Industrialized Countries ◽

Uncaria Tomentosa ◽

Beneficial Effects ◽

Microbial Infections ◽

Health Promoting

: Medicinal plants have been globally exploiting as an alternative to chemical drugs in the treatment of several diseases due to low unwanted side effects, environmentally friendly nature and low production costs, therefore, it is important to analyze the therapeutic properties of various medicinal plants to understand their potential bioactivity. Uncaria tomentosa is one of these medicinal plants with many health-promoting effects. Although the geographical resources of cat's claw go back to the remote tropics of the Amazon, industrialized countries use the plant extensively in trade. Various parts of the plants such as flowers, leaves, Stem, hook, and seed are mainly used medicinally to treat inflammation, asthma, allergies, skin impurities, microbial infections, neurodegenerative diseases, cancer, cirrhosis, gastrointestinal disorders, arthritis, heart disease, rheumatism, and fever. The end point of this review article is to prospectively scrutinize in vitro and in vivo the therapeutic potential of this plant, especially in terms of its nutritional applications and health beneficial effects.

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Vitex agnus-castus L.: Main Features and Nutraceutical Perspectives

Forests ◽

10.3390/f11070761 ◽

2020 ◽

Vol 11 (7) ◽

pp. 761

Author(s):

Eliana B. Souto ◽

Alessandra Durazzo ◽

Amirhossein Nazhand ◽

Massimo Lucarini ◽

Massimo Zaccardelli ◽

...

Keyword(s):

Medicinal Plants ◽

Therapeutic Potential ◽

Cost Effective ◽

Special Focus ◽

Tropical Regions ◽

Agnus Castus ◽

Health Promoting ◽

Therapeutic Properties

Medicinal plants are used worldwide due to their lower risk of side effects and eco-friendly, cost-effective production when compared to chemical drugs, encouraging researchers to further exploit the therapeutic potential of the former. One of the most popular medicinal plants is Vitex agnus-castus L., grown in tropical and sub-tropical regions, to which different health benefits have already been attributed. In this perspective article, the in vitro and in vivo therapeutic properties of V. agnus-castus L. have been analyzed and reviewed with a special focus on its health-promoting effects and potential nutraceutical applications.

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A survey of medicinal plants used to treat rheumatoid arthritis in two northern districts of Bangladesh

Planta Medica ◽

10.1055/s-0029-1234545 ◽

2009 ◽

Vol 75 (09) ◽

Author(s):

F Rahman ◽

S Hossan ◽

AH Mollik ◽

R Jahan ◽

M Rahmatullah

Keyword(s):

Rheumatoid Arthritis ◽

Medicinal Plants

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Medicinal plants used against rheumatoid arthritis by traditional medicinal practitioners of Bangladesh

Planta Medica ◽

10.1055/s-0029-1234537 ◽

2009 ◽

Vol 75 (09) ◽

Author(s):

AH Mollik ◽

S Hossan ◽

T Islam ◽

R Jahan ◽

M Rahmatullah

Keyword(s):

Rheumatoid Arthritis ◽

Medicinal Plants

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Rheumatoid Arthritis: History, Stages, Epidemiology, Pathogenesis, Diagnosis and Treatment

INTERNATIONAL JOURNAL OF TOXICOLOGICAL AND PHARMACOLOGICAL RESEARCH ◽

10.25258/ijtpr.v9i02.9052 ◽

2017 ◽

Vol 9 (02) ◽

Author(s):

Abeer Fauzi Al-Rubaye ◽

Mohanad Jawad Kadhim ◽

Imad Hadi Hameed

Keyword(s):

Rheumatoid Arthritis ◽

Medicinal Plants ◽

Systemic Disease ◽

Modern Medicine ◽

Whole Body ◽

Internal Organs ◽

Synthetic Drugs ◽

Relieve Pain ◽

Medicinal Treatment ◽

Natural Drugs

The pharmacological mechanisms of the medicinal plants traditionally used for RA in Persian medicine are discussed in the current review. Further investigations are mandatory to focus on bioefficacy of these phytochemicals for finding novel natural drugs. Rheumatoid arthritis is chronic, progressive, disabling autoimmune disease characterized by systemic inflammation of joints, damaging cartilage and bone around the joints. It is a systemic disease which means that it can affect the whole body and internal organs such as lungs, heart and eyes. Although numbers of synthetic drugs are being used as standard treatment for rheumatoid arthritis but they have adverse effect that can compromise the therapeutic treatment. Unfortunately, there is still no effective known medicinal treatment that cures rheumatoid arthritis as the modern medicine can only treat the symptoms of this disease that means to relieve pain and inflammation of joints. It is possible to use the herbs and plants in various forms in order to relieve the pain and inflammation in the joints. There are so many medicinal plants that have shown anti rheumatoid arthritis properties. So the plants and plant product with significant advantages are used for the treatment of rheumatoid arthritis. The present review is focused on the medicinal plants having anti rheumatoid arthritis activity

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Current Advances in the Biological Activity of Polysaccharides in Dendrobium with Intriguing Therapeutic Potential

Current Medicinal Chemistry ◽

10.2174/0929867324666170227114648 ◽

2018 ◽

Vol 25 (14) ◽

pp. 1663-1681 ◽

Cited By ~ 9

Author(s):

Chun-Ting Lee ◽

Heng-Chun Kuo ◽

Yung-Hsiang Chen ◽

Ming-Yen Tsai

Keyword(s):

Biological Activity ◽

Therapeutic Potential ◽

Biological Activities ◽

Biological Effects ◽

Herbal Medicines ◽

Research Field ◽

Protective Effects ◽

Pharmacological Effects ◽

The Family ◽

Anti Tumor Activity

The polysaccharides in many plants are attracting worldwide attention because of their biological activities and medical properties, such as anti-viral, anti-oxidative, antichronic inflammation, anti-hypertensive, immunomodulation, and neuron-protective effects, as well as anti-tumor activity. Denodrobium species, a genus of the family orchidaceae, have been used as herbal medicines for hundreds of years in China due to their pharmacological effects. These effects include nourishing the Yin, supplementing the stomach, increasing body fluids, and clearing heat. Recently, numerous researchers have investigated possible active compounds in Denodrobium species, such as lectins, phenanthrenes, alkaloids, trigonopol A, and polysaccharides. Unlike those of other plants, the biological effects of polysaccharides in Dendrobium are a novel research field. In this review, we focus on these novel findings to give readers an overall picture of the intriguing therapeutic potential of polysaccharides in Dendrobium, especially those of the four commonly-used Denodrobium species: D. huoshanense, D. offininale, D. nobile, and D. chrysotoxum.

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Medicinal Plants and Bioactive Compounds for Diabetes Management: Important Advances for Drug Discovery

Current Pharmaceutical Design ◽

10.2174/1381612826666200928160357 ◽

2020 ◽

Vol 26 ◽

Author(s):

Kondeti Ramudu Shanmugam ◽

Bhasha Shanmugam ◽

Gangigunta Venkatasubbaiah ◽

Sahukari Ravi ◽

Kesireddy Sathyavelu Reddy

Keyword(s):

Herbal Medicine ◽

Medicinal Plants ◽

Bioactive Compounds ◽

Diabetes Management ◽

Therapeutic Potential ◽

Public Health Problem ◽

In Vivo Studies ◽

Major Public Health Problem

Background : Diabetes is a major public health problem in the world. It affects each and every part of the human body and also leads to organ failure. Hence, great progress made in the field of herbal medicine and diabetic research. Objectives: Our review will focus on the effect of bioactive compounds of medicinal plants which are used to treat diabetes in India and other countries. Methods: Information regarding diabetes, oxidative stress, medicinal plants and bioactive compounds were collected from different search engines like Science direct, Springer, Wiley online library, Taylor and francis, Bentham Science, Pubmed and Google scholar. Data was analyzed and summarized in the review. Results and Conclusion: Anti-diabetic drugs that are in use have many side effects on vital organs like heart, liver, kidney and brain. There is an urgent need for alternative medicine to treat diabetes and their disorders. In India and other countries herbal medicine was used to treat diabetes. Many herbal plants have antidiabetic effects. The plants like ginger, phyllanthus, curcumin, aswagandha, aloe, hibiscus and curcuma showed significant anti-hyperglycemic activities in experimental models and humans. The bioactive compounds like Allicin, azadirachtin, cajanin, curcumin, querceitin, gingerol possesses anti-diabetic, antioxidant and other pharmacological properties. This review focuses on the role of bioactive compounds of medicinal plants in prevention and management of diabetes. Conclusion: Moreover, our review suggests that bioactive compounds have the potential therapeutic potential against diabetes. However, further in vitro and in vivo studies are needed to validate these findings.

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An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer

Nature Communications ◽

10.1038/s41467-020-20454-z ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Jinyoung Kim ◽

Kihyoun Park ◽

Min Jung Kim ◽

Hyejin Lim ◽

Kook Hwan Kim ◽

...

Keyword(s):

Cell Death ◽

Cell Function ◽

Therapeutic Potential ◽

Therapeutic Modality ◽

Protective Effects ◽

Β Cells ◽

Β Cell ◽

Islet Amyloid ◽

Amyloid Accumulation ◽

Human Diabetes

AbstractWe have reported that autophagy is crucial for clearance of amyloidogenic human IAPP (hIAPP) oligomer, suggesting that an autophagy enhancer could be a therapeutic modality against human diabetes with amyloid accumulation. Here, we show that a recently identified autophagy enhancer (MSL-7) reduces hIAPP oligomer accumulation in human induced pluripotent stem cell-derived β-cells (hiPSC-β-cells) and diminishes oligomer-mediated apoptosis of β-cells. Protective effects of MSL-7 against hIAPP oligomer accumulation and hIAPP oligomer-mediated β-cell death are significantly reduced in cells with knockout of MiTF/TFE family members such as Tfeb or Tfe3. MSL-7 improves glucose tolerance and β-cell function of hIAPP+ mice on high-fat diet, accompanied by reduced hIAPP oligomer/amyloid accumulation and β-cell apoptosis. Protective effects of MSL-7 against hIAPP oligomer-mediated β-cell death and the development of diabetes are also significantly reduced by β-cell-specific knockout of Tfeb. These results suggest that an autophagy enhancer could have therapeutic potential against human diabetes characterized by islet amyloid accumulation.

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