Biomacromolecule-Functionalized Nanoparticle-Based Conjugates for Potentiation of Anticancer Therapy

2021 ◽  
Vol 21 ◽  
Author(s):  
Priyank Shah ◽  
Pravin Shende
Keyword(s):  
Tumor Cells ◽  
Site Effect ◽  
Multi Drug Resistance ◽  
Short Term ◽  
Term Stability ◽  
Long Term Stability ◽  
Payload Capacity ◽  
Precision Therapy ◽  
Life Threatening

: Cancer is a rapidly growing life-threatening disease that affected 18.1 million people worldwide in 2018. Various conventional techniques like surgery, radiation, and chemotherapy are considered as a mainstream treatment for patients but show some limitations like cytotoxicity due to off-targeted action, poor intra-tumor localization, development of multi-drug resistance by tumor cells, physical and psychological stresses, etc. Such limitations have motivated the scientists to work towards more patient-centric and precision therapy using advanced drug delivery systems like liposomes, nanoparticles, nanoconjugates, etc. However, these carriers also face limitations like poor biocompatibility, lesser payload capacity, leakage of encapsulated drug, and short-term stability. So, this review article explores the profound insights for the development of biomacromolecule-functionalized nanoconjugates to potentiate the anticancer activity of therapeutic agents for various cancers like lung, colorectal, ovarian, breast and liver cancer. Researchers have shown interest in biofunctionalized nanoconjugates because of advantages like biocompatibility, site-specificity with better localization, higher entrapment with long-term stability and lesser off-target toxicity. The progressive trend of biomacromolecule nanoconjugates will encourage further research for the development of effective transport of drugs, nutraceuticals and phytoconstituents for on-site effect at cancer microenvironment and tumor cells with higher safety profile.

scholarly journals A survey of short-term and long-term stability of tube parameters in a mammography unit

2014 ◽  
Vol 29 (4) ◽  
pp. 321-325
Author(s):  
Jovica Praskalo ◽  
Jasna Davidovic ◽  
Biljana Kocic ◽  
Monika Zivkovic ◽  
Svetlana Pejovic
Keyword(s):  
Screening Program ◽  
Short Term ◽  
X Ray ◽  
Term Stability ◽  
Long Term Stability ◽  
Mammography Screening Program ◽  
The Republic ◽  
Set Up ◽  
The Given

In order to set up a successful mammography screening program in the Republic of Srpska, a Siemens Mammomat 1000 X-ray machine was selected for analysis as the said mammography system is widely used in clinical practice. The variations in tube parameters (specific air kerma, high-voltage accuracy and reproducibility, linearity between exposure and dose exposure time) were monitored over a five-year period, from 2008 to 2012. In addition, due to observed daily fluctuations for chosen parameters, a series of measurements were performed three times a day within a single-month period (mainly October 2012). The goal of such an experimental set up is to assess short-term and long-term stability of tube parameters in the given mammography unit and to make a comparison between them. The present paper shows how an early detection of significant parameter fluctuations can help eliminate irregularities and optimize the performance of mammography systems.

scholarly journals Research on the solidification of silt with cement and zeolite as additives

2016 ◽  
Vol 1 (1) ◽  
pp. 35
Author(s):  
Feng Cheng ◽  
Wang Baotian ◽  
Li Shoude
Keyword(s):  
Heavy Metal ◽  
Industrial Pollution ◽  
Unconfined Compressive Strength ◽  
Effective Solution ◽  
Short Term ◽  
Time Saving ◽  
Term Stability ◽  
Long Term Stability ◽  
Environment Problem

Silt solidification is an important method of silt disposal,and it’s proved to be quick effectiveness and time saving and large in capacity.In recent years,the industrial pollution has made the silt in the lake or the sea rich in harmful elements,such as heavy metal and organic matter,etc,which may strongly influence the solidification effect of silt and trigger secondary pollution.The author proposed a kind of choice,which could effectly decrease harmful elements leaching,based on engineering application.The performances of solidification with different ratio of cement and zeolite,such as unconfined compressive strength,compression coefficient,heavy metal fractions,heavy metal short-term stability and long-term stability are systematicly studied.The article confirmed that the addition of the cement and the zeolite increase the strength of the soil and effectly enhance its deformation resistant capability,Further more,they significantly decrease the activity of harmful elements and greatly reduce the threat to the environment,which finds an effective solution to the environment problem.

Fabrication of Boron Compensated Hydrogenated Amorphous Silicon Films with Significantly Improved Stability Using Plasma Enhanced Chemical Vapor Deposition Technique

1995 ◽  
Vol 377 ◽  
Author(s):  
Mohan K. Bhan
Keyword(s):  
Chemical Vapor ◽  
Short Term ◽  
Term Stability ◽  
Long Term Stability ◽  
Vapor Deposition Technique ◽  
Improved Stability ◽  
Donor Acceptor ◽  
B Doping ◽  
The Stability

ABSTRACTWe have systematically investigated the effects of addition of sub-ppm levels of boron on the stability of a-Si:H films and p-i-n devices, deposited by PE-CVD technique. The films thus produced with appropriate amounts of boron, show a significant improvement in stability, when soaked under both AM 1.5 (short-term) as well as 10×sun (long-term) illumination conditions. The opto-electronic properties of the films are quite respectable It is concluded that boron compensates the native impurities by forming donor-acceptor pairs, which reduces the “fast” defects and hence the initial degradation of the films. It is also speculated that boron may also be improving the short-term stability, by reducing the recombination of light generated electrons and holes, by converting D° into D+ states. The long-term stability appears to get affected by hydrogen dilution which seems to reduce the amount of “slow” defects. As a result of B doping of i-layer, the initial conversion efficiency of the devices decreases. It is presumed that our devices may contain an enhanced level of boron impurity, than expected, making them as worse material and to degrade less.

scholarly journals Weather fluctuations drive short‐term dynamics and long‐term stability in plant communities: A 25‐year study in a Central European dry grassland

2020 ◽  
Vol 31 (5) ◽  
pp. 711-721 ◽  
Author(s):  
Felícia M. Fischer ◽  
Kryštof Chytrý ◽  
Jakub Těšitel ◽  
Jiří Danihelka ◽  
Milan Chytrý
Keyword(s):  
Plant Communities ◽  
Short Term ◽  
Dry Grassland ◽  
Central European ◽  
Term Stability ◽  
Long Term Stability

Results of experimental tests for the evaluation of the signal-to-noise ratio, short-term stability, linearity in the time axis, and long-term stability of the GPR signal - according to COST Action TU1208 guidelines

2020 ◽  
Author(s):  
Milan Vrtunski ◽  
Lara Pajewski ◽  
Aleksandar Ristić ◽  
Željko Bugarinović ◽  
Miro Govedarica
Keyword(s):  
Ground Penetrating Radar ◽  
Signal To Noise Ratio ◽  
Experimental Tests ◽  
Time Axis ◽  
Short Term ◽  
Cost Action ◽  
Term Stability ◽  
Long Term Stability ◽  
Ground Penetrating

<p>Ground Penetrating Radar (GPR) systems need to be calibrated on a recurrent basis and their performance shall be periodically verified, in accordance with manufacturer recommendations and specifications. Nevertheless, most GPR owners in Europe employ their radar units and antennas for years without ever having them verified by manufacturers, unless major flaws or issues become evident. In this framework, Members of COST Action TU1208 have recently carried out a critical analysis of the few existing procedures for the calibration and performance verification of GPR systems; and, they have proposed four improved experimental tests to evaluate the signal-to-noise ratio, short-term stability, linearity in the time axis, and long-term stability of the GPR signal [1]. In this work, we present the results of the tests executed in Novi Sad, Serbia, on a GSSI SIR 3000 control unit equipped with GSSI ground-coupled antennas having central frequencies of 400 MHz and 900 MHz. We have experienced that the execution of the tests helps to attain stronger awareness about the behaviour and limits of owned GPR equipment. It is also interesting to check how the results of the tests change over time and in different environmental conditions, to analyze the performance evolution of the equipment. Main aim of this abstract is to spread the voice and encourage GPR owners and manufacturers to execute the tests. If a wide variety of control units and antennas are tested, of older and more recent conception, with different numbers of working hours, reliable thresholds for the tests can be established and the proposed procedures can be further refined and upgraded. Moreover, the results of the tests can be translated into accuracy levels of measured physical and geometrical quantities, to get some awareness about the uncertainty of results of a GPR survey (e.g., achieved accuracy levels in the estimation of layer thicknesses).</p><p> </p><p>[1] L. Pajewski, M. Vrtunski, Ž. Bugarinović, A. Ristić, M. Govedarica, A. van der Wielen, C. Grégoire, C. Van Geem, X. Dérobert, V. Borecky, S. Serkan Artagan, S. Fontul, V. Marecos, and S. Lambot, "GPR system performance compliance according to COST Action TU1208 guidelines,"  Ground Penetrating Radar, Volume 1, Issue 2, Article ID GPR-1-2-1, July 2018, pp. 2-36, doi.org/10.26376/GPR2018007.</p>

Long- and short-term in vitro D-dimer stability measured with INNOVANCE D-Dimer

2010 ◽  
Vol 103 (02) ◽  
pp. 461-465 ◽  
Author(s):  
Martina Böhm-Weigert ◽  
Thomas Wissel ◽  
Heidrun Muth ◽  
Bettina Kemkes-Matthes ◽  
Dirk Peetz
Keyword(s):  
Frozen Storage ◽  
Percentage Change ◽  
Short Term ◽  
Term Stability ◽  
Long Term Stability ◽  
Repeated Freezing ◽  
The Mean ◽  
D Dimer

Summary In vitro D-dimer stability in plasma is widely assumed, but has not yet been documented by systematic studies using samples covering a wide range of D-dimer. We investigated the short- and long-term stability of D-dimer in clinical citrated plasma samples with normal and pathological levels. The short-term stability was analysed by measuring D-dimer fresh, after storage of plasma for 4 hours at room temperature (RT) and after an additional 24 h storage at +2 to +8°C (n=40). Long-term stability samples (n=40) were measured fresh and after storage for 19, 25 and 36 months at ≤-60°C. The effect of repeated freezing was analysed by measuring samples (n=50) fresh and after four consecutive freeze-thaw cycles. D-dimer was measured on the BCS System using the INNOVANCE D-Dimer assay (Siemens Healthcare Diagnostics Products GmbH, Marburg, Germany). D-dimer values at baseline ranged from 0.23–22.2 mg/l FEU. The mean percentage change after storage for 4 hours at RT and additional 24 hours at +2 to +8°C was +3.8% and +2.7%, respectively. The mean percentage change after frozen storage for 19, 25 and 36 months at ≤-60°C was –11.7%, –4.8% and –9.3%, respectively. The small decrease of D-dimer values after frozen storage was not time-dependent. Repeated freezing did not significantly alter D-dimer values (mean change ≤5%). The data demonstrate stability of D-dimer in plasma prior to freezing for up to 4 hours at RT and for up to 24 hours at +2 to +8°C as well as in plasma stored for up to three years at ≤-60°C.

Study of NC Frequency Source Based on the GPS Atomic Clock System

2012 ◽  
Vol 546-547 ◽  
pp. 1608-1613
Author(s):  
Tian Qi Xu ◽  
Hai Dong Lei
Keyword(s):  
Closed Loop ◽  
Atomic Clock ◽  
Short Term ◽  
Compensation Circuit ◽  
Term Stability ◽  
Long Term Stability ◽  
Clock System ◽  
Specific Description ◽  
Frequency Source

This paper presents a new VCXO frequency source based on the GPS module, atomic clock in system and loop compensation circuit, the accuracy of the system, long-term stability, and short-term stability can be improved because of its new structure. Specific description of the closed-loop lock works, including the compensation circuit of the machine.

scholarly journals 24h urinary free cortisol in large-scale epidemiological studies: Short-term and long-term stability and sources of variability

2014 ◽  
Vol 47 ◽  
pp. 10-16 ◽  
Author(s):  
Judith G.M. Rosmalen ◽  
Ido P. Kema ◽  
Stefan Wüst ◽  
Claude van der Ley ◽  
Sipke T. Visser ◽  
...  
Keyword(s):  
Large Scale ◽  
Urinary Free Cortisol ◽  
Epidemiological Studies ◽  
Short Term ◽  
Term Stability ◽  
Long Term Stability ◽  
Free Cortisol
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