Epidemics and Peptide Vaccine Response: A Brief Review

2019 ◽  
Vol 18 (26) ◽  
pp. 2202-2208 ◽  
Author(s):  
Ashesh Nandy ◽  
Sumanta Dey ◽  
Proyasha Roy ◽  
Subhash C. Basak
Keyword(s):  
Nipah Virus ◽  
Peptide Vaccine ◽  
Financial Resources ◽  
The Novel ◽  
New Paradigm ◽  
Vaccine Response ◽  
Synthetic Vaccines ◽  
Pros And Cons ◽  
High Degree ◽  
New System

We briefly review the situations arising out of epidemics that erupt rather suddenly, threatening life and livelihoods of humans. Ebola, Zika and the Nipah virus outbreaks are recent examples where the viral epidemics have led to considerably high degree of fatalities or debilitating consequences. The problems are accentuated by a lack of drugs or vaccines effective against the new and emergent viruses, and the inordinate amount of temporal and financial resources that are required to combat the novel pathogens. Progress in computational, biological and informational sciences have made it possible to consider design of synthetic vaccines that can be rapidly developed and deployed to help stem the damages. In this review, we consider the pros and cons of this new paradigm and suggest a new system where the manufacturing process can be decentralized to provide more targeted vaccines to meet the urgent needs of protection in case of a rampaging epidemic.

Cognitive dominants of the conceptual sphere in the novel “of human bondage” by W. S. Maugham

2020 ◽  
Vol 6 (1) ◽  
pp. 48-61
Author(s):  
Olga B. Ponomareva ◽  
Valeriya I. Orlova
Keyword(s):  
Cognitive Linguistics ◽  
Meaning Of Life ◽  
The Novel ◽  
Thought Processes ◽  
New Paradigm ◽  
Comprehensive Description ◽  
Semantic Fields ◽  
Linguistic Representations ◽  
Basic Concepts ◽  
Linguistic Methods

This article presents a comprehensive analysis of the basic concepts that make up the conceptual sphere of the novel “Of Human Bondage” by W. S. Maugham. These concepts act as cognitive dominants of the linguistic consciousness of the protagonist’s linguistic personality in the work under study. The novelty of this research lies in the fact that it is performed within the framework of a new paradigm of linguistics — the cognitive linguistics, which involves the study of mental and linguistic representations of thought processes that occur during the perception of information. Moreover, the novel “Of Human Bondage” by W. S. Maugham has not attracted the attention of linguists-cognitologists previously, which adds to the novelty of this article. In addition, the present study provides a comprehensive description of the basic concepts making up the conceptual sphere of the novel. The linguistic methods of representing various concepts in the analyzed work are determined by the national, personal, cultural, and psychological aspects of Maugham’s thinking. The authors employ a communicative-cognitive methodological analysis proposed by N. S. Bolotnova involving the modeling of textual and intertextual semantic fields of artistic concepts and the analysis of the conceptual sphere of a literary text. The universal concepts RELIGION, LOVE, PASSION, THE MEANING OF LIFE, which constitute the conceptual sphere of the novel by W. S. Maugham “Of Human Bondage”, are analyzed. The main result of the study is that THE MEANING OF LIFE concept is universal, not individual, and it includes other universal concepts, such as RELIGION, LOVE, PASSION, THE MEANING OF LIFE, conceptual metaphors and metonyms, symbols, and other words-associates, which constitute the broad figurative and evaluative periphery of the conceptual sphere of the novel.

A Novel Recurrent Generalized Congruence Neural Network Measure for Objective Speech Quality Evaluation

2012 ◽  
Vol 433-440 ◽  
pp. 2282-2287
Author(s):  
Tian Yun Yan
Keyword(s):  
Neural Network ◽  
Quality Evaluation ◽  
Speech Quality ◽  
System Model ◽  
The Novel ◽  
Training Time ◽  
Network Measure ◽  
Comparison Results ◽  
Objective Speech Quality ◽  
New System

A new system model for objective speech quality evaluation based on the improved recurrent generalized congruence neural network (RGCNN/OSQE) is proposed. The performance of the RGCNN model is compared with the most commonly used RBFNN (radial basis function neural network) model in objective speech quality evaluation. Comparison results show that the RGCNN model has higher correlation coefficient, less deviation, and saves about half training time, i.e., the RGCNN model has obvious advantages over the RBFNN model. Therefore, the novel RGCNN model for objective speech quality evaluation is feasible and effective.

Bulk Materials Research for Thermoelectric Power Generation Applications

2007 ◽  
Vol 1044 ◽  
Author(s):  
George Nolas ◽  
Matthew Beekman ◽  
Joshua Martin ◽  
Dongli Wang ◽  
Xiunu sophie Lin
Keyword(s):  
Quantum Confinement ◽  
South Florida ◽  
Solid State Chemistry ◽  
The Novel ◽  
New Paradigm ◽  
Bulk Materials ◽  
Material Systems ◽  
Materials Research ◽  
Technological Improvements ◽  
The University

AbstractThere are a variety of material systems employing different strategies in an effort to establish a new paradigm for thermoelectric materials performance. One approach is the PGEC, or “phonon-glass electron crystal”, approach were research towards optimization of the electrical properties of very low thermal conductivity materials is key. Other efforts focus on materials that exhibit high power factors via quantum-confinement or nano-scale affects. Still others focus on “engineering” metastable phases that possess properties that are distinct, if not unique, to solid state chemistry. All these approaches are valid and provide a fundamental knowledge base whereby present and future scientific materials discoveries will lead to new technological improvements. This paper focuses on bulk materials, in particular those material systems currently under investigation in the novel materials laboratory at the University of South Florida and the requirements and strategies for their optimization towards improved thermoelectric properties.

PERTURBATION OF SCIENTIFIC SPECIALTIES IN LAW AND THE PLACE OF BUSINESS LAW IN THE NEW SYSTEM

2021 ◽  
Vol 3 (3) ◽  
pp. 196-213
Author(s):  
I.V. Ershova
Keyword(s):  
Business Law ◽  
New Paradigm ◽  
Sociological Study ◽  
Russian Science ◽  
Scientific Organizations ◽  
Number Of Factors ◽  
Scientific Specialty ◽  
History Of ◽  
Historical Methods ◽  
New System

Introduction: attention to the problems of scientific specialties is explained by a number of factors of a substantive and formal-institutional nature. The predicted change in the nomenclature of scientific specialties, including law, makes the research topical. Purpose: to identify the consequences and evaluate the results of future changes with extrapolation of conclusions to the science of business law. Methods: analysis, synthesis, comparison, historicism, description, interpretation, forecasting, as well as sociological and historical methods. Results: an excursion into the history of the issue is made: the pre-revolutionary, Soviet and post-Soviet periods are covered. Based on the actual data, it is shown that permanent changes in the system of scientific specialties in law are a tradition of Russian science. At the same time, the previously mentioned changes were of an evolutionary nature. The current situation with dissertation research within the current nomenclature is highlighted. Factors of popularity of the scientific specialty 12.00.03 are revealed, among which-stability, successful arrangement of branches, demand for scientists. The conclusion about the correctness of preserving business law within the same specialty with civil law is confirmed. Essential and bureaucratic problems of the scientific specialty 12.00.07 are shown. The article presents the data of a sociological study, the results of which indicate divergence and progressive autarky in the field of social Sciences. The characteristics of the main expected changes in the nomenclature of scientific specialties in law, including such as consolidation, rejection of the industry criterion in the formation are given. A forecast is made about the consequences of the introduction of these innovations. The author’s opinion is expressed regarding the place of business law in the new system of scientific specialties. Attention is drawn to possible problems and a way to overcome them is suggested. Conclusions: the new paradigm of scientific specialties in law should be evaluated positively. Its application allows us to approach the interdisciplinarity, complexity of scientific research, and the creation of dissertations as integral projects. In addition to the content side, the new nomenclature is designed to minimize problems in the formation of dissertation councils, selection of candidates for official opponents, and scientific organizations.

A Case of an IT-Enabled Organizational Change Intervention

2012 ◽  
pp. 190-212
Author(s):  
Bing Wang ◽  
David Paper
Keyword(s):  
Information Technology ◽  
Organizational Change ◽  
Change Management ◽  
New Technology ◽  
The Novel ◽  
New Paradigm ◽  
It Implementation ◽  
Perceived Change ◽  
Change Event

This case study documents an organizational change intervention concerning the implementation of a novel information technology at a university-owned research foundation (URF). It evidences the disparate expectations and reactions by key actors toward the change event, marking a mismatch between a new paradigm required by the new technology and existing information technology practices. Drawing upon change management and management information systems (MIS) literature, the authors discuss the perceived change management issues hindering the change process at URF. The discussion is tempered by a theoretical lens that attempts to integrate the literature bases drawn upon in this research. In particular, resistance from in-house IT specialists was observed as the strongest force obstructing the novel IT implementation. This study offers a forum to stimulate both researchers and practitioners to rethink the necessary elements required to enact change, especially with respect to novel IT implementations.

Emerging Telecommunications Technologies

2010 ◽  
pp. 545-561
Author(s):  
J. Joaquín Escudero-Garzás ◽  
Ana García-Armada
Keyword(s):  
Game Theory ◽  
Cognitive Radio ◽  
Cognitive Radios ◽  
Next Generation Networks ◽  
The Novel ◽  
New Paradigm ◽  
Wireless Telecommunications ◽  
New Type ◽  
Phy Layer ◽  
Novel Concept

The goal of this chapter is to introduce the novel concept of cognitive radio (CR) for wireless telecommunications. Cognitive radios are a new type of radio devices that include cognition and reconfigurability features. The raising number of studies in different areas of research shows their potential and the expectation created among the telecommunications community. In this chapter, the authors first introduce the reader to the new paradigm that cognitive radio networks have created; more specifically, they explain in detail the new next generation networks. Given that our intention is to introduce cognitive radio, the authors focus on the challenges in PHY layer and MAC sublayer and the most relevant studies in these fields. Finally, the integration of game theory and cognitive radio creates a new paradigm where the advantages of both technologies merge to solve complex problems.

scholarly journals Engineering and characterization of a novel Self Assembling Protein for Toxoplasma peptide vaccine in HLA-A*11:01, HLA-A*02:01 and HLA-B*07:02 transgenic mice

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kamal El Bissati ◽  
Ying Zhou ◽  
Sara M. Paulillo ◽  
Senthil K. Raman ◽  
Christopher P. Karch ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Immune Responses ◽  
Peptide Vaccine ◽  
New Paradigm ◽  
Mouse Splenocytes ◽  
Peptide Epitopes ◽  
Self Assembling ◽  
Tlr4 Ligand ◽  
Chimeric Polypeptide ◽  
Vaccine Approach

Abstract Fighting smart diseases requires smart vaccines. Novel ways to present protective immunogenic peptide epitopes to human immune systems are needed. Herein, we focus on Self Assembling Protein Nanoparticles (SAPNs) as scaffolds/platforms for vaccine delivery that produce strong immune responses against Toxoplasma gondii in HLA supermotif, transgenic mice. Herein, we present a useful platform to present peptides that elicit CD4+, CD8+ T and B cell immune responses in a core architecture, formed by flagellin, administered in combination with TLR4 ligand-emulsion (GLA-SE) adjuvant. We demonstrate protection of HLA-A*11:01, HLA-A*02:01, and HLA-B*07:02 mice against toxoplasmosis by (i) this novel chimeric polypeptide, containing epitopes that elicit CD8+ T cells, CD4+ T helper cells, and IgG2b antibodies, and (ii) adjuvant activation of innate immune TLR4 and TLR5 pathways. HLA-A*11:01, HLA-A*02:01, and HLA-B*07:02q11 transgenic mouse splenocytes with peptides demonstrated predicted genetic restrictions. This creates a new paradigm-shifting vaccine approach to prevent toxoplasmosis, extendable to other diseases.

scholarly journals COVID-19 infection presenting with acute epiglottitis

2020 ◽  
Vol 2020 (9) ◽  
Author(s):  
Alexander Fondaw ◽  
Muzamil Arshad ◽  
Saba Batool ◽  
Brenton Robinson ◽  
Toral Patel
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Pediatric Population ◽  
Neural Tissue ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
The Novel ◽  
Type B ◽  
Comorbid Conditions ◽  
Acute Epiglottitis ◽  
High Degree

Abstract In this case report, we present a novel presentation of acute epiglottitis in a patient with severe acute respiratory syndrome—coronavirus 2 (SARS-CoV-2) who presented to the emergency room in extremis and respiratory failure requiring emergent cricothyrotomy. Epiglottitis has become less common since the introduction and widespread use of the Haemophilus influenzae type B (Hib) vaccine. This reduction in cases has shifted demographics of the disease from the pediatric population towards adults with comorbid conditions. Interestingly there is a high degree of overlap between many of the comorbidities between epiglottitis and COVID-19. The novel severe acute respiratory syndrome—coronavirus 2 (SARS-CoV-2), also referred to as coronavirus disease 19 (COVID-19), has been reported to affect the gastrointestinal tract and neural tissue and has been implicated in necrotizing encephalitis. We report the first known case of the novel SARS-CoV-2 virus presenting with acute epiglottitis.

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