Synthesis and Biological Activity of Triclopyr Derivatives Containing the Pyridine Group

2020 ◽  
Vol 16 (4) ◽  
pp. 415-418
Author(s):  
Zi-Hui Yang ◽  
Gong-Zheng Yang ◽  
Yue-Yue Qi
Keyword(s):  
Biological Activity ◽  
Melting Point ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Basic Structure ◽  
Safety Test ◽  
Pyridine Group ◽  
Pine Trees ◽  
Leading Compounds ◽  
Internal Absorption

Background: Triclopyr(Dow-503), whose commercial name was green grass, was an internal absorption and selective novel herbicide, developed by Dow agricultural sciences using the basic structure of 2,4-D. Triclopyr was suitable for preventing broadleaf weeds for removing shrubs, maintaining fireproof lines, raising pine trees and forest areas. Moreover, it could be used in paddy fields to prevent some broad-leaved weeds at the dose of 150-500g/hm. Methods: Two novel Triclopyr derivatives were synthesized based on the structure of commerical herbicide Triclopyr. Their structures were confirmed by 1H NMR melting point and elemental analysis. The preliminary bioassay were also evaluated. Results: The preliminary bioassay results showed that the title compounds had some herbicidal activities at the dosage of 150 g/hm2.The compound 1 and 2 show the 100% inhibition against three kinds of test weeds. Further test revealed that compound 2 showed the 100% inhibition against the Amaranthus. The safety test for crop revealed that the compound 2 was safe for paddy at the dosage of 150 g/hm2. Conclusion: The two compounds can be used as the leading compounds with certain optimized value.

Synthesis and Biological Evaluation of Various New Substituted 1,3,4-oxadiazole-2-thiols

2008 ◽  
Vol 59 (4) ◽  
Author(s):  
Gabriela Laura Almajan ◽  
Stefania Felicia Barbuceanu ◽  
Ioana Saramet ◽  
Mihaela Dinu ◽  
Cristian Vasile Doicin ◽  
...  
Keyword(s):  
Biological Activity ◽  
Plant Growth ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Biological Evaluation ◽  
Ethyl Chloroacetate ◽  
Low Concentrations ◽  
Synthesis And Biological Evaluation

5-[4-(4X-phenylsulfonyl)phenyl]-1,3,4-oxadiazole-2-thiols, X=H, Cl, Br, reacted with ethyl chloroacetate to give S-alkylated compounds. Aminomethylation of the thione form of oxadiazoles yielded N(3)-derivatives. All the products have been characterized by elemental analysis, IR, 1H-NMR and 13C-NMR. The plant-growth regulating effects of the title compounds were examined. From the biological activity results, we found that most compounds showed weak stimulatory activities at low concentrations.

Synthesis of New Phenoxypropylamines and Evaluation of their Antiulcer Activity as H2 -Receptor Antagonist

2012 ◽  
Vol 554-556 ◽  
pp. 1849-1852
Author(s):  
Hui Zhang ◽  
Min Fan Wu ◽  
Yu Tian ◽  
Jian Tong ◽  
Li Hong Shang
Keyword(s):  
Biological Activity ◽  
Receptor Antagonist ◽  
Gastric Acid ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Antiulcer Activity ◽  
Antisecretory Activity ◽  
C Nmr

More new phenoxypropylamines have been synthesized. All the products have been characterized by elemental analysis, 1H-NMR, 1C-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activity reSuperscript textsults, we found that some of them showed significant gastric acid antisecretory activity.

Design and Synthesis of some novel 3-benzylidene-1H-benzo [4,5]imidazo[2,1-c] [1,4]oxazine-1,4(3H)-dione derivatives and evaluation of their biological activity

2021 ◽  
Vol 25 (11) ◽  
pp. 157-169
Author(s):  
Ch. Sunitha ◽  
G. Brahmeshwari
Keyword(s):  
Mass Spectrometry ◽  
Biological Activity ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
The Other ◽  
Good Activity ◽  
Design And Synthesis ◽  
Anti Oxidant ◽  
Anti Fungal

A novel series of 3-arylbenzylidene-1H-benzo[4,5] imidazo[2,1-c][1,4]oxazine-1,4(3H)-dione (4a-l) was synthesized in moderate to good yields. The structures of the newly synthesized compounds were confirmed by 1H NMR, 13C NMR mass spectrometry and elemental analysis. The synthesized compounds were evaluated for their anti-bacterial and anti-oxidant activities. Among all the derivatives tested, the compound 3-(3,5- dimethoxy benzylidene)-1H-benzo [4,5]imidazo[2,1- c][1,4]oxazine-1,4-(3H)-dione showed more potent activity and 3-(4-methoxybenzylidene)-1H benzo[4,5] imidazo[2,1-c][1,4]oxazine-1,4(3H)-dion exhibited good activity as compared to standard streptomycin. The anti-fungal activity reveals that the compound 3- (3,5-dimethoxy benzylidene)-1H-benzo[4,5]imidazo [2,1-c][1,4]oxazine-1,4-(3H)-dione showed more promising activity as compared to standard Itrazole. The remaining compounds showed moderate to poor activity. Similarly, the anti-oxidant activity results revealed that the compound 3-(3,5-dimethoxy benzylidene)-1H-benzo [4,5] imidazo[2,1-c][1,4] oxazine-1,4-(3H)-dione exhibited potent activity as compared to the other tested compounds.

scholarly journals Synthesis, Characterization and Biological Activity of (E)-9-Benzylidene-5-phenyl-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[3,4-ɑ]quinazoline

2020 ◽  
Vol 15 (3) ◽  
pp. 111-118
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Biological Activity ◽  
Carbonyl Compound ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Heterocyclic Compounds ◽  
Bacterial Activity ◽  
Favorable Effect ◽  
Unsaturated Carbonyl Compound ◽  
Quinazoline Derivatives

Abstract: Novel quinazoline derivatives were synthesized viathe reaction of unsaturated carbonyl compound subsidiaries with 3-aminotriazole. These compounds are convenient and important intermediates for the synthesis of a rangeof useful and novel heterocyclic compounds. The structures of these compounds were characterized using elemental analysis and IR, 1H NMR and mass spectroscopic methods.They were also tested with respect to their anti-bacterial activity against two types of bacteria,Staphylococcus aureusand Pseudomonas aeruginosa. Significant anti-bacterial activity was observed,and the results indicate the favorable effect of electron-releasing substituents on anti-bacterial activity

Synthesis, characterization, and biological activities of some transition metal(II) complexes with the thiosemicarbazone derived from 4-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]but-3-en-2-one

2006 ◽  
Vol 60 (3) ◽  
Author(s):  
J. Qu ◽  
G. Sun ◽  
L. Wang ◽  
L. Qu
Keyword(s):  
Biological Activity ◽  
Transition Metal ◽  
General Formula ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Nmr Spectra ◽  
Biological Activities ◽  
Antitumour Activity ◽  
Molar Conductivity

AbstractA new 4-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]but-3-en-2-one thiosemicarbazone (HL) was synthesized derived from 4-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]but-3-en-2-one. Four transition metal(II) complexes of HL have been prepared. Elemental analysis, molar conductivity, IR, UV, 1H NMR spectra, and TG-DTA have been used to characterize these complexes. The complexes have the general formula ML2, where M = Zn, Cu, Co, and Ni. The ligand and its complexes have been studied for their possible biological activity including anti-inflammatory, antibacterial, and antitumour activity in vitro.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL S-SUBSTITUTED PHENACYL-1, 3, 4-TRIAZOLE-THIOL DERIVATIVES FOR ANTIMICROBIAL STUDIES

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (08) ◽  
pp. 14-20
Author(s):  
S. S Kerur ◽  
◽  
K. R Alagawadi ◽  
H. Zhu ◽  
F. V Manvi
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Biological Activity ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Biological Evaluation ◽  
Triazole Derivatives ◽  
Antimicrobial Studies

In the present study, synthesis and antimicrobial activity of 2,5-disubstituted triazole derivatives 5a-f are described. The structures of the newly synthesized compounds were confirmed by FTIR, 1H NMR, mass and elemental analysis. All compounds were screened for antitubercular and antibacterial activity. The results revealed that most of the compounds showed high or moderate biological activity against tested microorganisms.

scholarly journals Correlation between the structure and biological activity of some coordination compounds of isatin Schiff bases

2003 ◽  
Vol 57 (10) ◽  
pp. 444-448 ◽  
Author(s):  
Blaga Radovanovic ◽  
Sandra Konstantinovic
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Transition Metal ◽  
Schiff Bases ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Coordination Compounds ◽  
Molar Conductivity ◽  
Enhanced Activity

The complexes of Co(ll), Ni(ll), Cu(ll) and Zn(ll) with isatin Schiff bases were synthetised and their structures established by using elemental analysis, as well as by measuring the molar conductivity, AA, FTIR, UV/VIS and 1H NMR and applying TG analysis.Isatin Schiff bases show different antimicrobial activity due to the different nature of the carbonyl and amino components as well as its substituent. The complexes have an enhanced activity compared to the ligands due to the transition metal involved in the coordination. It is also evident that the complexes have different antimicrobial activity, which is related to the nature and typeof coordinated metal.

scholarly journals Reactions of MoCl5 and MoO2Cl2 with Succinimide, 1, 4-Diaminobutane, 3-Methylpyridine, 1, 3-Diaminopropane, Pyrazole and 1- Methylpyrrolidine in Tetrahydrofuran

2021 ◽  
Vol 37 (3) ◽  
pp. 634-642
Author(s):  
Rakesh Kumar ◽  
Gursharan Singh
Keyword(s):  
Biological Activity ◽  
Transition Metals ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Inert Atmosphere ◽  
Biologically Active ◽  
Vacuum Line ◽  
Characterization Studies ◽  
Hydrolysis Of

It has been reported that molybdenum may extract oxygen from oxygen containing ligands. Oxo complexes of above bases with transition metals show numerous applications and are biologically active. So to study the biological activity of molybdenum complexes and to study oxo abstraction reactions by molybdenum, reactions of succinimide/1, 4-diaminobutane/3-methylpyridine/1, 3-diaminopropane/pyrazole/1-methylpyrrolidine with MoCl5/MoO2Cl2 have been carried out, in THF medium using equimolar/bimolar quantities of the ligand, at normal temperature. The products thus obtained are: Mo2O3Cl5(C4H5NO2)2(C4H8O)2, [1]; Mo2O2Cl2(C4H5NO2)2(C4H8O)2, [2]; MoO2Cl2(H2NCH2CH2CH2CH2NH2)2, [3]; Mo3Cl8(C6H7N)4(C4H8O)2, [4]; Mo3Cl6(C6H7N)6(C4H8O)6, [5]; MoO2Cl3(H2NCH2CH2CH2NH2)2, [6]; Mo2O4Cl4(C3H4N2)4, [7] and Mo2O6Cl8(C5H11N)4, [8]. There is oxygen abstraction by molybdenum during the reaction from the oxygen containing solvent THF. Formulations of these compounds were made and their properties were studied with FTIR(transmission mode), 1H NMR/13C NMR, microbiological studies, elemental analysis(Mo, Cl, C, H, N) and LC-MS. All preparations, separations and isolations were executed in vacuum line and inert atmosphere (dry nitrogen) to eliminate any oxidation/hydrolysis of products by air/moisture. The formulations proposed have been supported by the above characterization studies.

Solvent-Free Green Synthesis of 4-amino-5-substituted-1,2,4-triazole-3-thione by Grinding

2015 ◽  
Vol 1088 ◽  
pp. 367-370
Author(s):  
Yu Ting Liu ◽  
Si Meng Song ◽  
Da Wei Yin
Keyword(s):  
Melting Point ◽  
Green Synthesis ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Efficient Method ◽  
Cost Effective ◽  
Phosphorus Pentachloride ◽  
Synthetic Method ◽  
Melting Point Determination ◽  
Point Determination

A novel efficient method for the synthesis of 4-amino-5- substituted-1,2,4- triazole -3-thione was developed in which substituted aromatic/aliphatic acids with symmetrical dithiocarbohydrazones were used as starting materials and phosphorus pentachloride was used as catalyst.The structures of these products were confirmed by melting point determination, IR, 1H NMR and elemental analysis. This is a novel and cost-effective synthetic method. In addition, the synthetic method avoids the use of organic solvents and significantly improves reaction yields.

Synthesis, Characterization and Thermal studies of Novel Organomercury Driven from Sulfa Drugs Part 1

2011 ◽  
Vol 7 (2) ◽  
pp. 1338-1347
Author(s):  
Tarek Ali Fahad ◽  
Shaker.A.N. AL-Jadaan
Keyword(s):  
Thermal Decomposition ◽  
Thermal Behavior ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Thermal Studies ◽  
Spectroscopic Techniques ◽  
Sulfa Drugs ◽  
Acid Base ◽  
Ph Values ◽  
Multi Stage

Two new heterocyclic Organmercury compounds   were prepared from the reaction of Sulfamethaxazole and Sulfadiazine with 4-acetaminophenol as a coupler and separated as solids with characteristic colors. these compounds were characterized by F.T.IR-spectroscopy 1H-NMR , Micro-elemental Analysis and UV-Vis spectroscopic techniques . The work involves a study of acid – base properties compounds at different pH values, the ionization and protonation constants were calculated. The thermal behavior of these two compounds   were investigated on the basis of thermogravimetric (TGA) and differential thermogravimetric (DTG) analyses, Thermal decomposition of these compounds is multi-stage processes.

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