Iranian herbal medicines against hydatid cyst protoscoleces: A Systematic Review

2020 ◽  
Vol 20 ◽  
Author(s):  
Iraj Salimikia ◽  
Marzieh Hakami ◽  
Mohammad Kazem Shahmoradi
Keyword(s):  
Systematic Review ◽  
Hydatid Cyst ◽  
Web Of Science ◽  
Human Subjects ◽  
Herbal Medicines ◽  
Methanolic Extracts ◽  
Oil Plant ◽  
Present Systematic Review

Background: In recent years, more attention has been focused in the practice of both crude extract of medicinal plants, and the screening plant-derived compounds as substitute scolicidal agents during hydatid cyst surgery. The present study was designed to review the protoscolicidal effects of some Iranian herbal medicines against hydatid cyst protoscoleces. Methods: English databases, including PubMed, Google Scholar, Web of Science, EBSCO, Science Direct, and Scopus were searched for publications worldwide related to protoscolicidal effects of Iranian herbal medicines without date limitation so that identify all published articles (in vitro, in vivo, clinical and case-control) have studied. Keywords included “Protoscolicidal”, “Scolicidal”, “Herbal medicines”, “Extract”, “Essential oil”, “Plant”, “In vitro”, and “Iran”. Moreover, the language of data collection was limited to English. Results: In total, 40 papers up to 2020 were included in the present systematic review. The most studies were conducted on protoscolicidal activity of methanolic extracts (17 studies) followed by essential oils (15 studies), and aqueous extract (3 studies). The most commonly used part of herbs were leaves (21 herbs), seeds (8 herbs), and fruit (6 herbs), respectively. Moreover, the most prevalent herbal family was Lamiaceae (6 studies), followed by Apiaceae (5 studies) and Liliaceae (5 studies). Conclusion: Considering the high efficacy of Iranian herbal medicines against hydatid cyst protoscoleces, it can be concluded that Iranian herbal medicines have ability to consider as new alternative protoscolicidal agents during hydatid cyst surgery; however, more clinical studies are required to discover the precise protoscolicida activity of Iranian medicines in animal and human subjects.

The efficacy of herbal medicines against Toxoplasma gondii during the last 3 decades: a systematic review

2016 ◽  
Vol 94 (12) ◽  
pp. 1237-1248 ◽  
Author(s):  
Mahdi Sharif ◽  
Shahabeddin Sarvi ◽  
Abdol Sattar Pagheh ◽  
Shabnam Asfaram ◽  
Mohammad Taghi Rahimi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Toxoplasma Gondii ◽  
Web Of Science ◽  
Artemisia Annua ◽  
Herbal Medicines ◽  
Therapeutic Agents ◽  
Lower Side ◽  
Current Systematic Review

The objective of the current study was to systematically review papers discussing the efficacy of medicinal herbs against Toxoplasma gondii. Data were systematically collected from published papers about the efficacy of herbs used against T. gondii globally from 1988 to 2015, from PubMed, Google Scholar, ISI Web of Science, EBSCO, Science Direct, and Scopus. Forty-nine papers were included in the current systematic review reporting the evaluation of medicinal plants against T. gondii globally, both in vitro and in vivo. Sixty-one plants were evaluated. Most of the studies were carried out on Artemisia annua. The second highest number of studies were carried out on Glycyrrhiza glabra extracts. RH and ME49 were the predominant parasite strains used. Additionally, Swiss-Webster and BALB/c mice were the major animal models used. Alcoholic and aqueous extracts were used more than other types of extracts. Natural compounds mentioned here may be developed as novel and more effective therapeutic agents that improve the treatment of toxoplasmosis due to their lower side effects, higher availability, and better cultural acceptance compared with those of the chemical drugs that are currently being used.

scholarly journals Glycemic Index of Gluten-Free Bread and Their Main Ingredients: A Systematic Review and Meta-Analysis

Foods ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 506
Author(s):  
Bernardo Romão ◽  
Ana Luísa Falcomer ◽  
Gabriela Palos ◽  
Sandra Cavalcante ◽  
Raquel Braz Assunção Botelho ◽  
...  
Keyword(s):  
Systematic Review ◽  
Glycemic Index ◽  
Resistant Starch ◽  
Web Of Science ◽  
Meta Analysis ◽  
Gluten Free ◽  
Inclusion Criteria ◽  
Glycemic Profile

This study aimed to perform a systematic review and meta-analysis of the glycemic index (GI) of gluten-free bread (GFB) and its main ingredients. The systematic review followed PRISMA guidelines, using seven electronic databases (PubMed, EMBASE, Scopus, Science Direct, Web of Science, gray literature research with Google Scholar, and patents with Google Patent tool), from inception to November 2020. Eighteen studies met the inclusion criteria evaluating 132 GFB samples. Five articles tested GI in vivo, eleven in vitro; and two studies tested both methods. The analysis showed that 60.7% (95% CI: 40.2–78.1%) of the samples presented high glycemic indexes, evidencing a high glycemic profile for GFB. Only 18.2% (95% CI: 11.7–27.2%) of the bread samples presented in the studies were classified as a low GI. Meta-analysis presented moderate/low heterogenicity between studies (I2 = 61% and <1% for both high and low GIs) and reinforced the proportion of high GIs. Lower GIs were found in formulations based on Colocasia esculenta flour or enriched with fiber, yogurt and curd cheese, sourdough, psyllium, hydrocolloids, enzymes, fructans, and resistant starch, highlighting the efficacy of these ingredients to lower GFBs’ GI. GFB tends to present high GI, impacting the development of chronic diseases when consumed.

scholarly journals Screening of Chloroform and Methanolic Bark Extracts of Commiphora caudata for its In-vitro Anti-bacterial, Anti-fungal and In-vivo Anti-inflammatory Activity

2021 ◽  
Vol 12 (4) ◽  
pp. 853-857
Author(s):  
Raju H V ◽  
Kishori P Sutar ◽  
Prasanna S Sutar ◽  
Shailendra S Suryawanshi ◽  
Nisha S Shirkoli
Keyword(s):  
Research Work ◽  
Extraction Procedure ◽  
Herbal Medicines ◽  
Developed Countries ◽  
Inflammatory Activity ◽  
Methanolic Extracts ◽  
Anti Inflammatory ◽  
Bacteria And Fungi

Herbal medicines and their preparations have been widely used from the thousands of years in developing and developed countries in the primary health care of society and community. They have great demand due its safety, efficacy with minimum side or adverse effects. Commiphora caudata. It’s known as konda mava in kannada, ikkata in Sanskrit and hill mango in English. It’s widely used in the management of various disorders. Hence the identification of bioactive fractions from various parts of selected medicinal plant is important. In the present research work an attempt has been made to screen and assess the antibacterial, antifungal and anti-inflammatory activities of Commiphora caudata barks. The barks of selected plant material were collected, authenticated, powdered and subjected for extraction procedure. The extracts were screened for presence of various phytoconstituents. The antibacterial activity of chloroform and methanolic extracts were performed against various strains of bacteria and fungi. The extracts also were investigated for its in-vivo anti-inflammatory activity. The result of investigation concludes that chloroform and methanolic extract of plant were potential to inhibit the growth of selected strains of microorganism and also produced potential anti-inflammatory effect.

Anti Diabetic Evaluation of Methanolic Extract of Psoralea Corylifolia L. & Psoralea Esculenta L. Seeds in Streptozotocin Induced Diabetic Rats and Histopathological Changes in Diabetic Rats Pancreas: Comparative Study

2020 ◽  
Vol 10 ◽  
Author(s):  
Karuna S. Shukla ◽  
Neeraj Singh ◽  
Bipin Bihari ◽  
Akash Ved ◽  
Girendra Kumar Gautam
Keyword(s):  
Diabetes Mellitus ◽  
Methanolic Extract ◽  
Dominant Role ◽  
Herbal Medicines ◽  
Diabetic Rats ◽  
In Vivo Model ◽  
Psoralea Corylifolia ◽  
Methanolic Extracts

Background: Diabetes mellitus is a class of metabolic disorder which results high level of sugar due to inadequacy in insulin secretion. High Sugar level in diabetes is linked with the impairment and dysfunction of eyes, kidneys, blood vessels, nerves and heart. In current research there is extended interest in herbal medicines because of the side effects noticed with oral hypoglycemic for therapy of hyperglycemia. Herbal medicines could play a dominant role in the control of diabetes mellitus. Methods: Methanolic extracts of seeds of Psoralea corylifolia L & Psoralea esculenta L has been screened for both in-vitro and in-vivo antihyperglycemic role using streptozotocin induced diabetic rats. The methanolic extract of both plants were evaluated for pancreatic tissue studies. Results: According to the outcomes, a stunning blood glucose level decrement was observed in the diabetic groups treated by methanolic extracts of Psoralea corylifolia L. seeds. Conclusion: In this study, the methanolic extract of Psoralea corylifolia L. seeds used to evaluate antihyperglycemic potential showed appreciably notable and astonishing results, when compared with the Glibenclamide. Methanolic extract of Psoralea corylifolia L. seeds have potential to regulate hyperglycemia in the In-vivo model. Hence Psoralea corylifolia L. methanolic seeds extract may be selected for its antihyperglycemic activity.

The Effectiveness of Nanoparticles on Gene Therapy for Glioblastoma Cells Apoptosis: A Systematic Review

2021 ◽  
Vol 21 ◽  
Author(s):  
Firoozeh Alavian ◽  
Sorayya Ghasemi
Keyword(s):  
Systematic Review ◽  
Gene Therapy ◽  
Data Extraction ◽  
Gene Therapies ◽  
Gene Therapy Approach ◽  
Therapy Studies ◽  
Present Systematic Review

Background: Glioblastoma multiforme (GBM) is the most common and fatal type of glioma. Nanoparticles (NPs) are using new approaches for the delivery of gene therapy in the treatment of GBM. Introduction: This article was designed to review the efficacy of NPs as the targeted carriers in the gene therapy aimed at apoptosis in GBM. Method: The appropriate keywords such as nanoparticle, glioblastoma, gene therapy, apoptosis, and the related words were used to search from PubMed, ISI Web of Science, and Scopus for relevant publications up to September 4, 2020, with no language restrictions. The present systematic review was performed based on PRISMA protocol and reviewed the articles evaluating the effects of nanoparticles, carriers of various gene therapies essentials, on GBM cells apoptosis in vitro and in vivo. The selected articles were considered using specific scores on the quality of the articles. Data extraction and quality valuation were performed by two reviewers. Result: Of 101 articles retrieved, forty-two met the inclusion criteria and were, therefore, subjected to the final deduction. The most widely used NP in GBM gene therapy studies is polyamidoamine (PAMAM). The most common gene therapy approach for apoptosis in GBM is using siRNAs. Conclusions: In conclusion, these studies validated that NPs could be a practical choices to enhance the efficiency and specific delivery in gene therapies for GBM cell apoptosis. However, the choice of NP type and gene therapy mechanism affect the GBM cell apoptotic efficiency.

scholarly journals BIOACTIVITIES OF GUETTARDA SPECIOSA L. EXTRACTS

2020 ◽  
Vol 5 (1) ◽  
pp. 20-22
Author(s):  
Saravanan Vivekanandarajah Sathasivampillai ◽  
Moon Jain ◽  
Pholtan Rajeev Sebastian Rajamanoharan
Keyword(s):  
Systematic Review ◽  
Plant Species ◽  
Web Of Science ◽  
Antioxidant Activities ◽  
Bioactive Compound ◽  
Scientific Data ◽  
Anti Inflammatory

Guettarda speciosa L. is a tree of the Rubiaceae family. G. specious has been used to treat diarrhea, abscesses, wounds, epilepsy, and malaria in ethnomedicinal systems. So far, there is no systematic review for the bioactivities of G. speciosa. Therefore, the purpose of this minireview is to analyze, summarize and document the reported bioactivities of G. speciosa. Major electronic databases (Web of Science, Scopus, ScienceDirect, PubMed, and Semantic Scholar) were used to identify related studies from 1900 to January 2021. So far, in vivo and in vitro scientific data are available for the bioactivities of this plant species. Studies have reported that G. speciosa contains antidiarrheal, antiepileptic, anti-inflammatory, anti-ulcer, antimalarial, antineurodegenerative, and antioxidant activities. Furthermore, no bioactive compound of G. speciosa has been isolated. This work will be useful for researchers interested in bioactivity and phytochemical researches.

Anti-Trichophyton Effects of Curcumin: A Systematic Review

2021 ◽  
Vol 19 ◽  
Author(s):  
Pegah Shakib ◽  
Ali Safar Maken Ali ◽  
Ehsan Javanmard ◽  
Omid Mardanshah ◽  
Mohammad Ali Mohaghegh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Fungal Infections ◽  
Good Alternative ◽  
Potent Effect ◽  
Antifungal Effects ◽  
Review Study ◽  
Different Strains

Introduction: Today we see advances in the use of medicinal plants in the treatment of fungal infections. Curcumin has major antimicrobial, antifungal, antimutagenic, and anticancer activity. This systematic review study is designed to evaluate the effectiveness of curcuminon a dermatophyte fungus, Trichophyton spp. Methods: In this study, antifungal effects of curcumin on the different strains of Trichophytonwereevaluated. For this reason, several databases, including PubMed, Scopus, Web of Science, Embase and Google Scholar were searched systematically in years from1995 to 2020. Only articles with at least English abstracts were evaluated. The syntax was constructed with the combination of some key words along with specific tags used for each of the databases. Results: In this systematic review, studies showed that curcumin has a potent effect on the inhibition of Trichophyton growth. Of the 2,500 studies in the search step, only 11articleswere eligible for survey, 6 of which were on T.rubrum, 3 on T. mentagrophytes, 1 on both T. mentagrophyte and T. rubrum, and 1 on T. longifusus. Conclusion: Today, due to an increase in drug resistance to antifungal agents, plant extracts can be a good alternative in controlling fungal diseases. Curcumin and its compounds are effective in inhibiting or reducing Trichophyton infections in vitro and in vivo.

scholarly journals Curcumin as a Therapeutic Agent in Dementia: A Mini Systematic Review of Human Studies

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Natascia Brondino ◽  
Simona Re ◽  
Annalisa Boldrini ◽  
Antonella Cuccomarino ◽  
Niccolò Lanati ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Therapeutic Agent ◽  
Short Term ◽  
Dementia Patients ◽  
Indian Medicine ◽  
Present Systematic Review ◽  
Potential Use

Dementia is a leading health problem worldwide, with Alzheimer’s disease (AD) representing up to 60% of all dementia cases. A growing interest has recently risen on the potential use of natural molecules in this condition. Curcumin is a polyphenolic compound traditionally used in Indian medicine. Severalin vitroandin vivostudies have found a protective effect of curcumin in AD. In the present systematic review we aimed to evaluate the state-of-the-art of clinical trials of curcumin in AD. We retrieved three published studies, while there are several ongoing clinical trials. To date there is insufficient evidence to suggest the use of curcumin in dementia patients. Of note, short-term use of curcumin appears to be safe. Several reasons could be responsible for the discrepancy betweenin vitroandin vivofindings and human trials, such as low bioavailability and poor study design.

scholarly journals Comparison of the biocompatibility of calcium silicate-based materials to mineral trioxide aggregate: Systematic review

2018 ◽  
Vol 12 (02) ◽  
pp. 317-326 ◽  
Author(s):  
Natália Gomes de Oliveira ◽  
Pollyana Rodrigues de Souza Araújo ◽  
Marina Torreão da Silveira ◽  
Ana Paula Veras Sobral ◽  
Marianne de Vasconcelos Carvalho
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Mineral Trioxide Aggregate ◽  
Biological Properties ◽  
Exclusion Criteria ◽  
Pulp Inflammation ◽  
Prisma Statement ◽  
Low Cytotoxicity

ABSTRACTThe objective of this systematic review was to evaluate the biocompatibility and interaction of bioceramic materials with animal and human mesenchymal cells in vitro and in vivo and to compare them with mineral trioxide aggregate (MTA). Two independent researchers conducted PubMed/Medline, Web of Science, and Scopus searches to identify studies published in English, without restrictions on year of publication using the following keywords: “root canal sealer,” “root repair material,” “cytotoxicity,” and “bioceramics.” The articles were selected following the PRISMA statement. A total of 1486 titles were identified in the initial search. However, only 18 studies met the inclusion and exclusion criteria. The results showed that bioceramic materials have biological properties similar to those of MTA, including low cytotoxicity as well as promoting cell proliferation and adhesion, low expression of inflammatory cytokines, and reduced pulp inflammation. This systematic review therefore suggests that the choice of repair bioceramic materials or MTA based on biocompatibility should be the professional's decision.

The High Potential of Ozone Gas to Inactivate Echinococcus granulosus Protoscoleces During Hydatid Cyst Surgery

2020 ◽  
Vol 20 (5) ◽  
pp. 708-712
Author(s):  
Hossein Mahmoudvand ◽  
Majid Fasihi Harandi ◽  
Massumeh Niazi ◽  
Abdolreza Rouientan ◽  
Fazel Mohammadi-Moghadam ◽  
...  
Keyword(s):  
Hydatid Cyst ◽  
Ex Vivo ◽  
Human Subjects ◽  
Oral Bacteria ◽  
Vitro Assay ◽  
Low Concentrations ◽  
Wide Range ◽  
Resistant Strains

Background: In medicine, ozone therapy is effectively used in a broad spectrum of diseases. Reviews have shown that ozone gas demonstrates potent antimicrobial effects against a wide range of pathogenic microorganisms, such as oral bacteria, fungi, viruses, and parasite even in resistant strains. The present investigation was designed to assess the protoscolicidal effects of ozone gas on hydatid cysts protoscoleces in vitro and in vivo. Methods: Hydatid cyst protoscoleces were acquired from sheep livers that were slaughtered at Kerman slaughterhouse, Iran. The viability of protoscoleces was assessed by the eosin exclusion examination after exposure with ozone gas for 1 to 14 min in vitro and ex vivo. Results: In this study, in vitro assay showed that ozone gas at the concentration of 20 mg/L killed 85 and 100% of hydatid cyst protoscoleces after 4 and 6 min of treatment, respectively. However, in the ex vivo analysis, a longer time was needed to confirm a potent protoscolicidal activity such that ozone gas after an exposure time of 12 min, 100% of the protoscoleces were killed within the hydatid cyst. Conclusion: : In conclusion, the findings of the present study showed that ozone gas at low concentrations (20 mg/L) and short times (4-6 min) might be used as a novel protoscolicidal drug for use in hydatid cyst surgery. However, more clinical surveys are required to discover the precise biological activity of ozone gas in animal and human subjects.

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