The efficacy of herbal medicines against Toxoplasma gondii during the last 3 decades: a systematic review

2016 ◽  
Vol 94 (12) ◽  
pp. 1237-1248 ◽  
Author(s):  
Mahdi Sharif ◽  
Shahabeddin Sarvi ◽  
Abdol Sattar Pagheh ◽  
Shabnam Asfaram ◽  
Mohammad Taghi Rahimi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Toxoplasma Gondii ◽  
Web Of Science ◽  
Artemisia Annua ◽  
Herbal Medicines ◽  
Therapeutic Agents ◽  
Lower Side ◽  
Current Systematic Review

The objective of the current study was to systematically review papers discussing the efficacy of medicinal herbs against Toxoplasma gondii. Data were systematically collected from published papers about the efficacy of herbs used against T. gondii globally from 1988 to 2015, from PubMed, Google Scholar, ISI Web of Science, EBSCO, Science Direct, and Scopus. Forty-nine papers were included in the current systematic review reporting the evaluation of medicinal plants against T. gondii globally, both in vitro and in vivo. Sixty-one plants were evaluated. Most of the studies were carried out on Artemisia annua. The second highest number of studies were carried out on Glycyrrhiza glabra extracts. RH and ME49 were the predominant parasite strains used. Additionally, Swiss-Webster and BALB/c mice were the major animal models used. Alcoholic and aqueous extracts were used more than other types of extracts. Natural compounds mentioned here may be developed as novel and more effective therapeutic agents that improve the treatment of toxoplasmosis due to their lower side effects, higher availability, and better cultural acceptance compared with those of the chemical drugs that are currently being used.

Iranian herbal medicines against hydatid cyst protoscoleces: A Systematic Review

2020 ◽  
Vol 20 ◽  
Author(s):  
Iraj Salimikia ◽  
Marzieh Hakami ◽  
Mohammad Kazem Shahmoradi
Keyword(s):  
Systematic Review ◽  
Hydatid Cyst ◽  
Web Of Science ◽  
Human Subjects ◽  
Herbal Medicines ◽  
Methanolic Extracts ◽  
Oil Plant ◽  
Present Systematic Review

Background: In recent years, more attention has been focused in the practice of both crude extract of medicinal plants, and the screening plant-derived compounds as substitute scolicidal agents during hydatid cyst surgery. The present study was designed to review the protoscolicidal effects of some Iranian herbal medicines against hydatid cyst protoscoleces. Methods: English databases, including PubMed, Google Scholar, Web of Science, EBSCO, Science Direct, and Scopus were searched for publications worldwide related to protoscolicidal effects of Iranian herbal medicines without date limitation so that identify all published articles (in vitro, in vivo, clinical and case-control) have studied. Keywords included “Protoscolicidal”, “Scolicidal”, “Herbal medicines”, “Extract”, “Essential oil”, “Plant”, “In vitro”, and “Iran”. Moreover, the language of data collection was limited to English. Results: In total, 40 papers up to 2020 were included in the present systematic review. The most studies were conducted on protoscolicidal activity of methanolic extracts (17 studies) followed by essential oils (15 studies), and aqueous extract (3 studies). The most commonly used part of herbs were leaves (21 herbs), seeds (8 herbs), and fruit (6 herbs), respectively. Moreover, the most prevalent herbal family was Lamiaceae (6 studies), followed by Apiaceae (5 studies) and Liliaceae (5 studies). Conclusion: Considering the high efficacy of Iranian herbal medicines against hydatid cyst protoscoleces, it can be concluded that Iranian herbal medicines have ability to consider as new alternative protoscolicidal agents during hydatid cyst surgery; however, more clinical studies are required to discover the precise protoscolicida activity of Iranian medicines in animal and human subjects.

scholarly journals Glycemic Index of Gluten-Free Bread and Their Main Ingredients: A Systematic Review and Meta-Analysis

Foods ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 506
Author(s):  
Bernardo Romão ◽  
Ana Luísa Falcomer ◽  
Gabriela Palos ◽  
Sandra Cavalcante ◽  
Raquel Braz Assunção Botelho ◽  
...  
Keyword(s):  
Systematic Review ◽  
Glycemic Index ◽  
Resistant Starch ◽  
Web Of Science ◽  
Meta Analysis ◽  
Gluten Free ◽  
Inclusion Criteria ◽  
Glycemic Profile

This study aimed to perform a systematic review and meta-analysis of the glycemic index (GI) of gluten-free bread (GFB) and its main ingredients. The systematic review followed PRISMA guidelines, using seven electronic databases (PubMed, EMBASE, Scopus, Science Direct, Web of Science, gray literature research with Google Scholar, and patents with Google Patent tool), from inception to November 2020. Eighteen studies met the inclusion criteria evaluating 132 GFB samples. Five articles tested GI in vivo, eleven in vitro; and two studies tested both methods. The analysis showed that 60.7% (95% CI: 40.2–78.1%) of the samples presented high glycemic indexes, evidencing a high glycemic profile for GFB. Only 18.2% (95% CI: 11.7–27.2%) of the bread samples presented in the studies were classified as a low GI. Meta-analysis presented moderate/low heterogenicity between studies (I2 = 61% and <1% for both high and low GIs) and reinforced the proportion of high GIs. Lower GIs were found in formulations based on Colocasia esculenta flour or enriched with fiber, yogurt and curd cheese, sourdough, psyllium, hydrocolloids, enzymes, fructans, and resistant starch, highlighting the efficacy of these ingredients to lower GFBs’ GI. GFB tends to present high GI, impacting the development of chronic diseases when consumed.

scholarly journals Toxoplasma gondii: Effects of Artemisia annua L. on susceptibility to infection in experimental models in vitro and in vivo

2009 ◽  
Vol 122 (3) ◽  
pp. 233-241 ◽  
Author(s):  
Taísa Carrijo de Oliveira ◽  
Deise A. Oliveira Silva ◽  
Cristina Rostkowska ◽  
Samantha Ribeiro Béla ◽  
Eloisa A.V. Ferro ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Artemisia Annua ◽  
Experimental Models ◽  
Susceptibility To Infection ◽  
Artemisia Annua L

scholarly journals Are herbal drugs effective in COVID management? A review to demystify the current facts and claims

2020 ◽  
Author(s):  
Mohd Riyaz Beg ◽  
Barira Siddiqui ◽  
Pramod Waghmare ◽  
Shital Ghodinde ◽  
Snehal Bikkad
Keyword(s):  
Artemisia Annua ◽  
Scientific Evidence ◽  
Antiviral Drug ◽  
Herbal Medicines ◽  
Structural Diversity ◽  
Viral Disease ◽  
Fast Pace ◽  
New Research

Amid the SARS‐CoV‐2 pandemic, herbal medicines have received much attention in its evidence-based therapeutics. Scientists across the globe are integrating new research at an unprecedented fast pace for the discovery of novel molecules against this deadly viral disease. Ever since ancient times, phytochemicals have long been used traditionally for the cure of many viral diseases and lately many are being tested for their potential against the viral replications/transcriptions. The unmatched structural diversity of phytoconstituents may prove to be a gold mine for antiviral drug discovery. Many plants like Heteromorpha spp ., Bupleurum spp , Scrophularia scorodonia , Artemisia annua , Pyrrosia lingua , Lycoris radiate , and Lindera agregata have also been reported to have antiviral potential against SARS-CoV. Recently many synthetic molecules like remdesivir, tocilizumab, favipirapir, dexamethasone, glucocorticoid, and hydroxychloroquine etc. have been extensively investigated for their potential against the SARS‐CoV‐2, likewise, various plant-based molecules such as scutellarein, silvestrol, tryptanthrin, saikosaponin B2, quercetin, myricetin, caffeic acid, psoralidin, isobavachalcone, and lectins-griffiths in were also found to be equally effective. Needless to mention that, the herbal medicines are a valuable and powerful source of chemical compounds which need further chemical modifications and appropriate in-vitro and in-vivo testings for establishing their safety and efficacy as potential drugs against the battle with coronavirus pandemic. In this review, we will try to highlight the potential phytochemicals candidates with their possible molecular targets against the SARS‐CoV‐2and demystify the myths behind the purported remedies such as herbal therapies, teas, essential oils, tinctures, and silver products such as colloidal silver that have no scientific evidence to prevent or cure COVID-19. Apart from that, this review will also de-fabricate the surgency of objectionable claims that are continuously reckoning towards the treatment of COVID-19 with hundred per cent surety and are propagated by several herbal firms.

scholarly journals BIOACTIVITIES OF GUETTARDA SPECIOSA L. EXTRACTS

2020 ◽  
Vol 5 (1) ◽  
pp. 20-22
Author(s):  
Saravanan Vivekanandarajah Sathasivampillai ◽  
Moon Jain ◽  
Pholtan Rajeev Sebastian Rajamanoharan
Keyword(s):  
Systematic Review ◽  
Plant Species ◽  
Web Of Science ◽  
Antioxidant Activities ◽  
Bioactive Compound ◽  
Scientific Data ◽  
Anti Inflammatory

Guettarda speciosa L. is a tree of the Rubiaceae family. G. specious has been used to treat diarrhea, abscesses, wounds, epilepsy, and malaria in ethnomedicinal systems. So far, there is no systematic review for the bioactivities of G. speciosa. Therefore, the purpose of this minireview is to analyze, summarize and document the reported bioactivities of G. speciosa. Major electronic databases (Web of Science, Scopus, ScienceDirect, PubMed, and Semantic Scholar) were used to identify related studies from 1900 to January 2021. So far, in vivo and in vitro scientific data are available for the bioactivities of this plant species. Studies have reported that G. speciosa contains antidiarrheal, antiepileptic, anti-inflammatory, anti-ulcer, antimalarial, antineurodegenerative, and antioxidant activities. Furthermore, no bioactive compound of G. speciosa has been isolated. This work will be useful for researchers interested in bioactivity and phytochemical researches.

Anti-Trichophyton Effects of Curcumin: A Systematic Review

2021 ◽  
Vol 19 ◽  
Author(s):  
Pegah Shakib ◽  
Ali Safar Maken Ali ◽  
Ehsan Javanmard ◽  
Omid Mardanshah ◽  
Mohammad Ali Mohaghegh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Fungal Infections ◽  
Good Alternative ◽  
Potent Effect ◽  
Antifungal Effects ◽  
Review Study ◽  
Different Strains

Introduction: Today we see advances in the use of medicinal plants in the treatment of fungal infections. Curcumin has major antimicrobial, antifungal, antimutagenic, and anticancer activity. This systematic review study is designed to evaluate the effectiveness of curcuminon a dermatophyte fungus, Trichophyton spp. Methods: In this study, antifungal effects of curcumin on the different strains of Trichophytonwereevaluated. For this reason, several databases, including PubMed, Scopus, Web of Science, Embase and Google Scholar were searched systematically in years from1995 to 2020. Only articles with at least English abstracts were evaluated. The syntax was constructed with the combination of some key words along with specific tags used for each of the databases. Results: In this systematic review, studies showed that curcumin has a potent effect on the inhibition of Trichophyton growth. Of the 2,500 studies in the search step, only 11articleswere eligible for survey, 6 of which were on T.rubrum, 3 on T. mentagrophytes, 1 on both T. mentagrophyte and T. rubrum, and 1 on T. longifusus. Conclusion: Today, due to an increase in drug resistance to antifungal agents, plant extracts can be a good alternative in controlling fungal diseases. Curcumin and its compounds are effective in inhibiting or reducing Trichophyton infections in vitro and in vivo.

scholarly journals Comparison of the biocompatibility of calcium silicate-based materials to mineral trioxide aggregate: Systematic review

2018 ◽  
Vol 12 (02) ◽  
pp. 317-326 ◽  
Author(s):  
Natália Gomes de Oliveira ◽  
Pollyana Rodrigues de Souza Araújo ◽  
Marina Torreão da Silveira ◽  
Ana Paula Veras Sobral ◽  
Marianne de Vasconcelos Carvalho
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Mineral Trioxide Aggregate ◽  
Biological Properties ◽  
Exclusion Criteria ◽  
Pulp Inflammation ◽  
Prisma Statement ◽  
Low Cytotoxicity

ABSTRACTThe objective of this systematic review was to evaluate the biocompatibility and interaction of bioceramic materials with animal and human mesenchymal cells in vitro and in vivo and to compare them with mineral trioxide aggregate (MTA). Two independent researchers conducted PubMed/Medline, Web of Science, and Scopus searches to identify studies published in English, without restrictions on year of publication using the following keywords: “root canal sealer,” “root repair material,” “cytotoxicity,” and “bioceramics.” The articles were selected following the PRISMA statement. A total of 1486 titles were identified in the initial search. However, only 18 studies met the inclusion and exclusion criteria. The results showed that bioceramic materials have biological properties similar to those of MTA, including low cytotoxicity as well as promoting cell proliferation and adhesion, low expression of inflammatory cytokines, and reduced pulp inflammation. This systematic review therefore suggests that the choice of repair bioceramic materials or MTA based on biocompatibility should be the professional's decision.

scholarly journals Antibiotic Resistance of Legionella pneumophila in Clinical and Water Isolates—A Systematic Review

2020 ◽  
Vol 17 (16) ◽  
pp. 5809
Author(s):  
Olga Pappa ◽  
Dimosthenis Chochlakis ◽  
Vassilios Sandalakis ◽  
Chrysa Dioli ◽  
Anna Psaroulaki ◽  
...  
Keyword(s):  
Systematic Review ◽  
Legionella Pneumophila ◽  
Test Method ◽  
Resistance Testing ◽  
Interpretation Criteria ◽  
Current Systematic Review ◽  
Agar Dilution ◽  
Validity Criteria

The current systematic review investigates the antibiotic susceptibility pattern of Legionella pneumophila isolates from the 1980s to the present day, deriving data from clinical and/or water samples from studies carried out all over the world. Eighty-nine papers meeting the inclusion criteria, i.e., “Legionella pneumophila” and “resistance to antibiotics”, were evaluated according to pre-defined validity criteria. Sixty articles referred to clinical isolates, and 18 articles reported water-related L. pneumophila isolates, while 11 articles included both clinical and water isolates. Several methods have been proposed as suitable for the determination of MICs, such as the E-test, broth and agar dilution, and disk diffusion methods, in vivo and in vitro, using various media. The E-test method proposed by the European Society of Clinical Microbiology and Infectious Diseases (EUCAST) seems to be the second most frequently used method overall, but it is the preferred method in the most recent publications (2000–2019) for the interpretation criteria. Erythromycin has been proved to be the preference for resistance testing over the years. However, in the last 19 years, the antibiotics ciprofloxacin (CIP), erythromycin (ERM), levofloxacin (LEV) and azithromycin (AZM) were the ones that saw an increase in their use. A decrease in the sensitivity to antibiotics was identified in approximately half of the reviewed articles.

scholarly journals Secretome and Extracellular Vesicles as New Biological Therapies for Knee Osteoarthritis: A Systematic Review

2019 ◽  
Vol 8 (11) ◽  
pp. 1867 ◽  
Author(s):  
Daniele D’Arrigo ◽  
Alice Roffi ◽  
Magali Cucchiarini ◽  
Matteo Moretti ◽  
Christian Candrian ◽  
...  
Keyword(s):  
Systematic Review ◽  
Knee Osteoarthritis ◽  
Extracellular Vesicles ◽  
Web Of Science ◽  
Knee Oa ◽  
Positive Effects ◽  
Biological Approach ◽  
Synovial Tissues

Secretome and extracellular vesicles (EVs) are considered a promising option to exploit mesenchymal stem cells’ (MSCs) properties to address knee osteoarthritis (OA). The aim of this systematic review was to analyze both the in vitro and in vivo literature, in order to understand the potential of secretome and EVs as a minimally invasive injective biological approach. A systematic review of the literature was performed on PubMed, Embase, and Web of Science databases up to 31 August 2019. Twenty studies were analyzed; nine in vitro, nine in vitro and in vivo, and two in vivo. The analysis showed an increasing interest in this emerging field, with overall positive findings. Promising in vitro results were documented in terms of enhanced cell proliferation, reduction of inflammation, and down-regulation of catabolic pathways while promoting anabolic processes. The positive in vitro findings were confirmed in vivo, with studies showing positive effects on cartilage, subchondral bone, and synovial tissues in both OA and osteochondral models. However, several aspects remain to be clarified, such as the different effects induced by EVs and secretome, which is the most suitable cell source and production protocol, and the identification of patients who may benefit more from this new biological approach for knee OA treatment.

scholarly journals Denture Liners: A Systematic Review Relative to Adhesion and Mechanical Properties

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Simone Kreve ◽  
Andréa C. Dos Reis
Keyword(s):  
Systematic Review ◽  
Antimicrobial Agents ◽  
Web Of Science ◽  
Inclusion Criteria ◽  
Denture Base ◽  
Cochrane Database ◽  
Disinfection Process ◽  
Denture Liners

Purpose. The objective of this systematic review is to compare results concerning the properties of adhesion, roughness, and hardness of dental liners obtained in the last ten years. Methods. Searches on the databases LILACS, PubMed/Medline, Web of Science, and Cochrane Database of Systematic Reviews were supplemented with manual searches conducted between February and April of 2018. The inclusion criteria included experimental in vitro and in vivo, clinical, and laboratory studies on resilient and/or hard liners, assessment of hardness, roughness, and/or adhesion to the denture base, and physical/mechanical changes resulting from the disinfection process and changes in liners’ composition or application. Results. A total of 406 articles were identified and, from those, 44 are discussed. Twenty-four studies examined the bond strength, 13 surface roughness, and 19 the hardness. Of these 44 studies, 12 evaluated more than one property. Different substances were used in the attempt to improve adhesion. Considering roughness and hardness, the benefits of sealants have been tested, and the changes resulting from antimicrobial agents’ incorporation have been assessed. Conclusion. Adhesion to the prosthesis base is improved with surface treatments. Rough surfaces and changes in hardness compromise the material’s serviceability.

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