scholarly journals Specific Sensitization Age Dynamic in Patients with Atopic Dermatitis

2015 ◽  
Vol 9 (1) ◽  
pp. 25-29
Author(s):  
N.G. Ilina ◽  
Yu M. Krinitsyna ◽  
M. Yu. Denisov ◽  
I.G. Sergeeva
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Serum Level ◽  
Environmental Factors ◽  
Immunoglobulin E ◽  
Control Group ◽  
Dermatological Diseases ◽  
Acne Rosacea ◽  
Contact Characteristic

Background: Specific sensitization characterizes increased serum level of IgE to different groups of allergens (food, dust, domestic and contact). Characteristic of specific sensitization changes with age of patient. Spectrum of specific sensitization determined environmental factors, conditions of habitation. Objective: objective was to research characteristic of specific sensitization in patients with atopic dermatitis. Methods: There were 108 patients with atopic dermatitis, 1st group – 31 patient (17 boys and 14 girls) 0-3y.o., 2nd group – 30 (13 boys and 17 girls) 4-13 y.o., 3rd group – 47 (16 men and 31 women) 16-63 y.o. In control group, there were 25 patients (4 men, 21 women) 16-64 y.o. with another dermatological diseases such as psoriasis, acne, rosacea and etc., without atopic dermatitis. In patients of all 4 groups evaluated personal, family allergic anamnesis, drug and food allergy, sensitization by measuring common and specific levels of immunoglobulin E. Results: 10%, 32%, 27% patients of 1st, 2nd, 3rd groups had food allergy. The main allergens were citruses (37% cases), chocolate (27%) and milk (17%). Conclusion: 44-52% patients with atopic dermatitis and 4% patients without atopy had non-specific sensitization, that characterized five-fold increased serum level of IgE and more. 50-60% patients with atopic dermatitis had specific sensitization. 60% infants at the age under 3 y.o. with atopic dermatitis had sensitization for epithelium of homepets, 50% - for milk, 30% - white-egg. Among adults with atopic dermatitis sensitization was the same, as in control group. 35% patients with dermatoses without atopy had specific sensitization.

scholarly journals Probiotics Effect on Interleukin-4 (IL-4) and Imunoglobulin E (IgE) Levels on Asthmatic Patients

Sains Medika ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. 61 ◽  
Author(s):  
Pujiati Pujiati
Keyword(s):  
Serum Level ◽  
Childhood Asthma ◽  
Immunoglobulin E ◽  
Controlled Trial ◽  
Intervention Group ◽  
Serum Levels ◽  
Interleukin 4 ◽  
Control Group ◽  
Asthmatic Patients ◽  
Therapeutic Benefits

Introduction: Probiotics may play a role in immune system maturation and may reduce the risk of allergies and asthma in childhood. However, the therapeutic benefits of probiotics in asthma depend on various factors such as strain of probiotics and dosing regimen. Objectives: The aims of this study was to evaluate the effect of probiotic (LactoB®) on Immunoglobulin E (IgE) and Interleukin (IL-4) serum level in childhood Asthma. Methods: Forty children aged 1-5 years with asthma were recruited into a randomized controlled trial. The children were assigned into a probiotic (Lactobacillus acidophilus, Bifidobacterium longun, Streptococcus; Lacto B®) or an equivalent volume of placebo, twice daily orally for 8 weeks. The IgE and IL-4 serum level were determined by ELISA. The differences between groups were analyzed by t-test dependent with confidence interval of 95%. Results: In intervention group, mean of IgE serum levels after the probiotics treatment was significantly lower compared to that of before the treatment (148.18 pg/mg; 283.20 pg/mg; respectively). Mean of IL-4 serum levels after the treatment was significantly lower compared with that of before the treatment (111.03 pg/mg; 142.08 pg/mg respectively). In control group, there were no significant differences between IgE serum levels mean before the administration of placebo and after the intervention (292.39 pg/ml; 286.94 pg/ml respectively). There were no significant differences between IL-4 serum levels mean before and after the treatment (136.76 pg/ml; 139.56 pg/ml).Conclusion: there was an effect of probiotics supplementation on IgE and IL-4 serum levels in childhood asthma.

scholarly journals Atopic Dermatitis: From Etiology and History to Treatment

2021 ◽  
Vol 48 (3) ◽  
pp. 68-76
Author(s):  
L. Dourmishev ◽  
N. Mironova
Keyword(s):  
Atopic Dermatitis ◽  
Environmental Factors ◽  
Immunoglobulin E ◽  
Clinical Course ◽  
Inflammatory Skin Disease ◽  
Comprehensive Overview ◽  
Common Skin ◽  
Morphological Variants ◽  
Genetic And Environmental Factors ◽  
Developed World

Abstract Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease in patients with atopy. Atopy itself, is defined as a predisposition to develop immune response with overproduction of immunoglobulin E to low doses of allergens. AD is one of the most common skin disorders in the developed world, affecting up to 20% of children and about 3% of adults. The pathogenesis of the disease is complex, with both genetic and environmental factors playing a significant role in it. Clinically, hallmarks of atopic dermatitis include dry, itchy skin and various cutaneous efflorescence, compatible to dermatitis or eczema. Atopic dermatitis subdivides into three morphological variants manifesting during infancy, childhood and adulthood. Various environmental factors and associated diseases may have serious influence on the clinical course or may trigger disease relapses. The aim of this review article is to serve as a comprehensive overview of the etiology, pathogenesis, clinical course and diagnosis, as well as potential challenges facing the successful treatment of atopic dermatitis.

scholarly journals Food allergy and atopic dermatitis

2020 ◽  
Vol 2 (1) ◽  
pp. 35-38
Author(s):  
Tina Banzon ◽  
Donald Y.M. Leung ◽  
Lynda C. Schneider
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Immunoglobulin E ◽  
Growth Failure ◽  
Skin Barrier ◽  
Clinical History ◽  
Skin Inflammation ◽  
Specific Ige ◽  
Nutritional Deficiencies ◽  
Detailed Clinical History

Atopic dermatitis (AD), characterized by intense pruritus, eczematous lesions, and a relapsing disease course, is a chronic inflammatory skin disease that affects both children and adults. AD often begins in infancy and is associated with atopic diseases in the personal or family history.1 Environmental factors may trigger AD by affecting the skin barrier and by triggering inflammation. The elicitation of T-helper type 2 cytokines further impairs the epidermal barrier and leads to the penetration of irritants and allergens into the epidermis and thereby perpetuating inflammation. The presence of AD and its severity has been shown to positively correlate with risk of developing food allergy (FA). Children with AD are estimated to be six times more likely to develop FA compared with their healthy peers. It has been reported that nearly 40% of children with moderate-to-severe AD have immunoglobulin E (IgE) mediated FA compared with only 6% in the general population. Although analysis of experimental data has linked skin inflammation in AD to FA, with food challenges reproducing symptoms and avoidance diets improving AD, elimination diets are not known to cure AD and may have unfavorable consequences, such as loss of tolerance, which leads to immediate-type allergy, including anaphylaxis, nutritional deficiencies, growth failure, and reduction of quality of life for the patient and family. Exacerbation of AD can be inaccurately attributed to foods. Individuals with AD are often sensitized to foods with positive testing results, however, able to tolerate the food. In light of widespread ordering and commercial availability of serum specific IgE for FA, testing for FA is recommended only if, from a detailed clinical history, immediate-type allergic symptoms occur with ingestion of food, or in infants with AD who do not improve with optimal skin care.

scholarly journals Updates on Food Allergy, Increasingly Prevalent Challenge

2018 ◽  
Vol 10 (3) ◽  
pp. 152
Author(s):  
Tonny Tanus ◽  
Sunny Wangko
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Eosinophilic Esophagitis ◽  
Immunoglobulin E ◽  
Pediatric Population ◽  
Food Allergies ◽  
Food Protein ◽  
Safety Issues ◽  
Ige Mediated ◽  
Allergic Disorders

Abstrak: Prevalensi alergi makanan makin meningkat di seluruh dunia dan mengenai semua usia. Keparahan dan kompleksitas penyakit juga meningkat terlebih pada populasi anak. Terdapat beberapa jenis reaksi alergi yang dibahas: immunoglobulin E (IgE) mediated allergies and anaphylaxis, food triggered atopic dermatitis, eosinophilic esophagitis, dan non IgE mediated gastrointestinal food allergic disorders seperti food protein induced enterocolitis syndrome (FPIEs). Tes alergi, baik melalui kulit maupun IgE yang telah dikerjakan sekian lama masih dibebani dengan hasil positif palsu dan negatif palsu yang bermakna dengan manfaat terbatas pada beberapa alergi makanan. Selain menghindari, tidak terdapat terapi yang ampuh untuk alergi makanan. Berbagai imunoterapi telah dipelajari melalui jalur, subkutan, epikutan, oral dan sublingual yang hanya menghasilkan desensitisasi sementara dan dibebani dengan berbagai isu mengenai keamanannya. Agen biologik yang menghambat sitokin/interleukin (IL) dan molekul pada reaksi alergi makanan tampaknya merupakan pilihan yang menjanjikan. Anti IgE telah dipergunakan pada asma dan urtikaria kronis. Anti IL-4 dan IL-13 yang menghambat produksi IgE diindikasikan untuk dermatitis atopik. Anti eosinofil anti IL-5 berhasil menurunkan eksaserbasi asma. Berbagai agen biologik telah dipelajari untuk berbagai kondisi alergik dan imunologik, tetapi efektivitas dan kepraktisan terapi yang mahal ini untuk alergi makanan masih menjadi tanda tanya.Kata kunci: alergi makanan, reaksi alergi, terapi alergi makananAbstract: Food allergies have been increasing in prevalence for years affecting all ages. Disease severity and complexity have also increased, especially in the pediatric population. There are several types of reactions including: immunoglobulin-E (IgE) mediated allergies and anaphylaxis, food-triggered atopic dermatitis, eosinophilic esophagitis, and non IgE mediated gastrointestinal food allergic disorders such as FPIEs. Though allergy testing has been around for years, both skin and IgE testing are burdened by significant false positives and negatives, and are only useful in some food allergies. Avoidance is the sole therapy for food allergy. A variety of immunotherapies have been studied; subcutaneous, epicutaneous, oral, and sublingual. At best they only produce a temporary state of desensitization and have many safety issues. Examples of biologicals which block critical cytokines/interleukins (IL) in allergic conditions are Anti IgE, anti IL-4 and IL-13, and Anti eosinophils, Anti IL-5. Other biologicals are being studied for allergic conditions, but whether these expensive future treatments will be proven effective and practical in food allergy is unknown.Keywords: food allergy, allergic reaction, food allergy therapy

Moringa leaf extract potential in the incidence of allergy in experimental rats

2020 ◽  
Vol 45 (1) ◽  
pp. 115-124
Author(s):  
J. A. Adeyeye ◽  
E. J. Epipade ◽  
O. A. Taylor ◽  
K. A. Oyekale ◽  
R. A. Akinlade ◽  
...  
Keyword(s):  
Food Allergy ◽  
Leaf Extract ◽  
Immunoglobulin E ◽  
Positive Control ◽  
Male Rats ◽  
Medical Community ◽  
Health Concern ◽  
Positive Control Group ◽  
Control Group ◽  
Moringa Leaf Extract

The incidence of food allergy out break worldwide is becoming a public health concern. Food allergy is growing at an epidemic proportion affecting all age groups of human population especially such occurrence in young children is worrisome. Management of food allergy without side effect is still a challenge to the medical community. The objective of this study was to investigate the effectiveness of moringa leaf extract in the treatment of food allergy without side effects in experimental rats. Sixty (60) Wistar male rats, (4-6) weeks old, weighing between (100-120) g were grouped into five (5) sections. They were grouped under: Positive Control group, Negative Control group, Epinephrine control group, Chemotherapeutic and Chemo-preventive groups. The animals were allowed to acclimatize for two weeks where the rats were given free food ration and distilled water. After 15 days of consecutive administration of 1 ml crude peanut extract and 10µlcholera toxin as a potent adjuvant in rats, made food allergy established. Results from the study indicated that the means of rectal temperatures after 20th day of allergy induction were declined from (37.17- 34.47) ?C, (37.0-34.67) ?C, and (37.52-3542) ?C in Positive control group, Chemopreventive and Chemotherapeutic groups respectively. The reductions in rectal temperatures confirmed that food allergy was established in experimental rats. Also the study showed that moringa leaf extract reduced serum Immunoglobulin E levels from (324.50-275.4)ng/ml, (181.20-170.50)ng/ml, (279.50-44.38)ng/ml respectively under Epinephrine treatment, Chemopreventive and Chemotherapeutic experimental group treatments. This suggested that moringa leaf extract had potential to prevent and control food allergy.

scholarly journals The role of cutaneous T-cell attracting chemokine in the development of different phenotypes of atopic dermatitis in children

2021 ◽  
Vol 26 (3) ◽  
pp. 39-46
Author(s):  
V.O. Dytiatkovsky ◽  
O.Є. Abaturov ◽  
N.V. Naumenko ◽  
O.O. Alifirenko ◽  
I.A. Filatova ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Gastrointestinal Tract ◽  
T Cell ◽  
Serum Level ◽  
Significant Risk ◽  
Main Group ◽  
Control Group ◽  
Serum Concentrations ◽  
Atopic Diseases

The goal of this study was to detect the risk of developing different atopic dermatitis (AD) phenotypes in children (isolated or combined with other comorbid atopic diseases (AtD)) depending on serum concentrations of cutaneous T-cell attracting chemokine (CTACK)/CCL27. The main group comprised 39 children aged 3 to 18 years old suffering from different AD phenotypes – isolated (18 patients) and combined with comorbid AtD – AR/ARC and/or bronchial asthma (21 patients). The control group comprised 47 children aged 3 to 18 years old, suffering from diseases of the gastrointestinal tract (GIT). Serum CTACK/CCL 27 concentrations were detected in all children. In the full main group, the average level of CTACK/CCL27 was significantly higher compared to the patients of the control group: 4403.6 pg/ml (95% CI: 3726.2; 5148.7, p<0.001) and 3495.9 pg/ml (95% CI: 3197.8; 4186.8, p<0.001), respectively. Mean serum CTACK/CCL27 levels in patients of the main group with different AD phenotypes were higher than those in the full main group: with isolated AD – 4549.4 pg/ml (LQ; HQ: 3923.5; 5175.2, p<0.05), with AD associated with other AtD – 5116.6 pg/ml (LQ, HQ: 4062.8; 6170.5, p<0.05). In phenotypes of overall and isolated AD, the cut-off value of serum CTACK/ CCL27 is 3586.5 pg/ml (76.9% and 77.8%, respectively, and 38.3% in the control group). The risk of development at this concentration is 5.37 (95% CI: 2.05; 14.07, p<0.001) for the total AD phenotype and 5.64 (95% 1.56; 20.32, p<0.05) for the isolated AD phenotype. In AD phenotype combined with comorbid AtD, the cut-off value of serum CTACK/CCL27 is 4308.8 pg/ml (66.7% of the main and 21.3% in the control group). The risk of developing this AD phenotype at this concentration is 7.40 (95% CI: 2.30; 23.76, p<0.001). Serum CTACK/CCL27 levels are the reliable biomarker of the risk for developing different AD phenotypes in children. In the serum level of CTACK/CCL27=3658.5 pg/ml, the significant risk of developing total AD phenotype is 5.37, and isolated – AD=5.64. In the serum concentration of CTACK/CCL27=4308.8 pg/ml, the significant risk of developing AD phenotype combined with comorbid AtD is 7.40.

scholarly journals Increased lipoxin B4 levels in children with atopic dermatitis

2019 ◽  
Vol 59 (5) ◽  
pp. 271-5
Author(s):  
Himmet Haluk Akar ◽  
Mikdat Yildiz
Keyword(s):  
Atopic Dermatitis ◽  
Skin Prick Test ◽  
Inflammatory Mediator ◽  
Immunoglobulin E ◽  
Pediatric Population ◽  
Control Group ◽  
Prick Test ◽  
Significant Difference ◽  
Anti Inflammatory ◽  
And Control

Background Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the pediatric population. The pathophysiology of AD is complex and not clearly understood. The role of lipoxin B4 (LXB4), an anti-inflammatory mediator, has not been sufficiently investigated in children with AD to our knowledge. Objective To compare the levels of serum LXB4 between children with AD and healthy controls.   Methods Three groups of children were enrolled in this study: a SPT-Pos group (skin prick test positive 21 subjects with AD), a SPT-Neg group (skin prick test negative 22 subjects with AD), and a control group (23 healthy subjects). Subjects’ serum LXB4 levels of were measured with an ELISA technique. Also, eosinophil counts and total immunoglobulin E (IgE) levels were compared among all groups. Results We observed significantly higher LXB4 levels in AD patients than in controls. Also, LXB4 levels were significantly higher in the SPT-Pos group than in the SPT-Neg group and control group. However, no significant difference was observed between the SPT-Neg and control groups. Conclusion The LXB4 may have an anti-inflammatory mediator role in the pathogenesis of AD in children. The LXB4-associated pathways may be considered in the development of novel therapeutic approaches for the treatment of patients with AD.

scholarly journals WAYS OF OPTIMIZING THE DIAGNOSTICS OF FOOD ALLERGIES IN CHILDREN BASED ON THE CLINICAL AND IMMUNOLOGICAL CRITERIA

2020 ◽  
Vol 73 (10) ◽  
pp. 2255-2260
Author(s):  
Tetyana O. Kryuchko ◽  
Liudmyla M. Bubyr ◽  
Inna M. Nesina ◽  
Olha Y. Tkachenko ◽  
Olga V. Izmailova ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Interleukin 10 ◽  
Interleukin 4 ◽  
Food Allergies ◽  
Control Group ◽  
Allergic Reactions ◽  
Healthy Children ◽  
Clinical Criteria ◽  
Immunological Markers

The aim of the research was to investigate the spectrum of food sensitization, followed by the determination of the main clinical criteria and immunological markers of food allergy in children with gastroduodenal pathology and atopic dermatitis. Materials and methods: We conducted a comprehensive clinical and immunological examination of 120 children aged from 6 to 15 years with gastroduodenal pathology (group 1; n = 64) and atopic dermatitis (group 2; n = 56), who had a history of adverse allergic reactions to food. The control group consisted of 22 apparently healthy children. Results: In the group of children with gastroduodenal pathology, the spectrum of the most common significant food allergens was represented by legumes, the reaction to which was observed in 25 (39.1%) subjects, eggs (25.0%) and fish (23.4%), which were found in every fourth child. Among patients with atopic dermatitis, the leading positions were occupied by fruits, which were registered in 20 (35.7%) children, nuts – in 15 (26.8%), honey and vegetables – in 11 (19.6%) children, respectively. The study of immunological status in comparison with the control group revealed reliable increases in pro-inflammatory T-helper-2 cytokines – interleukin-4 and chemokine TARC/CCL-17 and a simultaneous decrease in anti-inflammatory interleukin-10 in children of the 1st and 2nd groups who had gastrointestinal and skin manifestations of allergic reactions when eating food products. Conclusions: The study of peculiarities of adverse reactions to food in the examined children allowed us to identify specific clinical criteria and immunological markers of food allergy, which had certain features depending on the skin or gastrointestinal manifestations.

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