Eugenol Supplementation as an Additive to Improve the Thermal Stability of Hedychium coronarium Koening Essential Oil

Background: Eugenol is a phenolic compound with a wide spectrum of biological activities such as antibacterial and antioxidant. Objective: Eugenol is an ideal candidate as a natural antioxidant additive, especially for those substances that are affected by lipoperoxidation process, this is the case of essential oils that have an important role in the food, perfumery and pharmaceutical industries, which easily deteriorate under high temperature, strong light, and reactive oxygen species. Methods: In order to evidence the influence of the addition of eugenol in the thermal properties of Hedychium coronarium Koening essential oil, were determined the chemical composition, antioxidant properties and TG/DTG analysis after the supplementation with different ratios of eugenol/essential oil. Results: The results showed a high content of oxygenated monoteropenes (50.33%), followed by monoterpene hydrocarbons (23.35%) and sesquiterpene (19.2%), the TG/DTG analysis presented a significant increment in the degradation temperature of the essential oil, being the major value 12 ºC at a supplementation of 4.7% (v/v) of eugenol. Conclusion: Finally, the supplementation with eugenol improved the thermal stability of the essential oil of Hedychium coronarium Koening, which could be applicable to other oils thereby improving their physicochemical properties.

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Effects of different monosaccharides on thermal stability of phycobiliproteins from Oscillatoria sp. (BTA-170): Analysis of kinetics, thermodynamics, colour and antioxidant properties

Food Bioscience ◽

10.1016/j.fbio.2021.101354 ◽

2021 ◽

Vol 44 ◽

pp. 101354

Author(s):

Ramesh Sharma ◽

Pinku Chandra Nath ◽

Kondi Vanitha ◽

Onkar Nath Tiwari ◽

Tarun Kanti Bandyopadhyay ◽

...

Keyword(s):

Thermal Stability ◽

Antioxidant Properties ◽

Thermal Stability Of

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Physicochemical and Antioxidant Properties of the Degradations of Polysaccharides from Dendrobium officinale and Their Suitable Molecular Weight Range on Inducing HeLa Cell Apoptosis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2019/4127360 ◽

2019 ◽

Vol 2019 ◽

pp. 1-11 ◽

Cited By ~ 2

Author(s):

Xiaofeng Zhang ◽

Yingyi Luo ◽

Gang Wei ◽

Yunrong Li ◽

Yuechun Huang ◽

...

Keyword(s):

Molecular Weight ◽

Antitumor Activity ◽

Hela Cells ◽

Biological Activities ◽

Antioxidant Properties ◽

Mitochondrial Pathway ◽

Influential Factor ◽

Dendrobium Officinale ◽

Molecular Weight Range ◽

Pharmaceutical Industries

Different molecular weight polysaccharides of Dendrobium officinale (DOPs) have gradually attracted attention because of their broad biological activities. They, however, remain poorly defined whether their antitumor activity is associated with molecular weight. In this study, the physicochemical, antioxidant, and antitumor properties of DOPs, including the crude polysaccharide (DOP) and its six degradation fractions (DOP1–DOP6) extracted from Dendrobium officinale, were determined. Consequently, DOPs were mainly composed of different ratios of mannose and glucose as follows: 5.15 : 1, 4.62 : 1, 4.19 : 1, 4.46 : 1, 4.32 : 1, 4.29 : 1, and 4.23 : 1, and their molecular weights were significantly different ranging from 652.29 kDa to 11.10 kDa. With the concentration increase of DOPs, the scavenging capacity against OH and DPPH free radicals increased. The antitumor ability of DOPs was different that DOP1–DOP5 (Mw: 176.29 kDa–28.48 kDa) exhibited the best antiproliferation activity than DOP (Mw: 652.29 kDa) and DOP6 (Mw: 11.10 kDa) in HeLa cells rather than PC9, A549, and HepG2 cells. Moreover, it is worth mentioning that DOP1 and DOP5 showed stronger capability on inducing apoptosis of HeLa cells than DOP and DOP6 via the mitochondrial pathway by upregulating the ratio of the Bax/Bal-2 mRNA expression. The results demonstrated that DOPs can be used as the potential natural antioxidant and antitumor products in pharmaceutical industries, and the molecular weight is a crucial influential factor of their antitumor activity that 28.48 kDa–176.29 kDa is a suitable range we may refer to.

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Chemical Composition of Essential Oil, Antioxidant, Antidiabetic, Anti-obesity, and Neuroprotective Properties of Prangos gaubae

Natural Product Communications ◽

10.1177/1934578x1701201233 ◽

2017 ◽

Vol 12 (12) ◽

pp. 1934578X1701201 ◽

Cited By ~ 5

Author(s):

Mir Babak Bahadori ◽

Gokhan Zengin ◽

Shahram Bahadori ◽

Filippo Maggi ◽

Leila Dinparast

Keyword(s):

Chemical Composition ◽

Essential Oil ◽

Skin Diseases ◽

Biological Activities ◽

Radical Scavenging Activity ◽

Radical Scavenging ◽

Reducing Power ◽

Volatile Components ◽

Total Antioxidant ◽

Pharmaceutical Industries

Chemical composition of essential oil and the potential of Prangos gaubae for the management of public health problems such as Alzheimer's disease, obesity, Diabetes mellitus, and skin diseases were evaluated for the first time. In this direction, enzyme inhibitory effects, antioxidant activity, and total bioactive contents of the plant were determined. EO showed high acetylcholinesterase (2.97 mg GEs/g oil), α-amylase (1.35 mmol ACEs/g oil), α-glucosidase (38.84 mmol ACEs/g oil), and lipase (1.59 mmol OEs/g oil) inhibitory activities. Moreover, strong antioxidant effects were observed in antiradical (DPPH and ABTS), reducing power (CUPRAC and FRAP), total antioxidant, and metal chelating assays. Methanol extract exhibited promising DPPH radical scavenging activity (0.47 mmol TEs/g extract) and also high reducing power in CUPRAC (0.89 mmol TEs/g extract) and FRAP (0.52 mmol TEs/g extract) assays. All extracts showed low total flavonoid but high total phenolics content. Furthermore, they exhibited strong skin-care effect in tyrosinase inhibition assay. EO analysis showed the presence of germacrene D (26.7%), caryophyllene oxide (14.3%), ( E)-caryophyllene (13.8%), and spathulenol (11.3%) as the major volatile components. Results indicated that P. gaubae has promising potential for possible uses in food, cosmetic, and pharmaceutical industries due to its valuable phytoconstituents and biological activities.

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Thymus mastichina: Composition and Biological Properties with a Focus on Antimicrobial Activity

Pharmaceuticals ◽

10.3390/ph13120479 ◽

2020 ◽

Vol 13 (12) ◽

pp. 479

Author(s):

Márcio Rodrigues ◽

Ana Clara Lopes ◽

Filipa Vaz ◽

Melanie Filipe ◽

Gilberto Alves ◽

...

Keyword(s):

Escherichia Coli ◽

Antimicrobial Activity ◽

Antioxidant Activity ◽

Essential Oil ◽

Biological Activities ◽

Scientific Information ◽

Biological Properties ◽

Fusarium Spp ◽

Candida Spp ◽

Pharmaceutical Industries

Thymus mastichina has the appearance of a semishrub and can be found in jungles and rocky lands of the Iberian Peninsula. This work aimed to review and gather available scientific information on the composition and biological properties of T. mastichina. The main constituents of T. mastichina essential oil are 1,8-cineole (or eucalyptol) and linalool, while the extracts are characterized by the presence of flavonoids, phenolic acids, and terpenes. The essential oil and extracts of T. mastichina have demonstrated a wide diversity of biological activities. They showed antibacterial activity against several bacteria such as Escherichia coli, Proteus mirabilis, Salmonella subsp., methicillin-resistant and methicillin-sensitive Staphylococcus aureus, Listeria monocytogenes EGD, Bacillus cereus, and Pseudomonas, among others, and antifungal activity against Candida spp. and Fusarium spp. Additionally, it has antioxidant activity, which has been evaluated through different methods. Furthermore, other activities have also been studied, such as anticancer, antiviral, insecticidal, repellent, anti-Alzheimer, and anti-inflammatory activity. In conclusion, considering the biological activities reported for the essential oil and extracts of T. mastichina, its potential as a preservative agent could be explored to be used in the food, cosmetic, or pharmaceutical industries.

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The Essential Oil and Hydrolats from Myristica fragrans Seeds with Magnesium Aluminometasilicate as Excipient: Antioxidant, Antibacterial, and Anti-inflammatory Activity

Foods ◽

10.3390/foods9010037 ◽

2020 ◽

Vol 9 (1) ◽

pp. 37 ◽

Cited By ~ 9

Author(s):

Inga Matulyte ◽

Aiste Jekabsone ◽

Lina Jankauskaite ◽

Paulina Zavistanaviciute ◽

Vytaute Sakiene ◽

...

Keyword(s):

Essential Oil ◽

Biological Activities ◽

Antioxidant Properties ◽

Radical Scavenging ◽

Inflammatory Activity ◽

Poly I:C ◽

Bioactive Substances ◽

Myristica Fragrans ◽

Anti Inflammatory ◽

Nutmeg Essential Oil

Nutmeg (Myristica fragrans) essential oil has antimicrobial, antiseptic, antiparasitic, anti-inflammatory, and antioxidant properties. We have recently demonstrated that hydrodistillation of nutmeg essential oil by applying magnesium aluminometasilicate as an excipient significantly increases both the content and amount of bioactive substances in the oil and hydrolats. In this study, we aimed to compare the antioxidant, antimicrobial, and anti-inflammatory activity of hydrolats and essential oil obtained by hydrodistillation in the presence and absence of magnesium aluminometasilicate as an excipient. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method revealed that magnesium aluminometasilicate did not significantly improved antioxidant activity of both essential oil and hydrolat. Antibacterial efficiency was evaluated by monitoring growth of 15 bacterial strains treated by a range of dilutions of the essential oil and the hydrolats. Essential oil with an excipient completely inhibited the growth of E. faecalis, S. mutans (referent), and P. multocida, whereas the pure oil was only efficient against the latter strain. Finally, the anti-inflammatory properties of the substances were assessed in a fibroblast cell culture treated with viral dsRNR mimetic Poly I:C. The essential oil with an excipient protected cells against Poly I:C-induced necrosis more efficiently compared to pure essential oil. Also, both the oil and the hydrolats with aluminometasilicate were more efficient in preventing IL-6 release in the presence of Poly I:C. Our results show that the use of magnesium aluminometasilicate as an excipient might change and in some cases improve the biological activities of nutmeg essential oil and hydrolats.

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Insecticidal, Repellent and Antifeedant Activity of Essential Oils from Blepharocalyx cruckshanksii (Hook. & Arn.) Nied. Leaves and Pilgerodendron uviferum (D. Don) Florin Heartwood against Horn Flies, Haematobia irritans (Diptera: Muscidae)

Molecules ◽

10.3390/molecules26226936 ◽

2021 ◽

Vol 26 (22) ◽

pp. 6936

Author(s):

Javier Espinoza ◽

Cristian Medina ◽

Washington Aniñir ◽

Paul Escobar-Bahamondes ◽

Emilio Ungerfeld ◽

...

Keyword(s):

Essential Oil ◽

Essential Oils ◽

Biological Activities ◽

Wide Spectrum ◽

Field Studies ◽

Blood Feeding ◽

Antifeedant Activity ◽

Haematobia Irritans ◽

Horn Fly ◽

Horn Flies

Haematobia irritans is a cosmopolitan obligate blood-feeding ectoparasite of cattle and is the major global pest of livestock production. Currently, H. irritans management is largely dependent on broad-spectrum pesticides, which has led to the development of insecticide resistance. Thus, alternative control methods are needed. Essential oils have been studied as an alternative due to their wide spectrum of biological activities against insects. Thus, the main aim of this study was to evaluate the insecticidal, repellent and antifeedant activity of the essential oils from Blepharocalyx cruckshanksii leaves and Pilgerodendron uviferum heartwood against horn flies in laboratory conditions. The composition of the essential oils was analyzed using gas chromatography coupled to mass spectrometry. Accordingly, α-pinene (36.50%) and limonene (20.50%) were the principal components of the B. cruckchanksii essential oil, and δ-cadinol (24.16%), cubenol (22.64%), 15-copaenol (15.46%) and δ-cadinene (10.81%) were the most abundant compounds in the P. uviferum essential oil. Mortality of flies and feeding behavior were evaluated by non-choice tests, and olfactory response was evaluated using a Y-tube olfactometer. Both essential oils were toxic to horn flies, with LC50 values for B. cruckchanksii essential oil of 3.58 µL L−1 air at 4 h, and for P. uviferum essential oil of 9.41 µL L−1 air and 1.02 µL L−1 air at 1 and 4 h, respectively. Moreover, the essential oils exhibited spatial repellency in the olfactometer using only 10 µg of each oil, and these significantly reduced the horn fly feeding at all doses evaluated. Although further laboratory and field studies related to the insectistatic and insecticide properties of these essential oils against H. irritans are necessary, B. cruckshanksii leaves and P. uviferum heartwood essential oils are promising candidates for horn fly management.

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Chemical composition, phytotoxic potential, biological activities and antioxidant properties of Myrcia hatschbachii D. Legrand essential oil

Brazilian Journal of Pharmaceutical Sciences ◽

10.1590/s2175-97902019000318402 ◽

2020 ◽

Vol 56 ◽

Author(s):

Larissa Junqueira Gatto ◽

Natasha Tiemi Fabri ◽

Angela Maria de Souza ◽

Natasha Stopinski Triaquim da Fonseca ◽

Alethéia dos Santos Furusho ◽

...

Keyword(s):

Chemical Composition ◽

Essential Oil ◽

Biological Activities ◽

Antioxidant Properties

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Clinical Applications of Antimicrobial Peptides (AMPs): Where do we Stand Now?

Protein and Peptide Letters ◽

10.2174/0929866526666190925152957 ◽

2020 ◽

Vol 27 (2) ◽

pp. 120-134 ◽

Cited By ~ 11

Author(s):

Mithoor Divyashree ◽

Madhu K. Mani ◽

Dhanasekhar Reddy ◽

Ranjith Kumavath ◽

Preetam Ghosh ◽

...

Keyword(s):

Antimicrobial Peptides ◽

Molecular Mechanisms ◽

Metabolic Diseases ◽

Therapeutic Potential ◽

Biological Activities ◽

Wide Spectrum ◽

Noncommunicable Diseases ◽

Multi Drug Resistance ◽

Food Preservatives ◽

Pharmaceutical Industries

: In this era of multi-drug resistance (MDR), antimicrobial peptides (AMPs) are one of the most promising classes of potential drug candidates to combat communicable as well as noncommunicable diseases such as cancers and diabetes. AMPs show a wide spectrum of biological activities which include antiviral, antifungal, anti-mitogenic, anticancer, and anti-inflammatory properties. Apart from these prospective therapeutic potentials, the AMPs can act as food preservatives and immune modulators. Therefore, AMPs have the potential to replace conventional drugs and may gain a significant global drug market share. Although several AMPs have shown therapeutic potential in vitro or in vivo, in most cases they have failed the clinical trial owing to various issues. In this review, we discuss in brief (i) molecular mechanisms of AMPs in various diseases, (ii) importance of AMPs in pharmaceutical industries, (iii) the challenges in using AMPs as therapeutics and how to overcome, (iv) available AMP therapeutics in market, and (v) AMPs under clinical trials. Here, we specifically focus on the therapeutic AMPs in the areas of dermatology, surgery, oncology and metabolic diseases.

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