Nanotechnology: A Novel Approach for Drug Development in Health Care System

2020 ◽  
Vol 5 (1) ◽  
pp. 12-25
Author(s):  
Biswa M. Sahoo ◽  
Bera V.V.R. Kumar ◽  
Ch. Niranjan Patra ◽  
Jnyanaranjan R. Panda ◽  
Bibhash C. Mohanta ◽  
...  

Background: Health is a lively state of the body which adjusts and adopt with the response to various environmental changes. There are several features that can influence the health status of human beings. Therefore, the continuous research study is highly essential to maintain a proper health care system in the community. Objective: The diverse area of innovation was made in nanotechnology for diagnosis and treatment of life-threatening diseases, such as obesity, diabetes, cardiovascular disorders, cancer, leukemia, neurodegenerative disorders like Alzheimer's disease and Parkinson's diseases, etc. Nanotechnology generally refers to the materials, devices, and systems in nanoscale which provides considerably improved physical, chemical and biological property. Methods: It is technology which deals with the design, synthesis, characterization of substances, devices and systems by arranging shape and size at their nanometer scale. It involves multidisciplinary research which includes both health science and technology for the treatment of human health. Nanotechnology can be applied at the cellular level in the human body with a high degree of specificity to treat the various diseases. Conclusion: This technology is potentially targeted to diseased tissue to achieve maximum therapeutic efficacy with fewer side effects. Nowadays, the rapidity of revolutionary discoveries in the field of nanotechnology is expected to accelerate in the next decade globally.

Author(s):  
Athar Parvez Ansari

AbstractSince antiquity, the Unani system of medicine has been participating in health care system. Usually, four modes of treatment viz. regimenal therapy, dietotherapy, pharmacotherapy and surgery are applied for the treatment of diseases. Regimenal therapy is an important mode in which the morbid matter present in the body is either dispersed/excreted or its unnecessary production is blocked or its flow is restricted and the diseases are cured by natural healer of the body, consequently bring back the humoural stability. Nearly 30 regimens have been mentioned in classical Unani literature. Commonest regimenal procedures such as fasd (venesection/phlebotomy), hijāma (cupping), ta‘līq al-‘alaq (hirudotherapy/leech therapy), ishāl (purgation), qay’ (emesis), idrār-i-bawl (diuresis), huqna (enema), ta’rīq (diaphoresis), riyādat (exercise), dalk (massage), hammām (bathing), tadhīn (oiling), natūl (irrigation), sakūb (douching/spraying), inkibāb (steam/vapour application), takmīd (fomentation) etc. are usually applied for the management of various ailments. These regimenal procedures are completely based on holistic approach and are potential but needs to be explored scientifically. This review outlines the therapeutic applications of various regimens of regimenal therapy used in Unani medicine.


2013 ◽  
Vol 24 (2) ◽  
pp. 162-168 ◽  
Author(s):  
Patricia Gonce Morton

Publishing in professional journals is a challenging and rewarding experience. By sharing their expertise and experiences through journal articles, nurses contribute to the body of literature that ultimately helps improve the health care system, the nursing profession, and care of patients and their families. The focus of this article is to help nurses implement strategies to get started in the process of publishing journal articles. Topics include facing excuses for not writing, implementing strategies to get started, and executing a plan for the manuscript.


Curationis ◽  
2018 ◽  
Vol 41 (1) ◽  
Author(s):  
Neo E. Nare ◽  
Abel J. Pienaar ◽  
Ditaba D. Mphuthi

Background: It is believed by western education systems that the first contact should be with the nurse in primary health care. However, it is not the case. Therefore, the researcher attempts to correct this misconception by conceptualising the correct beginning of health seeking behaviour in an indigenous African community, namely African Primal Health Care (APHC). ‘Primal’ was coined during a colloquium by Dr Mbulawa and Seboka team members; however no formal conceptualisation took place, only operational definition. Due to the study scope, conceptualisation is narrowed to mental health, but this concept is applicable in the broader health context. The research purpose was to contribute to the body of indigenous knowledge systems to advocate towards co-existence of primal health care and mental health care.Aim: Formulate APHC within a mental health care context.Objectives: To explore philosophical grounding of APHC and describe epistemology of APHC. To analyse and crystallise the exploration to establish understanding within mental health and conceptualise APHC within mental health care to enhance co-existence.Methodology: Narrative synthesis, concept analysis (qualitative design). Lekgotla was used as a method of data collection and data were analysed using Leedy and Ormrod’s five steps of data analysis.Results: APHC is a health care system that existed in Africa prior to the introduction of the western health care system. It is based on the African belief system and practices. The practices come from the community, for the community and are authenticated by the community. APHC uses a holistic approach and the family and community are involved in the healing process.


2021 ◽  
Vol 23 (11) ◽  
pp. 70-77
Author(s):  
M.R. Thiyagupriyadharsan ◽  
◽  
Dr.S. Suja ◽  

In the contemporary world, many dangerous disease which are affecting human beings and new pandemic disease is also raising alarm to have an effective health care system. In this aspect the technology plays a major role in improving and optimizing the health care system. The diagnostic is done by taking blood test, urine test, and medical imaging like X-ray, CT scan, Ultrasound scan and MRI scan system. Among these, the paper focus will be emphasized on MRI imaging in identifying the brain tumor using image processing. In the proposed work the fuzzy C means(FCM) algorithm along with firefly algorithm optimized support vector machine (SVM) are used to classify the MRI brain tumor images. The results of these works are compared using the performance metrics such as accuracy, sensitivity, specificity and precision. The proposed method gives best results for the classification of MRI brain tumor images.


Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 11-11
Author(s):  
Axel Matzdorff ◽  
Oliver Meyer

Background:Immune thrombocytopenia (ITP) is rare. The 1996 American Society of Hematology (ASH) ITP-Guideline for many years set the standards of ITP-care. In 2019 ASH published a new ITP guideline. We wanted to assess the acceptance of these new guideline recommendations by German physicians. Methods:This is a cross-sectional survey presenting ten recommendations on adult ITP from the new ASH ITP guideline to German hematologist, internists and other specialists at 4 medical educational activities on ITP between September 2019 and January 2020. We asked the physicians to express their preference for each recommendation on a 5-point scale. Numeric values were assigned to the degrees of agreement or disagreement. The numeric values of the responses were summed and divided by the number of respondents to create an average score. This was compared with the degree of support ASH experts expressed for each of their recommendation. Results:One hundred thirty questionnaires were distributed and 56 were retrieved (43%). There was consensus in 7 of 10 management issues but there were obvious differences in 3. (1) German physicians were less likely to give corticosteroids in newly diagnosed but asymptomatic or only mildly symptomatic patients, but (2) in case corticosteroids were given, German physicians were more likely to prescribe longer corticosteroid treatment, and (3) German physicians clearly prefer 2nd line thrombopoietin receptor agonists (TPO-RAs) over splenectomy. The different approach may be explained by easier access to medical care for patients (higher hospital- and physician-density than in the US), universal coverage in a publicly funded health care system, and a less developed medicolegal network pushing malpractice claims in Germany. Conclusion: The example of the recent ASH ITP guideline shows that recommendations must not be separated from the context in which they are produced. They cannot define a universal standard of care. Instead they need to be adapted and individualized, respecting the traditions of each health care system, physicians' experiences, patients' preferences, and health literacy. Guideline recommendations do not define a 'best treatment' or any universal standard of care, all they do is providing guidance to the physician in daily practice. Th. Jefferson's sentence still holds that all human beings are created equal, but this does not mean that all patients must be treated equally. Disclosures Matzdorff: UCB Biopharma SRL:Consultancy, Other: Honoraria paid to institution;Swedish Orphan Biovitrium GmbH:Consultancy, Other: Honoraria paid to institution;Grifols Deutschland GmbH:Consultancy, Other: Honoraria paid to institution;Amgen GmbH:Consultancy, Other: Honoraria paid to institution;Novartis Oncology:Consultancy, Other: Honoraria paid to institution;Roche Pharma AG:Other: Family stockownership.Meyer:Novartis Pharma GmbH:Honoraria;Amgen GmbH:Honoraria;Grifols Germany:Consultancy, Honoraria.


2014 ◽  
Vol 3 (1) ◽  
pp. 1-16
Author(s):  
P C Harigovind

Experimenting new drugs on human beings, is one of the crucial human right issues faced by the third world countries in the present century. It is true that the international law had taken high concern of this social issue after the Nuremberg Trials. The international law mandates informed consent to be obtained from the participants of clinical trials and this is the sole mechanism through which the rights of the trial subjects are being protected. The public health issues caused by illegal and unethical trials over patients are now evident in Indian health care system. The issue has come up for consideration before the Supreme Court of India recently. In India the law runs in tune with the international parameters for conducting human experimentation. The law on informed consent has a fatal impact over public health care issues, especially over the matter of clinical trials. Recent experiences in India reveal the threats caused to the society by clinical experimentations. Clinical trials and allied health issues are also brought to the notice of the judiciary. The law on informed consent in India is in its infant state. Exploring the doctrine of informed consent is crucial to this study. The present issue of clinical research which threatens the health care system is analysed and the doctrine of informed consent to regulate the system is assessed to check its efficacy and veracity. Analysis of the issue will help to communicate to the public about the need for better exercise of the rights of those who are subjected to clinical researches. The law of informed consent is in many ways inadequate to deal with the issues relating to clinical trials in India. The doctrine of informed consent has to be redefined to a great extent. The institutional review boards and Non- Government Organisations (NGO) can play a vital role in assuring proper observation of rules relating to regulation of human trials.


Author(s):  
Pavlo Volodymyrovych Herasymenko ◽  
Olena Volodymyrivna Herasymenko

Urgency of the research. The relevance of adherence to the principles of medical ethics in the analysis of complaints is determined by the complexity of decision-making during an examination of inconsistencies in medical practice, which mandatory element is interference in a person’s inner world. Target setting. The structure of complaints about activities of health professionals is quite complex. A decision after a complaint is not always in favor of a complainant. At the same time, inconsistencies in medical practice due to a fault of a medical institution have significant consequences: organizational, financial, image. Therefore, improvement and proper application of principles of medical ethics in complain handling is important at all stages of medical care. Actual scientific researches and issues analysis. The article mentions works of scientists and medical practitioners, summarizes the body of knowledge on the issues of adherence to medical ethics during medical intervention and possible complaints. Uninvestigated parts of general matters defining. At the present stage of development, the national health care system is in a state of radical change. The shares of the public, communal and private sectors are significantly redistributed. Their structure and development trends are changing dynamically. The volatility of the current national health care system requires better study and coverage, in order to share experiences and implement best practices in ethical patient management. The research objective of the publication is to expand scientific and practical knowledge and skills about the harmonious integration of the principles of medical ethics in modern Ukrainian medicine. The statement of basic materials. Variants of complaints from dissatisfied patients, ethical principles of the approach to their consideration, stages and features of complaint analysis, the role of each of the medical staff during such examinations are considered. Conclusions. The publication discusses the practical experience of applying the principles of medical ethics and deontology in the work of a private medical institution in the analysis of complaints. The main elements of an ethical approach to diagnostics, consideration and resolution of a complaint. The conditions and processes that accompany communication with the complainant are described. Variants of approaches to solving problems for the personnel of clinics and finalizing the elimination of the identified inconsistencies are proposed.


2014 ◽  
Vol 4 (1) ◽  
pp. 23-29
Author(s):  
Constance Hilory Tomberlin

There are a multitude of reasons that a teletinnitus program can be beneficial, not only to the patients, but also within the hospital and audiology department. The ability to use technology for the purpose of tinnitus management allows for improved appointment access for all patients, especially those who live at a distance, has been shown to be more cost effective when the patients travel is otherwise monetarily compensated, and allows for multiple patient's to be seen in the same time slots, allowing for greater access to the clinic for the patients wishing to be seen in-house. There is also the patient's excitement in being part of a new technology-based program. The Gulf Coast Veterans Health Care System (GCVHCS) saw the potential benefits of incorporating a teletinnitus program and began implementation in 2013. There were a few hurdles to work through during the beginning organizational process and the initial execution of the program. Since the establishment of the Teletinnitus program, the GCVHCS has seen an enhancement in patient care, reduction in travel compensation, improvement in clinic utilization, clinic availability, the genuine excitement of the use of a new healthcare media amongst staff and patients, and overall patient satisfaction.


2007 ◽  
Vol 38 (1) ◽  
pp. 18
Author(s):  
KEVIN GRUMBACH ◽  
ROBERT MOFFIT

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