Peptide Functionalised Nanocarriers for Bone Specific Delivery of PTH (1-34) in Osteoporosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Sagar Salave ◽  
Dhwani Rana ◽  
Derajram Benival
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Specific Interaction ◽  
Treatment Modalities ◽  
Bone Surface ◽  
Innovative Drug ◽  
Public Health Burden ◽  
Antiresorptive Drugs ◽  
Delivery Approach ◽  
Target Effects

: Osteoporosis represents a major public health burden especially considering the aging population worldwide. Treatment modalities for osteoporosis are classified into two categories based on the effect on bone remodelling: anabolic drugs and antiresorptive drugs. Anabolic drugs are preferred as it stimulates new bone formation. Currently, PTH (1-34) is the only peptide-based drug approved as an anabolic agent for the treatment of osteoporosis by both USFDA as well as EMA. However, its non-specific delivery results in prolonged kidney exposure, causing hypercalcemia. Nanotechnology-based drug delivery systems functionalized by conjugating it with homing moieties, such as peptides, offer an advantage of targeted delivery with reduced off-target effects. Here, we propose an innovative and targeted nanovesicle approach to efficiently deliver PTH (1-34) to the bone surface using peptides as a homing moiety. The proposed innovative delivery approach will augment the specific interaction between the drug and bone surface without producing side effects. This will reduce the off-target effects of PTH (1-34), and at the same time, it will also improve the outcome of anabolic therapy. Therefore, we postulate that the proposed innovative drug delivery approach for PTH (1-34) will establish as a promising therapy for osteoporotic patients, specifically in postmenopausal women who are at greater risk of bone fracture.

Controlled release and targeted delivery to cancer cells of doxorubicin from polysaccharide-functionalised single-walled carbon nanotubes

2015 ◽  
Vol 3 (9) ◽  
pp. 1846-1855 ◽  
Author(s):  
Yunfei Mo ◽  
Haowen Wang ◽  
Jianghui Liu ◽  
Yong Lan ◽  
Rui Guo ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Water Solubility ◽  
Single Walled Carbon Nanotubes ◽  
Innovative Drug ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

Carboxyl single-walled carbon nanotubes (SWNTs) were used to construct an innovative drug delivery system by modification with chitosan (CHI) to enhance water solubility and biocompatibility.

scholarly journals NANOPARTICLES: A PROMISING DRUG DELIVERY APPROACH

2018 ◽  
Vol 11 (1) ◽  
pp. 30 ◽  
Author(s):  
Renu Kadian
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Drug Transport ◽  
Size Range ◽  
Small Object ◽  
Routes Of Administration ◽  
Conventional Drug ◽  
Specific Uptake ◽  
Therapeutic Properties ◽  
Delivery Approach

  Nanoparticles are particles having a size range of 1 and 100 nanometers, defined as a small object behaving as a complete unit with respect to the drug transport and therapeutic properties. They have several advantages such as improvement in the intracellular infiltration, enhanced hydrophobic solubility, and circulation time of the drug. They reduce non-specific uptake and side effects of the conventional drug delivery systems. Nanoparticles offer more effective and convenient routes of administration (oral, pulmonary, parenteral, and transdermal) and used for drug delivery for treatment of cancer, diabetes, pain, asthma, allergy, infections, and so on. They allow targeted delivery and controlled release of the drug. Further research on their mechanism of action to meet better stability of nanoparticles in the biological system could be done.

scholarly journals The Proposition of the Pulmonary Route as an Attractive Drug Delivery Approach of Nano-Based Immune Therapies and Cancer Vaccines to Treat Lung Tumors

2021 ◽  
Vol 3 ◽  
Author(s):  
Michael Donkor ◽  
Harlan P. Jones
Keyword(s):  
Drug Delivery ◽  
Cancer Vaccines ◽  
Pulmonary Delivery ◽  
Lung Tumors ◽  
Health Concern ◽  
Treatment Modalities ◽  
Primary Tumors ◽  
Major Health ◽  
Immune Therapies ◽  
Delivery Approach

Lung cancer is the leading cause of cancer related deaths globally, making it a major health concern. The lung’s permissive rich microenvironment is ideal for supporting outgrowth of disseminated tumors from pre-existing extra-pulmonary malignancies usually resulting in high mortality. Tumors occurring in the lungs are difficult to treat, necessitating the need for the development of advanced treatment modalities against primary tumors and secondary lung metastasis. In this review, we explore the pulmonary route as an attractive drug delivery approach to treat lung tumors. We also discuss the potential of pulmonary delivery of cancer vaccine vectors to induce mucosal immunity capable of preventing the seeding of tumors in the lung.

Nanotherapeutics in Tumour Microenvironment for Cancer Therapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Dhwani Rana ◽  
Sagar Salave ◽  
Suraj Longare ◽  
Rishabh Agarwal ◽  
Kiran Kalia ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Surface Area ◽  
Targeted Delivery ◽  
Cancer Biology ◽  
High Specificity ◽  
Tumour Microenvironment ◽  
Chemotherapeutic Agents ◽  
Treatment Modalities ◽  
Stimuli Responsive ◽  
Target Effects

Background: Cancer continues to be the most annihilating illness and despite vast research in understanding cancer biology as well as rational drug designing progressing profoundly, cancer remains the second leading cause of death worldwide. The conventional chemotherapeutic agents being exploited for cancer therapy contain several limitations, including less selectivity, nonspecific targeting and high off-target effects, and the emergence of multidrug resistance. These drawbacks can be addressed by employing the use of nanotherapeutics. Objective: The main objective of this review is to summarize various mechanisms of cancer genesis. It focuses on several strategies employed for modifying nano formulations for localization and emerging stimuli-based nanotherapeutics with recent examples. Methods: The method involved the collection of the articles from different search engines like Google, PubMed, and ScienceDirect for the literature to get appropriate information regarding the topics. Results: Studies revealed that nanoscale-based therapy provides targeted delivery, minimizes the off-target effects, and improves the therapeutic efficacy of the treatment modalities. The characteristics of nanoparticles like larger surface area become favourable and provide a platform for surface modifications, thereby improving cell targeting, internalization, and opportunities for delivering multiple agents. Advances in rational designing like stimuli-responsive therapies employing the use of sensitive nanocarriers, further provide high specificity, controlled release, and more efficient delivery of chemotherapeutic agents. Conclusion: Characteristics of the nanoscale delivery system like larger surface area provide us with ample options for desired modifications, hence providing multimodal delivery of chemotherapeutic agents in cancer treatment. Nano therapy serves well as a potential tool for improving cancer therapies.

scholarly journals NANOPARTICLES: A PROMISING DRUG DELIVERY APPROACH

2018 ◽  
Vol 11 (1) ◽  
pp. 30
Author(s):  
Renu Kadian
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Drug Transport ◽  
Size Range ◽  
Small Object ◽  
Routes Of Administration ◽  
Conventional Drug ◽  
Specific Uptake ◽  
Therapeutic Properties ◽  
Delivery Approach

  Nanoparticles are particles having a size range of 1 and 100 nanometers, defined as a small object behaving as a complete unit with respect to the drug transport and therapeutic properties. They have several advantages such as improvement in the intracellular infiltration, enhanced hydrophobic solubility, and circulation time of the drug. They reduce non-specific uptake and side effects of the conventional drug delivery systems. Nanoparticles offer more effective and convenient routes of administration (oral, pulmonary, parenteral, and transdermal) and used for drug delivery for treatment of cancer, diabetes, pain, asthma, allergy, infections, and so on. They allow targeted delivery and controlled release of the drug. Further research on their mechanism of action to meet better stability of nanoparticles in the biological system could be done.

scholarly journals Synthetic Polymers as Drug-Delivery Vehicles in Medicine

2008 ◽  
Vol 2008 ◽  
pp. 1-19 ◽  
Author(s):  
Eberhard W. Neuse
Keyword(s):  
Drug Delivery ◽  
Water Solubility ◽  
Antitumor Agent ◽  
Water Soluble ◽  
Treatment Modalities ◽  
Cancer Tissue ◽  
Drug Conjugation ◽  
Cancerous Cell ◽  
Safe Transport ◽  
Delivery Approach

Cancerous diseases present a formidable health problem worldwide. While the chemotherapy of cancer, in conjunction with other treatment modalities, has reached a significant level of maturity, efficacious use of such agents is still restricted by numerous pharmacological deficiencies, such as poor water solubility, short serum circulation lifetimes, and low bioavailability resulting from lack of affinity to cancer tissue and inadequate mechanisms of cell entry. More critically still, most drugs suffer from toxic side effects and a risk of drug resistance. The class of platinum anticancer drugs, although outstandingly potent, is particularly notorious in that respect. Among the countless methods developed in recent years in an effort to overcome these deficiencies, the technology of polymer-drug conjugation stands out as a particularly advanced treatment modality. The strategy involves the bioreversible binding, conjugating, of a medicinal agent to a water-soluble macromolecular carrier. Following pharmacokinetic pathways distinctly different from those of the common, nonpolymeric drugs, the conjugate so obtained will act as a prodrug providing safe transport of the bioactive agent to and into the affected, that is, cancerous cell for its ultimate cell-killing activity. The present treatise will acquaint us with the pharmacological fundamentals of this drug delivery approach, applied here specifically to the metalorganic platinum-type drug systems and the organometallic ferrocene drug model. We will see just how this technology leads to conjugates distinctly superior in antiproliferative activity to cisplatin, a clinically used antitumor agent used here as a standard. Polymer-drug conjugation involving metal-based and other medicinal agents has unquestionably matured to a practical tool to the pharmaceutical scientist, and all indications point to an illustrious career for this nascent drug delivery approach in the fight against cancer and other human maladies.

Innovative Drug Delivery Strategies for Topical Photodynamic Therapy using Porphyrin Precursors

2007 ◽  
Vol 26 (2) ◽  
pp. 105-116 ◽  
Author(s):  
Desmond I. J. Morrow ◽  
Martin J. Garland ◽  
Paul A. McCarron ◽  
A. David Woolfson ◽  
Ryan F. Donnelly
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Innovative Drug ◽  
Delivery Strategies

Development and Characterization Colchicine-Loaded PEGylated Gelatin Nanoparticles for Targeted Delivery to Tumor

2013 ◽  
Vol 6 (2) ◽  
pp. 2058-2063
Author(s):  
G D Chandrethiya ◽  
P K Shelat ◽  
M N Zaveri
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
High Performance ◽  
Entrapment Efficiency ◽  
Stability Study ◽  
Spherical Particles ◽  
Precipitation Method ◽  
Antitumoral Activity ◽  
Gelatin Nanoparticles

PEGylated gelatin nanoparticles loaded with colchicine were prepared by ethanol precipitation method. Poly-(ethylene glycol)-5000-monomethylether (MPEG 5000), a hydrophilic polymer, was used to pegylate gelatin.  Gluteraldehyde was used as cross-linking agent. To obtain a high quality product, major formulation parameters were optimized.  Spherical particles with mean particles of 193 nm were measured by a Malvern particle size analyzer. Entrapment efficiency was found to be 71.7 ± 1.4% and determined with reverse phase high performance liquid charomatography (RP-HPLC). The in vitro drug release study was performed by dialysis bag method for a period of 168 hours. Lyophilizaton study showed sucrose at lower concentrations proved the best cryoprotectant for this formulation.  Stability study revealed that lyophilized nanoparticles were equally effective (p < 0.05) after one year of storage at 2-8°C with ambient humidity. In vitro antitumoral activity was accessed using the MCF-7 cell line by MTT assay.  The IC50 value was found to be 0.034 μg/ml for the prepared formulation. The results indicate that PEGylated gelatin nanoparticles could be utilized as a potential drug delivery for targeted drug delivery of tumors.  

Development of Innovative Orally Fast Disintegrating Film Dosage Forms: A Review

2012 ◽  
Vol 5 (2) ◽  
pp. 1666-1674 ◽  
Author(s):  
Bibhu Prasad Panda ◽  
N.S Dey ◽  
M.E.B. Rao
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Dosage Form ◽  
Geriatric Patients ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Design And Development ◽  
Innovative Drug ◽  
Potential Benefits ◽  
Pharmaceutical Industries

Over the past few decades, there has been an increased interest for innovative drug delivery systems to improve safety, efficacy and patient compliance, thereby increasing the product patent life cycle. The discovery and development of new chemical entities is not only an expensive but also time consuming affair. Hence the pharmaceutical industries are focusing on the design and development of innovative drug delivery systems for existing drugs. One such delivery system is the fast disintegrating oral film, which has gained popularity among pediatric and geriatric patients. This fast disintegrating film with many potential benefits of a fast disintegrating tablet but devoid of friability and risk of choking is more acceptable to pediatric and geriatric patients. Formulation of fast disintegrating film can be achieved by various techniques, but common methods of preparation include spraying and casting. These film forming techniques use hydrophilic film former in combination with suitable excipients, which allow the film to disintegrate or dissolve quickly in the mouth within a few seconds without the administration of water. In view of the advantages of the fast disintegrating films over the fast disintegrating tablets and other dosage forms, it has the potential for commercial exploitation. The oral film dosage form not only has certain advantages of other fast disintegrating systems but also satisfies the unmet needs of the market. The present review emphasizes on the potential benefits, design and development of robust, stable, and innovative orally fast- disintegrating films and their future scenarios on a global market as a pharmaceutical dosage form.  

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