Cosmeceutical Aptitudes of Azelaic Acid

2021 ◽  
Vol 13 ◽  
Author(s):  
Supriya Kumari Singh ◽  
Saumya Chaubey ◽  
Anil Bansal ◽  
Gurpreet Kaur ◽  
Deepinder Singh Malik
Keyword(s):  
Azelaic Acid ◽  
Physiological Role ◽  
Pharmacological Profile ◽  
Physiochemical Properties ◽  
Inflammatory Lesions ◽  
Microbial Properties ◽  
Acne Rosacea ◽  
Lipid Nanocarriers ◽  
Anti Oxidant ◽  
Novel Approaches

Background: Azelaic acid (AZA) is a white crystalline dicarboxylic acid naturally found in grains, rye and barley. AZA has substantial biological and therapeutic abilities (viz a viz) its anti-inflammatory, anti-oxidant, anti-keratinizing, anti-microbial properties, etc. which contribute to its applicability in the management of mild to harsh dermatological complications (acne, rosacea, dermatitis, hyper-pigmentation, carcinomas, etc.). AZA has shown its effectiveness against varied non-inflammatory and inflammatory lesions by normalizing the hyper-keratinization statie and attenuating the increased levels of microbial content. Topically AZA, either alone or in conjunction with other active moieties, has proved to be effective in preventing acne and several other hyper-pigmentary conditions. Objectives: Chronic applicability of AZA has been evidenced with the effects like itching, burning, stinging, redness, etc. To deal with the former issues, research is being conducted to substitute the conventional formulations with novel preparations (liposome’s, niosomes, micro sponges, lipid nanocarriers, etc.), which could enhance the overall pharmaceutical and pharmacological profile of the drug. Conclusion: This article is an attempt to highlight the basic physiochemical properties of AZA, its physiological role (especially in dermatology), various commercial preparations and recent novel approaches that are in research with an aim to augment the therapeutic and safety profile of AZA.

scholarly journals Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 567
Author(s):  
Ivona Tomić ◽  
Sandra Miočić ◽  
Ivan Pepić ◽  
Dubravka Šimić ◽  
Jelena Filipović-Grčić
Keyword(s):  
Azelaic Acid ◽  
Controlled Trial ◽  
Acne Vulgaris ◽  
Topical Therapy ◽  
Adverse Event Rate ◽  
Double Blind ◽  
Inflammatory Lesions ◽  
First Choice ◽  
In Situ Hydrogel

Acne vulgaris is a common, multifactorial, inflammatory skin disease affecting the pilosebaceous unit. Topical therapy is the first choice in the treatment of mild to moderate acne, and azelaic acid (AZA) is one of the most commonly used drugs. The aim of this study was to evaluate the safety and efficacy of a low-dose azelaic acid nanocrystal (AZA-NC) hydrogel in the treatment of mild to moderate facial acne. The study was designed as a double-blind, randomized controlled trial. Patients were randomized to treatment with AZA-NC hydrogel, 10%, or AZA cream, 20%, administered in quantities of approximately 1 g twice daily for 8 weeks. Efficacy of therapy was measured by the number of lesions and safety by the frequency and severity of adverse events. At week 8, the success rate of treatment with AZA-NC hydrogel, 10%, was 36.51% (p < 0.001) versus 30.37% (p < 0.001) with AZA cream. At week 8, treatment with AZA-NC hydrogel, 10%, resulted in a significant reduction in total inflammatory lesions from baseline of 39.15% (p < 0.001) versus 33.76% (p < 0.001) with AZA cream, and a reduction in non-inflammatory lesions from baseline of 34.58% (p < 0.001) versus 27.96% (p < 0.001) with AZA cream, respectively. The adverse event rate was low and mostly mild.

scholarly journals Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 615
Author(s):  
Martin Doseděl ◽  
Eduard Jirkovský ◽  
Kateřina Macáková ◽  
Lenka Krčmová ◽  
Lenka Javorská ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Iron Absorption ◽  
Plasma Concentrations ◽  
Physiological Role ◽  
Renal Stones ◽  
Anti Oxidant ◽  
High Doses ◽  
Epigenetic Processes

Vitamin C (L-ascorbic acid) has been known as an antioxidant for most people. However, its physiological role is much larger and encompasses very different processes ranging from facilitation of iron absorption through involvement in hormones and carnitine synthesis for important roles in epigenetic processes. Contrarily, high doses act as a pro-oxidant than an anti-oxidant. This may also be the reason why plasma levels are meticulously regulated on the level of absorption and excretion in the kidney. Interestingly, most cells contain vitamin C in millimolar concentrations, which is much higher than its plasma concentrations, and compared to other vitamins. The role of vitamin C is well demonstrated by miscellaneous symptoms of its absence—scurvy. The only clinically well-documented indication for vitamin C is scurvy. The effects of vitamin C administration on cancer, cardiovascular diseases, and infections are rather minor or even debatable in the general population. Vitamin C is relatively safe, but caution should be given to the administration of high doses, which can cause overt side effects in some susceptible patients (e.g., oxalate renal stones). Lastly, analytical methods for its determination with advantages and pitfalls are also discussed in this review.

scholarly journals A COMPARATIVE STUDY OF THE EFFICACY AND SAFETY OF 12 % GLYCOLIC ACID CREAM AND 10% AZELAIC ACID CREAM IN THE TREATMENT OF POST ACNE HYPERPIGMENTATION.

2021 ◽  
pp. 34-35
Author(s):  
Archana Rede ◽  
Sanjay N. Agrawal ◽  
Yoganand Kulkarni
Keyword(s):  
Comparative Study ◽  
Azelaic Acid ◽  
Glycolic Acid ◽  
Acne Vulgaris ◽  
Inflammatory Disorder ◽  
Efficacy And Safety ◽  
Common Complication ◽  
Pilosebaceous Unit ◽  
Inflammatory Lesions ◽  
Chronic Inflammatory Disorder

Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit that is associated with significant psychosocial repercussions. Post inflammatory hyperpigmentation is a most common complication seen after post acne. Therapeutic goal of treatment include promoting degradation of melanosomes and inhibiting their formation. Patient treated with Azelaic acid / Glycolic acid experienced of significant greater reduction in number of inflammatory lesions. This study focuses on the comparison of efficacy of 12% Glycolic acid and 10% Azelaic acid in treating post acne hyperpigmentation.

scholarly journals Anti-oxidant and anti-microbial properties of mutton nuggets incorporated with blends of essential oils

2018 ◽  
Vol 55 (2) ◽  
pp. 821-832 ◽  
Author(s):  
Sudheer Kumar ◽  
S. K. Mendiratta ◽  
Ravi Kant Agrawal ◽  
Heena Sharma ◽  
Bhanu Pratap Singh
Keyword(s):  
Essential Oils ◽  
Microbial Properties ◽  
Anti Oxidant

Zastosowanie kwasu azelainowego w wybranych schorzeniach dermatologicznych

2018 ◽  
Vol 21 (4) ◽  
Author(s):  
Paula Dębek ◽  
Anna Piotrowska ◽  
Magdalena Nastałek ◽  
Natalia Totko-Borkusiewicz ◽  
Olga Czerwińska-Ledwig ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trials ◽  
Mechanism Of Action ◽  
Azelaic Acid ◽  
Acid Treatment ◽  
Wide Spectrum ◽  
Acne Vulgaris ◽  
Acne Rosacea

Introduction. Dermatoses, such as acne vulgaris, acne rosacea and hyperpigmentations, are an increasingly common problem, their chronic character affecting the quality of life of the affected people. One of the substances with a multidirectional mechanism of action and a wide spectrum of applications is azelaic acid. Aim. The aim of this paper was to present azelaic acid as a substance suitable for treatment of many skin problems. Material and methods. The authors have analyzed the literature from 1986-2018, looking for works indicating the mechanism, effectiveness and safety of azelaic acid treatment in selected diseases. Results. This ingredient proved to meet the high requirements. Conclusions. Systematic use of azelaic acid reduces acne lesions, lightens discolorations and eliminates most of the symptoms of rosacea. It is used alone or in polytherapy, however combined therapies require further clinical trials indicating the directionality of such treatment.

scholarly journals Azelaic Acid Promotes Fatty Acid Desaturation in Caenorhabditis elegans at Cold Temperature, Thereby Enhancing Longevity

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 6-6
Author(s):  
Juan Bai ◽  
Miran Jang ◽  
Renalison Farias Pereira ◽  
Yuan Zhang ◽  
Hanqiu Xu ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Azelaic Acid ◽  
Physiological Role ◽  
Acid Synthesis ◽  
Pcr Analysis ◽  
Stressed Condition ◽  
C Elegans ◽  
Invertebrate Animal ◽  
Pumping Rates ◽  
The Republic

Abstract Objectives Azelaic acid (AzA), a naturally occurring α, ω-dicarboxylic acid in wheat, rye, barley and sorghum, has been reported to exert anti-inflammatory and anti-oxidation property. AzA has long been used as an antiacne drug by inhibiting bacterial DNA synthesis. Recently, its role in reducing high fat diet-induced adiposity through activation of olfactory receptor 544 has been reported. However, its physiological role in environmental stress (e.g., fasting and cold) and aging is unknown. Methods We conducted PCR analysis and lifespan assay under multiple stress conditions (fasting, cold, and oxidative stress) using C. elegans Results Using C. elegans as an invertebrate animal model, we demonstrate that AzA treatment resulted in a significant extension of the survival under cold and oxidative stressed condition with no effects on the pumping rates, locomotive activities and growth rate. This was accompanied by a marked increase in expression of fatty acid desaturases genes, such as fat-1, fat-5 and fat-7, with a decrease in lipolysis related genes such as aak-2 and atgl-1. Moreover, the effect of AzA on the survival under cold condition was abolished in the fat-1, fat-5, fat-7 and aak-2 mutants. Conclusions Taken together, our results suggested that azelaic acid contributes to lifespan extension at low temperature in C. elegans through augmentation of unsaturated fatty acid synthesis. Funding Sources The Rural Development Administration of the Republic of Korea.

Evaluation of Topical Metronidazole Gel in Acne Rosacea

1987 ◽  
Vol 21 (4) ◽  
pp. 346-351 ◽  
Author(s):  
Iris K. Aronson ◽  
Jean A. Rumsfield ◽  
Dennis P. West ◽  
Julia Alexander ◽  
James H. Fischer ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Therapeutic Agent ◽  
Serum Levels ◽  
Double Blind ◽  
Inflammatory Lesions ◽  
Double Blind Placebo ◽  
Acne Rosacea ◽  
Topical Metronidazole ◽  
Split Face ◽  
Low Serum

Topical metronidazole gel (0.75%) was compared to placebo gel in a randomized, double-blind, placebo-controlled, split-face clinical trial for the treatment of 59 patients with acne rosacea. Statistically significant differences in inflammatory lesions, erythema, and global assessments were seen at three, six, and nine weeks post-baseline in favor of the active treatment side. It did not, however, alter the telangiectatic component of the disease. No known drug-related side effects were detected, and the low topical dose along with low serum levels of metronidazole indicate a high safety profile for this therapeutic agent. This work suggests that metronidazole gel, as specifically formulated, is safe and effective in reducing the symptomatology of acne rosacea.

A Review of Various Pharmacological Effects of Quercetin with its Barriers and Approaches for Solubility and Permeability Enhancement

2021 ◽  
Vol 11 ◽  
Author(s):  
Rakesh Mishra ◽  
Shweta Kulkarni
Keyword(s):  
Solid Dispersions ◽  
Aqueous Solubility ◽  
Pharmacological Effects ◽  
Pharmacological Activities ◽  
Human Diet ◽  
Permeability Enhancement ◽  
Current Review ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Novel Approaches

Background: Quercetin, one of the most beneficial flavonoids, has been included in the human diet due to its therapeutic effect on health. Recently, Quercetin is gaining scientific attraction for its multifarious activities, including anti-oxidant, anti-inflammatory, antiviral, anti-diabetic, anti-cancer, anti-arthritic, as well as function to ease some cardiovascular diseases. However, these applications of quercetin in the pharmaceutical field are limited due to its poor aqueous solubility and poor permeability. Objective: The present review summarizes various pharmacological activities of quercetin, analyses the barriers like solubility and permeability, which restrict the therapeutic efficiency of quercetin, and also discusses novel approaches to enhance aqueous solubility and permeability of quercetin for its effective clinical use. Methods: The current review information sources were peer-reviewed relevant scientific articles of recognized journals from scientific engines and databases (Scopus, Web of Science, PubMed, Science Direct, Google Scholar) using different key words related to quercetin pharmacological effects, mechanism, solubility, permeability, absorption barriers, and formulation approaches. Results: Various novel approaches, including solid dispersions, inclusion complex, pro-drugs, nanoemulsion, micelles, liposomes, SNEEDS, and microspheres, have been developed to overcome the solubility and permeability barriers for efficient quercetin delivery. Conclusion: This review revealed that the multifaceted pharmacological activities of quercetin for management of various disease are enormously dependent on the development of novel and safe drug delivery systems of quercetin.

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